CA2734790C - Systems for generating nitric oxide - Google Patents
Systems for generating nitric oxide Download PDFInfo
- Publication number
- CA2734790C CA2734790C CA2734790A CA2734790A CA2734790C CA 2734790 C CA2734790 C CA 2734790C CA 2734790 A CA2734790 A CA 2734790A CA 2734790 A CA2734790 A CA 2734790A CA 2734790 C CA2734790 C CA 2734790C
- Authority
- CA
- Canada
- Prior art keywords
- gas
- nitric oxide
- ventilator
- gas source
- nitrogen dioxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title claims abstract description 154
- 239000007789 gas Substances 0.000 claims abstract description 77
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims abstract description 62
- MGWGWNFMUOTEHG-UHFFFAOYSA-N 4-(3,5-dimethylphenyl)-1,3-thiazol-2-amine Chemical compound CC1=CC(C)=CC(C=2N=C(N)SC=2)=C1 MGWGWNFMUOTEHG-UHFFFAOYSA-N 0.000 claims abstract description 60
- 238000006243 chemical reaction Methods 0.000 claims abstract description 46
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 16
- 239000001301 oxygen Substances 0.000 claims abstract description 16
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000011159 matrix material Substances 0.000 claims description 24
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 20
- 239000007787 solid Substances 0.000 description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 15
- 239000000741 silica gel Substances 0.000 description 15
- 229910002027 silica gel Inorganic materials 0.000 description 15
- 235000010323 ascorbic acid Nutrition 0.000 description 9
- 239000011668 ascorbic acid Substances 0.000 description 9
- 229960005070 ascorbic acid Drugs 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 5
- 239000003963 antioxidant agent Substances 0.000 description 5
- 235000006708 antioxidants Nutrition 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 229920005992 thermoplastic resin Polymers 0.000 description 5
- 239000011149 active material Substances 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 208000002815 pulmonary hypertension Diseases 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 208000004248 Familial Primary Pulmonary Hypertension Diseases 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 208000010378 Pulmonary Embolism Diseases 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 230000008570 general process Effects 0.000 description 2
- 230000007954 hypoxia Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 238000009428 plumbing Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000012047 saturated solution Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000024883 vasodilation Effects 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 1
- 206010001029 Acute pulmonary oedema Diseases 0.000 description 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 206010003504 Aspiration Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 208000003241 Fat Embolism Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000034388 Mountain sickness acute Diseases 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 208000005279 Status Asthmaticus Diseases 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000007950 acidosis Effects 0.000 description 1
- 208000026545 acidosis disease Diseases 0.000 description 1
- 208000018315 acute mountain sickness Diseases 0.000 description 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 206010006475 bronchopulmonary dysplasia Diseases 0.000 description 1
- -1 but not limited to Substances 0.000 description 1
- 238000007675 cardiac surgery Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000010382 gamma-tocopherol Nutrition 0.000 description 1
- 239000011491 glass wool Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000009984 peri-natal effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 201000008312 primary pulmonary hypertension Diseases 0.000 description 1
- 229940048914 protamine Drugs 0.000 description 1
- 230000008695 pulmonary vasoconstriction Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0051—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes with alarm devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B21/00—Nitrogen; Compounds thereof
- C01B21/20—Nitrogen oxides; Oxyacids of nitrogen; Salts thereof
- C01B21/24—Nitric oxide (NO)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
- A61M16/16—Devices to humidify the respiration air
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
- A61M2016/102—Measuring a parameter of the content of the delivered gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0266—Nitrogen (N)
- A61M2202/0275—Nitric oxide [NO]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9061608P | 2008-08-21 | 2008-08-21 | |
| US61/090,616 | 2008-08-21 | ||
| US12/541,141 US8701657B2 (en) | 2008-08-21 | 2009-08-13 | Systems for generating nitric oxide |
| US12/541,141 | 2009-08-13 | ||
| PCT/US2009/053949 WO2010021944A1 (en) | 2008-08-21 | 2009-08-14 | Systems for generating nitric oxide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2734790A1 CA2734790A1 (en) | 2010-02-25 |
| CA2734790C true CA2734790C (en) | 2018-10-16 |
Family
ID=41695167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2734790A Expired - Fee Related CA2734790C (en) | 2008-08-21 | 2009-08-14 | Systems for generating nitric oxide |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8701657B2 (https=) |
| EP (1) | EP2326382B1 (https=) |
| JP (2) | JP5688851B2 (https=) |
| AU (1) | AU2009282988B2 (https=) |
| CA (1) | CA2734790C (https=) |
| WO (1) | WO2010021944A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7618594B2 (en) | 2004-08-18 | 2009-11-17 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| AU2005277397B2 (en) | 2004-08-18 | 2011-08-25 | VERO Biotech LLC. | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| CA2713049C (en) | 2008-01-28 | 2017-02-28 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| US8607785B2 (en) * | 2008-08-21 | 2013-12-17 | Geno Llc | Systems and devices for generating nitric oxide |
| EP2445508B1 (en) | 2009-06-22 | 2018-11-14 | VERO Biotech LLC | Nitric oxide therapies |
| CA2781295C (en) * | 2009-11-20 | 2018-02-13 | Geno Llc | Nitric oxide delivery system |
| CA2819854A1 (en) | 2010-12-03 | 2012-06-07 | Geno Llc | Nitric oxide treatments |
| EP2713723B1 (en) | 2011-05-27 | 2018-09-12 | Geno LLC | Method of determining vasoreactivity using inhaled nitric oxide |
| AU2012294959C1 (en) | 2011-08-10 | 2025-03-06 | Fisher & Paykel Healthcare Limited | Conduit connector for a patient breathing device |
| JP2016500550A (ja) * | 2012-11-05 | 2016-01-14 | ゲノ エルエルシー | 一酸化窒素を含むガスを混合する方法 |
| AU2013337269A1 (en) * | 2012-11-05 | 2015-05-21 | Geno Llc | Dual platform system for the delivery of nitric oxide |
| US10525226B2 (en) * | 2014-05-14 | 2020-01-07 | Mallinckrodt Hospital Products IP Limited | Systems and methods for indicating lifetime of an NO2-to-NO reactor cartridge used to deliver NO for inhalation therapy to a patient |
| WO2016064928A1 (en) * | 2014-10-20 | 2016-04-28 | Geno Llc | Nitrogen dioxide storage cassette |
| RU2597131C2 (ru) * | 2014-12-31 | 2016-09-10 | Евгений Владимирович Печёнкин | Способ и устройство для формирования высокоскоростного no-содержащего газового потока для воздействия на биологический объект |
| CN112891694B (zh) | 2015-03-31 | 2026-03-17 | 费雪派克医疗保健有限公司 | 用于在呼吸支持系统中使用的设备 |
| AU2016243801B2 (en) | 2015-04-02 | 2020-05-21 | Hill-Rom Services Pte. Ltd. | Manifold for respiratory device |
| CA2987046A1 (en) * | 2015-05-25 | 2016-12-01 | Geno Llc | Nitric oxide treatment system and method |
| CN108472468B (zh) | 2015-09-04 | 2024-03-08 | 费雪派克医疗保健有限公司 | 导管连接器 |
| USD809656S1 (en) | 2016-06-10 | 2018-02-06 | Fisher & Paykel Healthcare Limited | Connector for a breathing circuit |
| WO2018157175A1 (en) | 2017-02-27 | 2018-08-30 | Third Pole, Inc. | Systems and methods for ambulatory generation of nitric oxide |
| MX2020010523A (es) | 2017-02-27 | 2021-02-09 | Third Pole Inc | Sistemas y metodos para generar oxido nitrico. |
| BR112019016708B1 (pt) * | 2017-02-27 | 2024-01-30 | Third Pole, Inc | Sistemas de geração de óxido nítrico |
| US20190290868A1 (en) * | 2018-03-26 | 2019-09-26 | Jarom C. HEATON | Portable anesthesia apparatus and transportation cart |
| US11754538B1 (en) * | 2018-07-18 | 2023-09-12 | Vero Biotech Inc. | Method and apparatus for automatic calibration |
| US11672938B1 (en) | 2018-07-18 | 2023-06-13 | Vero Biotech LLC | Start-up protocols for nitric oxide delivery device |
| EP3969416A4 (en) | 2019-05-15 | 2023-11-01 | Third Pole, Inc. | SYSTEMS AND DEVICES FOR GENERATING NITROGEN OXIDE |
| CN114269685A (zh) | 2019-05-15 | 2022-04-01 | 第三极股份有限公司 | 用于一氧化氮生成的电极 |
| WO2020232414A1 (en) | 2019-05-15 | 2020-11-19 | Third Pole, Inc. | Architectures for production of nitric oxide |
| USD1006981S1 (en) | 2019-09-06 | 2023-12-05 | Fisher & Paykel Healthcare Limited | Breathing conduit |
| USD948027S1 (en) | 2019-09-10 | 2022-04-05 | Fisher & Paykel Healthcare Limited | Connector for a breathing conduit |
| EP4069069A4 (en) | 2020-01-11 | 2024-07-03 | Third Pole, Inc. | SYSTEMS AND METHODS FOR NITROGEN OXIDE PRODUCTION WITH HUMIDITY CONTROL |
| USD940861S1 (en) | 2020-03-03 | 2022-01-11 | Fisher & Paykel Healthcare Limited | Connector for a respiratory system conduit |
| EP4167920A4 (en) | 2020-06-18 | 2024-06-12 | Third Pole, Inc. | Systems and methods for preventing and treating infections with nitric oxide |
| WO2022082072A1 (en) | 2020-10-16 | 2022-04-21 | Third Pole, Inc. | Nitric oxide generation process controls |
| USD974551S1 (en) | 2020-12-09 | 2023-01-03 | Fisher & Paykel Healthcare Limited | Connector assembly and connector |
| USD1073919S1 (en) | 2021-05-17 | 2025-05-06 | Fisher & Paykel Healthcare Limited | Respiratory system conduit with connector |
| USD995758S1 (en) | 2021-06-11 | 2023-08-15 | Fisher & Paykel Healthcare Limited | Tube assembly and connector |
| EP4405019A4 (en) | 2021-09-23 | 2025-07-16 | Third Pole Inc | SYSTEMS AND METHODS FOR PROVIDING NITRIC OXIDE |
| WO2023201363A2 (en) | 2022-04-14 | 2023-10-19 | Third Pole, Inc. | Delivery of medicinal gas in a liquid medium |
| DE102023113214A1 (de) * | 2023-05-19 | 2024-11-21 | Egor Egorov | Hypoxie-Vorrichtung und Verfahren zur Durchführung eines Hypoxie-Trainings |
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| US3272336A (en) * | 1965-04-05 | 1966-09-13 | Wix Corp | Liquid purifier and cleaner |
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| US4374094A (en) * | 1981-10-29 | 1983-02-15 | Chevron Research Company | Method and apparatus for uniform flow through radial reactor centerpipes |
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| US7870857B2 (en) | 2005-05-23 | 2011-01-18 | Aeon Research And Technology, Inc. | Patient interface assemblies for use in ventilator systems to deliver medication to a patient |
| US8561611B2 (en) * | 2005-06-21 | 2013-10-22 | Ric Investments, Llc | Respiratory device measurement system |
| US20070181126A1 (en) * | 2006-02-08 | 2007-08-09 | Tolmie Craig R | Method and apparatus for ventilating a patient with a breathing gas mixture formed from nitric oxide, air, and oxygen |
| JP2007332849A (ja) * | 2006-06-14 | 2007-12-27 | Hino Motors Ltd | 排気浄化装置 |
| GB0703172D0 (en) * | 2007-02-19 | 2007-03-28 | Pa Knowledge Ltd | Printed circuit boards |
-
2009
- 2009-08-13 US US12/541,141 patent/US8701657B2/en not_active Expired - Fee Related
- 2009-08-14 JP JP2011523893A patent/JP5688851B2/ja not_active Expired - Fee Related
- 2009-08-14 EP EP09808649.9A patent/EP2326382B1/en not_active Not-in-force
- 2009-08-14 AU AU2009282988A patent/AU2009282988B2/en not_active Ceased
- 2009-08-14 WO PCT/US2009/053949 patent/WO2010021944A1/en not_active Ceased
- 2009-08-14 CA CA2734790A patent/CA2734790C/en not_active Expired - Fee Related
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2014
- 2014-01-31 US US14/169,968 patent/US20140144444A1/en not_active Abandoned
- 2014-07-25 JP JP2014151601A patent/JP5977786B2/ja not_active Expired - Fee Related
-
2019
- 2019-06-18 US US16/444,791 patent/US20200139071A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20100043789A1 (en) | 2010-02-25 |
| JP5688851B2 (ja) | 2015-03-25 |
| CA2734790A1 (en) | 2010-02-25 |
| WO2010021944A1 (en) | 2010-02-25 |
| JP5977786B2 (ja) | 2016-08-24 |
| US8701657B2 (en) | 2014-04-22 |
| US20200139071A1 (en) | 2020-05-07 |
| JP2014237013A (ja) | 2014-12-18 |
| US20140144444A1 (en) | 2014-05-29 |
| JP2012500093A (ja) | 2012-01-05 |
| EP2326382B1 (en) | 2018-11-28 |
| EP2326382A1 (en) | 2011-06-01 |
| EP2326382A4 (en) | 2014-03-05 |
| AU2009282988B2 (en) | 2015-02-05 |
| AU2009282988A1 (en) | 2010-02-25 |
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