CA2686908A1 - Rna antagonist compounds for the modulation of her3 - Google Patents
Rna antagonist compounds for the modulation of her3 Download PDFInfo
- Publication number
- CA2686908A1 CA2686908A1 CA002686908A CA2686908A CA2686908A1 CA 2686908 A1 CA2686908 A1 CA 2686908A1 CA 002686908 A CA002686908 A CA 002686908A CA 2686908 A CA2686908 A CA 2686908A CA 2686908 A1 CA2686908 A1 CA 2686908A1
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- Prior art keywords
- seq
- oligomer
- her3
- sequence
- various embodiments
- Prior art date
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Classifications
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- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
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| US91739207P | 2007-05-11 | 2007-05-11 | |
| US60/917,392 | 2007-05-11 | ||
| US2325008P | 2008-01-24 | 2008-01-24 | |
| US61/023,250 | 2008-01-24 | ||
| PCT/EP2008/055779 WO2008138904A2 (en) | 2007-05-11 | 2008-05-09 | Rna antagonist compounds for the modulation of her3 |
Publications (1)
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| CA2686908A1 true CA2686908A1 (en) | 2008-11-20 |
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| CA002686908A Abandoned CA2686908A1 (en) | 2007-05-11 | 2008-05-09 | Rna antagonist compounds for the modulation of her3 |
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| US (2) | US8268793B2 (OSRAM) |
| EP (1) | EP2155877A2 (OSRAM) |
| JP (1) | JP2010526797A (OSRAM) |
| KR (1) | KR20100024410A (OSRAM) |
| CN (1) | CN101849007A (OSRAM) |
| AU (1) | AU2008250033A1 (OSRAM) |
| BR (1) | BRPI0811156A2 (OSRAM) |
| CA (1) | CA2686908A1 (OSRAM) |
| EA (1) | EA200971049A1 (OSRAM) |
| IL (1) | IL202038A0 (OSRAM) |
| MX (1) | MX2009012271A (OSRAM) |
| NZ (1) | NZ581201A (OSRAM) |
| TW (1) | TW200908987A (OSRAM) |
| WO (1) | WO2008138904A2 (OSRAM) |
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| BRPI0808055A2 (pt) | 2007-02-16 | 2013-07-30 | Merrimack Pharmaceuticals Inc | anticorpo monoclonal isolado ou porÇço do mesmo que se liga ao antÍgeno, composiÇço, Ácido nucleico isolado, vetor de expressço, cÉlula hospedeira, hibridoma, kit, uso de um anticorpo monoclonal isolado ou porÇço do mesmo que se liga ao antÍgeno, mÉtodo para diagnosticar um cÂncer associado com erbb3 em um paciente, e, anticorpo |
| EA200971049A1 (ru) | 2007-05-11 | 2010-04-30 | Сантарис Фарма А/С | Антагонисты phk и их применение для модуляции her3 |
| EA201170660A1 (ru) * | 2008-11-07 | 2011-12-30 | Сантарис Фарма А/С | Избирательная для erbb-3 (her3) комбинированная терапия |
| AR076053A1 (es) * | 2009-04-14 | 2011-05-18 | Schering Corp | Derivados de pirazolo[1,5-a]pirimidina como inhibidores de mtor |
| PL2544680T3 (pl) | 2010-03-11 | 2015-08-31 | Merrimack Pharmaceuticals Inc | Zastosowanie inhibitorów ERBB1 w leczeniu potrójnie ujemnego raka gruczołu sutkowego |
| EP3260540A1 (en) | 2010-11-12 | 2017-12-27 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
| CN103562226A (zh) | 2011-03-11 | 2014-02-05 | 梅里麦克制药股份有限公司 | 使用egfr家族受体的抑制剂来治疗激素难治性乳腺癌 |
| CA2828043A1 (en) | 2011-03-15 | 2012-09-20 | Merrimack Pharmaceuticals, Inc. | Overcoming resistance to erbb pathway inhibitors |
| DK2850189T3 (en) | 2012-05-16 | 2019-02-25 | Translate Bio Ma Inc | COMPOSITIONS AND PROCEDURES FOR MODULATING GENEPRESSION |
| AU2013262709A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating MECP2 expression |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| CN109234274B (zh) | 2013-03-27 | 2021-09-21 | 伊萨纳治疗有限公司 | 修饰的TGF-β寡核苷酸 |
| WO2015100459A2 (en) | 2013-12-27 | 2015-07-02 | Merrimack Pharmaceuticals, Inc. | Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies |
| CA2966044A1 (en) | 2014-10-30 | 2016-05-06 | The General Hospital Corporation | Methods for modulating atrx-dependent gene repression |
| EP3271460A4 (en) | 2015-03-17 | 2019-03-13 | The General Hospital Corporation | RNA INTERACTOM OF POLYCOMB REPRESSIVE COMPLEX 1 (PRC1) |
| US10184006B2 (en) | 2015-06-04 | 2019-01-22 | Merrimack Pharmaceuticals, Inc. | Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors |
| CN116492365A (zh) * | 2022-01-19 | 2023-07-28 | 圣诺生物医药技术(广州)有限公司 | 抑制HER2和HER3的siRNA药物组合物 |
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| US4914210A (en) | 1987-10-02 | 1990-04-03 | Cetus Corporation | Oligonucleotide functionalizing reagents |
| US4962029A (en) | 1987-10-02 | 1990-10-09 | Cetus Corporation | Covalent oligonucleotide-horseradish peroxidase conjugate |
| US20030206887A1 (en) * | 1992-05-14 | 2003-11-06 | David Morrissey | RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA) |
| US6133246A (en) * | 1997-08-13 | 2000-10-17 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide compositions and methods for the modulation of JNK proteins |
| WO1999034016A2 (en) | 1997-12-29 | 1999-07-08 | Genena Ltd. | A method for identifying and characterizing cells and tissues |
| WO2002081628A2 (en) * | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
| US6277640B1 (en) | 2000-07-31 | 2001-08-21 | Isis Pharmaceuticals, Inc. | Antisense modulation of Her-3 expression |
| US20050176024A1 (en) | 2001-05-18 | 2005-08-11 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of epidermal growth factor receptor (EGFR) gene expression using short interfering nucleic acid (siNA) |
| DK1527176T4 (en) * | 2002-08-05 | 2017-07-03 | Silence Therapeutics Gmbh | ADDITIONAL NEW FORMS OF INTERFERRING RNA MOLECULES |
| US7087229B2 (en) | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| CA2506576C (en) | 2002-11-18 | 2018-03-06 | Santaris Pharma A/S | Antisense gapmer oligonucleotides |
| US20050266409A1 (en) | 2003-02-04 | 2005-12-01 | Wyeth | Compositions and methods for diagnosing, preventing, and treating cancers |
| EP1606406B2 (en) * | 2003-03-21 | 2013-11-27 | Santaris Pharma A/S | SHORT INTERFERING RNA (siRNA) ANALOGUES |
| MXPA05011022A (es) | 2003-04-13 | 2006-04-27 | Enzon Pharmaceuticals Inc | Profarmacos oligonucleotidos polimericos. |
| EP2348110B1 (en) * | 2003-05-30 | 2013-03-27 | OncoTherapy Science, Inc. | Process for screening a drug response in cancer patients |
| DK2439285T3 (da) | 2004-03-31 | 2019-07-29 | Massachusetts Gen Hospital | Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor |
| WO2007031091A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
| EP2505646A1 (en) | 2006-05-05 | 2012-10-03 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of CRP |
| AU2007296055A1 (en) | 2006-09-15 | 2008-03-20 | Enzon Pharmaceuticals, Inc. | Polymeric conjugates containing positively-charged moieties |
| CA2662978A1 (en) | 2006-09-15 | 2008-03-20 | Enzon Pharmaceuticals, Inc. | Hindered ester-based biodegradable linkers for oligonucleotide delivery |
| EP2090127A2 (en) | 2006-10-30 | 2009-08-19 | Nokia Corporation | Method, apparatus and system providing operator controlled mobility for user equipment |
| US20100112687A1 (en) | 2007-03-02 | 2010-05-06 | Mdrna, Inc. | Nucleic acid compounds for inhibiting erbb family gene expression and uses thereof |
| US20110286997A1 (en) | 2007-03-13 | 2011-11-24 | Hakon Hakonarson | Genetic Alterations on Chromosome 16 and Methods of Use Thereof for the Diagnosis and Treatment of Type 1 Diabetes |
| EA200971049A1 (ru) | 2007-05-11 | 2010-04-30 | Сантарис Фарма А/С | Антагонисты phk и их применение для модуляции her3 |
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- 2008-05-09 BR BRPI0811156A patent/BRPI0811156A2/pt not_active IP Right Cessation
- 2008-05-09 EP EP08759503A patent/EP2155877A2/en not_active Withdrawn
- 2008-05-09 NZ NZ581201A patent/NZ581201A/en not_active IP Right Cessation
- 2008-05-09 WO PCT/EP2008/055779 patent/WO2008138904A2/en not_active Ceased
- 2008-05-09 CA CA002686908A patent/CA2686908A1/en not_active Abandoned
- 2008-05-09 TW TW097117351A patent/TW200908987A/zh unknown
- 2008-05-09 US US12/118,271 patent/US8268793B2/en not_active Expired - Fee Related
- 2008-05-09 CN CN200880024089A patent/CN101849007A/zh active Pending
- 2008-05-09 JP JP2010506953A patent/JP2010526797A/ja active Pending
- 2008-05-09 AU AU2008250033A patent/AU2008250033A1/en not_active Abandoned
- 2008-05-09 KR KR1020097025807A patent/KR20100024410A/ko not_active Ceased
-
2009
- 2009-11-10 IL IL202038A patent/IL202038A0/en unknown
-
2012
- 2012-06-22 US US13/531,307 patent/US20120295955A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EA200971049A1 (ru) | 2010-04-30 |
| MX2009012271A (es) | 2010-02-04 |
| NZ581201A (en) | 2012-05-25 |
| JP2010526797A (ja) | 2010-08-05 |
| IL202038A0 (en) | 2011-08-01 |
| US20120295955A1 (en) | 2012-11-22 |
| CN101849007A (zh) | 2010-09-29 |
| US20080318894A1 (en) | 2008-12-25 |
| WO2008138904A2 (en) | 2008-11-20 |
| EP2155877A2 (en) | 2010-02-24 |
| TW200908987A (en) | 2009-03-01 |
| WO2008138904A3 (en) | 2009-04-09 |
| US8268793B2 (en) | 2012-09-18 |
| AU2008250033A1 (en) | 2008-11-20 |
| BRPI0811156A2 (pt) | 2019-09-24 |
| KR20100024410A (ko) | 2010-03-05 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20130422 |
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| FZDE | Discontinued |
Effective date: 20150511 |