CA2673238A1 - A process for the preparation of secotaxanes - Google Patents

A process for the preparation of secotaxanes Download PDF

Info

Publication number
CA2673238A1
CA2673238A1 CA002673238A CA2673238A CA2673238A1 CA 2673238 A1 CA2673238 A1 CA 2673238A1 CA 002673238 A CA002673238 A CA 002673238A CA 2673238 A CA2673238 A CA 2673238A CA 2673238 A1 CA2673238 A1 CA 2673238A1
Authority
CA
Canada
Prior art keywords
formula
removal
branched
straight
oxazolidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002673238A
Other languages
English (en)
French (fr)
Inventor
Gabriele Fontana
Ezio Bombardelli
Bruno Gabetta
Giovanni Appendino
Francesco Mainieri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena S.P.A.
Gabriele Fontana
Ezio Bombardelli
Bruno Gabetta
Giovanni Appendino
Francesco Mainieri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena S.P.A., Gabriele Fontana, Ezio Bombardelli, Bruno Gabetta, Giovanni Appendino, Francesco Mainieri filed Critical Indena S.P.A.
Publication of CA2673238A1 publication Critical patent/CA2673238A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D305/08—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002673238A 2006-12-21 2007-12-17 A process for the preparation of secotaxanes Abandoned CA2673238A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2006A002479 2006-12-21
IT002479A ITMI20062479A1 (it) 2006-12-21 2006-12-21 Processo per la preparazione di secotassani
PCT/IB2007/003951 WO2008081247A2 (en) 2006-12-21 2007-12-17 A process for the preparation of secotaxanes

Publications (1)

Publication Number Publication Date
CA2673238A1 true CA2673238A1 (en) 2008-07-10

Family

ID=39589051

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002673238A Abandoned CA2673238A1 (en) 2006-12-21 2007-12-17 A process for the preparation of secotaxanes

Country Status (11)

Country Link
EP (1) EP2091931A2 (ko)
JP (1) JP2010513459A (ko)
KR (1) KR20090092285A (ko)
CN (1) CN101631782A (ko)
AU (1) AU2007341070A1 (ko)
CA (1) CA2673238A1 (ko)
IT (1) ITMI20062479A1 (ko)
MX (1) MX2009006581A (ko)
NO (1) NO20092337L (ko)
RU (1) RU2009123160A (ko)
WO (1) WO2008081247A2 (ko)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2696458B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
DE69433146T2 (de) * 1993-06-11 2004-06-09 Pharmacia & Upjohn Co., Kalamazoo Delta 6,7-Taxol Derivate antineoplastische Verbindungen und diese enthaltende pharmazeutische Zusammenstellungen
WO1996003394A1 (en) * 1994-07-26 1996-02-08 Indena S.P.A. Semi-synthetic taxanes with anti-tumoural activity
IT1308636B1 (it) * 1999-03-02 2002-01-09 Indena Spa Procedimento per la preparazione di tassani da 10-desacetilbaccatinaiii.
ITMI991483A1 (it) * 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof

Also Published As

Publication number Publication date
NO20092337L (no) 2009-07-14
AU2007341070A1 (en) 2008-07-10
WO2008081247A3 (en) 2008-10-09
EP2091931A2 (en) 2009-08-26
WO2008081247A2 (en) 2008-07-10
RU2009123160A (ru) 2010-12-27
KR20090092285A (ko) 2009-08-31
MX2009006581A (es) 2009-06-30
JP2010513459A (ja) 2010-04-30
ITMI20062479A1 (it) 2008-06-22
CN101631782A (zh) 2010-01-20

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Legal Events

Date Code Title Description
FZDE Discontinued