CA2687209A1 - Procede de preparation de la forme a du tegaserode - Google Patents

Procede de preparation de la forme a du tegaserode Download PDF

Info

Publication number
CA2687209A1
CA2687209A1 CA002687209A CA2687209A CA2687209A1 CA 2687209 A1 CA2687209 A1 CA 2687209A1 CA 002687209 A CA002687209 A CA 002687209A CA 2687209 A CA2687209 A CA 2687209A CA 2687209 A1 CA2687209 A1 CA 2687209A1
Authority
CA
Canada
Prior art keywords
tegaserod maleate
polymorphic form
tegaserod
maleate
polymorphic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002687209A
Other languages
English (en)
Inventor
Abhay Gaitonde
Bindu Manojkumar
Dattatrey Kokane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Generics UK Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2687209A1 publication Critical patent/CA2687209A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé de préparation de la forme polymorphique A du 2-[(5-5 methoxy-1H-indol-3-yl)méthylène]-N-pentylhydrazinecarboximidamide maléate (tégasérode maléate). L'invention se rapporte également à une forme A de tégasérode maléate sensiblement dépourvue d'autres formes polymorphes et d'impuretés chimiques, à des compositions comprenant la forme A du tégasérode maléate et à l'utilisation desdites compositions dans le traitement de troubles gastrointestinaux tels que le le syndrome du côlon irritable et le pyrosis.
CA002687209A 2007-05-17 2008-05-16 Procede de preparation de la forme a du tegaserode Abandoned CA2687209A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN927/MUM/2007 2007-05-17
IN927MU2007 2007-05-17
PCT/GB2008/050357 WO2008142445A1 (fr) 2007-05-17 2008-05-16 Procédé de préparation de la forme a du tégasérode

Publications (1)

Publication Number Publication Date
CA2687209A1 true CA2687209A1 (fr) 2008-11-27

Family

ID=39744024

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002687209A Abandoned CA2687209A1 (fr) 2007-05-17 2008-05-16 Procede de preparation de la forme a du tegaserode

Country Status (4)

Country Link
EP (1) EP2146958A1 (fr)
AU (1) AU2008252604A1 (fr)
CA (1) CA2687209A1 (fr)
WO (1) WO2008142445A1 (fr)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050119328A1 (en) * 2003-03-25 2005-06-02 Hetero Drugs Limited Novel crysalline forms of tegaserod maleate
PE20050253A1 (es) * 2003-07-24 2005-06-03 Novartis Ag Modificaciones estables de maleato de hidrogeno de tegaserod
WO2005058819A2 (fr) * 2003-12-16 2005-06-30 Teva Pharmaceutical Industries Ltd. Formes polymorphiques de la base du tegaserod et des sels de celui-ci
US20050272802A1 (en) * 2004-04-22 2005-12-08 Sundaram Venkataraman Process for preparing form I of tegaserod maleate
JP2007514777A (ja) * 2004-10-19 2007-06-07 テバ ファーマシューティカル インダストリーズ リミティド テガセロッドマレエートの精製
EP1893195A2 (fr) * 2005-06-22 2008-03-05 Teva Pharmaceutical Industries Ltd Formes polymorphes de maleate de tegaserod

Also Published As

Publication number Publication date
EP2146958A1 (fr) 2010-01-27
WO2008142445A1 (fr) 2008-11-27
AU2008252604A1 (en) 2008-11-27

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20110516