CA2723239C - Detecting genetic predisposition to osteoarthritis associated conditions - Google Patents
Detecting genetic predisposition to osteoarthritis associated conditions Download PDFInfo
- Publication number
- CA2723239C CA2723239C CA2723239A CA2723239A CA2723239C CA 2723239 C CA2723239 C CA 2723239C CA 2723239 A CA2723239 A CA 2723239A CA 2723239 A CA2723239 A CA 2723239A CA 2723239 C CA2723239 C CA 2723239C
- Authority
- CA
- Canada
- Prior art keywords
- subject
- allele
- il1rn
- osteoarthritis
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4999208P | 2008-05-02 | 2008-05-02 | |
| US61/049,992 | 2008-05-02 | ||
| US11874408P | 2008-12-01 | 2008-12-01 | |
| US61/118,744 | 2008-12-01 | ||
| PCT/US2009/042746 WO2009135218A2 (en) | 2008-05-02 | 2009-05-04 | Detecting genetic predisposition to osteoarthritis associated conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2723239A1 CA2723239A1 (en) | 2009-11-05 |
| CA2723239C true CA2723239C (en) | 2020-07-21 |
Family
ID=41210581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2723239A Active CA2723239C (en) | 2008-05-02 | 2009-05-04 | Detecting genetic predisposition to osteoarthritis associated conditions |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20100098775A1 (https=) |
| EP (3) | EP3059323B1 (https=) |
| JP (3) | JP5762282B2 (https=) |
| AU (1) | AU2009242490B2 (https=) |
| CA (1) | CA2723239C (https=) |
| DK (2) | DK3059323T3 (https=) |
| ES (2) | ES2561316T3 (https=) |
| NZ (1) | NZ589034A (https=) |
| WO (1) | WO2009135218A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5762282B2 (ja) * | 2008-05-02 | 2015-08-12 | インタールーキン ジェネティクス， インコーポレイテッド | 変形性関節症に関連する状態に対する遺伝的素因の検出 |
| US20120115137A1 (en) * | 2010-08-31 | 2012-05-10 | Kornman Kenneth S | Methods of Predicting Osteoarthritis |
| CN104736723B (zh) * | 2012-08-06 | 2017-10-31 | 默克专利有限公司 | 用于预测对fgf‑18化合物的响应性的遗传标记 |
| AU2013301607B2 (en) * | 2012-08-06 | 2018-10-18 | Merck Patent Gmbh | Prognosis biomarkers in cartilage disorders |
| WO2017123696A1 (en) | 2016-01-12 | 2017-07-20 | Interleukin Genetics, Inc. | Methods for predicting response to treatment |
| US10337070B2 (en) | 2017-01-12 | 2019-07-02 | Cardioforecast Ltd. | Methods and kits for treating cardiovascular disease |
| IL273613B2 (en) | 2017-09-29 | 2026-02-01 | Merck Patent Gmbh | Metabolic biomarkers for predicting response to FGF-18 compound |
| SI3688468T1 (sl) | 2017-09-29 | 2022-08-31 | Merck Patent Gmbh | Vnetni biomarkerji za predvidevanje odzivov na spojino FGF-18 |
| IL281333B2 (en) * | 2018-09-10 | 2025-11-01 | Merck Patent Gmbh | A method for reducing risk in a clinical trial |
| WO2020112853A1 (en) | 2018-11-28 | 2020-06-04 | Genascence Corporation | Methods and compositions for treating osteoarthritis |
| US20220249660A1 (en) | 2019-06-06 | 2022-08-11 | Sitokine Limited | Compositions and methods for treating lung, colorectal and breast cancer |
| EP4007819A4 (en) * | 2019-08-02 | 2023-08-09 | New York University | Methods and compositions for treating arthritis |
| WO2021028469A1 (en) | 2019-08-12 | 2021-02-18 | Sitokine Limited | Compositions and methods for treating cytokine release syndrome and neurotoxicity |
| WO2021205013A1 (en) | 2020-04-09 | 2021-10-14 | Sitokine Limited | Compositions and methods for treating covid-19 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8311018D0 (en) | 1983-04-22 | 1983-05-25 | Amersham Int Plc | Detecting mutations in dna |
| US4998617A (en) * | 1986-09-15 | 1991-03-12 | Laura Lupton Inc | Facial cosmetic liquid make up kit |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| US5459039A (en) | 1989-05-12 | 1995-10-17 | Duke University | Methods for mapping genetic mutations |
| FR2650840B1 (fr) | 1989-08-11 | 1991-11-29 | Bertin & Cie | Procede rapide de detection et/ou d'identification d'une seule base sur une sequence d'acide nucleique, et ses applications |
| US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
| DE69433811T2 (de) | 1993-01-07 | 2005-06-23 | Sequenom, Inc., San Diego | Dns - sequenzierung durch massenspektronomie |
| US5593826A (en) * | 1993-03-22 | 1997-01-14 | Perkin-Elmer Corporation, Applied Biosystems, Inc. | Enzymatic ligation of 3'amino-substituted oligonucleotides |
| US5686246A (en) * | 1995-08-03 | 1997-11-11 | Kornman; Kenneth S. | Detecting genetic predisposition to periodontal disease |
| US5942390A (en) | 1996-01-12 | 1999-08-24 | Cedars-Sinai Medical Center | Method of diagnosing predisposition for ulcerative colitis in Jewish population by detection of interleukin-1 receptor antagonist polymorphism |
| US5698399A (en) | 1996-04-05 | 1997-12-16 | Duff; Gordon W. | Detecting genetic predisposition for osteoporosis |
| GB9621129D0 (en) * | 1996-10-10 | 1996-11-27 | Duff Gordon W | Detecting genetic predisposition to sight-threatening diabetic retinopathy |
| GB9706359D0 (en) * | 1997-03-27 | 1997-05-14 | Gemini International Holdings | Polymorphisms of an il-1 receptor antagonist gene |
| GB9711040D0 (en) * | 1997-05-29 | 1997-07-23 | Duff Gordon W | Prediction of inflammatory disease |
| WO2003064600A2 (en) * | 2002-01-25 | 2003-08-07 | Interleukin Genetics, Inc. | The il-1 gene cluster and associated inflammatory polymorphisms and haplotypes |
| WO2005056837A2 (en) * | 2003-11-26 | 2005-06-23 | Applera Corporation | Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof |
| CA2631675A1 (en) * | 2005-11-30 | 2007-06-21 | The University Of North Carolina At Chapel Hill | Identification of genetic polymorphic variants associated with somatosensory disorders and methods of using the same |
| JP5762282B2 (ja) * | 2008-05-02 | 2015-08-12 | インタールーキン ジェネティクス， インコーポレイテッド | 変形性関節症に関連する状態に対する遺伝的素因の検出 |
| US9037472B2 (en) | 2012-04-20 | 2015-05-19 | Nuance Communications, Inc. | Method and system for facilitating communications for a user transaction |
-
2009
- 2009-05-04 JP JP2011507714A patent/JP5762282B2/ja active Active
- 2009-05-04 US US12/435,260 patent/US20100098775A1/en not_active Abandoned
- 2009-05-04 DK DK15193948.5T patent/DK3059323T3/en active
- 2009-05-04 EP EP15193948.5A patent/EP3059323B1/en not_active Not-in-force
- 2009-05-04 ES ES09740020.4T patent/ES2561316T3/es active Active
- 2009-05-04 EP EP18202413.3A patent/EP3467126A1/en not_active Withdrawn
- 2009-05-04 CA CA2723239A patent/CA2723239C/en active Active
- 2009-05-04 AU AU2009242490A patent/AU2009242490B2/en not_active Ceased
- 2009-05-04 DK DK09740020.4T patent/DK2283156T3/en active
- 2009-05-04 EP EP09740020.4A patent/EP2283156B1/en not_active Not-in-force
- 2009-05-04 NZ NZ589034A patent/NZ589034A/xx not_active IP Right Cessation
- 2009-05-04 ES ES15193948T patent/ES2708826T3/es active Active
- 2009-05-04 WO PCT/US2009/042746 patent/WO2009135218A2/en not_active Ceased
-
2015
- 2015-06-09 JP JP2015116397A patent/JP6263499B2/ja active Active
-
2016
- 2016-08-10 US US15/233,122 patent/US20160340734A1/en not_active Abandoned
-
2017
- 2017-12-18 JP JP2017241315A patent/JP2018038436A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP6263499B2 (ja) | 2018-01-17 |
| EP2283156B1 (en) | 2015-11-11 |
| WO2009135218A2 (en) | 2009-11-05 |
| JP5762282B2 (ja) | 2015-08-12 |
| JP2018038436A (ja) | 2018-03-15 |
| JP2011520433A (ja) | 2011-07-21 |
| US20100098775A1 (en) | 2010-04-22 |
| EP2283156A2 (en) | 2011-02-16 |
| ES2561316T3 (es) | 2016-02-25 |
| EP3059323B1 (en) | 2018-12-12 |
| ES2708826T3 (es) | 2019-04-11 |
| EP3059323A1 (en) | 2016-08-24 |
| DK2283156T3 (en) | 2016-02-15 |
| CA2723239A1 (en) | 2009-11-05 |
| JP2015211677A (ja) | 2015-11-26 |
| AU2009242490B2 (en) | 2015-01-22 |
| DK3059323T3 (en) | 2019-03-04 |
| US20160340734A1 (en) | 2016-11-24 |
| AU2009242490A1 (en) | 2009-11-05 |
| WO2009135218A3 (en) | 2010-04-01 |
| EP3467126A1 (en) | 2019-04-10 |
| NZ589034A (en) | 2012-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20140417 |
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| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 16TH ANNIV.) - STANDARD Year of fee payment: 16 |
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| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250505 |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250505 |