CA2702970A1 - Manufacture, compositions and uses of coagulation factor viia modulator - Google Patents
Manufacture, compositions and uses of coagulation factor viia modulator Download PDFInfo
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- CA2702970A1 CA2702970A1 CA2702970A CA2702970A CA2702970A1 CA 2702970 A1 CA2702970 A1 CA 2702970A1 CA 2702970 A CA2702970 A CA 2702970A CA 2702970 A CA2702970 A CA 2702970A CA 2702970 A1 CA2702970 A1 CA 2702970A1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98038607P | 2007-10-16 | 2007-10-16 | |
| US60/980,386 | 2007-10-16 | ||
| PCT/US2008/080221 WO2009052323A2 (en) | 2007-10-16 | 2008-10-16 | Manufacture, compositions and uses of coagulationfactor viia modulator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2702970A1 true CA2702970A1 (en) | 2009-04-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2702970A Abandoned CA2702970A1 (en) | 2007-10-16 | 2008-10-16 | Manufacture, compositions and uses of coagulation factor viia modulator |
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| Country | Link |
|---|---|
| US (3) | US8552046B2 (enExample) |
| EP (2) | EP2209801B1 (enExample) |
| JP (2) | JP5733744B2 (enExample) |
| KR (1) | KR20100093046A (enExample) |
| CN (2) | CN103705507A (enExample) |
| CA (1) | CA2702970A1 (enExample) |
| EA (2) | EA201370191A1 (enExample) |
| ES (1) | ES2403413T3 (enExample) |
| WO (1) | WO2009052323A2 (enExample) |
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| CN100513398C (zh) | 2002-12-03 | 2009-07-15 | Axys药物公司 | 作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物 |
| US8729117B2 (en) | 2004-06-02 | 2014-05-20 | Pharmacyclics, Inc. | Factor VIIa inhibitor |
| JP2008501700A (ja) | 2004-06-02 | 2008-01-24 | ファーマサイクリックス，インコーポレイティド | 第ＶＩＩａ因子阻害剤 |
| CN103705507A (zh) | 2007-10-16 | 2014-04-09 | 环状药物公司 | 凝血因子viia调节剂的制造、组合物和用途 |
| WO2012142317A1 (en) * | 2011-04-15 | 2012-10-18 | Gamma Therapeutics, Inc | Fast-clotting wound dressings |
| US8980823B2 (en) | 2012-03-07 | 2015-03-17 | Shaker A. Mousa | Formulations of Factor VIIa inhibitors and utility |
| HK1200695A1 (en) | 2012-04-16 | 2015-08-14 | Cantab Biopharmaceuticals Patents Limited | Optimised subcutaneous therapeutic agents |
| CA2917298C (en) * | 2013-07-05 | 2021-06-22 | Shaker A. Mousa | Novel formulations of factor viia inhibitors and utility |
| IL312865B2 (en) | 2013-09-11 | 2025-06-01 | Eagle Biologics Inc | Liquid protein formulations containing viscosity-lowering agents |
| SG11201702614SA (en) * | 2014-10-01 | 2017-04-27 | Eagle Biolog Inc | Polysaccharide and nucleic acid formulations containing viscosity-lowering agents |
| RU2641058C1 (ru) * | 2016-11-17 | 2018-01-15 | федеральное государственное автономное образовательное учреждение высшего образования "Российский университет дружбы народов" (РУДН) | Способ профилактики венозной тромбоэмболии у больных раком шейки матки |
| CN109627218B (zh) * | 2018-11-27 | 2022-03-29 | 深圳市龙华区中心医院 | 一种抗凝小分子化合物及其应用和包含其的药物 |
| CN116283896B (zh) * | 2022-09-07 | 2024-10-29 | 广东晨康生物科技有限公司 | 一种具有pd-l1抑制活性的联苯类化合物及其用途 |
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| RU2093176C1 (ru) * | 1992-12-16 | 1997-10-20 | Левон Никитович Мкртчян | Способ лечения рака молочной железы и рака тела матки |
| HUP0104987A3 (en) | 1998-12-18 | 2002-09-30 | Axys Pharmaceuticals Inc South | Benzimidazole or indole derivatives protease inhibitors, and pharmaceutical compositions containing them |
| US6465503B2 (en) | 2000-08-11 | 2002-10-15 | Axys Pharmaceuticals, Inc. | Selective urokinase inhibitors |
| US20020037912A1 (en) | 2000-08-11 | 2002-03-28 | Leahy Ellen M. | Factor viia inhibitors |
| EP1449555B1 (en) * | 2001-03-23 | 2006-06-21 | Novo Nordisk A/S | Needle cannula |
| WO2003006670A2 (en) | 2001-07-09 | 2003-01-23 | Axys Pharmaceuticals, Inc. | 2-[5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl]-succinic acid derivatives as factor viia inhibitors |
| KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
| EP1474400A1 (en) * | 2002-02-13 | 2004-11-10 | Axys Pharmaceuticals, Inc. | 2-[5-(5-carbamimidoyl-1h-heteroaryl)] -6-hydroxybiphenyl-3-yl derivatives as factor viia inhibitors |
| RU2297216C2 (ru) | 2002-04-08 | 2007-04-20 | Эм-Джи-Ай Джи-Пи,Инк. | Фармацевтические композиции, содержащие растворимые в воде пролекарства пропофола, и способы их применения |
| CN100513398C (zh) | 2002-12-03 | 2009-07-15 | Axys药物公司 | 作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物 |
| AU2003300106A1 (en) | 2003-01-08 | 2004-08-10 | Axys Pharmaceuticals, Inc. | 2-'5-(5-carbamimidoyl-1h-heteroaryl)-6-hydroxybiphenyl-3-yl!- carboxylic acid derivatives as factor viia inhibitors |
| CA2569170A1 (en) * | 2004-06-02 | 2005-12-22 | Pharmacyclics, Inc. | Factor viia inhibitor |
| JP2008501700A (ja) * | 2004-06-02 | 2008-01-24 | ファーマサイクリックス，インコーポレイティド | 第ＶＩＩａ因子阻害剤 |
| CN103705507A (zh) | 2007-10-16 | 2014-04-09 | 环状药物公司 | 凝血因子viia调节剂的制造、组合物和用途 |
| US20110299806A1 (en) * | 2010-06-08 | 2011-12-08 | Leonid Kashchenevsky | Spindle, shaft supporting device and method of supporting a rotatable shaft |
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2008
- 2008-10-16 CN CN201310334580.3A patent/CN103705507A/zh active Pending
- 2008-10-16 EP EP08839610A patent/EP2209801B1/en active Active
- 2008-10-16 ES ES08839610T patent/ES2403413T3/es active Active
- 2008-10-16 KR KR1020107010696A patent/KR20100093046A/ko not_active Ceased
- 2008-10-16 CA CA2702970A patent/CA2702970A1/en not_active Abandoned
- 2008-10-16 EA EA201370191A patent/EA201370191A1/ru unknown
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- 2008-10-16 EA EA201000633A patent/EA019258B1/ru unknown
- 2008-10-16 CN CN2008801165837A patent/CN101861335B/zh active Active
- 2008-10-16 EP EP12185553.0A patent/EP2586794A3/en not_active Withdrawn
- 2008-10-16 WO PCT/US2008/080221 patent/WO2009052323A2/en not_active Ceased
- 2008-10-16 JP JP2010530121A patent/JP5733744B2/ja not_active Expired - Fee Related
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2012
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Also Published As
| Publication number | Publication date |
|---|---|
| EA019258B1 (ru) | 2014-02-28 |
| EP2209801B1 (en) | 2013-01-16 |
| EA201370191A1 (ru) | 2014-05-30 |
| JP2015157830A (ja) | 2015-09-03 |
| EP2209801A2 (en) | 2010-07-28 |
| JP2011500717A (ja) | 2011-01-06 |
| CN103705507A (zh) | 2014-04-09 |
| EP2586794A3 (en) | 2013-07-17 |
| KR20100093046A (ko) | 2010-08-24 |
| US8748468B2 (en) | 2014-06-10 |
| US20140039022A1 (en) | 2014-02-06 |
| JP5733744B2 (ja) | 2015-06-10 |
| HK1147267A1 (en) | 2011-08-05 |
| US8552046B2 (en) | 2013-10-08 |
| CN101861335B (zh) | 2013-09-04 |
| CN101861335A (zh) | 2010-10-13 |
| US20100298396A1 (en) | 2010-11-25 |
| WO2009052323A3 (en) | 2009-09-11 |
| EA201000633A1 (ru) | 2011-04-29 |
| EP2209801A4 (en) | 2011-04-06 |
| US20130158089A1 (en) | 2013-06-20 |
| ES2403413T3 (es) | 2013-05-17 |
| WO2009052323A2 (en) | 2009-04-23 |
| EP2586794A2 (en) | 2013-05-01 |
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