CA2677286C - Closure cap for a container for receiving medical liquids, and container for receiving medical liquids - Google Patents

Closure cap for a container for receiving medical liquids, and container for receiving medical liquids Download PDF

Info

Publication number
CA2677286C
CA2677286C CA2677286A CA2677286A CA2677286C CA 2677286 C CA2677286 C CA 2677286C CA 2677286 A CA2677286 A CA 2677286A CA 2677286 A CA2677286 A CA 2677286A CA 2677286 C CA2677286 C CA 2677286C
Authority
CA
Canada
Prior art keywords
closure cap
recess
closing
membrane
connection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2677286A
Other languages
French (fr)
Other versions
CA2677286A1 (en
Inventor
Torsten Brandenburger
Gerhard Greier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Kabi Deutschland GmbH
Original Assignee
Fresenius Kabi Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Kabi Deutschland GmbH filed Critical Fresenius Kabi Deutschland GmbH
Publication of CA2677286A1 publication Critical patent/CA2677286A1/en
Application granted granted Critical
Publication of CA2677286C publication Critical patent/CA2677286C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1418—Threaded type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1431—Permanent type, e.g. welded or glued
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2044—Separating means having slits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Closures For Containers (AREA)

Abstract

The invention relates to a connector for medical liquid-containing packages, in particular to infusion or transfusion bags comprising a connection element (1) provided with a channel-shaped opening (1c) in which a self-sealing membrane (8) is arranged. A
breakable part (17) which is connected to the connection piece closes the channel-shaped opening. Above the membrane (8), said connection element is embodied in the form a connection piece (13) comprising an internal cone (14) and external thread (15), the membrane (8) being sealed for receiving a syringe cone shaft. The inventive connector makes it possible to inject an active substance by means of a conventional Luer lock syringe devoid of an injection cannula (needle).

Description

, CA 02677286 2009-07-31 ..

Closure cap for a container for receiving medical liquids, and container for receiving medical liquids The invention relates to a closure cap for a container for receiving medical liquids, and in particular an infusion or transfusion container, which closure cap has a cover portion and a rim portion. As well as this, the invention also relates to a container for receiving medical liquids, and in particular a BFS container, which has a closure cap of this kind.
There is a process, known as the blow-fill-seal process (BFS process), in which, in a single operation and sterilely and while remaining pyrogen-free, containers, such for example as bottles of extruded PE or PP, are blown to a desired shape and immediately on cooling are filled aseptically with a desired filling and are hermetically sealed. The containers, and in particular the bottles, which are produced by the blow-fill-seal process are also referred to as BFS containers.
When known BFS containers are used to receive sterile medical liquids, such for example as infusion solutions, they require a closure cap system which allows the infusion solution to be transferred to the patient by means of an infusion device. It should also be possible for medications to be added to the infusion solution.
Known from WO 96/23545 is an infusion bag which has an injection part and a withdrawal part. The withdrawal part is used to allow the infusion solution to be withdrawn by means of a spike, whereas the injection part is used to allow a medication to be fed in by means of an injection syringe which has a thin needle. The injection part comprises a tubular portion for connection which is closed off by a protective cap in the form of a break-off part. Seated in
2 the portion for connection is a self-sealing membrane (septum) which is pierced by the needle of the injection syringe. A piercable membrane in the portion for connection stops the septum from coming into contact with the solution before the infusion bag is used.
The withdrawal part does not have a self-sealing septum. The injection and withdrawal parts known from WO 96/23545 are intended to be welded into an infusion bag.
The known injection parts have proved satisfactory in practice. There are however disadvantages which arise from the use of an injection needle for injecting an active agent. On the one hand there is a risk of the connection between the injection needle and the septum becoming disconnected due to an unintentional pull on the syringe or a pressure above atmospheric inside the bag. On the other hand there is an increased risk of injury to the nursing staff due to the injection needle. The infusion bag into which the injection part is welded may also be damaged by the needle in the event of inexpert handling. As well as this, it is also more difficult for a viscous active agent to be fed in due to the small cross-section of the needle. In addition, it takes a relatively long time even to feed in an active agent of low viscosity due to the small cross-section of the needle.
For connecting up medical devices, there are in medical engineering known conical connectors with a conical tip and a conical socket whose conical surfaces are standardised.
The non-lockable conical connectors having standardised conical surfaces are referred to as Luer connectors and the lockable conical connectors are referred to as Luer-lock connectors.
Luer or Luer-lock connectors having a conical tip are referred to as male connectors and the connectors having conical sockets are referred to as female connectors.
DE 103 48 016 Al describes a connector for welding into an infusion bag which allows an active agent to be injected by means of a conventional Luer-lock syringe which does not have an injection needle. The known connector has a portion for connection which has a recess in the form of a passage in which a self-sealing membrane is arranged. A break-off part which is connected to the portion for connection seals off the recess in passage form.
Above the membrane, the portion for connection takes the form of a connecting piece having an internal cone and an outside thread, the membrane being slit to receive the conical tip of a syringe
3 while forming a seal against it. The connector is made up of an upper sub-section and a lower sub-section between which the self-sealing membrane is held by a clamping action.
Known from DE 20 2004 003 267 Ul is a closure cap for a BFS container which has a cover portion and an rim portion, a slit membrane which allows the spike of an infusion device to be inserted being inserted in the cover portion. The slit membrane is seated in the cover portion of the closure cap flush therewith.
The object underlying the invention is to provide a closure cap for a container for receiving medical liquids, and in particular a BFS container, which closure cap allows a liquid to be injected without the use of an injection needle. As well as this, it is also an object of the invention to provide a container for receiving medical liquids, and in particular a BFS
container, which makes it possible for a liquid to be injected without the use of an injection needle.
In some embodiments, the invention provides for a closure cap for a container for receiving medical liquids, which closure cap has a cover portion and a rim portion, an injection part for the injection of a medical liquid being arranged in the cover portion, and a withdrawal part to allow a medical liquid to be withdrawn with a spike being arranged in the cover portion, wherein the injection part for the injection of a medical liquid comprises an outward-pointing portion for connection having a conical recess to receive the conical tip of a needleless injection syringe while forming a seal against it, and an inward-pointing closing-off portion which has a self-sealing membrane to close off the recess in the portion for connection, which self-sealing membrane is slit, the outward-pointing portion for connection is sealed off by a break-off part which is connected to the top end of the portion for connection via an annular zone for fracture, the break-off part having a lateral tab for gripping which extends to the rim portion of the closure cap, and the withdrawal part comprises an outward-pointing portion for connection having a recess for receiving a spike, and an inward-pointing closing-off portion which has a piercable membrane for closing off the recess in the part for connection, the closing-off portion being closed off by a break-off part which is connection to the top end of 3a the portion for connection via an annular zone for fracture, the break-off part having a lateral tab for gripping which extends to the rim portion of the closure cap.
In some embodiments, the invention provides for a container, having the closure cap as described herein.
The closure cap according to the invention for a container for receiving medical liquids, and in particular a BFS container for receiving an infusion solution, has a cover portion and a rim portion, an injection part for the injection of a medical liquid being arranged in the cover portion.
The injection part has an outward-pointing portion for connection having a conical recess to receive the conical tip of a needleless injection syringe while forming a seal against it, and an inward-pointing closing-off portion which has a self-sealing membrane to close off the recess in the portion for connection. The self-sealing membrane is slit and the conical tip of the injection syringe can thus be inserted easily.
4 It is of advantage for the closure cap according to the invention to be formed in one piece except for the self-sealing membrane. This makes it possible for the closure cap to be manufactured in large numbers at low cost.
In a preferred embodiment of the closure cap, the closing-off portion of the injection part has a recess in which the self-sealing membrane is inserted by being snapped into place. The self-sealing membrane is preferably fixed in place in the recess by an inwardly projecting rim of the closing-off portion by a clamping action. Rather than an inwardly projecting rim which extends around the entire circumference of the closing-off portion, the closing-off portion may also have hooks arranged to be distributed around the circumference to fix the self-sealing membrane in position by a clamping action.
In a further preferred embodiment of the invention, the recess in the closing-off portion has a first cylindrical section which merges with the cover portion, and a second cylindrical section which follows on from the first cylindrical section, the first cylindrical section being of a smaller inside diameter than the second cylindrical section.
A preferred embodiment of the closure cap makes provision for the self-sealing membrane to have an annular section which is arranged in the second cylindrical section of larger inside diameter of the recess, and a dished section which follows on from the annular section by way of a central web and which is arranged in the first cylindrical section of smaller inside diameter. The self-sealing membrane thus has a secure hold in the recess in the closing-off portion.
The dished section of the self-sealing membrane preferably has a bowl-like depression. The bowl-like depression on the one hand ensures that that the conical tip of the syringe is reliably guided and on the other hand guarantees that the membrane seals reliably on the conical tip being withdrawn. It has been found in tests that the special configuration of the membrane is crucial to immediate re-closure, the sealing of the membrane being further increased as the internal pressure in the pack increases.

In an embodiment which is a particular preference, the closing-off portion of the injection part having the self-sealing membrane is so designed that, when the conical tip of the injection syringe is inserted, the membrane is compressed in the axial direction in the recess. As a result, the membrane opens when the conical tip is inserted. On the one hand the self-sealing membrane is adequately fixed in place in the recess in the closing-off portion but on the other hand is so freely movable that the membrane can be compressed in the axial direction when the conical tip is inserted. The height of the membrane is reduced when this happens, i.e. the top face of the membrane loses contact with the surface of the closing-off portion against which it rests.
The closing-off portion of the injection part may be designed for a Luer syringe or a Luer-lock syringe. The portion for connection of the injection part preferably has an outside thread, thus enabling a Luer-lock connection to be made to the syringe.
To allow the self-sealing membrane to be closed aseptically, the portion for connection is preferably sealed off by a break-off part which is connected to the top end of the portion for connection via an annular zone for fracture. On the break-off part being broken off, the self-sealing membrane is exposed and the conical tip of the syringe can thus be inserted.
To improve handling, the break-off part preferably has a lateral tab for gripping which extends to the rim portion of the cover portion of the closure cap.
As well as the injection part, the closure cap according to the invention may also have a withdrawal part to allow a medical liquid to be withdrawn with a spike. The withdrawal part preferably also has an outward-pointing portion for connection having a recess into which a spike is inserted, and an inward-pointing closing-off portion which is closed off by a self-sealing membrane.
The piercable membrane is inserted in a recess in the closing-off portion of the withdrawal part by being snapped into place. The membrane is preferably fixed in place by an inwardly projecting rim of the closing-off portion by a clamping action. The closing-off portion of the withdrawal part too is preferably closed off by a break-off part which is connected to the top end of the portion for connection via an annular zone for fracture. The break-off part of the withdrawal part too preferably has a lateral tab for gripping which extends to the rim portion of the cover portion.
The container according to the invention, which is in particular an infusion or transfusion container which preferably takes the form of a bottle, is closed off by the closure cap described above.
An embodiment of the invention will be described in what follows by reference to the drawings.
In the drawings:
Fig. 1 shows an embodiment of closure cap according to the invention, Fig. 2 is a side elevation of the closure cap shown in Fig. 1, Fig. 3 is an enlarged section through the closure cap shown in Fig. 1, on line Fig. 4a and 4b show the closure show the closure cap before and after the insertion of the conical tip of an injection syringe, Fig. 4c is an enlarged view of a detail of Fig. 4b, Fig. 5 is a view in section of the closure cap shown in Fig. 1 and Fig. 6 shows an embodiment of container according to the invention having the closure cap according to the invention.
Figs. 1 and 2 are side elevations of the closure cap according to the invention which has an injection part A and a withdrawal part B. Except for the self-sealing, or in other words piercable, membrane, the closure cap is a one-piece component made of plastics material which can be inexpensively manufactured in large numbers.
The closure cap 1 has a cover portion 2 and a rim portion 3. The cover portion 2 has an outer section 4, and an inner section 5 which projects outwards. From the inner section 5 which projects outwards, a portion for connection 6 for the insertion of the conical tip of a needleless injection syringe points outwards (Fig. 3). The portion for connection 6 has a conical recess 7 for receiving the conical tip of the syringe while forming a seal against it, and an outside thread 8. The conical recess 7 and the outside thread 8 are so designed that a standard commercial Luer-lock syringe can be connected to the portion for connection.
The portion for connection 6 is closed off by a break-off part 9 which is connected to the top end of the portion for connection via an annular zone for fracture 10. The break-off part 9 has a round cap 11 to which a lateral tab for gripping 13, which extends downwards to the rim portion of the cover portion, is connected via a narrow bridge 12. The tab for gripping 13 is so designed that it does not extend beyond the closure cap laterally.
From the central section 5 of the cover portion 2, a closing-off portion 14, which has a recess 15, points inwards. Inserted in the recess 15 in the closing-off portion 14 is a self-sealing membrane 16 which is seated in the recess by being snapped thereinto.
The recess 15 in the closing-off portion 14 has an upper cylindrical section 17 which merges with the central section 5 of the cover portion 2. Following on from the upper cylindrical section 17 is a lower cylindrical section 18 which is of a larger inside diameter than the upper cylindrical section 17. The self-sealing membrane 16 therefore has a lower annular section 19 of a larger outside diameter, which is seated in the lower cylindrical section 18 of the recess 15. An upper, dished section 21 of a smaller outside diameter, which is seated as a close fit in the upper cylindrical section 17 of the recess 15, follows on, via a central bridge 20, from the annular section 19 of the membrane 16. The closing-off portion has an inwardly projecting rim 35 which fixes the membrane 16 in place by a clamping action. The dished section 21 of the membrane 16 has a bowl-like depression 22 which is provided with one or more slits 23 and is for example slit in a cross.

The rim portion 3 of the closure cap 1 has at the bottom a rim 24 in bead form which has, on the underside, a groove extending round in a loop. The closure cap can be fitted onto a bottle, in which case the top edge of the neck of the bottle engages in the groove 25 in the rim 24 in bead form of the closure cap.
The way in which the injection part A of the closure cap operates will be described below by reference to Figs. 4A, 4B and 4C.
To allow a liquid, such for example as a medication, to be injected with a needleless injection syringe, the break-off part 9 is first broken off the portion for connection 6 by pivoting the tab for gripping 13 sideways. This exposes the self-sealing membrane 16. The conical tip 36 of a needleless injection syringe 26 is inserted in the conical recess 7 in the portion for connection 6. When this is done, the conical tip 36 presses against the dished section 22 of the self-sealing membrane 16, as a result of which the membrane is compressed (Fig.
4C). As a result, the central bridge 20 of the membrane 16 is pressed inwards, in which case the dished section 22 is opened in the region of the slits 23. The medication can now be injected.
As well as the injection part A, the closure cap also has a withdrawal part B.
The injection and withdrawal parts A, B are arranged next to one another, in the central section
5 of the cover portion 2 of the closure cap, laterally of the axis of the closure cap. The withdrawal part B is of the same construction as the injection part A (Fig. 5).
The withdrawal part B has a portion for connection 27 which points outwards from the central section 5 of the cover portion 2 and which has a recess 28 for the insertion of the spike of an infusion device. The recess 28 in the portion for connection 27 is closed off by a break-off part 29 which is connected to the top end of the portion for connection via an annular zone for fracture 30. The break-off part 30 once again has a lateral tab for gripping 31 which is of the same form as the tab for gripping of the break-off part of the injection part.
From the central section 5 of the cover portion 2, a closing-off portion 32, in which a membrane 33 able to be pierced by a spike is fixed in place by a clamping action, points downwards.
The membrane 33 is held in place by an inwardly projecting rim 34 of the closing-off portion 32. Once the break-off part 29 has been broken off, the membrane 33 is exposed, and is pierced by the spike. A liquid can be withdrawn with the spike.
Fig. 6 shows the closure cap according to the invention together with a container according to the invention, which in the present embodiment is a BSF bottle.
The closure cap 1 is seated firmly on the neck 37 of the bottle 38, which latter is filled with an infusion solution for example. Because the neck of the bottle is not closed off but is open in the region at the top, the liquid is in direct contact with the cap. It is thus possible for a medication to be injected with a needleless injection syringe. The closure cap preferably takes the form of a screw-cap which is screwed onto the neck 37 of the bottle. It is however also possible for the closure cap to be welded to the neck of the bottle.

Claims

CLAIMS:
1. A closure cap for a container for receiving medical liquids, which closure cap has a cover portion and a rim portion, an injection part for the injection of a medical liquid being arranged in the cover portion, and a withdrawal part to allow a medical liquid to be withdrawn with a spike being arranged in the cover portion, wherein the injection part for the injection of a medical liquid comprises an outward-pointing portion for connection having a conical recess to receive the conical tip of a needleless injection syringe while forming a seal against it, and an inward-pointing closing-off portion which has a self-sealing membrane to close off the recess in the portion for connection, which self-sealing membrane is slit, the outward-pointing portion for connection is sealed off by a break-off part which is connected to the top end of the portion for connection via an annular zone for fracture, the break-off part having a lateral tab for gripping which extends to the rim portion of the closure cap, and the withdrawal part comprises an outward-pointing portion for connection having a recess for receiving a spike, and an inward-pointing closing-off portion which has a piercable membrane for closing off the recess in the part for connection, the closing-off portion being closed off by a break-off part which is connection to the top end of the portion for connection via an annular zone for fracture, the break-off part having a lateral tab for gripping which extends to the rim portion of the closure cap.
2. The closure cap according to claim 1, wherein the closing-off portion of the injection part has a recess in which the self-sealing membrane is inserted by being snapped into place.

3. The closure cap according to claim 1 or 2, wherein the closing-off portion of the injection part has an inwardly projecting rim which fixes the self-sealing membrane in place in a recess in the closing-off portion of the injection part by a clamping action.
4. The closure cap according to one of claims 1 to 3, wherein the closing-off portion of the injection part having the self-sealing membrane is so designed that, when the conical tip of an injection syringe is inserted, the membrane is compressed in the axial direction in a recess in the closing-off portion of the injection part, thus causing the membrane to be opened.
5. The closure cap according to one of claims 1 to 4, wherein the recess in the closing-off portion of the injection part has a first cylindrical section which merges with the cover portion, and a second cylindrical section which follows on from the first cylindrical section and which is of a larger inside diameter than the first cylindrical section.
6. The closure cap according to claim 5, wherein the self-sealing membrane has an annular section which is arranged in the second cylindrical section of the recess, and a dished section which follows on from the annular section by way of a central web and which is arranged in the first cylindrical section.
7. The closure cap according to claim 6, wherein the dished section of the self-sealing membrane has a bowl-like depression.
8. The closure cap according to one of claims 1 to 7, wherein the portion for connection of the injection part has an outside thread.
9. The closure cap according to one of claims 1 to 8, wherein the piercable membrane in the withdrawal part is inserted in the recess by being snapped into place.
10. The closure cap according to claim 9, wherein the closing-off portion of the withdrawal part has an inwardly projecting rim which fixes the piercable membrane in place in the recess by a clamping action.

1 1 . A container, having the closure cap according to one of claims 1 to 10.
12. The container of claim 11, in the form of a Blow-Fill-Seal (BFS) container.
CA2677286A 2007-02-03 2008-02-04 Closure cap for a container for receiving medical liquids, and container for receiving medical liquids Active CA2677286C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE200710005407 DE102007005407A1 (en) 2007-02-03 2007-02-03 Cap for a container for holding medical fluids and container for receiving medical fluids
DE102007005407.8 2007-02-03
PCT/EP2008/000851 WO2008095665A1 (en) 2007-02-03 2008-02-04 Closure cap for a container for receiving medical liquids, and container for receiving medical liquids

Publications (2)

Publication Number Publication Date
CA2677286A1 CA2677286A1 (en) 2008-08-14
CA2677286C true CA2677286C (en) 2015-04-07

Family

ID=39361230

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2677286A Active CA2677286C (en) 2007-02-03 2008-02-04 Closure cap for a container for receiving medical liquids, and container for receiving medical liquids

Country Status (12)

Country Link
US (1) US9095500B2 (en)
EP (1) EP2114345B1 (en)
JP (1) JP5563310B2 (en)
KR (1) KR101462198B1 (en)
CN (1) CN101600411B (en)
AU (1) AU2008213344B2 (en)
BR (1) BRPI0807070B8 (en)
CA (1) CA2677286C (en)
DE (1) DE102007005407A1 (en)
MX (1) MX2009008272A (en)
WO (1) WO2008095665A1 (en)
ZA (1) ZA200904680B (en)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6695817B1 (en) 2000-07-11 2004-02-24 Icu Medical, Inc. Medical valve with positive flow characteristics
AU2005304987B2 (en) 2004-11-05 2011-08-11 Icu Medical, Inc. Medical connector having high flow rate characteristics
US7547300B2 (en) 2006-04-12 2009-06-16 Icu Medical, Inc. Vial adaptor for regulating pressure
US9700710B2 (en) 2006-06-22 2017-07-11 Excelsior Medical Corporation Antiseptic cap equipped syringe
US8167847B2 (en) 2006-06-22 2012-05-01 Excelsior Medical Corporation Antiseptic cap and antiseptic cap equipped plunger and syringe barrel assembly
US11229746B2 (en) 2006-06-22 2022-01-25 Excelsior Medical Corporation Antiseptic cap
US9259535B2 (en) 2006-06-22 2016-02-16 Excelsior Medical Corporation Antiseptic cap equipped syringe
US7883499B2 (en) 2007-03-09 2011-02-08 Icu Medical, Inc. Vial adaptors and vials for regulating pressure
WO2010022095A1 (en) 2008-08-20 2010-02-25 Icu Medical, Inc. Anti-reflux vial adaptors
DE102008048988A1 (en) * 2008-09-25 2010-04-08 Fresenius Kabi Deutschland Gmbh Device for connecting a syringe to a container or a hose line
DE102008060864A1 (en) 2008-12-09 2010-06-10 Fresenius Kabi Deutschland Gmbh Cap for containers for holding medical fluids and container for holding medical fluids
US8454579B2 (en) 2009-03-25 2013-06-04 Icu Medical, Inc. Medical connector with automatic valves and volume regulator
EP2359799A1 (en) * 2010-02-16 2011-08-24 Fresenius Kabi Deutschland GmbH Closure cap for a container for holding medicinal liquids and container
USD644731S1 (en) 2010-03-23 2011-09-06 Icu Medical, Inc. Medical connector
US8758306B2 (en) 2010-05-17 2014-06-24 Icu Medical, Inc. Medical connectors and methods of use
GB2483055A (en) * 2010-08-19 2012-02-29 Baxter Int Administration port for medical fluid containers
US10016587B2 (en) 2011-05-20 2018-07-10 Excelsior Medical Corporation Caps for needleless connectors
US10166381B2 (en) 2011-05-23 2019-01-01 Excelsior Medical Corporation Antiseptic cap
US9867975B2 (en) 2011-05-23 2018-01-16 Excelsior Medical Corporation Antiseptic line cap
EP2744469B2 (en) 2011-08-18 2025-07-23 ICU Medical, Inc. Pressure-regulating vial adaptors
AU2013207770B2 (en) 2012-01-13 2017-09-14 Icu Medical, Inc. Pressure-regulating vial adaptors and methods
SG192312A1 (en) 2012-02-02 2013-08-30 Becton Dickinson Holdings Pte Ltd Adaptor for coupling to a medical container
CN104203194B (en) 2012-02-02 2017-09-08 碧迪股份有限公司 Adapters for connection to medical containers
SG192310A1 (en) 2012-02-02 2013-08-30 Becton Dickinson Holdings Pte Ltd Adaptor for coupling to a medical container
AU2013204180B2 (en) 2012-03-22 2016-07-21 Icu Medical, Inc. Pressure-regulating vial adaptors
EP2692328A1 (en) 2012-08-03 2014-02-05 Becton Dickinson France Dose counting device for coupling with a medical container
EP2735300A1 (en) 2012-11-26 2014-05-28 Becton Dickinson France Adaptor for multidose medical container
US9089475B2 (en) 2013-01-23 2015-07-28 Icu Medical, Inc. Pressure-regulating vial adaptors
ES2966008T3 (en) 2013-01-23 2024-04-17 Icu Medical Inc Pressure Regulating Vial Adapters
US10456786B2 (en) 2013-03-12 2019-10-29 Abbott Laboratories Septums and related methods
HUE028829T2 (en) * 2013-07-16 2017-01-30 Fresenius Kabi Deutschland Gmbh Vial for a medical liquid and method for manufacturing a vial
CN110638645B (en) 2013-07-19 2022-10-18 伊库医学有限公司 Pressure regulated fluid delivery system and method
JP1526207S (en) 2013-08-05 2015-06-15
CN103919680B (en) * 2013-12-02 2016-01-20 江阴市鸿萌橡塑制品有限公司 A kind of no-needle transfusion combined sealed cap
AU2014364218B2 (en) 2013-12-11 2019-06-06 Icu Medical, Inc. Check valve
WO2015168677A1 (en) 2014-05-02 2015-11-05 Excelsior Medical Corporation Strip package for antiseptic cap
WO2015195844A1 (en) 2014-06-20 2015-12-23 Icu Medical, Inc. Pressure-regulating vial adaptors
USD786427S1 (en) 2014-12-03 2017-05-09 Icu Medical, Inc. Fluid manifold
USD793551S1 (en) 2014-12-03 2017-08-01 Icu Medical, Inc. Fluid manifold
WO2016156242A1 (en) 2015-03-27 2016-10-06 Fresenius Kabi Deutschland Gmbh Sealing cap for a container for holding a medical liquid
ES3040274T3 (en) 2015-05-08 2025-10-29 Icu Medical Inc Medical connectors configured to receive emitters of therapeutic agents
EP3297596B1 (en) 2015-05-22 2025-01-01 Fresenius Kabi Deutschland GmbH Connection assembly for guiding a medical liquid
US11883364B2 (en) 2015-05-22 2024-01-30 Fresenius Kabi Deutschland Gmbh Connection assembly for directing a medical liquid
NL2016005B1 (en) * 2015-12-22 2017-07-03 Scholle Ipn Ip Bv Needleless syringe connector cap.
WO2017132588A1 (en) 2016-01-29 2017-08-03 Icu Medical, Inc. Pressure-regulating vial adaptors
US12447112B2 (en) 2016-02-24 2025-10-21 Avent, Inc. Fluid transfer connector
CA3015885A1 (en) 2016-02-24 2017-08-31 Neomed, Inc. Fluid transfer connector
JP2019514504A (en) 2016-04-25 2019-06-06 コスカ ファミリー リミテッド Drug delivery system
CN109152698B (en) * 2016-05-16 2022-07-01 美国血液技术公司 Plasma bottle without sealing piece and top cover thereof
US11648179B2 (en) * 2016-05-16 2023-05-16 Haemonetics Corporation Sealer-less plasma bottle and top for same
DE102016009594A1 (en) 2016-08-06 2018-02-08 Kocher-Plastik Maschinenbau Gmbh Method for producing a closure in a container made of plastic
JP7063891B2 (en) 2016-09-30 2022-05-09 アイシーユー・メディカル・インコーポレーテッド Vial adapter
DE102016012059A1 (en) * 2016-10-08 2018-04-12 Fresenius Kabi Deutschland Gmbh Connector for a liquid containing medical packaging
US10744316B2 (en) 2016-10-14 2020-08-18 Icu Medical, Inc. Sanitizing caps for medical connectors
DE102017002401A1 (en) * 2017-03-07 2018-09-13 Kocher-Plastik Maschinenbau Gmbh Plastic container product
WO2018204206A2 (en) 2017-05-01 2018-11-08 Icu Medical, Inc. Medical fluid connectors and methods for providing additives in medical fluid lines
EP3710086A4 (en) 2017-11-17 2021-11-17 Koska Family Limited SYSTEMS AND PROCEDURES FOR LIQUID DISPENSER
AU2019272750B2 (en) * 2018-05-22 2024-10-10 Haemonetics Corporation Sealer-less plasma bottle and top for same
JP7260258B2 (en) * 2018-06-13 2023-04-18 株式会社 資生堂 Container with lid, multiple containers, and method of assembling container with lid
CN111498188B (en) * 2019-01-30 2023-03-28 百特国际有限公司 Medical fluid container filling system and method
KR102251446B1 (en) 2020-05-29 2021-05-13 주식회사 엔게인 Vial assembly for transporting medical fluid to syringe
USD1052082S1 (en) 2020-06-01 2024-11-19 Koska Family Limited Sealed fluid container
DE102020208146A1 (en) 2020-06-30 2021-12-30 B. Braun Melsungen Aktiengesellschaft Cap for medical fluid container, attachment part for cap, system comprising cap and attachment part, medical fluid container, system comprising medical fluid container and attachment part, method for producing a fluid container
DE102020118855A1 (en) 2020-07-16 2022-01-20 Sarstedt Ag & Co. Kg contraption
US12486085B2 (en) * 2021-02-19 2025-12-02 Braunform Gmbh Cap for closing a container for administering a medication, and method for producing same
EP4082599A1 (en) 2021-04-30 2022-11-02 B. Braun Melsungen AG Cap for a fluid container, fluid container comprising such cap and method for manufacturing such cap
EP4082600A1 (en) 2021-04-30 2022-11-02 B. Braun Melsungen AG Valve, method of manufacturing a valve, cap for a fluid container comprising such valve, fluid container containing such cap, and method for manufacturing such cap
USD992110S1 (en) 2021-08-10 2023-07-11 Koska Family Limited Sealed fluid container
CN118647355A (en) * 2022-02-04 2024-09-13 费森尤斯卡比德国有限公司 Medical container closure and assembly method thereof
US20240008724A1 (en) * 2022-07-08 2024-01-11 Boston Scientific Scimed, Inc. Hybrid water reservoir for an endoscope

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4368729A (en) 1980-10-14 1983-01-18 Baxter Travenol Laboratories, Inc. Aseptic system for total parenteral nutrition and the like
US5135489A (en) 1988-01-25 1992-08-04 Baxter International Inc. Pre-slit injection site and tapered cannula
IE66526B1 (en) 1989-03-17 1996-01-24 Baxter Int A pre-slit injection site usable with a blunt cannula
WO1995003841A1 (en) 1993-08-03 1995-02-09 I-Flow Corporation Valve for filling iv solution bag
FI101768B (en) 1995-02-02 1998-08-31 Orion Yhtymae Oy A connecting element to an infusion bag
DE29515680U1 (en) * 1995-10-02 1995-12-07 B. Braun Melsungen Ag, 34212 Melsungen Containers for medical liquids
GB9700177D0 (en) * 1997-01-07 1997-02-26 Nycomed Imaging As Container
US5957898A (en) * 1997-05-20 1999-09-28 Baxter International Inc. Needleless connector
IT243732Y1 (en) 1998-01-20 2002-03-06 Henkel Ecolab S P A DEVICE FOR THE CONVEYMENT OF DISINFECTANT LIQUIDS IN MEDICAL EQUIPMENT
US6681946B1 (en) * 1998-02-26 2004-01-27 Becton, Dickinson And Company Resealable medical transfer set
EP1211184B1 (en) 1999-04-20 2010-01-20 JMS Co., Ltd. Cap for container and adaptor for liquid communication
DE19958952B4 (en) * 1999-12-08 2004-05-27 Fresenius Kabi Deutschland Gmbh Withdrawal system for medical solutions and containers with such a removal system
DE10127823C1 (en) * 2001-06-07 2002-08-22 West Pharm Serv Drug Res Ltd Closure for a medication bottle and process for its manufacture
US6908459B2 (en) * 2001-12-07 2005-06-21 Becton, Dickinson And Company Needleless luer access connector
US7025744B2 (en) * 2002-10-04 2006-04-11 Dsu Medical Corporation Injection site for male luer or other tubular connector
DE10348016B4 (en) 2003-10-15 2007-05-03 Fresenius Kabi Deutschland Gmbh Connector for medical fluid containing packaging and packaging for medical fluids
DE202004003267U1 (en) 2004-03-03 2004-05-13 Herbert, Reinhold, Dipl.-Ing. Closure cap for blow-fill-seal containers with preferably liquid medicinal products incorporates a valve system
US9380975B2 (en) * 2004-05-07 2016-07-05 Becton, Dickinson And Company Contact activated lancet device
US8177760B2 (en) * 2004-05-12 2012-05-15 C. R. Bard, Inc. Valved connector
DE102004051300C5 (en) * 2004-10-20 2013-01-24 Fresenius Kabi Deutschland Gmbh Cap for containers filled with medical fluids
US7488311B2 (en) * 2004-12-23 2009-02-10 Hospira, Inc. Port closure system for intravenous fluid container
WO2008036101A2 (en) * 2005-11-07 2008-03-27 Industrie Borla S.P.A. Vented safe handling vial adapter

Also Published As

Publication number Publication date
JP2010517607A (en) 2010-05-27
BRPI0807070B8 (en) 2021-06-22
EP2114345B1 (en) 2016-12-07
KR20090113278A (en) 2009-10-29
WO2008095665A1 (en) 2008-08-14
US20100059474A1 (en) 2010-03-11
AU2008213344B2 (en) 2013-08-29
BRPI0807070A2 (en) 2014-04-08
BRPI0807070B1 (en) 2018-10-02
DE102007005407A1 (en) 2008-08-07
US9095500B2 (en) 2015-08-04
CN101600411A (en) 2009-12-09
AU2008213344A1 (en) 2008-08-14
KR101462198B1 (en) 2014-11-17
JP5563310B2 (en) 2014-07-30
CN101600411B (en) 2014-11-05
CA2677286A1 (en) 2008-08-14
MX2009008272A (en) 2009-08-12
ZA200904680B (en) 2010-04-28
EP2114345A1 (en) 2009-11-11

Similar Documents

Publication Publication Date Title
CA2677286C (en) Closure cap for a container for receiving medical liquids, and container for receiving medical liquids
US7857802B2 (en) Connector for medical liquid-containing packages and medical liquid-containing packages
AU743521B2 (en) A container closure with a frangible seal and a connector for a fluid transfer device
US9108031B2 (en) Connector having a membrane, for connecting a syringe to a container or tubing
EP1011603B1 (en) Container cap assembly having an enclosed penetrator
US9615996B2 (en) Closure cap for receptacles for receiving medical liquids and receptacle for receiving medical liquids
EP1029526A1 (en) Medicament container stopper with integral spike access means
EP3753544B1 (en) Vial assembly with luer fitting
RU2517242C2 (en) Closure cap for containers
US12213943B2 (en) Connector for a medical container
CN107580488A (en) Container for medical fluid
HK1133178A (en) Closure cap for a container for receiving medical liquids, and container for receiving medical liquids
HK1133178B (en) Closure cap for a container for receiving medical liquids, and container for receiving medical liquids
HK1089080B (en) Connector for medical liquid-containing packages and medical liquid-containing packages

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130204