CA2677168C - Derives de pteridinone servant d'inhibiteurs des pi3-kinases - Google Patents

Derives de pteridinone servant d'inhibiteurs des pi3-kinases Download PDF

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Publication number
CA2677168C
CA2677168C CA2677168A CA2677168A CA2677168C CA 2677168 C CA2677168 C CA 2677168C CA 2677168 A CA2677168 A CA 2677168A CA 2677168 A CA2677168 A CA 2677168A CA 2677168 C CA2677168 C CA 2677168C
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CA
Canada
Prior art keywords
denotes
mmol
alkyl
amino
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2677168A
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English (en)
Other versions
CA2677168A1 (fr
Inventor
Riccardo Giovannini
Sara Frattini
Trixi Brandl
Steffen Breitfelder
Enzo Cereda
Matthias Grauert
Matthias Hoffmann
Anne T. Joergensen
Udo Maier
Alexander Pautsch
Monica Quai
Stefan Scheuerer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CA2677168A1 publication Critical patent/CA2677168A1/fr
Application granted granted Critical
Publication of CA2677168C publication Critical patent/CA2677168C/fr
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne de nouveaux composés de formule (1) lesquels, en raison de leur activité pharmaceutique en tant que modulateurs des PI3-kinases, peuvent être utilisés dans le domaine thérapeutique pour le traitement de maladies inflammatoires ou allergiques. Les exemples de celles-ci comprennent des affections respiratoires inflammatoires et allergiques, des maladies inflammatoires du tractus gastro-intestinal et de l'appareil moteur, des maladies inflammatoires et allergiques de la peau, des maladies inflammatoires de l'AEil, des maladies de la muqueuse nasale, des affections inflammatoires ou allergiques mettant en jeu des réactions auto-immunes ou des inflammations du rein.
CA2677168A 2007-02-01 2008-01-28 Derives de pteridinone servant d'inhibiteurs des pi3-kinases Active CA2677168C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07101544A EP1953163A1 (fr) 2007-02-01 2007-02-01 Dérivés de Pteridinone comme inhibiteurs des Kinases PI3
EP07101544.0 2007-02-01
PCT/EP2008/050986 WO2008092831A1 (fr) 2007-02-01 2008-01-28 Dérivés de ptéridinone servant d'inhibiteurs des pi3-kinases

Publications (2)

Publication Number Publication Date
CA2677168A1 CA2677168A1 (fr) 2008-08-07
CA2677168C true CA2677168C (fr) 2016-09-27

Family

ID=38054568

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2677168A Active CA2677168C (fr) 2007-02-01 2008-01-28 Derives de pteridinone servant d'inhibiteurs des pi3-kinases

Country Status (11)

Country Link
US (1) US8410100B2 (fr)
EP (2) EP1953163A1 (fr)
JP (1) JP5484072B2 (fr)
AR (1) AR065123A1 (fr)
AT (1) ATE485298T1 (fr)
CA (1) CA2677168C (fr)
CL (1) CL2008000287A1 (fr)
DE (1) DE602008003098D1 (fr)
ES (1) ES2352443T3 (fr)
TW (1) TW200838538A (fr)
WO (1) WO2008092831A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2307400B1 (fr) 2008-05-30 2014-04-23 Amgen, Inc Inhibiteurs de la pi3 kinase
CN102020643A (zh) * 2009-09-22 2011-04-20 上海恒瑞医药有限公司 二氢喋啶酮类衍生物、其制备方法及其在医药上的应用
EP2776444A4 (fr) 2011-11-10 2015-07-22 Osi Pharmaceuticals Llc Dihydroptéridinones
CN103664845B (zh) * 2013-12-27 2016-02-10 湖南欧亚生物有限公司 一种Plk激酶抑制剂药物中间体7-氨基-2,3-二氢苯并呋喃-4-甲酸的制备方法
CA3020172A1 (fr) * 2016-04-07 2017-10-12 Dana-Farber Cancer Institute, Inc. Composes pyrimido-diazepinone d'echafaudage de kinase et procedes de traitement de troubles induits par pi3k
CN110343109B (zh) * 2019-08-21 2021-11-23 郑州大学 一种二氢蝶啶酮-磺酰胺类衍生物及其药学上可接受的盐、其制备方法及其应用
CN115124473B (zh) * 2022-07-12 2023-11-10 河北科技大学 西咪替丁有关物质b的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7169778B2 (en) * 1999-09-15 2007-01-30 Warner-Lambert Company Pteridinones as kinase inhibitors
UY27427A1 (es) * 2001-09-04 2003-03-31 Boehringer Ingelheim Pharma Nuevas dihidro-pteridinonas, procedimientos para su preparación y su utilización como medicamentos
PT2042504E (pt) * 2002-09-30 2011-09-07 Bayer Schering Pharma Ag Derivados da azolepirimidina fundida
WO2004052373A1 (fr) * 2002-12-06 2004-06-24 Warner-Lambert Company Llc Benzoxazin-3-ones et derives de ceux-ci utilises en tant qu'inhibiteurs de pi3k
PT1599478E (pt) 2003-02-26 2007-05-31 Boehringer Ingelheim Pharma Di-hidropteridinonas, proceso para a sua preparação e a sua utilização como medicamento
CN101031569B (zh) * 2004-05-13 2011-06-22 艾科斯有限公司 作为人磷脂酰肌醇3-激酶δ抑制剂的喹唑啉酮
EP1632493A1 (fr) * 2004-08-25 2006-03-08 Boehringer Ingelheim Pharma GmbH & Co.KG Dérivés de dihydropteridine, méthodes de préparation et utilisation en tant que médicament
WO2006091737A1 (fr) * 2005-02-24 2006-08-31 Kemia, Inc. Modulateurs de l'activite de gsk-3

Also Published As

Publication number Publication date
US8410100B2 (en) 2013-04-02
US20100099680A1 (en) 2010-04-22
ATE485298T1 (de) 2010-11-15
TW200838538A (en) 2008-10-01
EP1953163A1 (fr) 2008-08-06
AR065123A1 (es) 2009-05-20
WO2008092831A1 (fr) 2008-08-07
DE602008003098D1 (de) 2010-12-02
CA2677168A1 (fr) 2008-08-07
EP2114945A1 (fr) 2009-11-11
CL2008000287A1 (es) 2008-05-23
JP2010517957A (ja) 2010-05-27
EP2114945B1 (fr) 2010-10-20
ES2352443T3 (es) 2011-02-18
JP5484072B2 (ja) 2014-05-07

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Effective date: 20130125