CA2726050A1 - Achievement of high therapeutic index through molecular imaging guided targeted drug treatment - Google Patents

Achievement of high therapeutic index through molecular imaging guided targeted drug treatment Download PDF

Info

Publication number
CA2726050A1
CA2726050A1 CA2726050A CA2726050A CA2726050A1 CA 2726050 A1 CA2726050 A1 CA 2726050A1 CA 2726050 A CA2726050 A CA 2726050A CA 2726050 A CA2726050 A CA 2726050A CA 2726050 A1 CA2726050 A1 CA 2726050A1
Authority
CA
Canada
Prior art keywords
molecular imaging
achievement
drug treatment
therapeutic index
targeted drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2726050A
Other languages
English (en)
French (fr)
Inventor
Hartmuth C. Kolb
Joseph C. Walsh
Kai Chen
Dhanalakshmi Kasi
Umesh B. Gangadharmath
Peter J.H. Scott
Gang Chen
Vani P. Mocharla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Medical Solutions USA Inc
Original Assignee
Siemens Medical Solutions USA Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Medical Solutions USA Inc filed Critical Siemens Medical Solutions USA Inc
Publication of CA2726050A1 publication Critical patent/CA2726050A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CA2726050A 2008-05-30 2009-06-01 Achievement of high therapeutic index through molecular imaging guided targeted drug treatment Abandoned CA2726050A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5777408P 2008-05-30 2008-05-30
US61/057,774 2008-05-30
PCT/US2009/003309 WO2009148554A1 (en) 2008-05-30 2009-06-01 Achievement of high therapeutic index through molecular imaging guided targeted drug treatment

Publications (1)

Publication Number Publication Date
CA2726050A1 true CA2726050A1 (en) 2009-12-10

Family

ID=40904366

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2726050A Abandoned CA2726050A1 (en) 2008-05-30 2009-06-01 Achievement of high therapeutic index through molecular imaging guided targeted drug treatment

Country Status (6)

Country Link
US (1) US8293206B2 (cg-RX-API-DMAC7.html)
EP (1) EP2288388B1 (cg-RX-API-DMAC7.html)
JP (1) JP5681102B2 (cg-RX-API-DMAC7.html)
KR (1) KR20110020874A (cg-RX-API-DMAC7.html)
CA (1) CA2726050A1 (cg-RX-API-DMAC7.html)
WO (1) WO2009148554A1 (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012517447A (ja) 2009-02-10 2012-08-02 ザ スクリプス リサーチ インスティチュート 化学的にプログラムされたワクチン接種法
SI2890402T1 (sl) 2012-08-31 2019-07-31 Sutro Biopharma, Inc. Modificirane aminokisline vsebujoče acido skupino
UA118113C2 (uk) * 2013-12-16 2018-11-26 Дженентек, Інк. Пептидоміметичні сполуки та їх кон'югати антитіла з лікарським засобом
US10017577B2 (en) 2015-06-15 2018-07-10 Genentech, Inc. Antibodies and immunoconjugates
ES2907651T3 (es) * 2015-08-14 2022-04-25 Remegen Biosciences Inc Enlazadores covalentes en conjugados de anticuerpo-fármaco y métodos para obtener y usar los mismos

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769271A (en) * 1971-04-15 1973-10-30 Lilly Co Eli N-protected amino acids and peptides
US5188816A (en) 1984-10-18 1993-02-23 Board Of Regents, The University Of Texas System Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS
AU6621586A (en) 1985-11-18 1987-06-02 University Of Texas System, The Polychelating agents for image and spectral enhancement (and spectral shift)
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US5219553A (en) 1986-08-04 1993-06-15 Salutar, Inc. Composition of a n-carboxymethylated tetraazacyclododecane chelating agent, a paramagnetic metal and excess calcium ions for MRI
US5087440A (en) 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
US5262532A (en) 1991-07-22 1993-11-16 E.R. Squibb & Sons, Inc. Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging
US5358704A (en) 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
DE19728524A1 (de) 1997-07-04 1999-01-07 Merck Patent Gmbh Cyclische Azapeptide
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US20030125243A1 (en) 2000-07-20 2003-07-03 Jun Liu Synthesis of cyclic peptides
EP1796537A4 (en) * 2004-08-25 2012-03-07 Univ Michigan DENDRIMER BASED COMPOSITIONS AND METHOD FOR THEIR USE
CA2583389A1 (en) * 2004-10-07 2006-04-20 Emory University Multifunctional nanoparticles conjugates and their use
EP1733742A1 (en) 2005-06-17 2006-12-20 Universiteit Utrecht Holding B.V. Dendrimers multivalently substituted with active groups
EP1909846B1 (en) * 2005-08-05 2018-12-26 Syntarga B.V. Triazole-containing releasable linkers, conjugates comprising the same and processes for their preparation
US7666392B2 (en) 2006-09-15 2010-02-23 Siemens Medical Solutions Usa, Inc. Click chemistry-derived cyclopeptide derivatives as imaging agents for integrins
WO2008033557A2 (en) * 2006-09-15 2008-03-20 Siemens Medical Solutions Usa, Inc. Click chemistry-derived cyclic peptidomimetics as integrin markers
EP2182974B1 (en) 2007-07-27 2015-08-26 Siemens Medical Solutions USA, Inc. Cyclic azapeptides as integrin markers

Also Published As

Publication number Publication date
US8293206B2 (en) 2012-10-23
WO2009148554A1 (en) 2009-12-10
KR20110020874A (ko) 2011-03-03
EP2288388B1 (en) 2016-08-31
EP2288388A1 (en) 2011-03-02
JP5681102B2 (ja) 2015-03-04
US20100074910A1 (en) 2010-03-25
JP2011521947A (ja) 2011-07-28

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead

Effective date: 20140603