CA2689692A1 - New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission - Google Patents

New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission Download PDF

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Publication number
CA2689692A1
CA2689692A1 CA2689692A CA2689692A CA2689692A1 CA 2689692 A1 CA2689692 A1 CA 2689692A1 CA 2689692 A CA2689692 A CA 2689692A CA 2689692 A CA2689692 A CA 2689692A CA 2689692 A1 CA2689692 A1 CA 2689692A1
Authority
CA
Canada
Prior art keywords
disorder
compound
stereoisomers
difluorophenyl
pyrrolidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2689692A
Other languages
English (en)
French (fr)
Inventor
Clas Sonesson
Lars Swanson
Fredrik Pettersson
Nicholas Waters
Susanna Waters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NSAB Filial af Neurosearch Sweden AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2689692A1 publication Critical patent/CA2689692A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Pyrrole Compounds (AREA)
CA2689692A 2007-06-05 2008-06-04 New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission Abandoned CA2689692A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US94199307P 2007-06-05 2007-06-05
SE0701386-5 2007-06-05
US60/941,993 2007-06-05
SE0701386 2007-06-05
PCT/EP2008/056912 WO2008148799A1 (en) 2007-06-05 2008-06-04 New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

Publications (1)

Publication Number Publication Date
CA2689692A1 true CA2689692A1 (en) 2008-12-11

Family

ID=39672106

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2689692A Abandoned CA2689692A1 (en) 2007-06-05 2008-06-04 New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission

Country Status (11)

Country Link
US (1) US20100197760A1 (enExample)
EP (1) EP2155669B1 (enExample)
JP (1) JP2010529080A (enExample)
CN (1) CN101711234A (enExample)
AT (1) ATE508110T1 (enExample)
AU (1) AU2008258597A1 (enExample)
CA (1) CA2689692A1 (enExample)
DE (1) DE602008006720D1 (enExample)
MX (1) MX2009012716A (enExample)
NZ (1) NZ581363A (enExample)
WO (1) WO2008148799A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8188301B2 (en) 2007-06-05 2012-05-29 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
EP2367785B1 (en) 2008-11-24 2014-10-15 Integrative Research Laboratories Sweden AB Novel 3-phenyl-azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
JP5716202B2 (ja) 2008-11-24 2015-05-13 インテグレイティブ・リサーチ・ラボラトリーズ・スウェーデン・アーベー 皮質のカテコールアミン作動性神経伝達のモジュレーターとしての３−フェニル−３−メトキシピロリジン誘導体
CA2831435C (en) * 2011-03-31 2018-05-01 Chevron U.S.A. Inc. Novel process and catalyst system for improving dewaxing catalyst stability and lubricant oil yield

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US364414A (en) * 1887-06-07 Gael hollweg
US2878264A (en) * 1959-03-17 Substituted amino alcohols
US3118907A (en) * 1961-08-14 1964-01-21 Mead Johnson & Co 3-substituted-3-pyrrolidinols
US3647790A (en) * 1969-04-08 1972-03-07 American Home Prod Ouinoxalinyl-oxazolidines and -oxazines
ATE201669T1 (de) * 1991-04-17 2001-06-15 Upjohn Co Substituierte (s)-3-phenylpiperidin derivate, deren herstellung und deren verwendung als dopamin autorezeptor antagonisten
US5129962A (en) * 1991-10-22 1992-07-14 International Business Machines Corporation Tacky, no-clean thermally dissipated soldering flux
US20020169155A1 (en) * 1998-09-04 2002-11-14 Millennium Pharmaceuticals, Inc. Chemokine receptor anagonists and methods of use therefor
SE9904724D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission I
SE9904723D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission II
TWI308976B (en) * 2003-02-14 2009-04-21 Chunghwa Picture Tubes Ltd Process and structure of linquid crystal panel with one drop fill
AU2004233863B2 (en) * 2003-04-24 2010-06-17 Incyte Holdings Corporation Aza spiro alkane derivatives as inhibitors of metalloproteases
JP4765627B2 (ja) * 2003-09-22 2011-09-07 Ｍｓｄ株式会社 新規ピペリジン誘導体
TWI350168B (en) * 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
KR100690854B1 (ko) * 2005-11-08 2007-03-09 엘지전자 주식회사 멀티태스킹이 가능한 휴대용 단말기 및 그의 멀티태스킹처리방법
ES2412007T3 (es) * 2005-12-21 2013-07-09 Janssen Pharmaceutica, N.V. Derivados de pirazinona sustituida novedosos para uso en enfermedades mediadas por MCH-1
US20080070649A1 (en) * 2006-09-06 2008-03-20 Uchida Toshi K Free Space Optical Interconnections in Cellular Telephone Handsets

Also Published As

Publication number Publication date
US20100197760A1 (en) 2010-08-05
EP2155669A1 (en) 2010-02-24
NZ581363A (en) 2011-10-28
DE602008006720D1 (de) 2011-06-16
AU2008258597A1 (en) 2008-12-11
CN101711234A (zh) 2010-05-19
WO2008148799A1 (en) 2008-12-11
JP2010529080A (ja) 2010-08-26
ATE508110T1 (de) 2011-05-15
EP2155669B1 (en) 2011-05-04
MX2009012716A (es) 2009-12-14

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EP2155669B1 (en) New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
EP1963268B1 (en) Disubstituted phenylpiperidines as modulators of cortical catecholaminergic neurotransmission
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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20140604