CA2685213C - Engineered rabbit antibody variable domains and uses thereof - Google Patents

Engineered rabbit antibody variable domains and uses thereof Download PDF

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Publication number
CA2685213C
CA2685213C CA2685213A CA2685213A CA2685213C CA 2685213 C CA2685213 C CA 2685213C CA 2685213 A CA2685213 A CA 2685213A CA 2685213 A CA2685213 A CA 2685213A CA 2685213 C CA2685213 C CA 2685213C
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CA
Canada
Prior art keywords
domain
polypeptide
amino acid
rabbit
antigen
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CA2685213A
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English (en)
French (fr)
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CA2685213A1 (en
Inventor
Joao Manuel Braz Goncalves
Frederico Nuno Castanheira Aires Da Silva
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Technophage Investigacao e Desenvolvimento em Biotecnologia SA
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Technophage Investigacao e Desenvolvimento em Biotecnologia SA
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Publication of CA2685213A1 publication Critical patent/CA2685213A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CA2685213A 2007-05-04 2008-04-30 Engineered rabbit antibody variable domains and uses thereof Active CA2685213C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91622607P 2007-05-04 2007-05-04
US60/916,226 2007-05-04
PCT/PT2008/000018 WO2008136694A1 (en) 2007-05-04 2008-04-30 Engineered rabbit antibody variable domains and uses thereof

Publications (2)

Publication Number Publication Date
CA2685213A1 CA2685213A1 (en) 2008-11-13
CA2685213C true CA2685213C (en) 2017-02-21

Family

ID=39735911

Family Applications (1)

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CA2685213A Active CA2685213C (en) 2007-05-04 2008-04-30 Engineered rabbit antibody variable domains and uses thereof

Country Status (9)

Country Link
US (2) US10280211B2 (https=)
EP (1) EP2164868B1 (https=)
JP (3) JP5791895B2 (https=)
AU (1) AU2008246442B2 (https=)
CA (1) CA2685213C (https=)
ES (1) ES2540807T3 (https=)
PT (1) PT2164868E (https=)
SG (1) SG194368A1 (https=)
WO (1) WO2008136694A1 (https=)

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US11685773B2 (en) 2015-04-30 2023-06-27 Abcheck S.R.O. Method for mass humanization of rabbit antibodies
SMT202000633T1 (it) * 2015-06-19 2021-01-05 Eisai R&D Man Co Ltd Immunoglobuline coniugate a cys80
US20210221915A1 (en) * 2018-06-08 2021-07-22 Ventana Medical Systems, Inc. Universal or normalized antibody frameworks for improved functionality and manufacturability
CA3231704A1 (en) * 2021-09-13 2023-03-16 The Board Of Regents Of The University Of Texas System Trem2 antigen binding proteins and uses thereof

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Also Published As

Publication number Publication date
AU2008246442A1 (en) 2008-11-13
WO2008136694A9 (en) 2010-09-02
ES2540807T3 (es) 2015-07-13
EP2164868A1 (en) 2010-03-24
WO2008136694A1 (en) 2008-11-13
JP2010525808A (ja) 2010-07-29
SG194368A1 (en) 2013-11-29
US10280211B2 (en) 2019-05-07
CA2685213A1 (en) 2008-11-13
JP2015164940A (ja) 2015-09-17
US20190256578A1 (en) 2019-08-22
US20100136627A1 (en) 2010-06-03
EP2164868B1 (en) 2015-03-25
JP5791895B2 (ja) 2015-10-07
JP2015012869A (ja) 2015-01-22
AU2008246442B2 (en) 2014-07-03
PT2164868E (pt) 2015-08-04

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