CA2691044C - Procedes et trousses pour tester l'efficacite de composes therapeutiques et d'autres therapies destines a des cellules et des tissus tumoraux dans une matrice tridimensionnelle - Google Patents

Procedes et trousses pour tester l'efficacite de composes therapeutiques et d'autres therapies destines a des cellules et des tissus tumoraux dans une matrice tridimensionnelle Download PDF

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Publication number
CA2691044C
CA2691044C CA2691044A CA2691044A CA2691044C CA 2691044 C CA2691044 C CA 2691044C CA 2691044 A CA2691044 A CA 2691044A CA 2691044 A CA2691044 A CA 2691044A CA 2691044 C CA2691044 C CA 2691044C
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cells
tissue
matrix
therapeutic compounds
portions
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CA2691044A
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CA2691044A1 (fr
Inventor
Penelope Costello
Warren Mcdonald
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des matrices physiologiques tridimensionnelles, des procédés, un appareil et des trousses permettant la conception, l'analyse et l'évaluation accélérées de remèdes oncologiques. Les aspects principaux selon l'invention incluent des matrices, et particulièrement des matrices de gel, renfermant une ou plusieurs fibres physiologiques, qui sont conçues et disposées pour produire des conditions permettant d'évaluer des événements, tels que le déplacement de cellules loin des limites d'échantillons de tissu cible au travers de la matrice, selon un mode qui produit des données utiles à l'évaluation du statut oncologique et des caractéristiques des cellules. Dans un autre aspect important, l'invention concerne des tests et des analyses in vitro d'une ou de plusieurs thérapies classiques, expérimentales ou théoriques relatives à des tissus ou des cellules cibles spécifiques. Des composés thérapeutiques et leurs combinaisons, des thérapies par irradiation, des combinaisons de composés thérapeutiques et de radiations et de nombreuses autres thérapies possibles font partie de telles thérapies.
CA2691044A 2007-06-13 2007-06-15 Procedes et trousses pour tester l'efficacite de composes therapeutiques et d'autres therapies destines a des cellules et des tissus tumoraux dans une matrice tridimensionnelle Active CA2691044C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92912207P 2007-06-13 2007-06-13
PCT/IB2007/003494 WO2008012696A2 (fr) 2006-06-15 2007-06-15 Procédés et trousses pour tester l'efficacité de composés thérapeutiques et d'autres thérapies destinés à des cellules et des tissus tumoraux dans une matrice tridimensionnelle
US- 2008-09-12

Publications (2)

Publication Number Publication Date
CA2691044A1 CA2691044A1 (fr) 2008-01-31
CA2691044C true CA2691044C (fr) 2016-09-27

Family

ID=43607632

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2691044A Active CA2691044C (fr) 2007-06-13 2007-06-15 Procedes et trousses pour tester l'efficacite de composes therapeutiques et d'autres therapies destines a des cellules et des tissus tumoraux dans une matrice tridimensionnelle
CA2698338A Expired - Fee Related CA2698338C (fr) 2007-06-13 2007-06-15 Matrices physiologiques tridimensionnelles pour test oncologique et procedes pour leur production et leur utilisation

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2698338A Expired - Fee Related CA2698338C (fr) 2007-06-13 2007-06-15 Matrices physiologiques tridimensionnelles pour test oncologique et procedes pour leur production et leur utilisation

Country Status (2)

Country Link
CA (2) CA2691044C (fr)
WO (3) WO2008015581A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009038520B4 (de) * 2009-08-25 2012-07-05 Universität Rostock Verfahren und Vorrichtung zur Zellprobendiagnostik

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032508A (en) * 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5712161A (en) * 1993-12-30 1998-01-27 Nitta Gelatin Inc. Method for culturing animal cells in collagen drops on a support

Also Published As

Publication number Publication date
CA2698338C (fr) 2015-11-24
CA2691044A1 (fr) 2008-01-31
WO2008015581A2 (fr) 2008-02-07
WO2008020337A3 (fr) 2011-03-17
CA2698338A1 (fr) 2008-02-07
WO2008020337A2 (fr) 2008-02-21
WO2008015581A3 (fr) 2011-02-24
WO2008012696A2 (fr) 2008-01-31
WO2008012696A3 (fr) 2011-03-17

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