CA2693544A1 - Antibacterial combination therapy - Google Patents

Antibacterial combination therapy Download PDF

Info

Publication number
CA2693544A1
CA2693544A1 CA2693544A CA2693544A CA2693544A1 CA 2693544 A1 CA2693544 A1 CA 2693544A1 CA 2693544 A CA2693544 A CA 2693544A CA 2693544 A CA2693544 A CA 2693544A CA 2693544 A1 CA2693544 A1 CA 2693544A1
Authority
CA
Canada
Prior art keywords
group
phenyl
imidazole
derivative
disulfiram
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2693544A
Other languages
English (en)
French (fr)
Inventor
Malcolm Philip Young
Catherine Mary Thomas
Olusola Clement Idowu
Julie Ann Charlton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
E Therapeutics PLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2693544A1 publication Critical patent/CA2693544A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2693544A 2007-07-20 2008-07-18 Antibacterial combination therapy Abandoned CA2693544A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0714226.8 2007-07-20
GBGB0714226.8A GB0714226D0 (en) 2007-07-20 2007-07-20 anti-bacterial combination therapy
US96780107P 2007-09-07 2007-09-07
GB60/967,801 2007-09-07
PCT/GB2008/002499 WO2009013480A2 (en) 2007-07-20 2008-07-18 Antibacterial combination therapy

Publications (1)

Publication Number Publication Date
CA2693544A1 true CA2693544A1 (en) 2009-01-29

Family

ID=38476732

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2693544A Abandoned CA2693544A1 (en) 2007-07-20 2008-07-18 Antibacterial combination therapy

Country Status (9)

Country Link
US (1) US20110039906A1 (enExample)
EP (3) EP2180900A2 (enExample)
JP (1) JP2010534199A (enExample)
CN (1) CN101939026A (enExample)
AU (1) AU2008278827A1 (enExample)
CA (1) CA2693544A1 (enExample)
GB (1) GB0714226D0 (enExample)
WO (1) WO2009013480A2 (enExample)
ZA (1) ZA201000919B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007320928A1 (en) * 2006-11-16 2008-05-22 E-Therapeutics Limited Imidazoles for treating multi-drug resistant bacterial infections
GB0724996D0 (en) * 2007-12-21 2008-01-30 Therapeutics Ltd E Antibacterial combination therapy for the treatment of gram positive bacterial infections
GB0813211D0 (en) 2008-07-18 2008-08-27 E Therapeutics Plc Antibacterial combination therapy for the treatment of gram positive bacterial infections
BRPI0904249B1 (pt) * 2009-08-28 2018-03-06 Biolab Sanus Farmacêutica Ltda. Compostos éteres aralquil benzílicos, processo de preparação dos mesmos, uso dos referidos compostos, composição farmacêutica
CN107184581B (zh) * 2017-06-02 2020-11-20 郑州大学 胺基二硫代甲酸盐衍生物在抗菌领域的应用
US20240285586A1 (en) * 2021-06-11 2024-08-29 The Hong Kong Polytechnic University Methods for treating bacterial cell populations

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB148124A (en) 1915-12-20 1921-09-08 Valerius Smeu Improvements relating to apparatus for dissolving materials in or impregnating them with acids or the like
GB149428A (en) 1919-05-13 1920-08-13 James William Mcmyn Improvements relating to the application of dye stuffs containing the sulphonamide group to dyeing and printing
US3249109A (en) * 1963-11-01 1966-05-03 Maeth Harry Topical dressing
US3598122A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US4144317A (en) 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4262003A (en) 1975-12-08 1981-04-14 Alza Corporation Method and therapeutic system for administering scopolamine transdermally
US4307717A (en) * 1977-11-07 1981-12-29 Lectec Corporation Sterile improved bandage containing a medicament
NZ210840A (en) * 1984-01-18 1987-05-29 Johnson & Johnson Baby Prod Composition comprising synergistic combination of miconazole nitrate and zinc oxide
US4725439A (en) 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
FR2843302B1 (fr) * 2002-08-09 2004-10-22 Centre Nat Rech Scient Forme galenique pour la delivrance colique de principes actifs
US20040157837A1 (en) * 2002-11-07 2004-08-12 Serbedzija George N. Combinations for the treatment of fungal infections
AU2007320928A1 (en) * 2006-11-16 2008-05-22 E-Therapeutics Limited Imidazoles for treating multi-drug resistant bacterial infections
GB0813211D0 (en) * 2008-07-18 2008-08-27 E Therapeutics Plc Antibacterial combination therapy for the treatment of gram positive bacterial infections

Also Published As

Publication number Publication date
JP2010534199A (ja) 2010-11-04
WO2009013480A3 (en) 2009-06-25
AU2008278827A1 (en) 2009-01-29
US20110039906A1 (en) 2011-02-17
WO2009013480A8 (en) 2010-04-08
EP2529737A1 (en) 2012-12-05
ZA201000919B (en) 2012-02-29
WO2009013480A2 (en) 2009-01-29
GB0714226D0 (en) 2007-08-29
EP2529733A1 (en) 2012-12-05
CN101939026A (zh) 2011-01-05
EP2180900A2 (en) 2010-05-05

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Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20140718