CA2721938C - Chitosan-containing protective composition - Google Patents
Chitosan-containing protective composition Download PDFInfo
- Publication number
- CA2721938C CA2721938C CA2721938A CA2721938A CA2721938C CA 2721938 C CA2721938 C CA 2721938C CA 2721938 A CA2721938 A CA 2721938A CA 2721938 A CA2721938 A CA 2721938A CA 2721938 C CA2721938 C CA 2721938C
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- Prior art keywords
- polysaccharide
- chitosan
- composition
- derivative
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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| PCT/US2009/041592 WO2009132228A1 (en) | 2008-04-24 | 2009-04-23 | Chitosan-containing protective composition |
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| WO (1) | WO2009132228A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8932560B2 (en) | 2007-09-04 | 2015-01-13 | University of Maryland, College Parke | Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells |
| CN101848739A (zh) | 2007-08-28 | 2010-09-29 | T·阿萨纳夏季斯 | 手术用水凝胶 |
| US20110076332A1 (en) * | 2009-08-27 | 2011-03-31 | Xiaojun Yu | Dextran-chitosan based in-situ gelling hydrogels for biomedical applications |
| US8668899B2 (en) | 2009-11-13 | 2014-03-11 | University Of Maryland, College Park | Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds |
| US11407978B2 (en) * | 2010-10-25 | 2022-08-09 | Albert-Ludwigs-Universität Freiburg | Extracellular matrices which can be used as scaffold for living cells |
| CA2814148C (en) | 2010-10-27 | 2018-11-06 | Medtronic, Inc. | Artificial scab for use in an airway |
| US8398611B2 (en) * | 2010-12-28 | 2013-03-19 | Depuy Mitek, Inc. | Compositions and methods for treating joints |
| US8455436B2 (en) | 2010-12-28 | 2013-06-04 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| US8524662B2 (en) | 2010-12-28 | 2013-09-03 | Depuy Mitek, Llc | Compositions and methods for treating joints |
| US10500564B2 (en) | 2011-03-17 | 2019-12-10 | Perma-Fix Environmental Services, Inc. | Preparation of chitosan-based microporous composite material and its applications |
| US8623839B2 (en) | 2011-06-30 | 2014-01-07 | Depuy Mitek, Llc | Compositions and methods for stabilized polysaccharide formulations |
| US10441959B2 (en) | 2011-10-28 | 2019-10-15 | Medtronic Xomed, Inc. | Multi-orifice spray head |
| US8974436B2 (en) | 2011-10-28 | 2015-03-10 | Medtronic Xomed, Inc. | Multi-sectioned cannula with multiple lumens |
| US9486190B2 (en) * | 2011-10-28 | 2016-11-08 | Medtronic Xomed, Inc. | Spray delivery system |
| US20130105018A1 (en) | 2011-10-28 | 2013-05-02 | Medtronic Xomed, Inc. | Turbulence-inducing mixing device |
| CN109602944A (zh) * | 2011-11-13 | 2019-04-12 | 克里斯龙公司 | 原位可交联的聚合物组合物及其方法 |
| WO2014160136A1 (en) | 2013-03-13 | 2014-10-02 | University Of Maryland, Office Of Technology Commercialization | Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells |
| US9192692B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan stenting paste |
| US9192574B2 (en) | 2013-10-24 | 2015-11-24 | Medtronic Xomed, Inc. | Chitosan paste wound dressing |
| KR101664444B1 (ko) | 2013-12-13 | 2016-10-12 | 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 | 생분해성 의료용 접착제 또는 실란트 조성물 |
| ES2747808T3 (es) | 2014-05-07 | 2020-03-11 | Croma Pharma Ges M B H | Solución oftálmica acuosa y método para tratar el síndrome del ojo seco |
| KR102703232B1 (ko) * | 2014-05-29 | 2024-09-06 | 액세스클로저, 아이엔씨. | 키토산 및 폴리에틸렌 글리콜 공중합체 및 이를 사용하여 혈관 천공을 밀봉하기 위한 방법 및 디바이스 |
| AU2015349895B2 (en) * | 2014-11-19 | 2019-08-29 | Perma-Fix Environmental Services, Inc. | Preparation of chitosan-based microporous composite material and its applications |
| US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
| US10213521B2 (en) * | 2015-06-11 | 2019-02-26 | Medtronic Xomed, Inc. | Useful polysaccharide after radiation sterilization |
| WO2017072236A1 (en) | 2015-10-30 | 2017-05-04 | Croma-Pharma Gesellschaft M.B.H. | Therapeutic use of a sterile aqueous ophthalmic solution |
| CN108348457A (zh) | 2015-10-30 | 2018-07-31 | 克罗马药品股份有限公司 | 无菌水性眼用溶液的治疗用途 |
| US9655842B1 (en) * | 2015-12-04 | 2017-05-23 | Covidien Lp | Injectable non-aqueous compositions and methods of treating vascular disease |
| US20170157283A1 (en) | 2015-12-08 | 2017-06-08 | Medtronic Xomed, Inc. | Dissolvable nasal sinus sponge |
| RU2745077C2 (ru) | 2016-06-03 | 2021-03-19 | Конинклейке Филипс Н.В. | Введение веществ для ухода за полостью рта |
| US10576099B2 (en) | 2016-10-21 | 2020-03-03 | Covidien Lp | Injectable scaffold for treatment of intracranial aneurysms and related technology |
| CN106421875B (zh) * | 2016-11-15 | 2019-08-27 | 广州迈普再生医学科技股份有限公司 | 可降解吸收的止血纤维材料及其制备方法和止血纤维制品 |
| EP3618803A1 (en) | 2017-05-03 | 2020-03-11 | Croma-Pharma GmbH | Sterile aqueous ophthalmic solution containing n-(n-acetylcysteinyl)-chitosan for treating non-infectious corneal disorders |
| US12102729B2 (en) | 2017-08-04 | 2024-10-01 | Hcs Innovation, Llc | Natural polymer-based tissue adhesive with healing-promoting properties |
| US10835635B2 (en) | 2017-08-04 | 2020-11-17 | Hcs Innovation, Llc | Natural polymer based tissue adhesive with healing promoting properties |
| US11571492B2 (en) * | 2017-08-04 | 2023-02-07 | Hcs Innovation, Llc | Natural polymer-based tissue adhesive with healing-promoting properties |
| US10786596B2 (en) * | 2018-01-12 | 2020-09-29 | Boston Scientific Scimed, Inc. | Powder for achieving hemostasis |
| JP2021517593A (ja) * | 2018-03-14 | 2021-07-26 | マイコワークス， インコーポレイテッド | 真菌材料におけるキチンおよびキトサンの脱アセチル化および架橋ならびに調節可能な特性のためのそれらの複合材 |
| EP3801654B1 (en) * | 2018-05-31 | 2025-12-10 | Hcs Innovation Llc | Natural polymer-based tissue adhesive with healing-promoting properties |
| EP4054440B1 (en) | 2019-11-04 | 2024-06-05 | Covidien LP | Manufacturing method of devices for treatment of intracranial aneurysms |
| US12364793B2 (en) | 2021-03-16 | 2025-07-22 | Covidien Lp | Injectable biopolymer compositions and associated systems and methods |
Family Cites Families (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3122479A (en) * | 1957-11-14 | 1964-02-25 | David F Smith | Hemostatic surgical dressings |
| US3184385A (en) | 1961-10-16 | 1965-05-18 | Eastman Kodak Co | Dry, vitamin-active product and process for preparing same |
| US3914214A (en) | 1973-08-24 | 1975-10-21 | Us Agriculture | Thiolation of polysaccharides |
| US3989044A (en) | 1975-08-11 | 1976-11-02 | Warner-Lambert Company | Syringe |
| US4604384A (en) | 1982-06-24 | 1986-08-05 | Smith Robert A | Pharmaceutical gel composition |
| US4659700A (en) | 1984-03-02 | 1987-04-21 | Johnson & Johnson Products, Inc. | Chitosan-glycerol-water gel |
| US4895724A (en) | 1985-06-07 | 1990-01-23 | Pfizer Inc. | Chitosan compositions for controlled and prolonged release of macromolecules |
| US4960413A (en) | 1985-11-09 | 1990-10-02 | The Shirley Institute | Wound dressing |
| JPS62123112A (ja) | 1985-11-22 | 1987-06-04 | Sunstar Inc | 軟膏基剤 |
| US5346703A (en) | 1990-08-07 | 1994-09-13 | Mediventures, Inc. | Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels |
| GB9105995D0 (en) | 1991-03-21 | 1991-05-08 | Smith & Nephew | Wound dressing |
| US5318780A (en) | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| US5308546A (en) | 1991-12-09 | 1994-05-03 | Glow-Tec | Phosphorescent toy gel composition and methods of manufacture |
| US5550189A (en) | 1992-04-17 | 1996-08-27 | Kimberly-Clark Corporation | Modified polysaccharides having improved absorbent properties and process for the preparation thereof |
| US6197346B1 (en) | 1992-04-24 | 2001-03-06 | Brown Universtiy Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
| US5312324A (en) | 1992-09-15 | 1994-05-17 | Walthour Charles D | Nasal dressing system |
| GB2276819B (en) | 1993-03-23 | 1996-12-11 | Johnson & Johnson Medical | Aqueous wound treatment composition comprising a polysaccharide and hexylene glycol |
| US5709854A (en) | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
| US5744155A (en) | 1993-08-13 | 1998-04-28 | Friedman; Doron | Bioadhesive emulsion preparations for enhanced drug delivery |
| US5531716A (en) | 1993-09-29 | 1996-07-02 | Hercules Incorporated | Medical devices subject to triggered disintegration |
| US5622834A (en) | 1993-12-01 | 1997-04-22 | Marine Polymer Technologies, Inc. | Method of isolating poly-β-1-4-N-acetylglucosamine from microalgal culture |
| GB9416884D0 (en) | 1994-08-20 | 1994-10-12 | Danbiosyst Uk | Drug delivery compositions |
| GB9422571D0 (en) | 1994-11-09 | 1995-01-04 | Whitehall Lab Ltd | Haemorrihoidal compositions and method of use |
| CN1090022C (zh) | 1995-04-04 | 2002-09-04 | 俄克拉荷马创伤治疗所 | 通过光动力疗法与免疫佐剂联合应用治疗癌症 |
| US5679658A (en) | 1995-05-08 | 1997-10-21 | Chitogenics, Inc. | N,O-carbonxymethylchitosan for prevention of surgical adhesions |
| US6320029B1 (en) | 1996-11-29 | 2001-11-20 | The American National Red Cross | Methods of production and use of liquid formulations of plasma proteins |
| US6458889B1 (en) | 1995-12-18 | 2002-10-01 | Cohesion Technologies, Inc. | Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use |
| US5985312A (en) | 1996-01-26 | 1999-11-16 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers |
| IL118376A0 (en) | 1996-05-22 | 1996-09-12 | Univ Ben Gurion | Polysaccharide sponges for cell culture and transplantation |
| IN192791B (enExample) | 1996-06-28 | 2004-05-22 | Johnson & Johnson Medical | |
| US6706690B2 (en) | 1999-06-10 | 2004-03-16 | Baxter Healthcare Corporation | Hemoactive compositions and methods for their manufacture and use |
| US6545042B2 (en) | 1996-11-05 | 2003-04-08 | Gp Medical | Acellular biological material chemically treated with genipin |
| ATA7997A (de) | 1997-01-21 | 1998-03-15 | Bernkop Schnuerch Andreas | Verfahren zur herstellung von chitosan-ethylendiamintetraacetat konjugaten |
| US6224893B1 (en) | 1997-04-11 | 2001-05-01 | Massachusetts Institute Of Technology | Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering |
| US20050096282A1 (en) | 1997-04-21 | 2005-05-05 | Lewin Alfred S. | Adeno-associated virus-delivered ribozyme compositions and methods for the treatment of retinal diseases |
| US20030073663A1 (en) * | 1997-06-25 | 2003-04-17 | David M Wiseman | Bioabsorbable medical devices from oxidized polysaccharides |
| CA2212300A1 (en) | 1997-08-04 | 1999-02-04 | Abdellatif Chenite | In vitro or in vivo gelfying chitosan and therapeutic uses thereof |
| AU751182B2 (en) | 1997-12-02 | 2002-08-08 | Archimedes Development Limited | Compositions for nasal administration |
| US6514522B2 (en) | 1998-04-08 | 2003-02-04 | Chondros, Inc. | Polymer constructs |
| CA2341732C (en) | 1998-08-26 | 2008-08-19 | Teijin Limited | Powder composition for nasal administration |
| AT406054B (de) | 1998-11-04 | 2000-02-25 | Andreas Bernkop-Schnuerch | Verfahren zur verbesserung der mucoadhäsion von polymeren sowie deren herstellung und verwendung |
| EP1152013B1 (en) | 1998-11-10 | 2008-04-23 | Netech Inc. | Functional chitosan derivative |
| AU2707500A (en) | 1998-12-04 | 2000-06-26 | Incept Llc | Biocompatible crosslinked polymers |
| US6645947B1 (en) | 1999-05-20 | 2003-11-11 | Chitogenics, Inc. | Adhesive N, O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins |
| JP2003503367A (ja) | 1999-06-11 | 2003-01-28 | シアウォーター・コーポレイション | キトサンとポリ（エチレングリコール）または関連ポリマーから得られるヒドロゲル |
| AU782519B2 (en) | 1999-11-09 | 2005-08-04 | Denki Kagaku Kogyo Kabushiki Kaisha | Use of soluble cellulose derivative having been made hardly soluble in water and process for producing the same |
| BR0109162A (pt) | 2000-03-14 | 2005-01-11 | Alcon Inc | Viscoelásticos para uso na cirurgia do ouvido médio |
| US6719987B2 (en) | 2000-04-17 | 2004-04-13 | Nucryst Pharmaceuticals Corp. | Antimicrobial bioabsorbable materials |
| US6991652B2 (en) | 2000-06-13 | 2006-01-31 | Burg Karen J L | Tissue engineering composite |
| DE10035799A1 (de) * | 2000-07-22 | 2002-01-31 | Kalle Nalo Gmbh & Co Kg | Nach dem Aminoxidverfahren hergestellte Nahrungsmittelhüllen auf Cellulosebasis |
| US6989156B2 (en) | 2001-04-23 | 2006-01-24 | Nucryst Pharmaceuticals Corp. | Therapeutic treatments using the direct application of antimicrobial metal compositions |
| GB0018527D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Composition |
| US6417347B1 (en) | 2000-08-24 | 2002-07-09 | Scimed Life Systems, Inc. | High yield S-nitrosylation process |
| IT1317358B1 (it) | 2000-08-31 | 2003-06-16 | Fidia Advanced Biopolymers Srl | Derivati cross-linkati dell'acido ialuronico. |
| US6989373B2 (en) | 2000-11-15 | 2006-01-24 | Bio Syntech Canada Inc. | Method for restoring a fat-pad |
| AU2001298061A1 (en) | 2000-12-13 | 2003-07-09 | Purdue Research Foundation | Microencapsulation of drugs by solvent exchange |
| JP3611534B2 (ja) * | 2001-04-26 | 2005-01-19 | 株式会社エス・エヌ・シー | 高分子包接性化合物からなる有害物質除去のための繊維およびその製造方法ならびに使用 |
| US20020193812A1 (en) | 2001-05-04 | 2002-12-19 | Concentric Medical | Hydrogel vaso-occlusive device |
| US20060004314A1 (en) | 2001-06-14 | 2006-01-05 | Hemcon, Inc. | Antimicrobial barriers, systems, and methods formed from hydrophilic polymer structures such as chistosan |
| ATA13842001A (de) | 2001-08-31 | 2002-10-15 | Mucobiomer Biotechnologische F | Chitosan-thio-alkyl-amidin konjugate und deren kosmetische sowie pharmazeutische verwendung |
| DE10152407A1 (de) * | 2001-10-24 | 2003-05-08 | Aesculap Ag & Co Kg | Zusammensetzung aus mindestens zwei biokompatiblen chemisch vernetzbaren Komponenten |
| WO2003042250A1 (en) * | 2001-11-15 | 2003-05-22 | Biosyntech Canada Inc. | Composition and method to homogeneously modify or cross-link chitosan under neutral conditions |
| US20030187381A1 (en) | 2001-12-28 | 2003-10-02 | Genzyme Corporation | Bioresorbable foam packing device and use thereof |
| US6664301B1 (en) | 2002-02-20 | 2003-12-16 | Robert D. Kross | Method for using glycol additives to texturally modify natural gum hydrogels |
| GB2386900B (en) | 2002-03-25 | 2006-11-01 | Johnson & Johnson Medical Ltd | Use in wound dressings of chemically modified polysaccharides |
| AU2003227447A1 (en) | 2002-04-23 | 2003-11-10 | Netech Inc. | Medicinal compositions containing photocrosslinkable chitosan derivative |
| US20050176620A1 (en) | 2002-06-21 | 2005-08-11 | Prestwich Glenn D. | Crosslinked compounds and methods of making and using thereof |
| US20050019404A1 (en) | 2003-06-30 | 2005-01-27 | Hsing-Wen Sung | Drug-eluting biodegradable stent |
| US7070582B2 (en) | 2002-08-09 | 2006-07-04 | Boston Scientific Scimed, Inc. | Injection devices that provide reduced outflow of therapeutic agents and methods of delivering therapeutic agents |
| GB2393120A (en) * | 2002-09-18 | 2004-03-24 | Johnson & Johnson Medical Ltd | Compositions for wound treatment |
| US8673333B2 (en) | 2002-09-25 | 2014-03-18 | The Johns Hopkins University | Cross-linked polymer matrices, and methods of making and using same |
| US7862831B2 (en) | 2002-10-09 | 2011-01-04 | Synthasome, Inc. | Method and material for enhanced tissue-biomaterial integration |
| JP5102435B2 (ja) | 2002-10-08 | 2012-12-19 | 株式会社リコム | キトサン含有多糖、その製造方法及び用途 |
| US20050069572A1 (en) | 2002-10-09 | 2005-03-31 | Jennifer Elisseeff | Multi-layered polymerizing hydrogels for tissue regeneration |
| US7229966B2 (en) | 2002-12-17 | 2007-06-12 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity |
| TWI251596B (en) | 2002-12-31 | 2006-03-21 | Ind Tech Res Inst | Method for producing a double-crosslinked hyaluronate material |
| DE10318802A1 (de) | 2003-04-17 | 2004-11-04 | Aesculap Ag & Co. Kg | Selbsthaftendes resorbierbares Hämostyptikum |
| US7384557B2 (en) * | 2003-07-14 | 2008-06-10 | Applied Ambient Extraction Process Consultants, Llc | Method and apparatus for removing solute from a solid solute-bearing product |
| US7901707B2 (en) | 2004-03-15 | 2011-03-08 | Christine Allen | Biodegradable biocompatible implant and method of manufacturing same |
| US7740883B2 (en) * | 2004-03-28 | 2010-06-22 | University Of Debrecen | Nanoparticles from chitosan |
| WO2006008270A1 (de) | 2004-07-22 | 2006-01-26 | Thiomatrix Forschungs- Und Beratungs Gmbh | Verwendung von thiolgruppen-hältigen verbindungen als efflux-pumpen-hemmer |
| US7282194B2 (en) | 2004-10-05 | 2007-10-16 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| US8703659B2 (en) * | 2005-01-24 | 2014-04-22 | Halliburton Energy Services, Inc. | Sealant composition comprising a gel system and a reduced amount of cement for a permeable zone downhole |
| US7834065B2 (en) | 2005-01-31 | 2010-11-16 | Bmg Incorporated | Medical-use two part reactive adhesive and medical-use resin having self-degradation property |
| US8679484B2 (en) | 2005-03-02 | 2014-03-25 | Polyrizon Ltd. | Method for removal of toxins from mucosal membranes |
| CN101137359B (zh) | 2005-03-10 | 2011-01-12 | 3M创新有限公司 | 治疗耳感染的方法 |
| EP1880738A1 (en) | 2005-05-13 | 2008-01-23 | Netech Inc. | Medical composition for promotion of skin regeneration |
| DE102005030011A1 (de) | 2005-06-17 | 2006-12-21 | Aesculap Ag & Co. Kg | Verfahren zur Herstellung von sterilen Polysaccharidlösungen |
| US20070031467A1 (en) | 2005-08-04 | 2007-02-08 | Abrahams John M | Composition and method for vascular embolization |
| FR2889449B1 (fr) * | 2005-08-05 | 2011-06-10 | Khorionyx | Preparations implantables |
| US20070087059A1 (en) | 2005-10-17 | 2007-04-19 | Frank Everaerts | Bioactive delivery matrix compositions and methods |
| US20070110788A1 (en) | 2005-11-14 | 2007-05-17 | Hissong James B | Injectable formulation capable of forming a drug-releasing device |
| WO2007084725A2 (en) | 2006-01-19 | 2007-07-26 | Osteotech, Inc. | Injectable and moldable bone substitute materials |
| FR2897775B1 (fr) | 2006-02-24 | 2013-05-03 | Elisabeth Laugier | Biomateriau, implant injectable le comprenant, son procede de preparation et ses utilisations |
| WO2007120818A2 (en) * | 2006-04-12 | 2007-10-25 | Massachusetts Institute Of Technology | Compositions and methods for inhibiting adhesions |
| US20080075657A1 (en) * | 2006-04-18 | 2008-03-27 | Abrahams John M | Biopolymer system for tissue sealing |
| US20070243130A1 (en) | 2006-04-18 | 2007-10-18 | Weiliam Chen | Biopolymer system for tissue sealing |
| US20090010982A1 (en) | 2006-04-18 | 2009-01-08 | Endomedix, Inc. | Biocompatible adherent sheet for tissue sealing |
| US7854923B2 (en) | 2006-04-18 | 2010-12-21 | Endomedix, Inc. | Biopolymer system for tissue sealing |
| US7959943B2 (en) | 2006-05-10 | 2011-06-14 | Medtronics Xomed, Inc. | Solvating system and sealant for medical use in the middle or inner ear |
| CN100348272C (zh) | 2006-06-23 | 2007-11-14 | 华南理工大学 | 可溶性纤维素止血海绵的制备方法 |
| US8313762B2 (en) | 2006-07-05 | 2012-11-20 | Medtronic Xomed, Inc. | Flexible bioresorbable hemostatic packing and stent |
| WO2008008857A2 (en) | 2006-07-11 | 2008-01-17 | University Of Utah Research Foundation | Thiolated macromolecules and methods of making and using thereof |
| WO2008067655A1 (en) | 2006-12-05 | 2008-06-12 | Q6 Biomaterials Inc. | Biocompatible hydrogel-based scaffolds |
| JP2008247975A (ja) | 2007-03-29 | 2008-10-16 | Daicel Chem Ind Ltd | 架橋ゲルおよびそれを用いた吸収体 |
| JP2008285611A (ja) | 2007-05-18 | 2008-11-27 | Daicel Chem Ind Ltd | 架橋ゲルの製造方法及びその架橋ゲル |
| JP2009040697A (ja) | 2007-08-07 | 2009-02-26 | Asuka Corporation:Kk | 化粧料組成物 |
| US20090062233A1 (en) | 2007-08-09 | 2009-03-05 | Xin Ji | Modified starch material of biocompatible hemostasis |
| CN101848739A (zh) | 2007-08-28 | 2010-09-29 | T·阿萨纳夏季斯 | 手术用水凝胶 |
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| CN102883715A (zh) | 2013-01-16 |
| AU2009240513A1 (en) | 2009-10-29 |
| JP2011518839A (ja) | 2011-06-30 |
| US8530632B2 (en) | 2013-09-10 |
| CN102883715B (zh) | 2014-11-12 |
| AU2009240513B2 (en) | 2015-03-26 |
| CA2721938A1 (en) | 2009-10-29 |
| WO2009132228A1 (en) | 2009-10-29 |
| EP2296637B1 (en) | 2014-04-02 |
| EP2296637A1 (en) | 2011-03-23 |
| JP5757861B2 (ja) | 2015-08-05 |
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