CA2673193C

CA2673193C - Homogeneous paste and gel formulations

Homogeneous paste and gel formulations Download PDF

Info

Publication number: CA2673193C
Authority: CA; Canada
Prior art keywords: veterinary; pharmaceutical; paste; paragraph; oral
Prior art date: 2006-12-19
Legal status : Active

Application number

CA2673193A

Other languages

English (en)

French (fr)

Other versions

CA2673193A1 (en

Inventor

Hassan Nached

Keith Freehauf

Peter Hanson

Current Assignee

Boehringer Ingelheim Animal Health USA Inc

Original Assignee

Merial LLC

Priority date

2006-12-19

Filing date

2007-12-19

Publication date

2014-08-05

2006-12-19 Priority claimed from PCT/US2006/048672 external-priority patent/WO2007075827A2/en

2007-03-05 Priority claimed from US11/713,881 external-priority patent/US20080027011A1/en

2007-12-19 Application filed by Merial LLC filed Critical Merial LLC

2008-06-26 Publication of CA2673193A1 publication Critical patent/CA2673193A1/en

2014-08-05 Application granted granted Critical

2014-08-05 Publication of CA2673193C publication Critical patent/CA2673193C/en

Status Active legal-status Critical Current

2027-12-19 Anticipated expiration legal-status Critical

Links

239000000203 mixture Substances 0.000 title claims abstract description 165
238000009472 formulation Methods 0.000 title claims abstract description 131
239000002562 thickening agent Substances 0.000 claims abstract description 64
239000004034 viscosity adjusting agent Substances 0.000 claims abstract description 52
239000003814 drug Substances 0.000 claims abstract description 50
229940124597 therapeutic agent Drugs 0.000 claims abstract description 49
239000003086 colorant Substances 0.000 claims abstract description 37
239000002250 absorbent Substances 0.000 claims abstract description 27
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239000003755 preservative agent Substances 0.000 claims abstract description 27
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239000004094 surface-active agent Substances 0.000 claims abstract description 5
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 74
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 66
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical group [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 46
239000004408 titanium dioxide Substances 0.000 claims description 43
235000010215 titanium dioxide Nutrition 0.000 claims description 43
239000001095 magnesium carbonate Substances 0.000 claims description 42
229910000021 magnesium carbonate Inorganic materials 0.000 claims description 42
URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical group CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims description 38
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OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 description 15
239000007788 liquid Substances 0.000 description 15
RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 description 14
WPNHOHPRXXCPRA-TVXIRPTOSA-N eprinomectin Chemical compound O1[C@@H](C)[C@@H](NC(C)=O)[C@H](OC)C[C@@H]1O[C@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C\C=C/[C@@H]2C)\C)O[C@H]1C WPNHOHPRXXCPRA-TVXIRPTOSA-N 0.000 description 14
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CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical group [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 12
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 12
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical group [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 12
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PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical group [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 12
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