CA2709994A1 - Affichage alternatif de phage de fusion de proteine de support par la fusion en plx du phage m13 - Google Patents
Affichage alternatif de phage de fusion de proteine de support par la fusion en plx du phage m13 Download PDFInfo
- Publication number
- CA2709994A1 CA2709994A1 CA2709994A CA2709994A CA2709994A1 CA 2709994 A1 CA2709994 A1 CA 2709994A1 CA 2709994 A CA2709994 A CA 2709994A CA 2709994 A CA2709994 A CA 2709994A CA 2709994 A1 CA2709994 A1 CA 2709994A1
- Authority
- CA
- Canada
- Prior art keywords
- protein
- phage
- antibody
- seq
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1477807P | 2007-12-19 | 2007-12-19 | |
US61/014,778 | 2007-12-19 | ||
PCT/US2008/087696 WO2009086116A2 (fr) | 2007-12-19 | 2008-12-19 | Affichage alternatif de phage de fusion de protéine de support par la fusion en plx du phage m13 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2709994A1 true CA2709994A1 (fr) | 2009-07-09 |
Family
ID=40825038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2709994A Abandoned CA2709994A1 (fr) | 2007-12-19 | 2008-12-19 | Affichage alternatif de phage de fusion de proteine de support par la fusion en plx du phage m13 |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP2238247A2 (fr) |
JP (1) | JP2011507529A (fr) |
AU (1) | AU2008345674A1 (fr) |
CA (1) | CA2709994A1 (fr) |
IL (1) | IL206409A0 (fr) |
WO (1) | WO2009086116A2 (fr) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004296376B2 (en) | 2003-12-05 | 2010-03-04 | Bristol-Myers Squibb Company | Inhibitors of type 2 vascular endothelial growth factor receptors |
US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
BRPI0719597A2 (pt) | 2006-11-22 | 2013-12-17 | Adnexus A Bristol Myers Squibb R & D Company | Produtos terapêuticos objetivados baseados em proteínas manipuladas para receptores de quinases de tirosina, incluindo igf-ir |
WO2009102421A2 (fr) | 2008-02-14 | 2009-08-20 | Bristol-Myers Squibb Company | Agents thérapeutiques cibles basés sur des protéines fabriquées qui se lient au récepteur de l’egf |
JP2011520961A (ja) | 2008-05-22 | 2011-07-21 | ブリストル−マイヤーズ スクイブ カンパニー | 多価フィブロネクチンをベースとする足場ドメインタンパク質 |
US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
PL2356269T3 (pl) | 2008-10-31 | 2016-12-30 | Kompozycje białek rusztowania oparte na domenie fibronektyny typu III, sposoby i zastosowania | |
TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
US8241623B1 (en) | 2009-02-09 | 2012-08-14 | David Bermudes | Protease sensitivity expression system |
US8771669B1 (en) | 2010-02-09 | 2014-07-08 | David Gordon Bermudes | Immunization and/or treatment of parasites and infectious agents by live bacteria |
US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
US8524220B1 (en) | 2010-02-09 | 2013-09-03 | David Gordon Bermudes | Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria |
EP3569256B1 (fr) * | 2010-04-30 | 2022-06-15 | Janssen Biotech, Inc. | Compositions de domaine de fibronectine stabilisées, procédés et utilisations |
TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
US9562089B2 (en) | 2010-05-26 | 2017-02-07 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins having improved stability |
PT2697257T (pt) | 2011-04-13 | 2016-12-28 | Bristol Myers Squibb Co | Proteínas de fusão fc compreendendo novos ligantes ou arranjos |
EP2709669A1 (fr) | 2011-05-17 | 2014-03-26 | Bristol-Myers Squibb Company | Procédés de maintien de la pegylation de polypeptides |
EP3318880B1 (fr) | 2011-05-17 | 2020-12-16 | Bristol-Myers Squibb Company | Procédés améliorés pour la sélection de protéines de liaison |
EP3540100B8 (fr) | 2011-09-27 | 2022-11-02 | Janssen Biotech, Inc. | Échafaudage de protéine à base de répétition de fibronectine de type iii avec des surfaces de liaison alternatives |
US9522951B2 (en) | 2011-10-31 | 2016-12-20 | Bristol-Myers Squibb Company | Fibronectin binding domains with reduced immunogenicity |
CN104768969B (zh) | 2012-09-13 | 2021-04-16 | 百时美施贵宝公司 | 结合至肌生成抑制素的基于纤连蛋白的支架结构域蛋白 |
US20150361159A1 (en) | 2013-02-01 | 2015-12-17 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins |
EP3406629B1 (fr) | 2013-02-06 | 2020-06-24 | Bristol-Myers Squibb Company | Protéines du domaine de la fibronectine de type iii à solubilité améliorée |
US10065987B2 (en) | 2013-02-12 | 2018-09-04 | Bristol-Myers Squibb Company | High pH protein refolding methods |
WO2014126871A1 (fr) | 2013-02-12 | 2014-08-21 | Bristol-Myers Squibb Company | Procédés de repliement de protéine utilisant la filtration tangentielle |
US9593339B1 (en) | 2013-02-14 | 2017-03-14 | David Gordon Bermudes | Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment |
EP2968587A2 (fr) | 2013-03-13 | 2016-01-20 | Bristol-Myers Squibb Company | Domaines d'échafaudage à base de fibronectine liés à une sérum albumine ou fragment se liant à celle-ci |
US9737592B1 (en) | 2014-02-14 | 2017-08-22 | David Gordon Bermudes | Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment |
MX2016011580A (es) | 2014-03-20 | 2016-11-29 | Bristol Myers Squibb Co | Dominios de fibronectina tipo iii que se unen a albumina de suero. |
EP3647322B1 (fr) | 2014-03-20 | 2021-10-20 | Bristol-Myers Squibb Company | Molécules de charpente à base de fibronectine stabilisée |
CN107207379B (zh) | 2014-11-25 | 2021-08-10 | 百时美施贵宝公司 | 用于生物制品的18f-放射性标记的方法和组合物 |
CN115043943A (zh) | 2015-05-15 | 2022-09-13 | 综合医院公司 | 拮抗性抗肿瘤坏死因子受体超家族抗体 |
EP3708580B1 (fr) | 2015-09-23 | 2023-11-01 | Bristol-Myers Squibb Company | Domaines de la fibronectine de type iii se liant à l'albumine sérique à vitesse de dissociation élevée |
US10994033B2 (en) | 2016-06-01 | 2021-05-04 | Bristol-Myers Squibb Company | Imaging methods using 18F-radiolabeled biologics |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US10626165B2 (en) | 2016-12-14 | 2020-04-21 | Janssen Biotech, Inc. | CD8a-binding fibronectin type III domains |
EP3554535A4 (fr) | 2016-12-14 | 2020-10-21 | Janssen Biotech, Inc. | Domaines de fibronectine de type iii se liant à pd-l1 |
WO2018111978A1 (fr) | 2016-12-14 | 2018-06-21 | Janssen Biotech, Inc. | Domaines de fibronectine de type iii à liaison au cd137 |
US11628222B2 (en) | 2019-10-14 | 2023-04-18 | Aro Biotherapeutics Company | CD71 binding fibronectin type III domains |
WO2021076574A2 (fr) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Conjugués domaine fn3-arnsi et leurs utilisations |
JP2023515633A (ja) | 2020-02-28 | 2023-04-13 | ブリストル-マイヤーズ スクイブ カンパニー | 放射性標識されたフィブロネクチンに基づく足場および抗体ならびにそのセラノスティクス的使用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030148263A1 (en) * | 1997-08-29 | 2003-08-07 | Selective Genetics, Inc. | Methods and compositions using genetic package display |
-
2008
- 2008-12-19 JP JP2010539875A patent/JP2011507529A/ja active Pending
- 2008-12-19 CA CA2709994A patent/CA2709994A1/fr not_active Abandoned
- 2008-12-19 EP EP08868131A patent/EP2238247A2/fr not_active Withdrawn
- 2008-12-19 AU AU2008345674A patent/AU2008345674A1/en not_active Abandoned
- 2008-12-19 WO PCT/US2008/087696 patent/WO2009086116A2/fr active Application Filing
-
2010
- 2010-06-16 IL IL206409A patent/IL206409A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2008345674A1 (en) | 2009-07-09 |
IL206409A0 (en) | 2010-12-30 |
WO2009086116A2 (fr) | 2009-07-09 |
EP2238247A2 (fr) | 2010-10-13 |
WO2009086116A3 (fr) | 2009-10-08 |
JP2011507529A (ja) | 2011-03-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2709994A1 (fr) | Affichage alternatif de phage de fusion de proteine de support par la fusion en plx du phage m13 | |
JP4829457B2 (ja) | 抗体模倣物および他の結合タンパク質のタンパク質骨格 | |
Clackson et al. | In vitro selection from protein and peptide libraries | |
AU2004242851B2 (en) | Generation of artificial binding proteins based on ubiquitin proteins | |
US5625033A (en) | Totally synthetic affinity reagents | |
JP5868346B2 (ja) | 抗体模倣物および他の結合タンパク質のためのタンパク質骨格 | |
EP0774118B1 (fr) | Triages specifiques de cibles et leur utilisation permettant la decouverte de petits groupements pharmacophores moleculaires organiques | |
US20100021477A1 (en) | DESIGN AND GENERATION OF HUMAN DE NOVO pIX PHAGE DISPLAY LIBRARIES | |
US20020137053A1 (en) | Collections of binding proteins and tags and uses thereof for nested sorting and high throughput screening | |
AU2001241850A1 (en) | Protein scaffolds for antibody mimics and other binding proteins | |
CN105247050B (zh) | 用于文库构建、亲和力结合剂筛选和其表达的整合系统 | |
US20030143612A1 (en) | Collections of binding proteins and tags and uses thereof for nested sorting and high throughput screening | |
WO2014100419A1 (fr) | Compositions et méthodes pour identifier et isoler des fragments de liaison spécifiques de protéines de membranes cellulaires | |
US8728982B2 (en) | Engineered hybrid phage vectors for the design and the generation of a human non-antibody peptide or protein phage library via fusion to pIX of M13 phage | |
JP2020534796A (ja) | エピトープ翻訳後修飾状態に特異的な抗体の開発方法及び開発のための組成物 | |
Mandecki et al. | Phage Display and Selection of Protein Ligands | |
Liotta | Hot Methods Clinic: PHAGE EPITOPE DISPLAY LIBRARIES | |
AU2769002A (en) | Target specific screens and their use for discovering small organic molecular pharmacophores | |
AU5713899A (en) | Target specific screens and their use for discovering small organic molecular pharmacophores |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |
Effective date: 20121219 |