CA2695167C - Methods for the treatment of elevated cholesterol levels - Google Patents

Methods for the treatment of elevated cholesterol levels Download PDF

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Publication number
CA2695167C
CA2695167C CA2695167A CA2695167A CA2695167C CA 2695167 C CA2695167 C CA 2695167C CA 2695167 A CA2695167 A CA 2695167A CA 2695167 A CA2695167 A CA 2695167A CA 2695167 C CA2695167 C CA 2695167C
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CA
Canada
Prior art keywords
alkyl
acyl
sdat
glycerol
dha
Prior art date
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Active
Application number
CA2695167A
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English (en)
French (fr)
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CA2695167A1 (en
Inventor
Dayan Goodenowe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Med-Life Discoveries Lp
Original Assignee
Phenomenome Discoveries Inc
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Publication date
Application filed by Phenomenome Discoveries Inc filed Critical Phenomenome Discoveries Inc
Publication of CA2695167A1 publication Critical patent/CA2695167A1/en
Application granted granted Critical
Publication of CA2695167C publication Critical patent/CA2695167C/en
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2695167A 2007-02-08 2007-08-27 Methods for the treatment of elevated cholesterol levels Active CA2695167C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88888307P 2007-02-08 2007-02-08
US60/888,883 2007-02-08
CA2620274A CA2620274C (en) 2007-02-08 2007-08-27 Methods for the treatment of senile dementia of the alzheimer's type

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2620274A Division CA2620274C (en) 2007-02-08 2007-08-27 Methods for the treatment of senile dementia of the alzheimer's type

Publications (2)

Publication Number Publication Date
CA2695167A1 CA2695167A1 (en) 2008-06-20
CA2695167C true CA2695167C (en) 2011-11-01

Family

ID=39537686

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2695167A Active CA2695167C (en) 2007-02-08 2007-08-27 Methods for the treatment of elevated cholesterol levels
CA2620274A Active CA2620274C (en) 2007-02-08 2007-08-27 Methods for the treatment of senile dementia of the alzheimer's type

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2620274A Active CA2620274C (en) 2007-02-08 2007-08-27 Methods for the treatment of senile dementia of the alzheimer's type

Country Status (8)

Country Link
US (5) US9034923B2 (https=)
EP (2) EP2620147B1 (https=)
JP (1) JP5470050B2 (https=)
AU (1) AU2007346587C1 (https=)
CA (2) CA2695167C (https=)
IL (1) IL200029A0 (https=)
SG (1) SG173418A1 (https=)
WO (1) WO2008095275A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2620147B1 (en) 2007-02-08 2020-06-03 Med-Life Discoveries LP Compounds for lowering cholesterol
TWI475989B (zh) 2008-12-22 2015-03-11 Phenomenome Discoveries Inc 縮醛磷脂類化合物，含彼之醫藥組成物以及治療老化疾病的方法
SG10201405975VA (en) 2009-10-01 2014-11-27 Phenomenome Discoveries Inc Serum-based biomarkers of pancreatic cancer and uses thereof for diseasedetection and diagnosis
EP3684463B1 (en) 2017-09-19 2025-05-14 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement
US11717686B2 (en) 2017-12-04 2023-08-08 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to facilitate learning and performance
US11478603B2 (en) 2017-12-31 2022-10-25 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
US12280219B2 (en) 2017-12-31 2025-04-22 NeuroLight, Inc. Method and apparatus for neuroenhancement to enhance emotional response
US11364361B2 (en) 2018-04-20 2022-06-21 Neuroenhancement Lab, LLC System and method for inducing sleep by transplanting mental states
CN113382683A (zh) 2018-09-14 2021-09-10 纽罗因恒思蒙特实验有限责任公司 改善睡眠的系统和方法
US11786694B2 (en) 2019-05-24 2023-10-17 NeuroLight, Inc. Device, method, and app for facilitating sleep
CN114236019B (zh) * 2022-02-24 2022-05-06 宝枫生物科技（北京）有限公司 脑白质病变的生物标志物的应用
WO2025057966A1 (ja) * 2023-09-12 2025-03-20 シンバイオシス・ソリューションズ株式会社 軽度認知障害の予防又は改善用の食品
CN118512461A (zh) * 2024-06-03 2024-08-20 东莞市第八人民医院（东莞市儿童医院） 一种母乳来源磷脂在防治支气管肺发育不良的应用
CN119876292B (zh) * 2025-03-27 2025-06-03 浙江省白马湖实验室有限公司 一种酰胺类缩醛磷脂化合物的制备方法及应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994009371A1 (en) 1992-10-09 1994-04-28 Massachusetts Institute Of Technology Antemortem diagnostic test for alzheimer's disease
FR2736265B1 (fr) 1995-07-07 1997-09-26 Forgeot Marcel Nouvelles compositions a base de phosphoglycero ethers et leur utilisation dans le traitement des maladies neuro-degeneratives
US5731354A (en) 1996-05-06 1998-03-24 Clarion Pharmaceuticals Inc. Treatment for the inhibition of neuro-degenerative disease states
US6177476B1 (en) 1998-08-27 2001-01-23 Clarion Pharmaceuticals Inc. Nutritional supplements for replenishing plasmalogens
CA2298181C (en) 2000-02-02 2006-09-19 Dayan Burke Goodnough Non-targeted complex sample analysis
US20020009740A1 (en) 2000-04-14 2002-01-24 Rima Kaddurah-Daouk Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US6835750B1 (en) 2000-05-01 2004-12-28 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II
WO2002021139A2 (en) 2000-09-08 2002-03-14 Oxford Glycosciences (Uk) Ltd. Automated identification of peptides
US6838452B2 (en) * 2000-11-24 2005-01-04 Vascular Biogenics Ltd. Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
DE10291524D2 (de) 2001-04-06 2004-07-01 Anker Thorsten Verfahren zum Nachweis chronisch-demenzieller Erkrankungen, zugehörige Peptide und Nachweisreagenzien
CA2446666A1 (en) 2001-05-09 2002-11-14 Biovision Ag Method for detecting progredient chronic dementia, and associated peptides and detection reagents
US7348143B2 (en) 2002-03-22 2008-03-25 Phenmenome Discoveries Inc. Method of visualizing non-targeted metabolomic data generated from fourier transform ion cyclotron resonance mass spectrometers
JP2004026803A (ja) 2002-03-29 2004-01-29 Nof Corp 神経細胞死予防剤
PT1535076E (pt) 2002-08-23 2008-11-03 Bayer Healthcare Ag Marcadores biológicos para diagnóstico da doença de alzheimer
SE0203886D0 (sv) * 2002-12-27 2002-12-27 Ltp Lipid Technologies Provide Glycerolesterprodukt och dess användning
US20040191294A1 (en) * 2003-03-27 2004-09-30 Ramaprasad Talahalli Ravichandra Health composition
JPWO2004093910A1 (ja) 2003-04-22 2006-07-13 アステラス製薬株式会社 ＰＰＡＲδアゴニストによる脳神経変性疾患治療剤
JP4796967B2 (ja) 2003-11-07 2011-10-19 ヴァーミリオン インコーポレイテッド アルツハイマー病のためのバイオマーカー
WO2005085838A2 (en) 2004-03-02 2005-09-15 Vanderbilt University Computational analysis of mass spectroscopic lipid data
WO2005116659A2 (en) 2004-05-18 2005-12-08 Neurodx, Llc Compositions and methods relating to alzheimer’s disease
WO2007002285A2 (en) * 2005-06-21 2007-01-04 The Trustees Of The University Of Pennsylvania Methods for treating neurological and psychiatric conditions
JP4176749B2 (ja) 2005-07-29 2008-11-05 学校法人帝京大学 疾病検査法
KR20080049821A (ko) 2005-09-12 2008-06-04 페노미넘 디스커버리스 인코포레이티드 비타민 ｅ-관련 대사산물의 측정에 의한 결장암 및난소암의 진단방법
EP1932164B1 (en) 2005-09-15 2013-04-24 Phenomenome Discoveries Inc. Method and apparatus for fourier transform ion cyclotron resonance mass spectrometry
KR20080104350A (ko) 2006-02-28 2008-12-02 페노미넘 디스커버리스 인코포레이티드 치매 및 다른 신경 장애의 진단을 위한 방법
EP2644588A3 (en) 2006-05-26 2013-12-25 Phenomenome Discoveries Inc. Biomarkers for diagnosing multiple sclerosis, and methods thereof
JPWO2008093709A1 (ja) * 2007-01-30 2010-05-20 株式会社プロジェクト・エム アミロイド蛋白質の凝集抑制および分解促進によりアミロイドーシスと関連する疾患を予防または治療するための組成物
EP2620147B1 (en) 2007-02-08 2020-06-03 Med-Life Discoveries LP Compounds for lowering cholesterol
US8026099B2 (en) 2007-07-26 2011-09-27 Washington University Lipid profile as a biomarker for early detection of neurological disorders

Also Published As

Publication number Publication date
IL200029A0 (en) 2010-04-15
US20170056363A1 (en) 2017-03-02
US9034923B2 (en) 2015-05-19
US20150306057A1 (en) 2015-10-29
AU2007346587A1 (en) 2008-08-14
AU2007346587C1 (en) 2015-01-22
EP2117527A4 (en) 2012-09-12
SG173418A1 (en) 2011-08-29
CA2620274C (en) 2011-10-04
EP2117527B1 (en) 2020-06-17
US10123989B2 (en) 2018-11-13
US20120129934A1 (en) 2012-05-24
US8993623B2 (en) 2015-03-31
JP2010518029A (ja) 2010-05-27
AU2007346587B2 (en) 2014-03-27
WO2008095275A1 (en) 2008-08-14
US9517222B2 (en) 2016-12-13
EP2620147A3 (en) 2013-10-02
CA2695167A1 (en) 2008-06-20
US20130046016A1 (en) 2013-02-21
JP5470050B2 (ja) 2014-04-16
EP2620147B1 (en) 2020-06-03
EP2620147A2 (en) 2013-07-31
US20160015673A1 (en) 2016-01-21
EP2117527A1 (en) 2009-11-18
CA2620274A1 (en) 2008-06-20

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