CA2734397C - Oxadiazole derivatives for the treatment of diabetes - Google Patents
Oxadiazole derivatives for the treatment of diabetes Download PDFInfo
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- CA2734397C CA2734397C CA2734397A CA2734397A CA2734397C CA 2734397 C CA2734397 C CA 2734397C CA 2734397 A CA2734397 A CA 2734397A CA 2734397 A CA2734397 A CA 2734397A CA 2734397 C CA2734397 C CA 2734397C
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- compounds
- mixture
- treatment
- solvate
- pharmaceutically usable
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- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008038220A DE102008038220A1 (de) | 2008-08-18 | 2008-08-18 | Oxadiazolderivate |
| DE102008038220.5 | 2008-08-18 | ||
| PCT/EP2009/004992 WO2010020305A1 (de) | 2008-08-18 | 2009-07-09 | Oxadiazolderivate für die behandlung von diabetes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2734397A1 CA2734397A1 (en) | 2010-02-25 |
| CA2734397C true CA2734397C (en) | 2016-09-20 |
Family
ID=41010866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2734397A Expired - Fee Related CA2734397C (en) | 2008-08-18 | 2009-07-09 | Oxadiazole derivatives for the treatment of diabetes |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8377975B2 (enExample) |
| EP (1) | EP2313380B1 (enExample) |
| JP (1) | JP5571665B2 (enExample) |
| AU (1) | AU2009284453B2 (enExample) |
| CA (1) | CA2734397C (enExample) |
| DE (1) | DE102008038220A1 (enExample) |
| ES (1) | ES2444129T3 (enExample) |
| IL (1) | IL211267A (enExample) |
| WO (1) | WO2010020305A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2853722A1 (en) * | 2011-10-27 | 2013-05-02 | Mayo Foundation For Medical Education And Research | Inhibiting g protein coupled receptor 6 kinase polypeptides |
| DE102013226711A1 (de) * | 2013-12-19 | 2015-06-25 | Beiersdorf Ag | Verwendung von Alkylamidothiazolen in kosmetischen oder dermatologischen Zubereitungen zur Prophylaxe vor und Behandlung von sensibler Haut |
| US9902739B2 (en) | 2014-04-21 | 2018-02-27 | Mayo Foundation For Medical Education And Research | Small molecule inhibitors of G protein coupled receptor 6 kinases polypeptides |
| CN111511723A (zh) * | 2017-08-21 | 2020-08-07 | 米可如比奥提克斯有限公司 | 用作抗菌剂的代谢稳定的n-酰基氨基噁二唑 |
| US11447482B1 (en) | 2019-02-14 | 2022-09-20 | KUDA Therapeutics, Inc. | Imidazopyridine and oxazolopyridine derivatives and analogs thereof, methods of preparation thereof, methods of HIF-2A pathway inhibition, and induction of ferroptosis |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE35261C (de) | FIRMA CARL UHL & CO. in Braunschweig | Neuerung an Stimmschrauben | ||
| DD35261A1 (de) * | 1962-08-31 | 1965-02-15 | Verfahren zur Herstellung von 5-substituierten 2-Amino-1,3,4-oxdiazolen | |
| US3790588A (en) * | 1969-10-24 | 1974-02-05 | Gulf Research Development Co | Method of manufacturing dialkylamino-1,3,4-oxadiazoles and 1,3,4-thiadiazoles |
| NZ227841A (en) | 1988-02-12 | 1991-08-27 | Merck Sharp & Dohme | Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions |
| US5256680A (en) * | 1988-11-29 | 1993-10-26 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxy-phenyl-1,2,4-thiadazoles, oxadiazoles and triazoles as antiinflammatory agents |
| US5155122A (en) * | 1988-11-29 | 1992-10-13 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxy-phenyl-1,2,4-thiadazoles, oxadiazoles and triazoles as antiinflammatory agents |
| NZ231534A (en) | 1988-11-29 | 1992-02-25 | Warner Lambert Co | 3,5-di-t-butyl-4-hydroxyphenyl-triazoles, oxadiazoles and thiadiazoles; anti-inflammatory compositions |
| DE19917990A1 (de) | 1999-04-20 | 2000-11-02 | Florian Lang | Arzneimittel enthaltend Hemmstoffe der zellvolumenregulierten humanen Kinase h-sgk |
| DE10042137A1 (de) | 2000-08-28 | 2002-03-14 | Florian Lang | sgk2 und sgk3 als diagnostische und therapeutische Targets |
| WO2002072549A1 (en) | 2001-03-12 | 2002-09-19 | Millennium Pharmaceuticals, Inc. | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor |
| US20030108403A1 (en) | 2001-12-14 | 2003-06-12 | Scoyoc James E. Van | Fluid flow bolt system |
| AU2002353186A1 (en) | 2001-12-19 | 2003-06-30 | Smithkline Beecham P.L.C. | (1-h-indazol-3-yl) -amide derivatives as gsk-3 inhibitors |
| TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
| WO2003097610A1 (en) | 2002-05-17 | 2003-11-27 | Pharmacia Italia S.P.A. | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| AU2003293376A1 (en) | 2002-12-10 | 2004-06-30 | Imclone Systems Incorporated | Anti-angiogenic compounds and their use in cancer treatment |
| US20050019366A1 (en) | 2002-12-31 | 2005-01-27 | Zeldis Jerome B. | Drug-coated stents and methods of use therefor |
| WO2005000813A1 (en) | 2003-05-30 | 2005-01-06 | Imclone Systems Incorporated | Heteroarylamino-phenylketone derivatives and their use as kinase inhibitors |
| US20050090529A1 (en) | 2003-07-31 | 2005-04-28 | Pfizer Inc | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
| TW200524601A (en) | 2003-12-05 | 2005-08-01 | Bristol Myers Squibb Co | Heterocyclic anti-migraine agents |
| US20070071394A1 (en) | 2003-12-24 | 2007-03-29 | Faccio Daniele F A | Low loss microring resonator device |
| WO2005105788A1 (en) | 2004-04-23 | 2005-11-10 | Takeda San Diego, Inc. | Indole derivatives and use thereof as kinase inhibitors |
| EP1751133B1 (en) * | 2004-04-28 | 2010-04-14 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of rock and other protein kinases |
| NZ588896A (en) * | 2004-08-25 | 2012-05-25 | Targegen Inc | Heterocyclic compounds and methods of use |
| JP4931823B2 (ja) | 2004-10-18 | 2012-05-16 | アムジエン・インコーポレーテツド | チアジアゾール化合物及び使用方法 |
| BRPI0519058A2 (pt) | 2004-12-14 | 2008-12-23 | Astrazeneca Ab | composto ou um sal prà-droga farmaceuticamente aceitÁvel do mesmo, mÉtodos para produzir uma inibiÇço da atividade de dgat1 e para tratar diabete melito e/ou obesidade em um animal de sangue quente, uso de um composto, composiÇço farmacÊutica, e, processo para preparar um composto |
| WO2006064375A2 (en) | 2004-12-16 | 2006-06-22 | Ab Science | Aminoaryl substituted five-membered ring heterocyclic compounds for the treatment of diseases |
| US7728017B2 (en) | 2005-11-30 | 2010-06-01 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-Met and uses thereof |
| RS55630B1 (sr) | 2005-12-21 | 2017-06-30 | Janssen Pharmaceutica Nv | Triazolopiridazini kao modulatori tirozin kinaze |
| CA2651979A1 (en) | 2006-05-30 | 2007-12-06 | Pfizer Products Inc. | Triazolopyridazine derivatives |
| PE20121506A1 (es) | 2006-07-14 | 2012-11-26 | Amgen Inc | Compuestos triazolopiridinas como inhibidores de c-met |
| DE102006048728A1 (de) * | 2006-10-16 | 2008-04-17 | Merck Patent Gmbh | 3-Amino-imidazo{1,2-a]pyridinderivate |
| EA016527B1 (ru) | 2006-10-23 | 2012-05-30 | ЭсДжиЭкс ФАРМАСЬЮТИКАЛЗ, ИНК. | Триазолопиридазиновые модуляторы протеинкиназ |
| EP1939187A1 (en) | 2006-12-20 | 2008-07-02 | Sanofi-Aventis | Substituted heteroaryl pyridopyrimidone derivatives |
| DE102007002717A1 (de) | 2007-01-18 | 2008-07-24 | Merck Patent Gmbh | Heterocyclische Indazolderivate |
-
2008
- 2008-08-18 DE DE102008038220A patent/DE102008038220A1/de not_active Withdrawn
-
2009
- 2009-07-09 CA CA2734397A patent/CA2734397C/en not_active Expired - Fee Related
- 2009-07-09 US US13/059,079 patent/US8377975B2/en not_active Expired - Fee Related
- 2009-07-09 JP JP2011523312A patent/JP5571665B2/ja not_active Expired - Fee Related
- 2009-07-09 ES ES09777077.0T patent/ES2444129T3/es active Active
- 2009-07-09 WO PCT/EP2009/004992 patent/WO2010020305A1/de not_active Ceased
- 2009-07-09 AU AU2009284453A patent/AU2009284453B2/en not_active Ceased
- 2009-07-09 EP EP09777077.0A patent/EP2313380B1/de not_active Not-in-force
-
2011
- 2011-02-17 IL IL211267A patent/IL211267A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012500232A (ja) | 2012-01-05 |
| EP2313380A1 (de) | 2011-04-27 |
| US8377975B2 (en) | 2013-02-19 |
| AU2009284453B2 (en) | 2014-02-20 |
| WO2010020305A1 (de) | 2010-02-25 |
| IL211267A0 (en) | 2011-04-28 |
| EP2313380B1 (de) | 2013-12-11 |
| US20110139654A1 (en) | 2011-06-16 |
| AU2009284453A1 (en) | 2010-02-25 |
| ES2444129T3 (es) | 2014-02-24 |
| CA2734397A1 (en) | 2010-02-25 |
| IL211267A (en) | 2015-07-30 |
| JP5571665B2 (ja) | 2014-08-13 |
| DE102008038220A1 (de) | 2010-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140707 |
|
| MKLA | Lapsed |
Effective date: 20210709 |