CA2731067C - Compositions and methods for treating osteoarthritis - Google Patents

Compositions and methods for treating osteoarthritis Download PDF

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Publication number
CA2731067C
CA2731067C CA2731067A CA2731067A CA2731067C CA 2731067 C CA2731067 C CA 2731067C CA 2731067 A CA2731067 A CA 2731067A CA 2731067 A CA2731067 A CA 2731067A CA 2731067 C CA2731067 C CA 2731067C
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mrna
predicted
protein
similar
column
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CA2731067A
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English (en)
French (fr)
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CA2731067A1 (en
Inventor
Ryan Michael Yamka
Nolan Zebulon Frantz
Xiangming Gao
Samer Al Murrani
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Hills Pet Nutrition Inc
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Hills Pet Nutrition Inc
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/30—Oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2731067A 2008-07-18 2009-07-20 Compositions and methods for treating osteoarthritis Active CA2731067C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8218508P 2008-07-18 2008-07-18
US61/082,185 2008-07-18
PCT/US2009/051169 WO2010009474A1 (en) 2008-07-18 2009-07-20 Compositions and methods for treating osteoarthritis

Publications (2)

Publication Number Publication Date
CA2731067A1 CA2731067A1 (en) 2010-01-21
CA2731067C true CA2731067C (en) 2013-10-01

Family

ID=41059867

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2731067A Active CA2731067C (en) 2008-07-18 2009-07-20 Compositions and methods for treating osteoarthritis

Country Status (12)

Country Link
US (1) US9629382B2 (cg-RX-API-DMAC7.html)
EP (1) EP2323638B1 (cg-RX-API-DMAC7.html)
JP (2) JP2011528668A (cg-RX-API-DMAC7.html)
CN (1) CN102159197A (cg-RX-API-DMAC7.html)
AU (1) AU2009270718B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0915986A2 (cg-RX-API-DMAC7.html)
CA (1) CA2731067C (cg-RX-API-DMAC7.html)
DK (1) DK2323638T3 (cg-RX-API-DMAC7.html)
ES (1) ES2480193T3 (cg-RX-API-DMAC7.html)
RU (1) RU2619553C2 (cg-RX-API-DMAC7.html)
WO (1) WO2010009474A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201101055B (cg-RX-API-DMAC7.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2323638B1 (en) * 2008-07-18 2014-05-07 Hill's Pet Nutrition, Inc. Compositions and methods for treating osteoarthritis
US20110159500A1 (en) * 2009-12-29 2011-06-30 Hill's Pet Nutrition, Inc. Compositions including ginger for the amelioration or prevention of inflammatory conditions
CN102138961A (zh) * 2010-02-02 2011-08-03 北京绿色金可生物技术股份有限公司 黑豆皮提取物在预防和治疗骨关节炎的产品中的应用
JP2013528800A (ja) * 2010-05-12 2013-07-11 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド ネコの炎症を診断、抑制および予防し、炎症状態を緩和するための方法
CN102884434B (zh) 2010-05-12 2015-08-19 希尔氏宠物营养品公司 用于诊断、控制和预防犬科动物炎症及减轻犬科动物炎性病况的方法
JP2013532128A (ja) * 2010-05-12 2013-08-15 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド 愛玩動物の炎症を抑制および予防し、炎症状態を緩和する方法
EP2619319A2 (en) * 2010-09-20 2013-07-31 Progenika Biopharma, S.A. Markers for joint displasia, osteoarthritis and conditions secondary thereto
WO2012150504A1 (en) * 2011-05-05 2012-11-08 Life Science Nutrition As Performance enhancing compositions and methods of use
BR112014007947A2 (pt) 2011-10-03 2017-04-18 Univ Los Andes método para monitoramento, diagnóstico e/ou prognóstico de distúrbios relacionados à hipoxia usando nfat5
WO2013095935A1 (en) 2011-12-19 2013-06-27 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and treating hyperthyroidism in companion animals
US20140220006A1 (en) * 2013-02-01 2014-08-07 Meso Scale Technologies, Llc Lung cancer biomarkers
EP4306041A1 (en) * 2015-01-06 2024-01-17 David Burton Mobile wearable monitoring systems
US9943572B2 (en) * 2015-04-08 2018-04-17 Microvascular Health Solutions, LLC Synergistic glycocalyx treatment compositions and methods
CA3021343C (en) * 2016-04-20 2024-05-28 Crescendo Bioscience Biomarkers and methods for assessing response to inflammatory disease therapy
EP3564367A4 (en) * 2016-12-28 2020-08-12 Kyowa Kirin Co., Ltd. CELL SELECTION METHOD
JP7136807B2 (ja) 2017-04-17 2022-09-13 ザ・ユニバーシティ・オブ・シカゴ ヒトの健康及び疾患の治療用途向けの短鎖脂肪酸の腸への送達用ポリマー材料
CN107412240A (zh) * 2017-07-24 2017-12-01 冯纪敏 一种组合物及其应用
MX2020004739A (es) * 2017-11-17 2020-09-21 Hills Pet Nutrition Inc Composiciones que comprenden acidos grasos de cadena media y poliinsaturados omega-3.
JP7402225B2 (ja) 2018-05-11 2023-12-20 ロード アイランド ホスピタル ヌクレオシド系逆転写酵素阻害剤を用いて関節障害を処置するための組成物および方法
CN109266738A (zh) * 2018-11-19 2019-01-25 山西中医药大学 类风湿关节炎大鼠炎症因子检测引物及其方法
CN109680046B (zh) * 2019-01-17 2021-08-10 浙江大学 骨关节炎第一亚型的生物标记物以及用途
CN109965124A (zh) * 2019-03-29 2019-07-05 华熙生物科技股份有限公司 一种宠物食品及其制备方法
CN110511937B (zh) * 2019-08-05 2021-07-09 华南农业大学 Snf7基因及其防治瓢虫的应用
AU2019479043B2 (en) * 2019-12-16 2023-11-23 Hill's Pet Nutrition, Inc. Pet food compositions
US20240382518A1 (en) * 2021-09-17 2024-11-21 Seoul National University R&Db Foundation Pharmaceutical composition and health functional food for prevention or treatment of osteoarthritis

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0951909T4 (da) * 1998-03-19 2011-01-24 Sigma Tau Ind Farmaceuti Kombinationspræparat omfattende en L-carnitin eller en alkanoyl-L-carnitin, en glycosaminoglycan og/eller bestanddel deraf
US6506785B2 (en) * 1998-05-22 2003-01-14 Pfizer, Inc. Treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in mammals using carprofen and derivatives
CN1420769A (zh) * 1998-09-08 2003-05-28 孟山都公司 用可诱导的氧化氮合成酶的抑制剂治疗骨关节炎的方法
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6277842B1 (en) * 2000-10-17 2001-08-21 James Alexander Carthron Dietary supplemental method for fat and weight reduction
US20020099032A1 (en) * 2000-11-10 2002-07-25 Kiyotsugu Higashi Preparations and method of producing the same
US20060240037A1 (en) * 2003-06-04 2006-10-26 Edward Fey Methods and compositions for the treatment and prevention of degenerative joint disorders
DK1656130T3 (da) * 2003-08-11 2008-11-24 Hills Pet Nutrition Inc Omega-3-fedtsyrer til behandling af osteoarthritis hos hunde
US8633246B2 (en) 2003-08-11 2014-01-21 Hill's Pet Nutrition, Inc. Omega-3 fatty acids for osteoarthritis
US8633247B2 (en) 2003-08-11 2014-01-21 Hill's Pet Nutrition, Inc. Method for decreasing cartilage damage in dogs
US8377904B2 (en) * 2004-02-09 2013-02-19 Hill's Pet Nutrition, Inc. Composition and method for use in cartilage affecting conditions
CN1997425B (zh) * 2004-07-01 2010-10-13 雀巢技术公司 犬骨关节炎饮食配方
RU2433819C2 (ru) * 2004-11-09 2011-11-20 Хилл'С Пет Ньютришн, Инк. Применение антиоксидантов для модуляции генов
EP1896077B1 (en) * 2005-06-29 2012-08-15 Hill's Pet Nutrition, Inc. Methods and compositions for the prevention and treatment of inflammatory disease
WO2007079301A2 (en) * 2005-12-28 2007-07-12 Hill's Pet Nutrition, Inc. Method of diagnosing a body weight condition or predisposition in an animal
US8021659B2 (en) * 2006-04-28 2011-09-20 Naidu Lp Coenzyme Q10, lactoferrin and angiogenin compositions and uses thereof
EP2323638B1 (en) * 2008-07-18 2014-05-07 Hill's Pet Nutrition, Inc. Compositions and methods for treating osteoarthritis

Also Published As

Publication number Publication date
JP2011528668A (ja) 2011-11-24
AU2009270718A1 (en) 2010-01-21
RU2619553C2 (ru) 2017-05-16
US20110183006A1 (en) 2011-07-28
DK2323638T3 (da) 2014-08-11
EP2323638B1 (en) 2014-05-07
WO2010009474A1 (en) 2010-01-21
EP2323638A1 (en) 2011-05-25
JP6047128B2 (ja) 2016-12-21
CN102159197A (zh) 2011-08-17
ZA201101055B (en) 2014-07-30
RU2011106033A (ru) 2012-08-27
US9629382B2 (en) 2017-04-25
CA2731067A1 (en) 2010-01-21
JP2014237709A (ja) 2014-12-18
AU2009270718B2 (en) 2012-09-06
ES2480193T3 (es) 2014-07-25
BRPI0915986A2 (pt) 2015-11-03

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