CA2669695C - Tetrahydropyridinyl compounds for inflammation and immune-related uses - Google Patents

Tetrahydropyridinyl compounds for inflammation and immune-related uses Download PDF

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Publication number
CA2669695C
CA2669695C CA2669695A CA2669695A CA2669695C CA 2669695 C CA2669695 C CA 2669695C CA 2669695 A CA2669695 A CA 2669695A CA 2669695 A CA2669695 A CA 2669695A CA 2669695 C CA2669695 C CA 2669695C
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Prior art keywords
optionally substituted
compound
methyl
nr6r7
nr5c
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Expired - Fee Related
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CA2669695A
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English (en)
French (fr)
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CA2669695A1 (en
Inventor
Gary Bohnert
Shoujun Chen
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Synta Phamaceuticals Corp
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Synta Phamaceuticals Corp
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    • C07—ORGANIC CHEMISTRY
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
CA2669695A 2006-11-13 2007-11-12 Tetrahydropyridinyl compounds for inflammation and immune-related uses Expired - Fee Related CA2669695C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85861006P 2006-11-13 2006-11-13
US60/858,610 2006-11-13
PCT/US2007/023853 WO2008063504A2 (en) 2006-11-13 2007-11-12 Cyclohexenyl-aryl compounds for inflammation and immune-related uses

Publications (2)

Publication Number Publication Date
CA2669695A1 CA2669695A1 (en) 2008-05-29
CA2669695C true CA2669695C (en) 2012-10-30

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ID=39430312

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2669695A Expired - Fee Related CA2669695C (en) 2006-11-13 2007-11-12 Tetrahydropyridinyl compounds for inflammation and immune-related uses

Country Status (8)

Country Link
US (1) US20080207641A1 (zh)
EP (1) EP2086326B1 (zh)
JP (1) JP5538894B2 (zh)
AU (1) AU2007322116B2 (zh)
CA (1) CA2669695C (zh)
HK (1) HK1133553A1 (zh)
TW (1) TWI428338B (zh)
WO (1) WO2008063504A2 (zh)

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EP1984337B1 (en) 2006-01-25 2014-04-30 Synta Pharmaceuticals Corp. Vinyl-phenyl derivatives for inflammation and immune-related uses
JP5430943B2 (ja) * 2006-01-25 2014-03-05 シンタ ファーマシューティカルズ コーポレーション 炎症及び免疫関連用途のための置換芳香族化合物
CA2639927A1 (en) * 2006-01-25 2007-08-02 Synta Pharmaceuticals Corp. Substituted biaryl compounds for inflammation and immune-related uses
AU2007227210A1 (en) 2006-03-20 2007-09-27 Synta Pharmaceuticals Corp. Benzoimidazolyl-parazine compounds for inflammation and immune-related uses
US8779154B2 (en) * 2006-09-26 2014-07-15 Qinglin Che Fused ring compounds for inflammation and immune-related uses
CL2008001933A1 (es) 2007-06-29 2009-09-25 Millennium Pharm Inc Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros.
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RU2465272C2 (ru) 2007-09-10 2012-10-27 КалсиМедика, Инк. Соединения, моделирующие внутриклеточный кальций
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US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
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US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
EP2477982A4 (en) 2009-09-16 2013-04-03 Calcimedica Inc COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM
US8377970B2 (en) 2009-10-08 2013-02-19 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel
US8993612B2 (en) 2009-10-08 2015-03-31 Rhizen Pharmaceuticals Sa Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer
CA2781532A1 (en) 2009-11-20 2011-05-26 Amgen Inc. Anti-orai1 antigen binding protein that binds the second extracellular loop of orai1
CN102971304A (zh) * 2010-02-01 2013-03-13 日本化学医药株式会社 Gpr119激动剂
JP2013525448A (ja) 2010-04-27 2013-06-20 カルシメディカ，インク． 細胞内カルシウムを調節する化合物
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