CA2706946A1 - 2-fluoropyrazolo[1,5-a] pyrimidines en tant qu'inhibiteurs de proteine kinase - Google Patents
2-fluoropyrazolo[1,5-a] pyrimidines en tant qu'inhibiteurs de proteine kinase Download PDFInfo
- Publication number
- CA2706946A1 CA2706946A1 CA2706946A CA2706946A CA2706946A1 CA 2706946 A1 CA2706946 A1 CA 2706946A1 CA 2706946 A CA2706946 A CA 2706946A CA 2706946 A CA2706946 A CA 2706946A CA 2706946 A1 CA2706946 A1 CA 2706946A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- alkyl
- group
- heteroaryl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99073607P | 2007-11-28 | 2007-11-28 | |
US60/990,736 | 2007-11-28 | ||
PCT/US2008/084643 WO2009070567A1 (fr) | 2007-11-28 | 2008-11-25 | 2-fluoropyrazolo[1,5-a] pyrimidines en tant qu'inhibiteurs de protéine kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2706946A1 true CA2706946A1 (fr) | 2009-06-04 |
Family
ID=40343608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2706946A Abandoned CA2706946A1 (fr) | 2007-11-28 | 2008-11-25 | 2-fluoropyrazolo[1,5-a] pyrimidines en tant qu'inhibiteurs de proteine kinase |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP2225247A1 (fr) |
JP (1) | JP2011504931A (fr) |
CN (1) | CN101970440A (fr) |
CA (1) | CA2706946A1 (fr) |
MX (1) | MX2010005950A (fr) |
WO (1) | WO2009070567A1 (fr) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY32192A (es) | 2008-10-22 | 2011-05-31 | Array Biopharma Inc | COMPUESTOS PIRAZOLO[1,5-a]PIRIMIDINA SUSTITUIDA COMO INHIBIDORES DE TRK CINASA |
AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
HUE035337T2 (en) | 2010-05-20 | 2018-05-02 | Array Biopharma Inc | Macrocyclic compounds as TRK kinase inhibitors |
US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
DK3486245T3 (da) | 2012-12-07 | 2021-07-19 | Vertex Pharma | 2-amino-n-(piperidin-1-yl-pyridin-3-yl) pyrazolo[1,5alpha]pyrimidin-3-carboxamid som hæmmer for atr kinase |
US9663519B2 (en) | 2013-03-15 | 2017-05-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
EP2970289A1 (fr) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Inc. | Composés utiles en tant qu'inhibiteurs de la kinase atr |
EP2970288A1 (fr) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Incorporated | Composés utiles en tant qu'inhibiteurs de la kinase atr |
SI3077397T1 (sl) | 2013-12-06 | 2020-02-28 | Vertex Pharmaceuticals Inc. | 2-amino-6-fluoro-N-(5-fluoro-piridin-3-IL)pirazolo(1,5-A)pirimidin-3- karboksamidna spojina, koristna kot inhibitor kinaze ATR, njena priprava, različne trdne oblike in njeni radioaktivno označeni derivati |
EP3087069B1 (fr) | 2013-12-23 | 2019-01-30 | Norgine B.V. | Composés utiles en tant que modulateurs du ccr9 |
SG10201902206QA (en) | 2014-06-05 | 2019-04-29 | Vertex Pharma | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof |
HUE044280T2 (hu) | 2014-06-17 | 2019-10-28 | Vertex Pharma | Rosszindulatú daganatok kezelése Chk1- és ATR-gátlók kombinációjával |
US10118930B2 (en) | 2014-11-03 | 2018-11-06 | Bayer Pharma Aktiengesellschaft | Piperidinylpyrazolopyrimidinones and their use |
WO2016073891A1 (fr) | 2014-11-06 | 2016-05-12 | Lysosomal Therapeutics Inc. | Pyrrolo[1,2-a]pyrimidines substituées et leur utilisation dans le traitement de troubles médicaux |
ES2958391T3 (es) | 2014-11-06 | 2024-02-08 | Bial R&D Invest S A | Imidazo[1,5-a]pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos |
MX2017005940A (es) | 2014-11-06 | 2018-01-11 | Lysosomal Therapeutics Inc | Pyrazolo [1, 5-a] pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos. |
KR102649887B1 (ko) | 2014-11-16 | 2024-03-22 | 어레이 바이오파마 인크. | (s)-n-(5-((r)-2-(2,5-디플루오로페닐)-피롤리딘-1-일)-피라졸로[1,5-a]피리미딘-3-일)-3-히드록시피롤리딘-1-카르복스아미드 히드로겐 술페이트의 결정질 형태 |
SI3233839T1 (sl) * | 2014-12-19 | 2019-12-31 | Janssen Pharmaceutica Nv | Heterociklil vezani derivati imidazopiridazina kot inhibitorji PI3Kbeta |
KR20180054657A (ko) | 2015-09-30 | 2018-05-24 | 버텍스 파마슈티칼스 인코포레이티드 | Dna 손상제 및 atr 저해제의 병용물을 사용한 암 치료 방법 |
TN2018000138A1 (en) | 2015-10-26 | 2019-10-04 | Array Biopharma Inc | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
MX2018012163A (es) | 2016-04-04 | 2019-07-08 | Loxo Oncology Inc | Formulaciones liquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirr olidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina- 1-carboxamida. |
JP7046827B2 (ja) | 2016-04-06 | 2022-04-04 | リソソーマル・セラピューティクス・インコーポレイテッド | イミダゾ[1,5-a]ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用 |
CA3020310A1 (fr) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Composes pyrrolo[1,2-a]pyrimidinyl carboxamide et leur utilisation dans le traitement de troubles medicaux |
JP7038063B2 (ja) | 2016-04-06 | 2022-03-17 | リソソーマル・セラピューティクス・インコーポレイテッド | ピラゾロ[1,5-a]ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用 |
WO2017192931A1 (fr) | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | Imidazo[1,2-a]pyridines substituées, imidazo[1,2-a]pyrazines substituées, composés apparentés et leur utilisation dans le traitement de troubles médicaux |
SG11201809693SA (en) | 2016-05-05 | 2018-11-29 | Lysosomal Therapeutics Inc | SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
JP7443057B2 (ja) | 2016-05-18 | 2024-03-05 | ロクソ オンコロジー, インコーポレイテッド | (S)-N-(5-((R)-2-(2,5-ジフルオロフェニル)ピロリジン-1-イル)-ピラゾロ[1,5-a]ピリミジン-3-イル)-3-ヒドロキシピロリジン-1-カルボキサミドの調製 |
US10611779B2 (en) | 2016-09-19 | 2020-04-07 | Bayer Cropscience Aktiengesellschaft | Fused bicyclic heterocycle derivatives as pesticides |
JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
CA3174507A1 (fr) * | 2020-03-06 | 2021-09-10 | Bayer Aktiengesellschaft | Imidazotriazines agissant sur le cancer par inhibition de cdk12 |
EP4163282A1 (fr) * | 2020-06-01 | 2023-04-12 | Unimatec Co., Ltd. | Composé pyrimidine à cycle condensé contenant du fluor et son procédé de production |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003299651A1 (en) * | 2002-12-11 | 2004-06-30 | Merck And Co., Inc. | Tyrosine kinase inhibitors |
AU2004215481B2 (en) * | 2003-02-28 | 2010-11-11 | Teijin Pharma Limited | Pyrazolo(1,5-A)pyrimidine derivatives |
EP1856122A2 (fr) * | 2005-03-02 | 2007-11-21 | Basf Aktiengesellschaft | 7-amino-azolopyrimidine 2-substituee, son procede de fabrication et son utilisation pour lutter contre les champignons nuisibles, et agents renfermant ce compose |
-
2008
- 2008-11-25 MX MX2010005950A patent/MX2010005950A/es not_active Application Discontinuation
- 2008-11-25 CN CN2008801257650A patent/CN101970440A/zh active Pending
- 2008-11-25 WO PCT/US2008/084643 patent/WO2009070567A1/fr active Application Filing
- 2008-11-25 EP EP08854702A patent/EP2225247A1/fr not_active Withdrawn
- 2008-11-25 JP JP2010536116A patent/JP2011504931A/ja not_active Withdrawn
- 2008-11-25 CA CA2706946A patent/CA2706946A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2009070567A1 (fr) | 2009-06-04 |
EP2225247A1 (fr) | 2010-09-08 |
JP2011504931A (ja) | 2011-02-17 |
MX2010005950A (es) | 2010-06-17 |
CN101970440A (zh) | 2011-02-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |