CA2695935A1 - Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections - Google Patents

Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections Download PDF

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Publication number
CA2695935A1
CA2695935A1 CA2695935A CA2695935A CA2695935A1 CA 2695935 A1 CA2695935 A1 CA 2695935A1 CA 2695935 A CA2695935 A CA 2695935A CA 2695935 A CA2695935 A CA 2695935A CA 2695935 A1 CA2695935 A1 CA 2695935A1
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CA
Canada
Prior art keywords
genes
expression
determining
patients
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2695935A
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English (en)
French (fr)
Inventor
Jacques F. Banchereau
Anna Karolina Palucka
Octavio Ramilo
Damien Chaussabel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor Research Institute
University of Texas System
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2695935A1 publication Critical patent/CA2695935A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2695935A 2006-08-11 2007-08-10 Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections Abandoned CA2695935A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83714806P 2006-08-11 2006-08-11
US60/837,148 2006-08-11
PCT/US2007/075713 WO2008024642A2 (en) 2006-08-11 2007-08-10 Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections

Publications (1)

Publication Number Publication Date
CA2695935A1 true CA2695935A1 (en) 2008-02-28

Family

ID=39107529

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2695935A Abandoned CA2695935A1 (en) 2006-08-11 2007-08-10 Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections

Country Status (8)

Country Link
US (1) US20080171323A1 (OSRAM)
EP (1) EP2057286A4 (OSRAM)
JP (2) JP2010500038A (OSRAM)
CN (1) CN101541976A (OSRAM)
AU (1) AU2007286915B2 (OSRAM)
CA (1) CA2695935A1 (OSRAM)
SG (1) SG177956A1 (OSRAM)
WO (1) WO2008024642A2 (OSRAM)

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US9201068B2 (en) * 2008-09-03 2015-12-01 Clarkson University Bioelectronic tongue for food allergy detection
US10552710B2 (en) * 2009-09-28 2020-02-04 Oracle International Corporation Hierarchical sequential clustering
US20110078194A1 (en) * 2009-09-28 2011-03-31 Oracle International Corporation Sequential information retrieval
US10013641B2 (en) * 2009-09-28 2018-07-03 Oracle International Corporation Interactive dendrogram controls
CN103119444B (zh) * 2010-04-21 2016-10-26 米密德诊断学有限公司 区分细菌与病毒感染的标记物和决定因素以及其使用方法
IN2014MN01780A (OSRAM) 2012-02-09 2015-07-03 Memed Diagnostics Ltd
KR101459186B1 (ko) 2012-04-26 2014-11-07 울산대학교 산학협력단 지속적 황색포도알균 균혈증의 조기 진단용 조성물 및 조기 진단방법
DK2872891T3 (da) * 2012-07-10 2019-05-13 Nepean Blue Mountains Local Health Distr Risikostratificering ved influenza
WO2015048098A1 (en) 2013-09-24 2015-04-02 Washington University Diagnostic methods for infectious disease using endogenous gene expression
WO2015103664A1 (en) * 2014-01-09 2015-07-16 Nepean Blue Montains Local Health District Risk stratification in influenza
CA2954601C (en) 2014-08-14 2023-04-18 Memed Diagnostics Ltd. Computational analysis of biological data using manifold and a hyperplane
WO2016026258A1 (en) 2014-08-22 2016-02-25 Institute Of Biophysics, Chinese Academy Of Sciences Methods and compositions for treating and/or preventing a disease or disorder associated with abnormal level and/or activity of the ifp35 family of proteins
US20170234873A1 (en) 2014-10-14 2017-08-17 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof
US20170269081A1 (en) 2014-12-11 2017-09-21 Memed Diagnostics Ltd. Marker combinations for diagnosing infections and methods of use thereof
CN105316404B (zh) * 2015-02-27 2017-02-22 中南大学湘雅二医院 系统性红斑狼疮生物标志物及其诊断试剂盒
JP7002037B2 (ja) * 2015-07-01 2022-02-04 デューク・ユニヴァーシティ 急性呼吸器感染症を診断および処置するための方法
WO2017004448A1 (en) * 2015-07-02 2017-01-05 Indevr, Inc. Methods of processing and classifying microarray data for the detection and characterization of pathogens
KR20170027258A (ko) * 2015-09-01 2017-03-09 제이더블유바이오사이언스 주식회사 트립토파닐 티알엔에이 합성효소를 이용한 패혈증의 진단용 조성물과 진단 마커 검출 방법
IL294121B2 (en) 2016-03-03 2023-09-01 Memed Diagnostics Ltd An RNA test to diagnose the type of infection
WO2017149548A1 (en) 2016-03-03 2017-09-08 Memed Diagnostics Ltd. Rna determinants for distinguishing between bacterial and viral infections
US11340223B2 (en) 2016-07-10 2022-05-24 Memed Diagnostics Ltd. Early diagnosis of infections
WO2018011795A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
CN110073220A (zh) 2016-09-29 2019-07-30 米密德诊断学有限公司 风险评估和疾病分类的方法
US11385241B2 (en) 2016-09-29 2022-07-12 Memed Diagnostics Ltd. Methods of prognosis and treatment
US10209260B2 (en) 2017-07-05 2019-02-19 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
EP3489686B1 (en) 2017-11-22 2020-12-30 Dewact Labs GmbH Method and device for discriminating between viral and bacterial infections
CN108846258B (zh) * 2018-06-08 2021-05-18 中国人民解放军军事科学院军事医学研究院 一种自动检测分节段rna病毒重配的方法
CN112080559B (zh) * 2019-06-14 2023-09-01 复旦大学附属华山医院 Ppp1cb基因snp位点在制备检测寻常型银屑病易感性产品中的应用
CN110656177A (zh) * 2019-10-15 2020-01-07 合肥艾迪康医学检验实验室有限公司 用于检测af1q基因相对表达量的引物、探针及方法和试剂盒
EP4058606A4 (en) * 2019-11-13 2024-02-28 The Regents Of The University Of Colorado, A Body Corporate Identification of host rna biomarkers of infection
CN116209776A (zh) * 2020-05-29 2023-06-02 宾夕法尼亚大学董事会 用于检测包括冠状病毒在内的呼吸道病毒的组合物和方法
JP2023145811A (ja) * 2020-08-17 2023-10-12 孝章 赤池 学習モデルの生成方法、プログラム、演算装置
WO2022235765A2 (en) * 2021-05-04 2022-11-10 Inflammatix, Inc. Systems and methods for assessing a bacterial or viral status of a sample
US20240218468A1 (en) * 2021-05-11 2024-07-04 Inflammatix, Inc. Methods of diagnosis of respiratory viral infections
CN114236140B (zh) * 2021-12-27 2024-06-11 江苏贝索生物工程有限公司 基于试管法的血型智能判读方法
GB2639818A (en) * 2024-01-05 2025-10-08 Cytomics Ltd Fever triage

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US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US20040246906A1 (en) * 2003-06-06 2004-12-09 Hardy William Christopher Methods and systems for accelerating inference engines used in expert systems
US20050227222A1 (en) * 2004-04-09 2005-10-13 Massachusetts Institute Of Technology Pathogen identification method
US7608395B2 (en) * 2005-09-15 2009-10-27 Baylor Research Institute Systemic lupus erythematosus diagnostic assay
US20100266610A1 (en) * 2007-05-03 2010-10-21 Medimmune, Llc Auto-antibody markers of autoimmune disease

Also Published As

Publication number Publication date
AU2007286915B2 (en) 2014-05-15
WO2008024642A2 (en) 2008-02-28
WO2008024642A3 (en) 2008-12-04
JP2010500038A (ja) 2010-01-07
CN101541976A (zh) 2009-09-23
EP2057286A2 (en) 2009-05-13
EP2057286A4 (en) 2010-06-16
AU2007286915A2 (en) 2009-07-09
JP2013066474A (ja) 2013-04-18
WO2008024642A8 (en) 2011-02-17
AU2007286915A1 (en) 2008-02-28
US20080171323A1 (en) 2008-07-17
SG177956A1 (en) 2012-02-28

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Effective date: 20160212