CA2720982A1 - Method of treating brain cancer - Google Patents
Method of treating brain cancer Download PDFInfo
- Publication number
- CA2720982A1 CA2720982A1 CA2720982A CA2720982A CA2720982A1 CA 2720982 A1 CA2720982 A1 CA 2720982A1 CA 2720982 A CA2720982 A CA 2720982A CA 2720982 A CA2720982 A CA 2720982A CA 2720982 A1 CA2720982 A1 CA 2720982A1
- Authority
- CA
- Canada
- Prior art keywords
- methyl
- methoxy
- quinazolin
- phenyl
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000003174 Brain Neoplasms Diseases 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title description 18
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- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims description 25
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
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- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US60/910,975 | 2007-04-10 | ||
| PCT/US2008/059905 WO2008124822A1 (en) | 2007-04-10 | 2008-04-10 | Method of treating brain cancer |
Publications (1)
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|---|---|
| CA2720982A1 true CA2720982A1 (en) | 2008-10-16 |
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| CA2720982A Abandoned CA2720982A1 (en) | 2007-04-10 | 2008-04-10 | Method of treating brain cancer |
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| US (1) | US20100129470A1 (enExample) |
| EP (1) | EP2144504A4 (enExample) |
| JP (1) | JP2010523696A (enExample) |
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| CA (1) | CA2720982A1 (enExample) |
| NZ (1) | NZ580866A (enExample) |
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| CN101198312A (zh) * | 2005-06-16 | 2008-06-11 | 美瑞德生物工程公司 | 药物组合物及其用途 |
| CA2720983A1 (en) * | 2007-04-10 | 2008-10-16 | Myrexis, Inc. | Method of treating melanoma |
| NZ580868A (en) * | 2007-04-10 | 2011-07-29 | Myriad Pharmaceuticals Inc | Dosages and methods for the treatment of cancer |
| NZ580869A (en) * | 2007-04-10 | 2011-02-25 | Myriad Pharmaceuticals Inc | Methods for treating cancer |
| WO2008124828A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Methods for treating vascular disruption disorders |
| JP2011527693A (ja) * | 2008-07-11 | 2011-11-04 | ミレクシス， インコーポレイテッド | 細胞傷害性薬剤としての薬学的化合物およびそれの使用 |
| US20110224240A1 (en) * | 2010-01-11 | 2011-09-15 | Myrexis, Inc. | Methods of treating cancer and related diseases |
| KR101343959B1 (ko) | 2012-09-19 | 2013-12-24 | 한국기계연구원 | 통합 코팅 장치 |
| US10278981B2 (en) * | 2013-06-05 | 2019-05-07 | Cytrx Corporation | Cytotoxic agents for the treatment of cancer |
| CN105288629B (zh) * | 2014-05-28 | 2021-02-19 | 北京大学 | 具有药效叠加作用及毒性分散效应的组合药物 |
| WO2016168637A2 (en) * | 2015-04-17 | 2016-10-20 | Duquesne University Of The Holy Spirit | Cyclopenta[d]pyrimidines and substituted cyclopenta[d]pyrimidines as antitubulin and microtubule targeting agents, monocyclic pyrimidines as tubulin inhibitors, and pyrrolopyrimidines as targeted antifolates and tubulin and multiple receptor tyrosine kinase inhibition and antitumor agents |
| ES2965807T3 (es) * | 2018-05-02 | 2024-04-16 | Tel Hashomer Medical Res Infrastructure & Services Ltd | Combinación de temozolomida y un conjugado de PAR-1 para tratar el glioblastoma |
| KR102894505B1 (ko) * | 2018-07-31 | 2025-12-02 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트 투여에 의한 전이성 뇌종양의 치료 |
| CN111825610B (zh) * | 2020-06-24 | 2023-03-31 | 中国药科大学 | 一种具有抗肿瘤活性的2-甲基喹啉类衍生物及其合成方法和用途 |
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| JP2002516823A (ja) * | 1998-05-28 | 2002-06-11 | パーカー ヒューズ インスティテュート | 脳腫瘍の治療のためのキナゾリン |
| US7001926B2 (en) * | 2000-03-10 | 2006-02-21 | Oxigene, Inc. | Tubulin binding agents and corresponding prodrug constructs |
| US20040229960A1 (en) * | 2001-07-13 | 2004-11-18 | David Sherris | Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases |
| MXPA04002621A (es) * | 2001-09-21 | 2004-07-08 | Univ Tulane | Conjugados de analogos de somatostatina o bombesina para diagnostico o terapeuticos y usos de los mismos. |
| US7470723B2 (en) * | 2003-03-05 | 2008-12-30 | Celgene Corporation | Diphenylethylene compounds and uses thereof |
| CN1984660B (zh) * | 2003-07-03 | 2010-12-15 | 美瑞德生物工程公司 | 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉 |
| JP2007502807A (ja) * | 2003-08-18 | 2007-02-15 | ファイザー・プロダクツ・インク | Ｅｒｂｂ２抗がん剤の投与スケジュール |
| GB0321648D0 (en) * | 2003-09-16 | 2003-10-15 | Astrazeneca Ab | Quinazoline derivatives |
| US8258145B2 (en) * | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| AU2006204052A1 (en) * | 2005-01-03 | 2006-07-13 | Cytovia, Inc. | Method of treating brain cancer |
| ES2678448T3 (es) * | 2005-02-18 | 2018-08-10 | Abraxis Bioscience, Llc | Combinaciones y modos de administración de agentes terapéuticos y terapia combinada |
| CN101198312A (zh) * | 2005-06-16 | 2008-06-11 | 美瑞德生物工程公司 | 药物组合物及其用途 |
| US20070249640A1 (en) * | 2005-06-16 | 2007-10-25 | Myriad Genetics, Incorporated | Pharmaceutical compositions and use thereof |
| US20070065449A1 (en) * | 2005-09-16 | 2007-03-22 | Claire Verschraegen | Method of treating cancer, especially soft tissue sarcoma utilizing gemcitabine in combination with docetaxel and anti-VEGF therapy (bevacizumab) |
| WO2008124828A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Methods for treating vascular disruption disorders |
| NZ580868A (en) * | 2007-04-10 | 2011-07-29 | Myriad Pharmaceuticals Inc | Dosages and methods for the treatment of cancer |
| NZ580869A (en) * | 2007-04-10 | 2011-02-25 | Myriad Pharmaceuticals Inc | Methods for treating cancer |
| CA2720983A1 (en) * | 2007-04-10 | 2008-10-16 | Myrexis, Inc. | Method of treating melanoma |
| WO2009023876A1 (en) * | 2007-08-16 | 2009-02-19 | Myriad Genetics, Inc. | Method of treating non-small cell lung cancer |
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2008
- 2008-04-10 AU AU2008236993A patent/AU2008236993A1/en not_active Abandoned
- 2008-04-10 CA CA2720982A patent/CA2720982A1/en not_active Abandoned
- 2008-04-10 JP JP2010503205A patent/JP2010523696A/ja active Pending
- 2008-04-10 NZ NZ580866A patent/NZ580866A/en not_active IP Right Cessation
- 2008-04-10 CN CN200880019674A patent/CN101742910A/zh active Pending
- 2008-04-10 WO PCT/US2008/059905 patent/WO2008124822A1/en not_active Ceased
- 2008-04-10 KR KR1020097023414A patent/KR20100016385A/ko not_active Ceased
- 2008-04-10 EP EP08745503A patent/EP2144504A4/en not_active Withdrawn
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2009
- 2009-10-08 US US12/575,922 patent/US20100129470A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101742910A (zh) | 2010-06-16 |
| EP2144504A4 (en) | 2012-10-03 |
| US20100129470A1 (en) | 2010-05-27 |
| AU2008236993A1 (en) | 2008-10-16 |
| JP2010523696A (ja) | 2010-07-15 |
| WO2008124822A1 (en) | 2008-10-16 |
| KR20100016385A (ko) | 2010-02-12 |
| EP2144504A1 (en) | 2010-01-20 |
| NZ580866A (en) | 2011-02-25 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20140410 |