CA2721985C - Thiolated chitosan gel for treating mucosal tissue - Google Patents

Thiolated chitosan gel for treating mucosal tissue Download PDF

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Publication number
CA2721985C
CA2721985C CA2721985A CA2721985A CA2721985C CA 2721985 C CA2721985 C CA 2721985C CA 2721985 A CA2721985 A CA 2721985A CA 2721985 A CA2721985 A CA 2721985A CA 2721985 C CA2721985 C CA 2721985C
Authority
CA
Canada
Prior art keywords
fluid layer
thiolated chitosan
layer
minutes
chitosan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2721985A
Other languages
English (en)
French (fr)
Other versions
CA2721985A1 (en
Inventor
Maria Nieves Gonzalez
Edze Jan Tijsma
Nancy Schaffhausen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Inc
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40745190&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2721985(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medtronic Inc filed Critical Medtronic Inc
Publication of CA2721985A1 publication Critical patent/CA2721985A1/en
Application granted granted Critical
Publication of CA2721985C publication Critical patent/CA2721985C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2721985A 2008-04-24 2009-04-23 Thiolated chitosan gel for treating mucosal tissue Active CA2721985C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4759008P 2008-04-24 2008-04-24
US61/047,590 2008-04-24
US5503708P 2008-05-21 2008-05-21
US61/055,037 2008-05-21
PCT/US2009/041590 WO2009132226A1 (en) 2008-04-24 2009-04-23 Thiolated chitosan gel

Publications (2)

Publication Number Publication Date
CA2721985A1 CA2721985A1 (en) 2009-10-29
CA2721985C true CA2721985C (en) 2016-06-21

Family

ID=40745190

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2721985A Active CA2721985C (en) 2008-04-24 2009-04-23 Thiolated chitosan gel for treating mucosal tissue

Country Status (7)

Country Link
US (1) US20090269417A1 (cg-RX-API-DMAC10.html)
EP (1) EP2313104B2 (cg-RX-API-DMAC10.html)
JP (1) JP5711113B2 (cg-RX-API-DMAC10.html)
CN (1) CN102159220A (cg-RX-API-DMAC10.html)
AU (1) AU2009240511B2 (cg-RX-API-DMAC10.html)
CA (1) CA2721985C (cg-RX-API-DMAC10.html)
WO (1) WO2009132226A1 (cg-RX-API-DMAC10.html)

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CN102399295B (zh) * 2010-09-09 2013-11-06 常州百瑞吉生物医药有限公司 低巯基化改性度生物相容高分子巯基化衍生物及其交联材料和用途
US9486190B2 (en) 2011-10-28 2016-11-08 Medtronic Xomed, Inc. Spray delivery system
US10441959B2 (en) * 2011-10-28 2019-10-15 Medtronic Xomed, Inc. Multi-orifice spray head
US9987391B2 (en) 2013-03-13 2018-06-05 St. Jude Medical Coordination Center Bvba Injectable hydrogels
US9192692B2 (en) 2013-10-24 2015-11-24 Medtronic Xomed, Inc. Chitosan stenting paste
US9192574B2 (en) 2013-10-24 2015-11-24 Medtronic Xomed, Inc. Chitosan paste wound dressing
US9480828B2 (en) 2013-11-14 2016-11-01 Gyrus Acmi, Inc. Treatment method for the inferior turbinate
EP3139903B1 (en) 2014-05-07 2019-07-03 Croma-Pharma Gesellschaft m.b.H. Aqueous ophthalmic solution and method for treating dry eye syndrome
PL3368006T3 (pl) 2015-10-30 2020-06-01 Croma-Pharma Gesellschaft M.B.H. Zastosowanie terapeutyczne sterylnego wodnego roztworu oftalmicznego
CN108348455B (zh) 2015-10-30 2021-04-09 克罗马药品股份有限公司 无菌水性眼用溶液的治疗用途
CN107684550B (zh) * 2016-08-03 2020-04-10 徐天宏 糖尿病治疗产品及其制备与应用
CN107684551A (zh) * 2016-08-03 2018-02-13 徐天宏 糖尿病或肥胖疾病治疗产品及其制备与应用
WO2018202783A1 (en) 2017-05-03 2018-11-08 Croma-Pharma Gmbh Sterile aqueous ophthalmic solution containing n-(n-acetylcysteinyl)-chitosan for treating non-infectious corneal disorders
JP7339267B2 (ja) * 2017-11-07 2023-09-05 ロイヤル カレッジ オブ サージョンズ イン アイルランド 固形腫瘍癌の治療としての腫瘍内投与のための熱応答性ヒドロゲル
CN112334167A (zh) 2018-06-15 2021-02-05 克罗马药品有限责任公司 包含交联聚合物的水凝胶组合物
BR112020024654B1 (pt) 2018-06-15 2024-02-27 Croma-Pharma Gmbh Composição de hidrogel estéril, unidade de aplicação para injeção,seus usos, método cosmético, enchimento de tecido mole, e implante ou depósito
WO2021123247A1 (en) 2019-12-19 2021-06-24 Croma-Pharma Gmbh Thiol-modified hyaluronan and hydrogel comprising the crosslinked hyaluronan

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Also Published As

Publication number Publication date
EP2313104A1 (en) 2011-04-27
CN102159220A (zh) 2011-08-17
EP2313104B2 (en) 2020-08-26
CA2721985A1 (en) 2009-10-29
EP2313104B1 (en) 2017-11-01
AU2009240511B2 (en) 2015-01-22
US20090269417A1 (en) 2009-10-29
JP2011518619A (ja) 2011-06-30
JP5711113B2 (ja) 2015-04-30
AU2009240511A1 (en) 2009-10-29
WO2009132226A1 (en) 2009-10-29

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