CA2686951C - Diacylglycerol acyltransferase inhibitors - Google Patents
Diacylglycerol acyltransferase inhibitors Download PDFInfo
- Publication number
- CA2686951C CA2686951C CA2686951A CA2686951A CA2686951C CA 2686951 C CA2686951 C CA 2686951C CA 2686951 A CA2686951 A CA 2686951A CA 2686951 A CA2686951 A CA 2686951A CA 2686951 C CA2686951 C CA 2686951C
- Authority
- CA
- Canada
- Prior art keywords
- phenyl
- trifluoromethyl
- amino
- carbonyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93132707P | 2007-05-22 | 2007-05-22 | |
| US93130307P | 2007-05-22 | 2007-05-22 | |
| US93136907P | 2007-05-22 | 2007-05-22 | |
| US93127307P | 2007-05-22 | 2007-05-22 | |
| US60/931,369 | 2007-05-22 | ||
| US60/931,303 | 2007-05-22 | ||
| US60/931,327 | 2007-05-22 | ||
| US60/931,273 | 2007-05-22 | ||
| PCT/EP2008/055843 WO2008141976A1 (en) | 2007-05-22 | 2008-05-13 | Diacylglycerol acyltransferase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2686951A1 CA2686951A1 (en) | 2008-11-27 |
| CA2686951C true CA2686951C (en) | 2016-03-22 |
Family
ID=39619031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2686951A Expired - Fee Related CA2686951C (en) | 2007-05-22 | 2008-05-13 | Diacylglycerol acyltransferase inhibitors |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2155687A1 (es) |
| CN (1) | CN101835757B (es) |
| AU (1) | AU2008253118B2 (es) |
| BR (1) | BRPI0811947A2 (es) |
| CA (1) | CA2686951C (es) |
| HK (1) | HK1148519A1 (es) |
| MX (1) | MX2009012285A (es) |
| WO (1) | WO2008141976A1 (es) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ587106A (en) | 2004-12-14 | 2012-03-30 | Astrazeneca Ab | Oxadiazole derivatives as dgat inhibitors |
| US7749997B2 (en) | 2005-12-22 | 2010-07-06 | Astrazeneca Ab | Pyrimido [4,5-B] -Oxazines for use as DGAT inhibitors |
| ES2430115T3 (es) | 2006-03-31 | 2013-11-19 | Novartis Ag | Inhibidor de DGAT |
| US8084478B2 (en) | 2006-05-30 | 2011-12-27 | Asstrazeneca Ab | Substituted 5- phenylamino- 1, 3, 4-oxadiazol-2-ylcarbonylamino-4-phenoxy-cyclohexane carboxylic acid as inhibitors of acetyl coenzyme A diacylglycerol acyltransferase |
| US8115011B2 (en) | 2007-05-22 | 2012-02-14 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8058299B2 (en) | 2007-05-22 | 2011-11-15 | Via Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8153644B2 (en) | 2007-05-22 | 2012-04-10 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| JP5443342B2 (ja) | 2007-06-08 | 2014-03-19 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ピペリジン／ピペラジン誘導体 |
| WO2008148851A1 (en) | 2007-06-08 | 2008-12-11 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| AR066911A1 (es) | 2007-06-08 | 2009-09-23 | Janssen Pharmaceutica Nv | Derivados de piperidina / piperazina |
| AR066169A1 (es) | 2007-09-28 | 2009-07-29 | Novartis Ag | Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat |
| JP5579170B2 (ja) | 2008-06-05 | 2014-08-27 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｄｇａｔ阻害剤とｐｐａｒ作動薬を含有する薬剤組み合わせ物 |
| US8211884B2 (en) | 2008-08-06 | 2012-07-03 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8324385B2 (en) | 2008-10-30 | 2012-12-04 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| AU2009316786A1 (en) | 2008-11-19 | 2010-05-27 | Merck Sharp & Dohme Corp. | Inhibitors of diacylglycerol acyltransferase |
| EP2367817A4 (en) * | 2008-12-03 | 2012-05-09 | Via Pharmaceuticals Inc | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE ENZYME |
| EP2378878A4 (en) * | 2008-12-17 | 2012-08-01 | Via Pharmaceuticals Inc | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE |
| WO2010101246A1 (ja) | 2009-03-05 | 2010-09-10 | 塩野義製薬株式会社 | Ｎｐｙ ｙ５受容体拮抗作用を有するピペリジンおよびピロリジン誘導体 |
| WO2011078102A1 (ja) * | 2009-12-22 | 2011-06-30 | 第一三共株式会社 | 新規フェノキシピリミジン誘導体 |
| US9452980B2 (en) * | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| EP2657230A4 (en) | 2010-10-14 | 2016-04-06 | Mitsubishi Tanabe Pharma Corp | AMIDE DERIVATIVE AND USE THEREOF |
| TW201236685A (en) * | 2010-11-11 | 2012-09-16 | Daiichi Sankyo Co Ltd | New pyrazole amide derivatives |
| US9453003B2 (en) * | 2011-08-11 | 2016-09-27 | Jikai Biosciences, Inc. | Pyrimidine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof |
| US9452995B2 (en) * | 2011-08-11 | 2016-09-27 | Jikai Biosciences, Inc. | Pyridine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof |
| CN102924445B (zh) * | 2011-08-11 | 2015-07-08 | 上海吉铠医药科技有限公司 | Pim激酶抑制剂及其制备方法与在制药中的应用 |
| US9458151B2 (en) * | 2011-08-11 | 2016-10-04 | Jikai Biosciences, Inc. | Isothiazole derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof |
| CN104271565B (zh) | 2012-04-13 | 2016-09-28 | 田边三菱制药株式会社 | 酰胺吡啶衍生物及其用途 |
| CN104592151A (zh) * | 2015-02-10 | 2015-05-06 | 佛山市赛维斯医药科技有限公司 | 一类含叔丁基脒结构sglt2/sglt1双靶点抑制剂及用途 |
| CN104610187B (zh) * | 2015-02-10 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | 一类含脒结构的烷氧苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途 |
| CN104710382A (zh) * | 2015-02-10 | 2015-06-17 | 佛山市赛维斯医药科技有限公司 | 一类含叔丁基脒结构的卤代苯基噻唑羧酸酰胺类化合物及用途 |
| CN104672166A (zh) * | 2015-02-10 | 2015-06-03 | 佛山市赛维斯医药科技有限公司 | 一种含脒结构的腈基苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途 |
| CN104557765A (zh) * | 2015-02-10 | 2015-04-29 | 佛山市赛维斯医药科技有限公司 | 一类含脒结构的卤代苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途 |
| CN104592149A (zh) * | 2015-02-10 | 2015-05-06 | 佛山市赛维斯医药科技有限公司 | 一类含叔丁基脒结构的烷氧苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途 |
| CN104672164A (zh) * | 2015-02-10 | 2015-06-03 | 佛山市赛维斯医药科技有限公司 | 一类含苯基脒结构的sglt2/sglt1双靶点抑制剂、其制备方法及用途 |
| CN104610189A (zh) * | 2015-02-10 | 2015-05-13 | 佛山市赛维斯医药科技有限公司 | 一类含环丙基脒结构sglt2/sglt1双靶点抑制剂及用途 |
| CN104672165B (zh) * | 2015-02-10 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 一类含环丙基脒结构的烷氧苯基噻唑羧酸酰胺类双靶点抑制剂、其制备方法及用途 |
| KR102537050B1 (ko) | 2016-03-17 | 2023-05-26 | 에프. 호프만-라 로슈 아게 | Taar의 작용제로서 활성을 갖는 5-에틸-4-메틸-피라졸-3-카복스아미드 유도체 |
| EA202090871A1 (ru) | 2017-10-06 | 2020-07-03 | Форма Терапьютикс, Инк. | Ингибирование убиквитин-специфической пептидазы 30 |
| EP4218934A1 (en) | 2018-10-05 | 2023-08-02 | Forma Therapeutics, Inc. | Inhibiting ubiquitin-specific protease 30 (usp30) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ531440A (en) * | 2001-08-31 | 2005-10-28 | Aventis Pharma Gmbh | Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as PPAR activators |
| AU2003261935A1 (en) * | 2002-09-06 | 2004-03-29 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
| CA2610188A1 (en) * | 2005-06-11 | 2006-12-21 | Astrazeneca Ab | Oxadiazole derivatives as dgat inhibitors |
| WO2007060140A2 (en) * | 2005-11-28 | 2007-05-31 | F. Hoffmann-La Roche Ag | Inhibitors of diacyglycerol acyltransferase (dgat) |
-
2008
- 2008-05-13 AU AU2008253118A patent/AU2008253118B2/en not_active Ceased
- 2008-05-13 BR BRPI0811947-3A2A patent/BRPI0811947A2/pt not_active IP Right Cessation
- 2008-05-13 CN CN200880025656.1A patent/CN101835757B/zh not_active Expired - Fee Related
- 2008-05-13 CA CA2686951A patent/CA2686951C/en not_active Expired - Fee Related
- 2008-05-13 WO PCT/EP2008/055843 patent/WO2008141976A1/en active Application Filing
- 2008-05-13 EP EP08759547A patent/EP2155687A1/en not_active Withdrawn
- 2008-05-13 MX MX2009012285A patent/MX2009012285A/es active IP Right Grant
-
2011
- 2011-03-15 HK HK11102583.6A patent/HK1148519A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0811947A2 (pt) | 2014-11-11 |
| AU2008253118B2 (en) | 2013-11-21 |
| AU2008253118A1 (en) | 2008-11-27 |
| WO2008141976A1 (en) | 2008-11-27 |
| EP2155687A1 (en) | 2010-02-24 |
| HK1148519A1 (en) | 2011-09-09 |
| CN101835757B (zh) | 2014-03-05 |
| CA2686951A1 (en) | 2008-11-27 |
| CN101835757A (zh) | 2010-09-15 |
| MX2009012285A (es) | 2009-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2686951C (en) | Diacylglycerol acyltransferase inhibitors | |
| US8058299B2 (en) | Diacylglycerol acyltransferase inhibitors | |
| US8115011B2 (en) | Diacylglycerol acyltransferase inhibitors | |
| US8153644B2 (en) | Diacylglycerol acyltransferase inhibitors | |
| JP5076091B2 (ja) | ジアシルグリセロールアシルトランスフェラーゼ（ｄｇａｔ）のインヒビター | |
| US20090099201A1 (en) | Diacylglycerol Acyltransferase Inhibitors | |
| US8124766B2 (en) | Inhibitors of diacylglycerol acyltransferase | |
| DK2265578T3 (en) | Azetidin-DERIVATIVES | |
| US8211914B2 (en) | Inhibitors of diacylglycerol acyltransferase | |
| EP2197875A1 (en) | Diacylglycerol acyltransferase inhibitors | |
| US8211884B2 (en) | Diacylglycerol acyltransferase inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20130513 |
|
| MKLA | Lapsed |
Effective date: 20180514 |