AU2008236993A1 - Method of treating brain cancer - Google Patents
Method of treating brain cancer Download PDFInfo
- Publication number
- AU2008236993A1 AU2008236993A1 AU2008236993A AU2008236993A AU2008236993A1 AU 2008236993 A1 AU2008236993 A1 AU 2008236993A1 AU 2008236993 A AU2008236993 A AU 2008236993A AU 2008236993 A AU2008236993 A AU 2008236993A AU 2008236993 A1 AU2008236993 A1 AU 2008236993A1
- Authority
- AU
- Australia
- Prior art keywords
- methyl
- administered
- methoxy
- quinazolin
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000003174 Brain Neoplasms Diseases 0.000 title claims description 24
- 238000000034 method Methods 0.000 title description 18
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- 206010028980 Neoplasm Diseases 0.000 claims description 45
- 150000001875 compounds Chemical class 0.000 claims description 24
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims description 23
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US60/910,975 | 2007-04-10 | ||
| PCT/US2008/059905 WO2008124822A1 (en) | 2007-04-10 | 2008-04-10 | Method of treating brain cancer |
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| AU2008236993A1 true AU2008236993A1 (en) | 2008-10-16 |
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| EP (1) | EP2144504A4 (enExample) |
| JP (1) | JP2010523696A (enExample) |
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| NZ (1) | NZ580866A (enExample) |
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| JP5235662B2 (ja) * | 2005-06-16 | 2013-07-10 | ミリアド ジェネティクス， インコーポレイテッド | 薬学的組成物およびその使用 |
| WO2008124828A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Methods for treating vascular disruption disorders |
| EP2144886A4 (en) * | 2007-04-10 | 2012-10-03 | Myrexis Inc | METHOD OF TREATING MELANOMA |
| AU2008236997A1 (en) * | 2007-04-10 | 2008-10-16 | Myrexis, Inc. | Methods for treating cancer |
| WO2008124824A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Dosages and methods for the treatment of cancer |
| EP2309856A4 (en) * | 2008-07-11 | 2012-03-28 | Myrexis Inc | PHARMACEUTICAL COMPOUNDS AS CYTOTOXICA AND ITS APPLICATION |
| US20110224240A1 (en) * | 2010-01-11 | 2011-09-15 | Myrexis, Inc. | Methods of treating cancer and related diseases |
| KR101343959B1 (ko) | 2012-09-19 | 2013-12-24 | 한국기계연구원 | 통합 코팅 장치 |
| JP2016521705A (ja) * | 2013-06-05 | 2016-07-25 | サイトレックス コーポレイション | がんを処置するための細胞傷害剤 |
| CN105288629B (zh) * | 2014-05-28 | 2021-02-19 | 北京大学 | 具有药效叠加作用及毒性分散效应的组合药物 |
| WO2016168637A2 (en) | 2015-04-17 | 2016-10-20 | Duquesne University Of The Holy Spirit | Cyclopenta[d]pyrimidines and substituted cyclopenta[d]pyrimidines as antitubulin and microtubule targeting agents, monocyclic pyrimidines as tubulin inhibitors, and pyrrolopyrimidines as targeted antifolates and tubulin and multiple receptor tyrosine kinase inhibition and antitumor agents |
| US11497793B2 (en) * | 2018-05-02 | 2022-11-15 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Compositions and methods for treating glioblastoma |
| US12220604B2 (en) * | 2018-07-31 | 2025-02-11 | Daiichi Sankyo Company, Limited | Treatment of metastatic brain tumor by administration of an antibody-drug conjugate |
| CN111825610B (zh) * | 2020-06-24 | 2023-03-31 | 中国药科大学 | 一种具有抗肿瘤活性的2-甲基喹啉类衍生物及其合成方法和用途 |
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| AU4317399A (en) * | 1998-05-28 | 1999-12-13 | Parker Hughes Institute | Quinazolines for treating brain tumor |
| US7001926B2 (en) * | 2000-03-10 | 2006-02-21 | Oxigene, Inc. | Tubulin binding agents and corresponding prodrug constructs |
| US20040229960A1 (en) * | 2001-07-13 | 2004-11-18 | David Sherris | Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases |
| PL369336A1 (en) * | 2001-09-21 | 2005-04-18 | The Administrators Of The Tulane Educational Fund | Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof |
| US7470723B2 (en) * | 2003-03-05 | 2008-12-30 | Celgene Corporation | Diphenylethylene compounds and uses thereof |
| NZ544472A (en) * | 2003-07-03 | 2009-04-30 | Myriad Genetics Inc | Compounds and therapeutical use thereof |
| SG135193A1 (en) * | 2003-08-18 | 2007-09-28 | Pfizer Prod Inc | Dosing schedule for erbb2 anticancer agents |
| GB0321648D0 (en) * | 2003-09-16 | 2003-10-15 | Astrazeneca Ab | Quinazoline derivatives |
| US8258145B2 (en) * | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| JP2008526776A (ja) * | 2005-01-03 | 2008-07-24 | ミリアド ジェネティクス， インコーポレイテッド | 脳癌の治療の方法 |
| HUE038768T2 (hu) * | 2005-02-18 | 2018-11-28 | Abraxis Bioscience Llc | Terápiás szerek kombinációi, valamint beadásukra szolgáló módszerek, és kombinációs terápia |
| US20070249640A1 (en) * | 2005-06-16 | 2007-10-25 | Myriad Genetics, Incorporated | Pharmaceutical compositions and use thereof |
| JP5235662B2 (ja) * | 2005-06-16 | 2013-07-10 | ミリアド ジェネティクス， インコーポレイテッド | 薬学的組成物およびその使用 |
| US20070065449A1 (en) * | 2005-09-16 | 2007-03-22 | Claire Verschraegen | Method of treating cancer, especially soft tissue sarcoma utilizing gemcitabine in combination with docetaxel and anti-VEGF therapy (bevacizumab) |
| WO2008124828A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Methods for treating vascular disruption disorders |
| WO2008124824A1 (en) * | 2007-04-10 | 2008-10-16 | Myriad Genetics, Inc. | Dosages and methods for the treatment of cancer |
| AU2008236997A1 (en) * | 2007-04-10 | 2008-10-16 | Myrexis, Inc. | Methods for treating cancer |
| EP2144886A4 (en) * | 2007-04-10 | 2012-10-03 | Myrexis Inc | METHOD OF TREATING MELANOMA |
| WO2009023876A1 (en) * | 2007-08-16 | 2009-02-19 | Myriad Genetics, Inc. | Method of treating non-small cell lung cancer |
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2008
- 2008-04-10 AU AU2008236993A patent/AU2008236993A1/en not_active Abandoned
- 2008-04-10 JP JP2010503205A patent/JP2010523696A/ja active Pending
- 2008-04-10 CN CN200880019674A patent/CN101742910A/zh active Pending
- 2008-04-10 WO PCT/US2008/059905 patent/WO2008124822A1/en not_active Ceased
- 2008-04-10 CA CA2720982A patent/CA2720982A1/en not_active Abandoned
- 2008-04-10 NZ NZ580866A patent/NZ580866A/en not_active IP Right Cessation
- 2008-04-10 EP EP08745503A patent/EP2144504A4/en not_active Withdrawn
- 2008-04-10 KR KR1020097023414A patent/KR20100016385A/ko not_active Ceased
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2009
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Also Published As
| Publication number | Publication date |
|---|---|
| US20100129470A1 (en) | 2010-05-27 |
| EP2144504A1 (en) | 2010-01-20 |
| JP2010523696A (ja) | 2010-07-15 |
| NZ580866A (en) | 2011-02-25 |
| EP2144504A4 (en) | 2012-10-03 |
| CA2720982A1 (en) | 2008-10-16 |
| CN101742910A (zh) | 2010-06-16 |
| WO2008124822A1 (en) | 2008-10-16 |
| KR20100016385A (ko) | 2010-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |