CA2679485A1 - Delta-9 elongases and their use in making polyunsaturated fatty acids - Google Patents
Delta-9 elongases and their use in making polyunsaturated fatty acids Download PDFInfo
- Publication number
- CA2679485A1 CA2679485A1 CA002679485A CA2679485A CA2679485A1 CA 2679485 A1 CA2679485 A1 CA 2679485A1 CA 002679485 A CA002679485 A CA 002679485A CA 2679485 A CA2679485 A CA 2679485A CA 2679485 A1 CA2679485 A1 CA 2679485A1
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- Prior art keywords
- delta
- seq
- elongase
- desaturase
- plant
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- RWVGQQGBQSJDQV-UHFFFAOYSA-M sodium;3-[[4-[(e)-[4-(4-ethoxyanilino)phenyl]-[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]-2-methylcyclohexa-2,5-dien-1-ylidene]methyl]-n-ethyl-3-methylanilino]methyl]benzenesulfonate Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C(=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C)C=2C(=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C)C=C1 RWVGQQGBQSJDQV-UHFFFAOYSA-M 0.000 description 1
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- 208000024891 symptom Diseases 0.000 description 1
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- 235000020357 syrup Nutrition 0.000 description 1
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- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 150000003595 thromboxanes Chemical class 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 230000009772 tissue formation Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
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- AQWHMKSIVLSRNY-UHFFFAOYSA-N trans-Octadec-5-ensaeure Natural products CCCCCCCCCCCCC=CCCCC(O)=O AQWHMKSIVLSRNY-UHFFFAOYSA-N 0.000 description 1
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- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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- RYYVLZVUVIJVGH-UHFFFAOYSA-N trimethylxanthine Natural products CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 1
- PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings or cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings or cooking oils characterised by ingredients other than fatty acid triglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
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- Genetics & Genomics (AREA)
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- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Animal Husbandry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
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| US60/911,925 | 2007-04-16 | ||
| PCT/US2008/060393 WO2008128240A1 (en) | 2007-04-16 | 2008-04-16 | Delta 9 elongases and their use in making polyunsaturated fatty acids |
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| CA2679485A1 true CA2679485A1 (en) | 2008-10-23 |
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| WO (2) | WO2008128240A1 (enExample) |
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| US7807849B2 (en) | 2004-04-22 | 2010-10-05 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| RU2009111266A (ru) | 2006-08-29 | 2010-10-10 | Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) | Синтез жирных кислот |
| US8119860B2 (en) * | 2007-04-16 | 2012-02-21 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| CA2687610C (en) * | 2007-05-25 | 2017-01-24 | Suntory Holdings Limited | Lysophosphatidic acid acyltransferase genes |
| US8168858B2 (en) | 2008-06-20 | 2012-05-01 | E. I. Du Pont De Nemours And Company | Delta-9 fatty acid elongase genes and their use in making polyunsaturated fatty acids |
| ES2644883T3 (es) | 2008-11-18 | 2017-11-30 | Commonwealth Scientific And Industrial Research Organisation | Enzimas y métodos para producir ácidos grasos omega-3 |
| CA2744716C (en) * | 2008-12-18 | 2017-05-23 | E.I. Du Pont De Nemours And Company | Reducing byproduction of malonates in a fermentation process |
| AU2010260234B2 (en) | 2009-06-16 | 2015-02-26 | E. I. Du Pont De Nemours And Company | High eicosapentaenoic acid oils from improved optimized strains of Yarrowia lipolytica |
| US8188335B2 (en) | 2009-07-17 | 2012-05-29 | Abbott Laboratories | Δ9-elongase for production of polyunsaturated fatty acid-enriched oils |
| WO2011054801A1 (en) | 2009-11-03 | 2011-05-12 | Dsm Ip Assets B.V. | Vegatable oil comprising a polyunsaturaded fatty acid having at least 20 carbon atoms |
| US20130129902A1 (en) | 2009-11-03 | 2013-05-23 | Dsm Ip Assets B.V. | Composition comprising cells and a polyunsaturated fatty acid having at least 20 carbon atoms (lc-pufa) |
| US20110263709A1 (en) | 2010-04-22 | 2011-10-27 | E. I. Du Pont De Nemours And Company | Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass |
| AU2011293189B2 (en) | 2010-08-26 | 2017-02-16 | E. I. Du Pont De Nemours And Company | Mutant HPGG motif and HDASH motif delta-5 desaturases and their use in making polyunsaturated fatty acids |
| KR20130138760A (ko) | 2010-08-26 | 2013-12-19 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 고농도의 에이코사펜타엔산 생성을 위한 재조합 미생물 숙주 세포 |
| AU2011293167B2 (en) | 2010-08-26 | 2016-12-08 | E. I. Du Pont De Nemours And Company | Mutant delta-9 elongases and their use in making polyunsaturated fatty acids |
| WO2012091812A1 (en) | 2010-12-30 | 2012-07-05 | E. I. Du Pont De Nemours And Company | Use of saccharomyces cerevisiae suc2 gene in yarrowia lipolytica for sucrose utilization |
| US20130040340A1 (en) | 2011-02-07 | 2013-02-14 | E. I. Du Pont De Nemours And Company | Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms |
| CA3082388A1 (en) | 2012-06-15 | 2013-12-19 | Commonwealth Scientific And Industrial Research Organisation | Genetic constructs for producing long chain polyunsaturated fatty acids in plant cells |
| CA2892516A1 (en) | 2012-12-21 | 2014-06-26 | E. I. Du Pont De Nemours And Company | Down-regulation of a polynucleotide encoding a sou2 sorbitol utilization protein to modify lipid production in microbial cells |
| BR112016008036A2 (pt) | 2013-10-25 | 2018-01-16 | Pioneer Hi Bred Int | método de identificação de uma primeira planta, kit, polinucleotídeo isolado, planta, germoplasma ou grão de soja |
| CA3241340A1 (en) | 2013-12-18 | 2015-06-25 | Grains Research And Development Corporation | Lipid comprising long chain polyunsaturated fatty acids |
| CA2953008C (en) | 2014-06-27 | 2024-03-19 | Nuseed Pty Ltd | Lipid comprising docosapentaenoic acid |
| CN106916796B (zh) * | 2015-12-28 | 2021-06-29 | 丰益(上海)生物技术研发中心有限公司 | 裂殖壶菌delta-12脂肪酸脱饱和酶相关序列及其应用 |
| US11096344B2 (en) | 2016-02-05 | 2021-08-24 | Pioneer Hi-Bred International, Inc. | Genetic loci associated with brown stem rot resistance in soybean and methods of use |
| EA201991467A1 (ru) | 2016-12-15 | 2019-11-29 | Состав смеси, содержащий силикат и микробные и/или растительные клетки и полиненасыщенную жирную кислоту, имеющую по меньшей мере 20 атомов углерода (lc-pufa) |
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| US7238482B2 (en) * | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
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| CN1860211B (zh) | 2003-08-01 | 2010-08-04 | 巴斯福植物科学有限公司 | 用于在转基因生物中产生多不饱和脂肪酸的方法 |
| AU2004290051A1 (en) | 2003-11-12 | 2005-05-26 | E.I. Dupont De Nemours And Company | Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oilseed plants and oleaginous yeast |
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| PL1723220T3 (pl) | 2004-02-27 | 2013-09-30 | Basf Plant Science Gmbh | Sposób wytwarzania wielokrotnie nienasyconych kwasów tłuszczowych w roślinach transgenicznych |
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| CA3023314C (en) | 2004-04-22 | 2019-12-10 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| WO2006012325A1 (en) | 2004-06-25 | 2006-02-02 | E.I. Dupont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7465564B2 (en) * | 2004-08-10 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Production of γ-linolenic acid in oleaginous yeast |
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| WO2007061742A1 (en) * | 2005-11-23 | 2007-05-31 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| US7465793B2 (en) * | 2006-04-20 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Synthetic Δ17 desaturase derived from Phytophthora ramourum and its use in making polyunsaturated fatty acids |
| US7943823B2 (en) | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7678560B2 (en) | 2006-05-17 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Δ 5 desaturase and its use in making polyunsaturated fatty acids |
| US8013215B2 (en) * | 2007-02-12 | 2011-09-06 | E.I. Du Pont De Nemours And Company | Production of arachidonic acid in oilseed plants |
| CA2679988A1 (en) * | 2007-04-03 | 2008-10-16 | E. I. Du Pont De Nemours And Company | Multizymes and their use in making polyunsaturated fatty acids |
| US7790156B2 (en) * | 2007-04-10 | 2010-09-07 | E. I. Du Pont De Nemours And Company | Δ-8 desaturases and their use in making polyunsaturated fatty acids |
| US8119860B2 (en) * | 2007-04-16 | 2012-02-21 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| EP2195415A1 (en) * | 2007-10-03 | 2010-06-16 | E. I. du Pont de Nemours and Company | Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production |
| CA2719361A1 (en) * | 2008-04-03 | 2009-10-08 | E.I. Du Pont De Nemours And Company | Multizymes |
| AU2010313379B2 (en) | 2009-10-30 | 2015-11-05 | Recor Medical, Inc. | Method and apparatus for treatment of hypertension through percutaneous ultrasound renal denervation |
| US9979908B2 (en) | 2014-03-31 | 2018-05-22 | Agency For Science, Technology And Research | Image processing devices and image processing methods with interpolation for improving image resolution |
-
2008
- 2008-04-15 US US12/102,979 patent/US8119860B2/en active Active
- 2008-04-15 US US12/102,879 patent/US7794701B2/en not_active Expired - Fee Related
- 2008-04-16 DK DK08745904.6T patent/DK2137304T3/da active
- 2008-04-16 WO PCT/US2008/060393 patent/WO2008128240A1/en not_active Ceased
- 2008-04-16 WO PCT/US2008/060396 patent/WO2008128241A1/en not_active Ceased
- 2008-04-16 JP JP2010504199A patent/JP5501954B2/ja not_active Expired - Fee Related
- 2008-04-16 BR BRPI0807291-4A2A patent/BRPI0807291A2/pt not_active Application Discontinuation
- 2008-04-16 AU AU2008240029A patent/AU2008240029B2/en not_active Ceased
- 2008-04-16 CA CA002679485A patent/CA2679485A1/en not_active Abandoned
- 2008-04-16 CA CA002682962A patent/CA2682962A1/en not_active Abandoned
- 2008-04-16 EP EP08745901.2A patent/EP2134837B1/en not_active Not-in-force
- 2008-04-16 EP EP08745904.6A patent/EP2137304B1/en not_active Not-in-force
- 2008-04-16 CN CN2008800203954A patent/CN101848996B/zh not_active Expired - Fee Related
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- 2008-04-16 US US12/530,481 patent/US20100162435A1/en not_active Abandoned
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2010
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2012
- 2012-01-11 US US13/347,938 patent/US8377673B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20080254195A1 (en) | 2008-10-16 |
| CN101848996B (zh) | 2013-05-29 |
| US20120100595A1 (en) | 2012-04-26 |
| WO2008128241A1 (en) | 2008-10-23 |
| EP2137304B1 (en) | 2013-08-14 |
| US8298797B2 (en) | 2012-10-30 |
| CN101848996A (zh) | 2010-09-29 |
| AU2008240029B2 (en) | 2013-05-02 |
| AU2008240029A1 (en) | 2008-10-23 |
| EP2137304A1 (en) | 2009-12-30 |
| WO2008128240A1 (en) | 2008-10-23 |
| US8377673B2 (en) | 2013-02-19 |
| BRPI0807291A2 (pt) | 2014-04-29 |
| US20100267098A1 (en) | 2010-10-21 |
| CA2682962A1 (en) | 2008-10-23 |
| EP2134837A1 (en) | 2009-12-23 |
| US20100162435A1 (en) | 2010-06-24 |
| EP2134837B1 (en) | 2014-01-01 |
| US20080254522A1 (en) | 2008-10-16 |
| JP2010524468A (ja) | 2010-07-22 |
| DK2137304T3 (da) | 2013-11-11 |
| AU2008240028A1 (en) | 2008-10-23 |
| US8119860B2 (en) | 2012-02-21 |
| JP5501954B2 (ja) | 2014-05-28 |
| US7794701B2 (en) | 2010-09-14 |
| AU2008240028B2 (en) | 2014-03-06 |
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| EEER | Examination request |
Effective date: 20130326 |
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| FZDE | Discontinued |
Effective date: 20171214 |