CA2681516A1 - Compounds useful as inhibitors of janus kinases - Google Patents

Compounds useful as inhibitors of janus kinases Download PDF

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Publication number
CA2681516A1
CA2681516A1 CA002681516A CA2681516A CA2681516A1 CA 2681516 A1 CA2681516 A1 CA 2681516A1 CA 002681516 A CA002681516 A CA 002681516A CA 2681516 A CA2681516 A CA 2681516A CA 2681516 A1 CA2681516 A1 CA 2681516A1
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Canada
Prior art keywords
compound according
aliphatic
optionally substituted
ring
occurrences
Prior art date
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Abandoned
Application number
CA002681516A
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English (en)
French (fr)
Inventor
Marion Wannamaker
Francesco Salituro
Albert Pierce
Alexander Aronov
Gabriel Martinez-Botella
Jian Wang
Luc Farmer
Mark Ledeboer
Tiansheng Wang
Randy Bethiel
Brian Ledford
Emilie Porter
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Vertex Pharmaceuticals Inc
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Individual
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Publication of CA2681516A1 publication Critical patent/CA2681516A1/en
Abandoned legal-status Critical Current

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
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  • Rheumatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
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  • Pain & Pain Management (AREA)
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  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • AIDS & HIV (AREA)
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CA002681516A 2007-03-22 2008-03-21 Compounds useful as inhibitors of janus kinases Abandoned CA2681516A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91946907P 2007-03-22 2007-03-22
US60/919,469 2007-03-22
PCT/US2008/057797 WO2008116139A2 (en) 2007-03-22 2008-03-21 N-heterocyclic compounds useful as inhibitors of janus kinases

Publications (1)

Publication Number Publication Date
CA2681516A1 true CA2681516A1 (en) 2008-09-25

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Application Number Title Priority Date Filing Date
CA002681516A Abandoned CA2681516A1 (en) 2007-03-22 2008-03-21 Compounds useful as inhibitors of janus kinases

Country Status (10)

Country Link
US (3) US20100160287A1 (https=)
EP (1) EP2144878A2 (https=)
JP (2) JP5642973B2 (https=)
KR (1) KR20090129488A (https=)
CN (1) CN101778825A (https=)
AU (1) AU2008228768A1 (https=)
CA (1) CA2681516A1 (https=)
IL (1) IL201064A0 (https=)
MX (1) MX2009010127A (https=)
WO (1) WO2008116139A2 (https=)

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TW201100441A (en) 2009-06-01 2011-01-01 Osi Pharm Inc Amino pyrimidine anticancer compounds
CA2767091A1 (en) * 2009-07-15 2011-01-20 Abbott Laboratories Pyrrolopyrazine inhibitors of kinases
AU2010339531A1 (en) 2009-12-30 2012-08-23 Arqule, Inc. Substituted naphthalenyl-pyrimidine compounds
JP2013147428A (ja) * 2010-04-27 2013-08-01 Dainippon Sumitomo Pharma Co Ltd 新規２−ヘテロアリール単環ピリミジン誘導体
WO2012030948A1 (en) 2010-09-01 2012-03-08 Ambit Biosciences Corporation Quinazoline compounds and methods of use thereof
US9133224B2 (en) 2010-11-29 2015-09-15 OSI Pharmaceuticals, LLC Macrocyclic kinase inhibitors
CA2819373A1 (en) * 2010-12-09 2012-06-14 Amgen Inc. Bicyclic compounds as pim inhibitors
EP2688886A1 (en) 2011-03-22 2014-01-29 Amgen Inc. Azole compounds as pim inhibitors
JP6116554B2 (ja) 2011-07-07 2017-04-19 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ がんの処置のための置換されたアザ複素環
EP4556010A3 (en) 2011-11-30 2025-07-23 Emory University Jak inhibitors for use in the prevention or treatment of a viral disease caused by a coronaviridae
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