CA2705134C - Radiomarquage selectif de biomolecules - Google Patents

Radiomarquage selectif de biomolecules Download PDF

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Publication number
CA2705134C
CA2705134C CA2705134A CA2705134A CA2705134C CA 2705134 C CA2705134 C CA 2705134C CA 2705134 A CA2705134 A CA 2705134A CA 2705134 A CA2705134 A CA 2705134A CA 2705134 C CA2705134 C CA 2705134C
Authority
CA
Canada
Prior art keywords
group
thiol
linker
alkyne
reactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2705134A
Other languages
English (en)
Other versions
CA2705134A1 (fr
Inventor
Omayra Liz Padilla De Jesus
Ernest William Kovacs
Matthias Eberhard Glaser
Erik Arstad
Faisal Ahmed Syud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
General Electric Co
Original Assignee
GE Healthcare Ltd
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/961,108 external-priority patent/US8071718B2/en
Application filed by GE Healthcare Ltd, General Electric Co filed Critical GE Healthcare Ltd
Publication of CA2705134A1 publication Critical patent/CA2705134A1/fr
Application granted granted Critical
Publication of CA2705134C publication Critical patent/CA2705134C/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne des procédés d'introduction d'un atome de fluor sur une biomolécule qui comprennent les opérations suivantes : (i) utilisation d'un lieur comportant une terminaison thiol-réactive et une terminaison azido/alcyne-réactive; (ii) réaction de la terminaison thiol-réactive du liant avec une biomolécule comportant au moins un groupe thiol ou un dérivé réactif de celui-ci; et (iii) réaction ultérieure de la terminaison azido/alcyne-réactive de lieur avec un azide ou un alcyne substitué par du fluor respectivement. L'invention concerne également des compositions et un procédé de synthèse de liants bifonctionnnels et de bioconjugués ainsi que des agents de radiodiagnostic comportant des biomolécules marquées par le fluor.
CA2705134A 2007-12-20 2008-12-12 Radiomarquage selectif de biomolecules Expired - Fee Related CA2705134C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/961,108 US8071718B2 (en) 2004-12-22 2007-12-20 Selective radiolabeling of biomolecules
US11/961,108 2007-12-20
PCT/EP2008/067413 WO2009080561A1 (fr) 2007-12-20 2008-12-12 Radiomarquage sélectif de biomolécules

Publications (2)

Publication Number Publication Date
CA2705134A1 CA2705134A1 (fr) 2009-07-02
CA2705134C true CA2705134C (fr) 2018-05-08

Family

ID=40510013

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2705134A Expired - Fee Related CA2705134C (fr) 2007-12-20 2008-12-12 Radiomarquage selectif de biomolecules

Country Status (14)

Country Link
EP (2) EP2591808A3 (fr)
JP (1) JP5566905B2 (fr)
KR (1) KR101563758B1 (fr)
CN (1) CN101903047B (fr)
AU (1) AU2008340449B2 (fr)
BR (1) BRPI0821300A8 (fr)
CA (1) CA2705134C (fr)
ES (1) ES2662495T3 (fr)
HK (1) HK1151225A1 (fr)
IL (1) IL205392A (fr)
MX (1) MX2010006910A (fr)
NZ (1) NZ584900A (fr)
RU (1) RU2491958C2 (fr)
WO (1) WO2009080561A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201203793D0 (en) * 2012-03-05 2012-04-18 Ge Healthcare Ltd Imaging neural activity
WO2014179715A1 (fr) * 2013-05-02 2014-11-06 Duke University Composés prothétiques pour le marquage de biomolécules d'internalisation
GB201504755D0 (en) * 2015-03-20 2015-05-06 Isis Innovation Fluorination process
KR102230657B1 (ko) * 2018-07-17 2021-03-23 한국원자력연구원 방사성 원소의 표지방법, 방사성 표지화합물 및 이를 포함하는 방사성 원소 표지 키트
JPWO2022154127A1 (fr) * 2021-01-18 2022-07-21

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0428012D0 (en) * 2004-12-22 2005-01-26 Hammersmith Imanet Ltd Radiolabelling methods
WO2006126689A1 (fr) * 2005-05-26 2006-11-30 Japan Science And Technology Agency Nouvelle nanoparticule metallique immobilisee par un sucre, procede pour mesurer l’interaction proteine-sucre en utilisant celle-ci et procede pour recuperer la proteine a partir d’un interactant proteine-sucre
US20070020620A1 (en) * 2005-07-14 2007-01-25 Finn M G Compositions and methods for coupling a plurality of compounds to a scaffold
WO2007080114A2 (fr) * 2006-01-11 2007-07-19 Biotech Igg Ab Conjugué de macromolecule

Also Published As

Publication number Publication date
KR20100098405A (ko) 2010-09-06
AU2008340449B2 (en) 2014-05-22
IL205392A0 (en) 2010-12-30
EP2231201B1 (fr) 2018-02-14
EP2231201A1 (fr) 2010-09-29
AU2008340449A1 (en) 2009-07-02
HK1151225A1 (zh) 2012-01-27
NZ584900A (en) 2012-09-28
MX2010006910A (es) 2010-10-25
CN101903047A (zh) 2010-12-01
CA2705134A1 (fr) 2009-07-02
EP2591808A2 (fr) 2013-05-15
WO2009080561A1 (fr) 2009-07-02
EP2591808A3 (fr) 2014-06-25
JP2011508194A (ja) 2011-03-10
KR101563758B1 (ko) 2015-10-27
RU2010123475A (ru) 2012-01-27
ES2662495T3 (es) 2018-04-06
RU2491958C2 (ru) 2013-09-10
CN101903047B (zh) 2015-10-21
BRPI0821300A8 (pt) 2017-10-03
JP5566905B2 (ja) 2014-08-06
IL205392A (en) 2015-07-30
BRPI0821300A2 (pt) 2015-06-16

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Effective date: 20131112

MKLA Lapsed

Effective date: 20201214