CA2683433C - Nitro-imidazole hypoxia imaging agents - Google Patents
Nitro-imidazole hypoxia imaging agents Download PDFInfo
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- CA2683433C CA2683433C CA2683433A CA2683433A CA2683433C CA 2683433 C CA2683433 C CA 2683433C CA 2683433 A CA2683433 A CA 2683433A CA 2683433 A CA2683433 A CA 2683433A CA 2683433 C CA2683433 C CA 2683433C
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- alkyl
- alkylenyl
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- 230000007954 hypoxia Effects 0.000 title claims description 21
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US92193207P | 2007-04-05 | 2007-04-05 | |
| US60/921,932 | 2007-04-05 | ||
| US96425407P | 2007-08-10 | 2007-08-10 | |
| US60/964,254 | 2007-08-10 | ||
| PCT/US2008/059505 WO2008124651A2 (en) | 2007-04-05 | 2008-04-04 | Nitro-imidazole hypoxia imaging agents |
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| CA2683433A1 CA2683433A1 (en) | 2008-10-16 |
| CA2683433C true CA2683433C (en) | 2016-10-11 |
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| CA2683433A Expired - Fee Related CA2683433C (en) | 2007-04-05 | 2008-04-04 | Nitro-imidazole hypoxia imaging agents |
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| EP (1) | EP2132200B1 (cg-RX-API-DMAC7.html) |
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| WO (1) | WO2008124651A2 (cg-RX-API-DMAC7.html) |
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| EP2132200B1 (en) * | 2007-04-05 | 2016-03-23 | Threshold Pharmaceuticals, Inc. | Nitro-imidazole hypoxia imaging agents |
| CN101709060B (zh) * | 2009-12-02 | 2013-05-01 | 北京师范大学 | 一种f-三唑环-聚乙二醇-甲硝唑化合物及其制备方法 |
| KR20170033873A (ko) | 2010-02-08 | 2017-03-27 | 랜티우스 메디컬 이메징, 인크. | 조영제 및 이의 중간체를 합성하는 방법 및 장치 |
| US10639608B2 (en) | 2010-04-08 | 2020-05-05 | Siemens Medical Solutions Usa, Inc. | System, device and method for preparing tracers and transferring materials during radiosynthesis |
| US9023316B2 (en) | 2010-04-08 | 2015-05-05 | Siemens Medical Solutions Usa, Inc. | Synthesis of 18F-labeled tracers in hydrous organic solvents |
| CN101921263A (zh) * | 2010-04-16 | 2010-12-22 | 兰州大学 | 2-硝基咪唑衍生物及其用途和制备方法 |
| KR102008635B1 (ko) | 2010-05-11 | 2019-08-07 | 랜티우스 메디컬 이메징, 인크. | 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템 |
| DK2753605T3 (da) | 2011-09-09 | 2019-06-17 | Lantheus Medical Imaging Inc | Sammensætninger, fremgangsmåder, og systemer til syntesen og anvendelsen af billeddannelsesmidler |
| US9061143B2 (en) | 2011-10-14 | 2015-06-23 | Sumitomo Heavy Industries, Ltd. | Charged particle beam irradiation system and charged particle beam irradiation planning method |
| EP2793871A4 (en) * | 2011-12-23 | 2015-07-22 | Auckland Uniservices Ltd | COMPOUNDS AND METHODS FOR SELECTIVE IMAGING AND / OR ABLATION |
| US9278124B2 (en) | 2012-10-16 | 2016-03-08 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
| ES2580334T3 (es) | 2014-01-13 | 2016-08-23 | Yang, Guanghua | Composiciones de dendrímeros, métodos de síntesis, y sus usos |
| KR20170058360A (ko) * | 2014-09-25 | 2017-05-26 | 니혼 메디피직스 가부시키가이샤 | 신장 이미징제 |
| US10695446B2 (en) | 2015-05-01 | 2020-06-30 | Vanderbilt University | Composition and method for detecting hypoxia |
| US10695450B2 (en) | 2016-07-26 | 2020-06-30 | Laboratoires Cyclopharma | Synthesis of a radioactive agent composition |
| CN106977501A (zh) * | 2017-03-20 | 2017-07-25 | 华东师范大学 | 一种基于2‑硝基咪唑‑1‑烷基醇的低氧激活前药 |
| FR3068695B1 (fr) * | 2017-07-05 | 2019-08-16 | Centre National De La Recherche Scientifique | Composes utiles comme agent d'imagerie de l'hypoxie |
| CN111372940A (zh) * | 2017-09-19 | 2020-07-03 | 阿尔伯塔大学理事会 | 生物还原活化的化合物、其前药、放射性药物、组合物及其在包括癌症在内的低氧疾病的多模式治疗控制中的应用 |
| CN111356698B (zh) * | 2017-09-19 | 2025-02-25 | 威奇生物科技公司 | 用于低氧成像、映射和治疗的标记物、缀合物、组合物和方法 |
| EP4085056A1 (en) | 2020-01-03 | 2022-11-09 | Berg LLC | Polycyclic amides as ube2k modulators for treating cancer |
| CN111233821B (zh) * | 2020-01-20 | 2022-12-27 | 上海交通大学医学院附属仁济医院 | 含3-羟基苯甲酸基团的新抗霉素衍生物及其制备方法和应用 |
| CN114478489B (zh) * | 2022-01-18 | 2023-04-28 | 中国科学院精密测量科学与技术创新研究院 | 一种氟-19修饰的硝基咪唑化合物及其衍生物的制备方法和应用 |
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| US5674693A (en) * | 1994-03-18 | 1997-10-07 | Natural Pharmacia International Inc. | Derivatives of 2-nitro-imidazoles as hypoxic cell markers |
| US5721265A (en) * | 1994-08-05 | 1998-02-24 | Sri International | Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells |
| WO2001012575A1 (en) * | 1999-08-11 | 2001-02-22 | Universite Catholique De Louvain | Methods for preparing perfluorinated [18f]-radiolabelled nitroimidazole derivatives for cellular hypoxia detection |
| EP2132200B1 (en) * | 2007-04-05 | 2016-03-23 | Threshold Pharmaceuticals, Inc. | Nitro-imidazole hypoxia imaging agents |
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2008
- 2008-04-04 EP EP08745183.7A patent/EP2132200B1/en not_active Not-in-force
- 2008-04-04 CN CN200880011415.1A patent/CN101652360B/zh not_active Expired - Fee Related
- 2008-04-04 JP JP2010502341A patent/JP5347164B2/ja not_active Expired - Fee Related
- 2008-04-04 KR KR1020097023183A patent/KR101523257B1/ko not_active Expired - Fee Related
- 2008-04-04 WO PCT/US2008/059505 patent/WO2008124651A2/en not_active Ceased
- 2008-04-04 US US12/098,390 patent/US7807394B2/en not_active Expired - Fee Related
- 2008-04-04 CA CA2683433A patent/CA2683433C/en not_active Expired - Fee Related
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2010
- 2010-07-15 US US12/836,926 patent/US7977361B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20090010846A1 (en) | 2009-01-08 |
| KR101523257B1 (ko) | 2015-05-27 |
| KR20090130106A (ko) | 2009-12-17 |
| WO2008124651A3 (en) | 2009-04-02 |
| WO2008124651A2 (en) | 2008-10-16 |
| JP5347164B2 (ja) | 2013-11-20 |
| CN101652360A (zh) | 2010-02-17 |
| US7977361B2 (en) | 2011-07-12 |
| CN101652360B (zh) | 2014-06-25 |
| CA2683433A1 (en) | 2008-10-16 |
| EP2132200A2 (en) | 2009-12-16 |
| JP2010523596A (ja) | 2010-07-15 |
| US7807394B2 (en) | 2010-10-05 |
| EP2132200B1 (en) | 2016-03-23 |
| US20110002850A1 (en) | 2011-01-06 |
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