CA2739250C - Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same - Google Patents
Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same Download PDFInfo
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- CA2739250C CA2739250C CA2739250A CA2739250A CA2739250C CA 2739250 C CA2739250 C CA 2739250C CA 2739250 A CA2739250 A CA 2739250A CA 2739250 A CA2739250 A CA 2739250A CA 2739250 C CA2739250 C CA 2739250C
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
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- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2993404A CA2993404C (en) | 2008-10-01 | 2009-09-30 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/242,988 | 2008-10-01 | ||
| US12/242,988 US8252804B2 (en) | 2008-10-01 | 2008-10-01 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same |
| PCT/US2009/058968 WO2010039792A1 (en) | 2008-10-01 | 2009-09-30 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2993404A Division CA2993404C (en) | 2008-10-01 | 2009-09-30 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2739250A1 CA2739250A1 (en) | 2010-04-08 |
| CA2739250C true CA2739250C (en) | 2018-03-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CA2739250A Expired - Fee Related CA2739250C (en) | 2008-10-01 | 2009-09-30 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same |
| CA2993404A Expired - Fee Related CA2993404C (en) | 2008-10-01 | 2009-09-30 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same |
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| US20110082158A1 (en) * | 2008-10-01 | 2011-04-07 | Aleem Gangjee | Selective proton coupled folate transporter and folate receptor, and garftase and/or other folate metabolizing enzymes inhibitor compounds and methods of using the same |
| US8252804B2 (en) | 2008-10-01 | 2012-08-28 | Duquesne University Of The Holy Spirit | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same |
| WO2016089670A1 (en) * | 2014-12-02 | 2016-06-09 | Eli Lilly And Company | 1 -oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonamide compounds, formulations containing those compounds, and their use as aicarft inhibitors in the treatment of cancers |
| US9481678B2 (en) * | 2015-02-09 | 2016-11-01 | Duquesne University Of The Holy Ghost | Substituted pyrrolo[2,3-D]dipyrimidines for selectively targeting tumor cells with FR-alpha and FR-beta type receptors |
| CN105111197B (zh) * | 2015-08-26 | 2021-05-04 | 上海鼎雅药物化学科技有限公司 | 雷替曲塞的合成方法 |
| WO2023086821A1 (en) * | 2021-11-11 | 2023-05-19 | Duquesne University Of The Holy Spirit | Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer |
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| US4496639A (en) | 1983-07-05 | 1985-01-29 | Ceramatec, Inc. | Hydrogen selenide treatment of electrolytes |
| AU6355190A (en) | 1989-06-13 | 1991-01-17 | Smithkline Beecham Corporation | Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages |
| JPH03173890A (ja) * | 1989-09-21 | 1991-07-29 | Takeda Chem Ind Ltd | ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体 |
| US5248775A (en) * | 1989-12-11 | 1993-09-28 | The Trustees Of Princeton University | Pyrrolo(2,3-d)pyrimidines |
| US4996206A (en) * | 1989-12-11 | 1991-02-26 | The Trustees Of Princeton University | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives |
| JPH04117381A (ja) | 1989-12-20 | 1992-04-17 | Takeda Chem Ind Ltd | 縮合複素環化合物，その製造法，用途及び中間体 |
| EP0438261A3 (en) | 1990-01-16 | 1992-02-26 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic glutamic acid derivatives, their production and use |
| JPH0578362A (ja) | 1990-01-16 | 1993-03-30 | Takeda Chem Ind Ltd | 縮合複素環化合物，その製造法，用途及び中間体 |
| US5939420A (en) | 1991-04-08 | 1999-08-17 | Duquesne University Of The Holy Ghost | Pyrrolo 2,3d!derivatives |
| JP3144903B2 (ja) | 1991-08-21 | 2001-03-12 | エーザイ株式会社 | 縮合ピリミジン誘導体 |
| ATE173251T1 (de) * | 1991-08-21 | 1998-11-15 | Eisai Co Ltd | Kondensierte pyrimidinderivate als antitumorverbindungen |
| JPH06172358A (ja) * | 1991-12-27 | 1994-06-21 | Takeda Chem Ind Ltd | 縮合ピリミジン誘導体、その製造法および用途 |
| EP0549291A1 (en) | 1991-12-27 | 1993-06-30 | Takeda Chemical Industries, Ltd. | Thymidylate synthase inhibitors |
| US5608082A (en) * | 1994-07-28 | 1997-03-04 | Agouron Pharmaceuticals, Inc. | Compounds useful as antiproliferative agents and GARFT inhibitors |
| IL119142A (en) | 1996-08-28 | 2002-03-10 | Yissum Res Dev Co | Slow release agrochemical composition |
| EP0923287A4 (en) | 1996-08-30 | 2001-08-01 | Lilly Co Eli | NON-CLASSIC PYRROLO (2,3-D) PYRIMIDINE ANTIFOLATE |
| WO2000013688A1 (en) | 1998-09-04 | 2000-03-16 | Agouron Pharmaceuticals, Inc. | Compounds useful as aicarft inhibitors |
| WO2003020719A1 (en) | 2001-09-03 | 2003-03-13 | Takeda Chemical Industries, Ltd. | 1,3-benzothiazinone derivatives and use thereof |
| WO2004012769A1 (en) | 2002-08-02 | 2004-02-12 | The Regents Of The University Of California | Therapeutic inhibitionof protein kinases in cancer cells |
| US20050165029A1 (en) | 2004-01-13 | 2005-07-28 | Ambit Biosciences Corporation | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases |
| US8030319B2 (en) | 2005-02-10 | 2011-10-04 | Duquesne University Of The Holy Ghost | Methods for treating cancer and other pathological proliferating disorders by inhibiting mitosis using pyrrolo[2 3-d]pyrimidines |
| US7981902B2 (en) * | 2006-06-28 | 2011-07-19 | Duquesne University Of The Holy Ghost | Substituted pyrrolo[2,3-d]pyrimidines for selectively targeting tumor cells with FR type receptors |
| US8258143B2 (en) * | 2006-06-28 | 2012-09-04 | Duquesne University Of The Holy Ghost | Methods of using substituted pyrrolo[2,3-d]pyrimidines for targeting tumor cells and treating cancer |
| WO2008027949A2 (en) | 2006-09-01 | 2008-03-06 | Duquesne University Of The Holy Spirit | Thieno pyrimidine compounds |
| CN101195625A (zh) * | 2007-12-06 | 2008-06-11 | 上海交通大学 | 用于抗肿瘤药物抗叶酸剂及其盐和中间体 |
| US8252804B2 (en) | 2008-10-01 | 2012-08-28 | Duquesne University Of The Holy Spirit | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same |
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2008
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2009
- 2009-09-30 CA CA2739250A patent/CA2739250C/en not_active Expired - Fee Related
- 2009-09-30 EP EP09818418.7A patent/EP2348843B1/en not_active Not-in-force
- 2009-09-30 EP EP15187759.4A patent/EP2995199B1/en not_active Not-in-force
- 2009-09-30 CA CA2993404A patent/CA2993404C/en not_active Expired - Fee Related
- 2009-09-30 JP JP2011530162A patent/JP2012504631A/ja not_active Withdrawn
- 2009-09-30 WO PCT/US2009/058968 patent/WO2010039792A1/en not_active Ceased
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2012
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2014
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2016
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2020
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2348843A1 (en) | 2011-08-03 |
| JP2012504631A (ja) | 2012-02-23 |
| US20170114066A1 (en) | 2017-04-27 |
| US10611767B2 (en) | 2020-04-07 |
| US10000498B2 (en) | 2018-06-19 |
| CA2993404C (en) | 2020-07-07 |
| US11053252B2 (en) | 2021-07-06 |
| EP2995199B1 (en) | 2018-03-14 |
| CA2739250A1 (en) | 2010-04-08 |
| EP2995199A1 (en) | 2016-03-16 |
| US20120295926A1 (en) | 2012-11-22 |
| US9511069B2 (en) | 2016-12-06 |
| CA2993404A1 (en) | 2010-04-08 |
| US20100081676A1 (en) | 2010-04-01 |
| US20200190097A1 (en) | 2020-06-18 |
| EP2348843A4 (en) | 2012-08-08 |
| JP2014224159A (ja) | 2014-12-04 |
| US20180346474A1 (en) | 2018-12-06 |
| WO2010039792A1 (en) | 2010-04-08 |
| EP2348843B1 (en) | 2015-11-11 |
| US8252804B2 (en) | 2012-08-28 |
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