CA2698753A1 - Pyrazolo-pyridines as tyrosine kinase inhibitors - Google Patents
Pyrazolo-pyridines as tyrosine kinase inhibitors Download PDFInfo
- Publication number
- CA2698753A1 CA2698753A1 CA2698753A CA2698753A CA2698753A1 CA 2698753 A1 CA2698753 A1 CA 2698753A1 CA 2698753 A CA2698753 A CA 2698753A CA 2698753 A CA2698753 A CA 2698753A CA 2698753 A1 CA2698753 A1 CA 2698753A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- compound
- nr10r11
- heteroaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000005483 tyrosine kinase inhibitor Substances 0.000 title description 3
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 title description 3
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- 238000000034 method Methods 0.000 claims abstract description 124
- 150000003839 salts Chemical class 0.000 claims abstract description 39
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- 125000006736 (C6-C20) aryl group Chemical group 0.000 claims description 38
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Landscapes
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- Organic Chemistry (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97047207P | 2007-09-06 | 2007-09-06 | |
| US60/970,472 | 2007-09-06 | ||
| PCT/US2008/075477 WO2009033084A1 (en) | 2007-09-06 | 2008-09-05 | Pyrazolo-pyridines as tyrosine kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2698753A1 true CA2698753A1 (en) | 2009-03-12 |
Family
ID=39876737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2698753A Abandoned CA2698753A1 (en) | 2007-09-06 | 2008-09-05 | Pyrazolo-pyridines as tyrosine kinase inhibitors |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110130406A1 (enExample) |
| EP (1) | EP2193130A1 (enExample) |
| JP (1) | JP2010538094A (enExample) |
| CN (1) | CN101918403A (enExample) |
| CA (1) | CA2698753A1 (enExample) |
| WO (1) | WO2009033084A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009539878A (ja) * | 2006-06-08 | 2009-11-19 | アレイ バイオファーマ、インコーポレイテッド | キノリン化合物および使用方法 |
| JP2011513427A (ja) * | 2008-03-06 | 2011-04-28 | ジェネンテック， インコーポレイテッド | ｃ−ｍｅｔ及びＥＧＦＲアンタゴニストの併用療法 |
| US8293897B2 (en) | 2008-10-14 | 2012-10-23 | Ning Xi | Compounds comprising a spiro-ring and methods of use |
| RU2011142597A (ru) | 2009-03-21 | 2013-04-27 | Саншайн Лейк Фарма Ко., Лтд. | Производные сложных эфиров аминокислот, их соли и способы применения |
| WO2011139891A1 (en) | 2010-04-29 | 2011-11-10 | Deciphera Pharmaceuticals, Llc | Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activites |
| BR112012027743A2 (pt) | 2010-04-29 | 2017-03-14 | Deciphera Pharmaceuticals Llc | ciclopropil dicarboxamidas e análogos exibindo atividades anticâncer e antiproliferativas |
| US20130315895A1 (en) | 2010-07-01 | 2013-11-28 | Takeda Pharmaceutical Company Limited | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET |
| TW201247631A (en) | 2011-04-28 | 2012-12-01 | Du Pont | Herbicidal pyrazinones |
| CN104230922B (zh) * | 2013-06-19 | 2016-12-28 | 中国科学院上海药物研究所 | 一类五元杂环并吡啶类化合物及其制备方法和用途 |
| EP3122900A1 (en) | 2014-03-24 | 2017-02-01 | F. Hoffmann-La Roche AG | Cancer treatment with c-met antagonists and correlation of the latter with hgf expression |
| WO2016004305A2 (en) * | 2014-07-02 | 2016-01-07 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| ES2764299T3 (es) | 2014-12-09 | 2020-06-02 | Inst Nat Sante Rech Med | Anticuerpos monoclonales humanos contra AXL |
| WO2016135041A1 (en) | 2015-02-26 | 2016-09-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Fusion proteins and antibodies comprising thereof for promoting apoptosis |
| SG10201907667RA (en) | 2015-03-17 | 2019-09-27 | Nippon Chemiphar Co Ltd | Morphinan derivative |
| EA202092442A3 (ru) | 2016-06-07 | 2021-08-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| US10246462B2 (en) | 2016-09-09 | 2019-04-02 | Flx Bio, Inc. | Chemokine receptor modulators and uses thereof |
| US11633392B2 (en) | 2016-09-16 | 2023-04-25 | Nippon Chemiphar Co., Ltd. | Use of morphinan derivative for therapeutic treatment of opioid delta receptor agonist-related disease |
| KR102317480B1 (ko) | 2017-03-23 | 2021-10-25 | 자코바이오 파마슈티칼스 컴퍼니 리미티드 | Shp2 억제제로서 유용한 신규한 헤테로환형 유도체 |
| WO2020063760A1 (en) | 2018-09-26 | 2020-04-02 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as shp2 inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1773826A4 (en) * | 2004-07-02 | 2009-06-03 | Exelixis Inc | MODULATORS OF C-MET AND THEIR METHOD OF USE |
| US7547782B2 (en) * | 2005-09-30 | 2009-06-16 | Bristol-Myers Squibb Company | Met kinase inhibitors |
-
2008
- 2008-09-05 US US12/676,790 patent/US20110130406A1/en not_active Abandoned
- 2008-09-05 JP JP2010524200A patent/JP2010538094A/ja not_active Withdrawn
- 2008-09-05 EP EP08799257A patent/EP2193130A1/en not_active Withdrawn
- 2008-09-05 CN CN2008801150441A patent/CN101918403A/zh active Pending
- 2008-09-05 WO PCT/US2008/075477 patent/WO2009033084A1/en not_active Ceased
- 2008-09-05 CA CA2698753A patent/CA2698753A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110130406A1 (en) | 2011-06-02 |
| WO2009033084A1 (en) | 2009-03-12 |
| EP2193130A1 (en) | 2010-06-09 |
| CN101918403A (zh) | 2010-12-15 |
| JP2010538094A (ja) | 2010-12-09 |
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