CA2667737A1 - Cancer susceptibility variants on chr8q24.21 - Google Patents
Cancer susceptibility variants on chr8q24.21 Download PDFInfo
- Publication number
- CA2667737A1 CA2667737A1 CA002667737A CA2667737A CA2667737A1 CA 2667737 A1 CA2667737 A1 CA 2667737A1 CA 002667737 A CA002667737 A CA 002667737A CA 2667737 A CA2667737 A CA 2667737A CA 2667737 A1 CA2667737 A1 CA 2667737A1
- Authority
- CA
- Canada
- Prior art keywords
- cancer
- allele
- marker
- markers
- prostate cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 363
- 201000011510 cancer Diseases 0.000 title claims abstract description 316
- 102000054766 genetic haplotypes Human genes 0.000 claims abstract description 338
- 206010060862 Prostate cancer Diseases 0.000 claims abstract description 328
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims abstract description 326
- 108700028369 Alleles Proteins 0.000 claims description 350
- 239000003550 marker Substances 0.000 claims description 322
- 238000000034 method Methods 0.000 claims description 230
- 239000000523 sample Substances 0.000 claims description 193
- 150000007523 nucleic acids Chemical class 0.000 claims description 163
- 102000039446 nucleic acids Human genes 0.000 claims description 149
- 108020004707 nucleic acids Proteins 0.000 claims description 149
- 239000002773 nucleotide Substances 0.000 claims description 112
- 125000003729 nucleotide group Chemical group 0.000 claims description 112
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 87
- 201000010099 disease Diseases 0.000 claims description 86
- 238000001514 detection method Methods 0.000 claims description 84
- 230000002068 genetic effect Effects 0.000 claims description 79
- 102210029477 rs16901979 Human genes 0.000 claims description 74
- 208000026310 Breast neoplasm Diseases 0.000 claims description 72
- 206010006187 Breast cancer Diseases 0.000 claims description 71
- 201000001441 melanoma Diseases 0.000 claims description 64
- 208000020816 lung neoplasm Diseases 0.000 claims description 61
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 60
- 201000005202 lung cancer Diseases 0.000 claims description 60
- 230000003247 decreasing effect Effects 0.000 claims description 50
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims description 48
- 239000002751 oligonucleotide probe Substances 0.000 claims description 48
- 108091034117 Oligonucleotide Proteins 0.000 claims description 47
- 238000011282 treatment Methods 0.000 claims description 47
- 238000004458 analytical method Methods 0.000 claims description 43
- 239000003814 drug Substances 0.000 claims description 41
- 238000009396 hybridization Methods 0.000 claims description 40
- 230000000295 complement effect Effects 0.000 claims description 34
- 206010009944 Colon cancer Diseases 0.000 claims description 32
- 238000003556 assay Methods 0.000 claims description 32
- 208000029742 colonic neoplasm Diseases 0.000 claims description 32
- 102000054765 polymorphisms of proteins Human genes 0.000 claims description 32
- 239000003623 enhancer Substances 0.000 claims description 29
- 238000003745 diagnosis Methods 0.000 claims description 27
- 239000012634 fragment Substances 0.000 claims description 27
- 239000003153 chemical reaction reagent Substances 0.000 claims description 26
- 229940124597 therapeutic agent Drugs 0.000 claims description 24
- 238000004393 prognosis Methods 0.000 claims description 23
- 238000003752 polymerase chain reaction Methods 0.000 claims description 21
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 17
- 230000003321 amplification Effects 0.000 claims description 16
- 239000013068 control sample Substances 0.000 claims description 16
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 16
- 230000004044 response Effects 0.000 claims description 16
- 238000003205 genotyping method Methods 0.000 claims description 14
- 208000024891 symptom Diseases 0.000 claims description 14
- 239000000090 biomarker Substances 0.000 claims description 12
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 11
- 206010057644 Testis cancer Diseases 0.000 claims description 11
- 238000012217 deletion Methods 0.000 claims description 11
- 230000037430 deletion Effects 0.000 claims description 11
- 238000012163 sequencing technique Methods 0.000 claims description 11
- 201000003120 testicular cancer Diseases 0.000 claims description 11
- 210000004369 blood Anatomy 0.000 claims description 10
- 239000008280 blood Substances 0.000 claims description 10
- 238000012502 risk assessment Methods 0.000 claims description 10
- 230000000392 somatic effect Effects 0.000 claims description 10
- 102000004533 Endonucleases Human genes 0.000 claims description 9
- 108010042407 Endonucleases Proteins 0.000 claims description 9
- 230000008707 rearrangement Effects 0.000 claims description 9
- 238000011277 treatment modality Methods 0.000 claims description 9
- 238000003780 insertion Methods 0.000 claims description 8
- 230000037431 insertion Effects 0.000 claims description 8
- 238000012544 monitoring process Methods 0.000 claims description 8
- 230000008569 process Effects 0.000 claims description 7
- 238000001574 biopsy Methods 0.000 claims description 6
- 230000005945 translocation Effects 0.000 claims description 6
- 230000029087 digestion Effects 0.000 claims description 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
- 201000004949 exfoliation syndrome Diseases 0.000 claims description 4
- 239000002243 precursor Substances 0.000 claims description 4
- 238000010791 quenching Methods 0.000 claims description 4
- 230000000171 quenching effect Effects 0.000 claims description 4
- 239000000872 buffer Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000005259 measurement Methods 0.000 claims description 3
- 238000001712 DNA sequencing Methods 0.000 claims description 2
- 206010074026 Exfoliation glaucoma Diseases 0.000 claims description 2
- 108010010677 Phosphodiesterase I Proteins 0.000 claims description 2
- 238000011325 biochemical measurement Methods 0.000 claims description 2
- 210000000349 chromosome Anatomy 0.000 abstract description 31
- 108090000623 proteins and genes Proteins 0.000 description 135
- 108020004414 DNA Proteins 0.000 description 74
- 108090000765 processed proteins & peptides Proteins 0.000 description 72
- 229920001184 polypeptide Polymers 0.000 description 71
- 102000004196 processed proteins & peptides Human genes 0.000 description 71
- 230000014509 gene expression Effects 0.000 description 60
- 238000012360 testing method Methods 0.000 description 57
- 102000004169 proteins and genes Human genes 0.000 description 49
- 210000004027 cell Anatomy 0.000 description 33
- 102000007066 Prostate-Specific Antigen Human genes 0.000 description 30
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 30
- 108091092878 Microsatellite Proteins 0.000 description 29
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 28
- 108020004999 messenger RNA Proteins 0.000 description 27
- 239000013615 primer Substances 0.000 description 26
- 230000006798 recombination Effects 0.000 description 21
- 238000005215 recombination Methods 0.000 description 21
- 239000000203 mixture Substances 0.000 description 20
- 230000035772 mutation Effects 0.000 description 19
- 210000002307 prostate Anatomy 0.000 description 19
- 210000001519 tissue Anatomy 0.000 description 19
- 208000035392 hereditary 6 prostate cancer Diseases 0.000 description 17
- 208000032154 hereditary 8 prostate cancer Diseases 0.000 description 17
- 108091028043 Nucleic acid sequence Proteins 0.000 description 16
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 15
- 150000001875 compounds Chemical class 0.000 description 15
- 229940079593 drug Drugs 0.000 description 15
- 230000009368 gene silencing by RNA Effects 0.000 description 15
- 230000001681 protective effect Effects 0.000 description 15
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 14
- 230000004075 alteration Effects 0.000 description 14
- 239000003795 chemical substances by application Substances 0.000 description 14
- 230000000875 corresponding effect Effects 0.000 description 14
- 230000000694 effects Effects 0.000 description 14
- 239000002853 nucleic acid probe Substances 0.000 description 14
- 102000004190 Enzymes Human genes 0.000 description 13
- 108090000790 Enzymes Proteins 0.000 description 13
- 150000001413 amino acids Chemical class 0.000 description 13
- 229940088598 enzyme Drugs 0.000 description 13
- 239000000047 product Substances 0.000 description 13
- 108020004459 Small interfering RNA Proteins 0.000 description 12
- 230000000692 anti-sense effect Effects 0.000 description 12
- 239000004055 small Interfering RNA Substances 0.000 description 12
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 11
- 238000012216 screening Methods 0.000 description 11
- 238000002560 therapeutic procedure Methods 0.000 description 11
- 239000000969 carrier Substances 0.000 description 10
- 230000008859 change Effects 0.000 description 10
- 230000034994 death Effects 0.000 description 10
- 231100000517 death Toxicity 0.000 description 10
- 239000002987 primer (paints) Substances 0.000 description 10
- 230000001225 therapeutic effect Effects 0.000 description 10
- 108700020796 Oncogene Proteins 0.000 description 9
- 238000013461 design Methods 0.000 description 9
- 230000006870 function Effects 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 230000037361 pathway Effects 0.000 description 9
- 101710135898 Myc proto-oncogene protein Proteins 0.000 description 8
- 102100038895 Myc proto-oncogene protein Human genes 0.000 description 8
- 108091093037 Peptide nucleic acid Proteins 0.000 description 8
- 101710150448 Transcriptional regulator Myc Proteins 0.000 description 8
- 238000004422 calculation algorithm Methods 0.000 description 8
- 239000002299 complementary DNA Substances 0.000 description 8
- 230000002596 correlated effect Effects 0.000 description 8
- 230000007613 environmental effect Effects 0.000 description 8
- 238000010561 standard procedure Methods 0.000 description 8
- 206010027476 Metastases Diseases 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 7
- 210000004408 hybridoma Anatomy 0.000 description 7
- 238000002844 melting Methods 0.000 description 7
- 230000008018 melting Effects 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
- 102100027962 2-5A-dependent ribonuclease Human genes 0.000 description 6
- 101001080057 Homo sapiens 2-5A-dependent ribonuclease Proteins 0.000 description 6
- 108060003951 Immunoglobulin Proteins 0.000 description 6
- 108700026244 Open Reading Frames Proteins 0.000 description 6
- 108091027967 Small hairpin RNA Proteins 0.000 description 6
- 238000003491 array Methods 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 230000002759 chromosomal effect Effects 0.000 description 6
- 238000009826 distribution Methods 0.000 description 6
- 102000018358 immunoglobulin Human genes 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 6
- 230000009401 metastasis Effects 0.000 description 6
- 230000001105 regulatory effect Effects 0.000 description 6
- 230000010076 replication Effects 0.000 description 6
- 102100032187 Androgen receptor Human genes 0.000 description 5
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 5
- 102100024458 Cyclin-dependent kinase inhibitor 2A Human genes 0.000 description 5
- 102000053602 DNA Human genes 0.000 description 5
- 241001326189 Gyrodactylus prostae Species 0.000 description 5
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 5
- 238000007476 Maximum Likelihood Methods 0.000 description 5
- 108010080146 androgen receptors Proteins 0.000 description 5
- 238000013459 approach Methods 0.000 description 5
- 108700024542 myc Genes Proteins 0.000 description 5
- 238000013188 needle biopsy Methods 0.000 description 5
- 238000002966 oligonucleotide array Methods 0.000 description 5
- 230000008439 repair process Effects 0.000 description 5
- 241000894007 species Species 0.000 description 5
- 238000001356 surgical procedure Methods 0.000 description 5
- 230000008685 targeting Effects 0.000 description 5
- 230000014616 translation Effects 0.000 description 5
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 4
- 108700020463 BRCA1 Proteins 0.000 description 4
- 102000036365 BRCA1 Human genes 0.000 description 4
- 101150072950 BRCA1 gene Proteins 0.000 description 4
- 108700020462 BRCA2 Proteins 0.000 description 4
- 102000052609 BRCA2 Human genes 0.000 description 4
- 101150008921 Brca2 gene Proteins 0.000 description 4
- 108020004705 Codon Proteins 0.000 description 4
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 description 4
- 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 description 4
- 230000033616 DNA repair Effects 0.000 description 4
- 238000002965 ELISA Methods 0.000 description 4
- 238000000729 Fisher's exact test Methods 0.000 description 4
- 241000282412 Homo Species 0.000 description 4
- 101001134216 Homo sapiens Macrophage scavenger receptor types I and II Proteins 0.000 description 4
- 238000003657 Likelihood-ratio test Methods 0.000 description 4
- 102100034184 Macrophage scavenger receptor types I and II Human genes 0.000 description 4
- 108020004511 Recombinant DNA Proteins 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 4
- 239000000427 antigen Substances 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 239000012472 biological sample Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 210000000481 breast Anatomy 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 238000002512 chemotherapy Methods 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 230000037433 frameshift Effects 0.000 description 4
- 238000003197 gene knockdown Methods 0.000 description 4
- 230000030279 gene silencing Effects 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 238000002372 labelling Methods 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 230000000869 mutational effect Effects 0.000 description 4
- 230000003449 preventive effect Effects 0.000 description 4
- 230000000391 smoking effect Effects 0.000 description 4
- 238000013519 translation Methods 0.000 description 4
- 230000003612 virological effect Effects 0.000 description 4
- 102000015779 HDL Lipoproteins Human genes 0.000 description 3
- 108010010234 HDL Lipoproteins Proteins 0.000 description 3
- 241000701806 Human papillomavirus Species 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 238000012300 Sequence Analysis Methods 0.000 description 3
- 102100021719 Steroid 17-alpha-hydroxylase/17,20 lyase Human genes 0.000 description 3
- 101710163849 Steroid 17-alpha-hydroxylase/17,20 lyase Proteins 0.000 description 3
- 238000011256 aggressive treatment Methods 0.000 description 3
- 239000000074 antisense oligonucleotide Substances 0.000 description 3
- 238000012230 antisense oligonucleotides Methods 0.000 description 3
- 238000012098 association analyses Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 229960002685 biotin Drugs 0.000 description 3
- 235000020958 biotin Nutrition 0.000 description 3
- 239000011616 biotin Substances 0.000 description 3
- 231100000504 carcinogenesis Toxicity 0.000 description 3
- 239000003183 carcinogenic agent Substances 0.000 description 3
- 210000000038 chest Anatomy 0.000 description 3
- 238000003776 cleavage reaction Methods 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 238000002405 diagnostic procedure Methods 0.000 description 3
- 238000013399 early diagnosis Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000012226 gene silencing method Methods 0.000 description 3
- 230000009395 genetic defect Effects 0.000 description 3
- 230000007614 genetic variation Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000002962 histologic effect Effects 0.000 description 3
- 230000003053 immunization Effects 0.000 description 3
- 230000002163 immunogen Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000003834 intracellular effect Effects 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 230000003211 malignant effect Effects 0.000 description 3
- 238000013507 mapping Methods 0.000 description 3
- 210000002752 melanocyte Anatomy 0.000 description 3
- 239000002679 microRNA Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 238000005192 partition Methods 0.000 description 3
- 238000002823 phage display Methods 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 238000001959 radiotherapy Methods 0.000 description 3
- 238000007894 restriction fragment length polymorphism technique Methods 0.000 description 3
- 238000012552 review Methods 0.000 description 3
- 102200112570 rs4792311 Human genes 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 238000001308 synthesis method Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- 238000013518 transcription Methods 0.000 description 3
- 238000011269 treatment regimen Methods 0.000 description 3
- 239000013598 vector Substances 0.000 description 3
- 208000035657 Abasia Diseases 0.000 description 2
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 2
- 108020000948 Antisense Oligonucleotides Proteins 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 2
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 2
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 2
- 108091026890 Coding region Proteins 0.000 description 2
- 108020003215 DNA Probes Proteins 0.000 description 2
- 239000003298 DNA probe Substances 0.000 description 2
- 108010036364 Deoxyribonuclease IV (Phage T4-Induced) Proteins 0.000 description 2
- 208000034826 Genetic Predisposition to Disease Diseases 0.000 description 2
- 208000010412 Glaucoma Diseases 0.000 description 2
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 description 2
- 101000669028 Homo sapiens Zinc phosphodiesterase ELAC protein 2 Proteins 0.000 description 2
- 108060001084 Luciferase Proteins 0.000 description 2
- 239000005089 Luciferase Substances 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- WGZDBVOTUVNQFP-UHFFFAOYSA-N N-(1-phthalazinylamino)carbamic acid ethyl ester Chemical compound C1=CC=C2C(NNC(=O)OCC)=NN=CC2=C1 WGZDBVOTUVNQFP-UHFFFAOYSA-N 0.000 description 2
- 108700019961 Neoplasm Genes Proteins 0.000 description 2
- 102000048850 Neoplasm Genes Human genes 0.000 description 2
- 208000007256 Nevus Diseases 0.000 description 2
- 108020004485 Nonsense Codon Proteins 0.000 description 2
- 206010033128 Ovarian cancer Diseases 0.000 description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 description 2
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 2
- 108010087705 Proto-Oncogene Proteins c-myc Proteins 0.000 description 2
- 102000009092 Proto-Oncogene Proteins c-myc Human genes 0.000 description 2
- 101100017043 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HIR3 gene Proteins 0.000 description 2
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 description 2
- 102100026715 Serine/threonine-protein kinase STK11 Human genes 0.000 description 2
- 108010090804 Streptavidin Proteins 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 108700025716 Tumor Suppressor Genes Proteins 0.000 description 2
- 102000044209 Tumor Suppressor Genes Human genes 0.000 description 2
- 102100039877 Zinc phosphodiesterase ELAC protein 2 Human genes 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 210000004381 amniotic fluid Anatomy 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 230000007321 biological mechanism Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 230000000711 cancerogenic effect Effects 0.000 description 2
- 231100000357 carcinogen Toxicity 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 238000007876 drug discovery Methods 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 238000001962 electrophoresis Methods 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 210000003754 fetus Anatomy 0.000 description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
- 239000007850 fluorescent dye Substances 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 238000003209 gene knockout Methods 0.000 description 2
- 102000054767 gene variant Human genes 0.000 description 2
- 230000004077 genetic alteration Effects 0.000 description 2
- 238000012252 genetic analysis Methods 0.000 description 2
- 210000004602 germ cell Anatomy 0.000 description 2
- 108010027853 glutathione S-transferase T1 Proteins 0.000 description 2
- 230000005802 health problem Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 238000001114 immunoprecipitation Methods 0.000 description 2
- 238000007901 in situ hybridization Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 201000005249 lung adenocarcinoma Diseases 0.000 description 2
- 210000004698 lymphocyte Anatomy 0.000 description 2
- 238000007726 management method Methods 0.000 description 2
- 230000037353 metabolic pathway Effects 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 230000001394 metastastic effect Effects 0.000 description 2
- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- 230000009456 molecular mechanism Effects 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 210000004940 nucleus Anatomy 0.000 description 2
- 238000011275 oncology therapy Methods 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 230000002974 pharmacogenomic effect Effects 0.000 description 2
- 210000002826 placenta Anatomy 0.000 description 2
- 238000010837 poor prognosis Methods 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 208000023958 prostate neoplasm Diseases 0.000 description 2
- 238000011471 prostatectomy Methods 0.000 description 2
- 230000004853 protein function Effects 0.000 description 2
- 239000012857 radioactive material Substances 0.000 description 2
- 238000003753 real-time PCR Methods 0.000 description 2
- 230000022983 regulation of cell cycle Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 108091008146 restriction endonucleases Proteins 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000019491 signal transduction Effects 0.000 description 2
- 229940126586 small molecule drug Drugs 0.000 description 2
- 238000011895 specific detection Methods 0.000 description 2
- 230000004960 subcellular localization Effects 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 238000012384 transportation and delivery Methods 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 1
- PIINGYXNCHTJTF-UHFFFAOYSA-N 2-(2-azaniumylethylamino)acetate Chemical group NCCNCC(O)=O PIINGYXNCHTJTF-UHFFFAOYSA-N 0.000 description 1
- HUHGPYXAVBJSJV-UHFFFAOYSA-N 2-[3,5-bis(2-hydroxyethyl)-1,3,5-triazinan-1-yl]ethanol Chemical compound OCCN1CN(CCO)CN(CCO)C1 HUHGPYXAVBJSJV-UHFFFAOYSA-N 0.000 description 1
- 102100033400 4F2 cell-surface antigen heavy chain Human genes 0.000 description 1
- CJIJXIFQYOPWTF-UHFFFAOYSA-N 7-hydroxycoumarin Natural products O1C(=O)C=CC2=CC(O)=CC=C21 CJIJXIFQYOPWTF-UHFFFAOYSA-N 0.000 description 1
- 108010022752 Acetylcholinesterase Proteins 0.000 description 1
- 102000012440 Acetylcholinesterase Human genes 0.000 description 1
- 206010069754 Acquired gene mutation Diseases 0.000 description 1
- ORILYTVJVMAKLC-UHFFFAOYSA-N Adamantane Natural products C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 1
- 108010000239 Aequorin Proteins 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 102000007592 Apolipoproteins Human genes 0.000 description 1
- 108010071619 Apolipoproteins Proteins 0.000 description 1
- 108091023037 Aptamer Proteins 0.000 description 1
- 241000713836 Avian myelocytomatosis virus Species 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 231100000699 Bacterial toxin Toxicity 0.000 description 1
- 102100026189 Beta-galactosidase Human genes 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 208000011691 Burkitt lymphomas Diseases 0.000 description 1
- 108010074051 C-Reactive Protein Proteins 0.000 description 1
- 102100032752 C-reactive protein Human genes 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 108090000994 Catalytic RNA Proteins 0.000 description 1
- 102000053642 Catalytic RNA Human genes 0.000 description 1
- 229940123587 Cell cycle inhibitor Drugs 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 208000016216 Choristoma Diseases 0.000 description 1
- 244000175448 Citrus madurensis Species 0.000 description 1
- 235000004332 Citrus madurensis Nutrition 0.000 description 1
- 235000007438 Citrus mitis Nutrition 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 108020004394 Complementary RNA Proteins 0.000 description 1
- 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 description 1
- 108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 description 1
- 102000009508 Cyclin-Dependent Kinase Inhibitor p16 Human genes 0.000 description 1
- 102100026804 Cyclin-dependent kinase 6 Human genes 0.000 description 1
- 102100026278 Cysteine sulfinic acid decarboxylase Human genes 0.000 description 1
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 description 1
- 102100021704 Cytochrome P450 2D6 Human genes 0.000 description 1
- IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 1
- 230000004544 DNA amplification Effects 0.000 description 1
- 239000003155 DNA primer Substances 0.000 description 1
- 102100027829 DNA repair protein XRCC3 Human genes 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
- XPDXVDYUQZHFPV-UHFFFAOYSA-N Dansyl Chloride Chemical compound C1=CC=C2C(N(C)C)=CC=CC2=C1S(Cl)(=O)=O XPDXVDYUQZHFPV-UHFFFAOYSA-N 0.000 description 1
- CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 1
- 241000702421 Dependoparvovirus Species 0.000 description 1
- 108700003861 Dominant Genes Proteins 0.000 description 1
- 102100028836 E3 SUMO-protein ligase NSE2 Human genes 0.000 description 1
- 101150116954 Elac2 gene Proteins 0.000 description 1
- 102000002494 Endoribonucleases Human genes 0.000 description 1
- 108010093099 Endoribonucleases Proteins 0.000 description 1
- 102000009024 Epidermal Growth Factor Human genes 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000002846 Familial prostate cancer Diseases 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 102000008857 Ferritin Human genes 0.000 description 1
- 108050000784 Ferritin Proteins 0.000 description 1
- 238000008416 Ferritin Methods 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 1
- 101710113436 GTPase KRas Proteins 0.000 description 1
- 240000005702 Galium aparine Species 0.000 description 1
- 235000014820 Galium aparine Nutrition 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 102100035184 General transcription and DNA repair factor IIH helicase subunit XPD Human genes 0.000 description 1
- 102100036534 Glutathione S-transferase Mu 1 Human genes 0.000 description 1
- 108091027305 Heteroduplex Proteins 0.000 description 1
- 101000800023 Homo sapiens 4F2 cell-surface antigen heavy chain Proteins 0.000 description 1
- 101000577736 Homo sapiens E3 SUMO-protein ligase NSE2 Proteins 0.000 description 1
- 101000876511 Homo sapiens General transcription and DNA repair factor IIH helicase subunit XPD Proteins 0.000 description 1
- 101001071694 Homo sapiens Glutathione S-transferase Mu 1 Proteins 0.000 description 1
- 101001128138 Homo sapiens NACHT, LRR and PYD domains-containing protein 2 Proteins 0.000 description 1
- 101000981336 Homo sapiens Nibrin Proteins 0.000 description 1
- 101100082065 Homo sapiens POU5F1B gene Proteins 0.000 description 1
- 101001017783 Homo sapiens Protein LRATD2 Proteins 0.000 description 1
- 101000738546 Homo sapiens Protein PTHB1 Proteins 0.000 description 1
- 101000628562 Homo sapiens Serine/threonine-protein kinase STK11 Proteins 0.000 description 1
- 101001030226 Homo sapiens Unconventional myosin-XVIIIb Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 208000005016 Intestinal Neoplasms Diseases 0.000 description 1
- 102400000704 Intracellular domain 1 Human genes 0.000 description 1
- 101800001559 Intracellular domain 1 Proteins 0.000 description 1
- 108010044467 Isoenzymes Proteins 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 238000008214 LDL Cholesterol Methods 0.000 description 1
- 108010007622 LDL Lipoproteins Proteins 0.000 description 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 1
- 241000713666 Lentivirus Species 0.000 description 1
- DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 1
- 206010064912 Malignant transformation Diseases 0.000 description 1
- 241000997826 Melanocetus johnsonii Species 0.000 description 1
- 102100034216 Melanocyte-stimulating hormone receptor Human genes 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 241000713862 Moloney murine sarcoma virus Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 102000010645 MutS Proteins Human genes 0.000 description 1
- 108010038272 MutS Proteins Proteins 0.000 description 1
- 108020000284 NAD(P)H dehydrogenase (quinone) Proteins 0.000 description 1
- 102100024403 Nibrin Human genes 0.000 description 1
- 238000000636 Northern blotting Methods 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 description 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 description 1
- 108091093018 PVT1 Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 108010004729 Phycoerythrin Proteins 0.000 description 1
- 241000364051 Pima Species 0.000 description 1
- 231100000742 Plant toxin Toxicity 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 241000276498 Pollachius virens Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 101710098940 Pro-epidermal growth factor Proteins 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100034145 Putative POU domain, class 5, transcription factor 1B Human genes 0.000 description 1
- 208000030555 Pygmy Diseases 0.000 description 1
- 101150090155 R gene Proteins 0.000 description 1
- 108020004518 RNA Probes Proteins 0.000 description 1
- 239000003391 RNA probe Substances 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 108700008625 Reporter Genes Proteins 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
- 108010039491 Ricin Proteins 0.000 description 1
- 230000018199 S phase Effects 0.000 description 1
- 101150043975 SRRM1 gene Proteins 0.000 description 1
- 101710181599 Serine/threonine-protein kinase STK11 Proteins 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 108091036066 Three prime untranslated region Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 108010079351 Tumor Suppressor Protein p14ARF Proteins 0.000 description 1
- 108010021428 Type 1 Melanocortin Receptor Proteins 0.000 description 1
- 102100038892 Unconventional myosin-XVIIIb Human genes 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 206010046555 Urinary retention Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 108020000999 Viral RNA Proteins 0.000 description 1
- 101710101493 Viral myc transforming protein Proteins 0.000 description 1
- 108010074310 X-ray repair cross complementing protein 3 Proteins 0.000 description 1
- DUDJTRNGXIUJEB-UHFFFAOYSA-N [N].NCC(O)=O Chemical group [N].NCC(O)=O DUDJTRNGXIUJEB-UHFFFAOYSA-N 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229940022698 acetylcholinesterase Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000007844 allele-specific PCR Methods 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- 125000006295 amino methylene group Chemical group [H]N(*)C([H])([H])* 0.000 description 1
- 238000002669 amniocentesis Methods 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 229960003473 androstanolone Drugs 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000003172 anti-dna Effects 0.000 description 1
- 210000000628 antibody-producing cell Anatomy 0.000 description 1
- 238000007846 asymmetric PCR Methods 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000000688 bacterial toxin Substances 0.000 description 1
- 230000037429 base substitution Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- -1 c-MYC Proteins 0.000 description 1
- 238000010804 cDNA synthesis Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000003560 cancer drug Substances 0.000 description 1
- 239000012830 cancer therapeutic Substances 0.000 description 1
- 230000005773 cancer-related death Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000006369 cell cycle progression Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000004671 cell-free system Anatomy 0.000 description 1
- 108091092328 cellular RNA Proteins 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 239000012707 chemical precursor Substances 0.000 description 1
- 210000004252 chorionic villi Anatomy 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000003184 complementary RNA Substances 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 238000009109 curative therapy Methods 0.000 description 1
- 208000030381 cutaneous melanoma Diseases 0.000 description 1
- 230000002559 cytogenic effect Effects 0.000 description 1
- 238000004163 cytometry Methods 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 238000003936 denaturing gel electrophoresis Methods 0.000 description 1
- 238000003935 denaturing gradient gel electrophoresis Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229940124466 diagnostic for cancer Drugs 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000005782 double-strand break Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 238000009585 enzyme analysis Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000010195 expression analysis Methods 0.000 description 1
- 208000020735 familial prostate carcinoma Diseases 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 231100000221 frame shift mutation induction Toxicity 0.000 description 1
- 125000003843 furanosyl group Chemical group 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 231100000118 genetic alteration Toxicity 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000007773 growth pattern Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 102000051324 human BBS9 Human genes 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 208000006575 hypertriglyceridemia Diseases 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 201000002313 intestinal cancer Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000001155 isoelectric focusing Methods 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 150000002617 leukotrienes Chemical class 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 238000007477 logistic regression Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 208000037841 lung tumor Diseases 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 108091005485 macrophage scavenger receptors Proteins 0.000 description 1
- 230000036212 malign transformation Effects 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 201000010893 malignant breast melanoma Diseases 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000010197 meta-analysis Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical class CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000002297 mitogenic effect Effects 0.000 description 1
- 238000001823 molecular biology technique Methods 0.000 description 1
- 230000003990 molecular pathway Effects 0.000 description 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- ZTLGJPIZUOVDMT-UHFFFAOYSA-N n,n-dichlorotriazin-4-amine Chemical compound ClN(Cl)C1=CC=NN=N1 ZTLGJPIZUOVDMT-UHFFFAOYSA-N 0.000 description 1
- JTSLALYXYSRPGW-UHFFFAOYSA-N n-[5-(4-cyanophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide Chemical compound C=1C=CN=CC=1C(=O)NC(C1=C2)=CNC1=NC=C2C1=CC=C(C#N)C=C1 JTSLALYXYSRPGW-UHFFFAOYSA-N 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 238000007857 nested PCR Methods 0.000 description 1
- 230000006780 non-homologous end joining Effects 0.000 description 1
- 238000007826 nucleic acid assay Methods 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 238000002515 oligonucleotide synthesis Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000006320 pegylation Effects 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 238000001558 permutation test Methods 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 210000004694 pigment cell Anatomy 0.000 description 1
- 238000013439 planning Methods 0.000 description 1
- 239000003123 plant toxin Substances 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 108010040003 polyglutamine Proteins 0.000 description 1
- 229920000155 polyglutamine Polymers 0.000 description 1
- 238000011176 pooling Methods 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 201000007094 prostatitis Diseases 0.000 description 1
- 108010064775 protein C activator peptide Proteins 0.000 description 1
- 238000000734 protein sequencing Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 108091092562 ribozyme Proteins 0.000 description 1
- 102000014452 scavenger receptors Human genes 0.000 description 1
- 238000007423 screening assay Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000009758 senescence Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000037439 somatic mutation Effects 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 210000004988 splenocyte Anatomy 0.000 description 1
- 201000010700 sporadic breast cancer Diseases 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000003239 susceptibility assay Methods 0.000 description 1
- 238000012956 testing procedure Methods 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 238000005382 thermal cycling Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000009752 translational inhibition Effects 0.000 description 1
- 230000017105 transposition Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 231100000588 tumorigenic Toxicity 0.000 description 1
- 230000000381 tumorigenic effect Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
- 230000004222 uncontrolled growth Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000010451 viral insertion Methods 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 102000009310 vitamin D receptors Human genes 0.000 description 1
- 108050000156 vitamin D receptors Proteins 0.000 description 1
- 108700026215 vpr Genes Proteins 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IS8560 | 2006-10-27 | ||
| IS8560 | 2006-10-27 | ||
| PCT/IS2007/000019 WO2008050356A1 (en) | 2006-10-27 | 2007-10-26 | Cancer susceptibility variants on chr8q24.21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2667737A1 true CA2667737A1 (en) | 2008-05-02 |
Family
ID=39060300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002667737A Abandoned CA2667737A1 (en) | 2006-10-27 | 2007-10-26 | Cancer susceptibility variants on chr8q24.21 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100129799A1 (enExample) |
| EP (1) | EP2089548A1 (enExample) |
| JP (1) | JP5631000B2 (enExample) |
| CN (1) | CN101641451A (enExample) |
| AU (1) | AU2007310412B2 (enExample) |
| BR (1) | BRPI0718322A2 (enExample) |
| CA (1) | CA2667737A1 (enExample) |
| IL (1) | IL198305A0 (enExample) |
| MX (1) | MX2009004522A (enExample) |
| NZ (1) | NZ576591A (enExample) |
| SG (1) | SG175680A1 (enExample) |
| WO (1) | WO2008050356A1 (enExample) |
| ZA (1) | ZA200903173B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12366585B2 (en) | 2006-05-18 | 2025-07-22 | Caris Mpi, Inc. | Molecular profiling of tumors |
| WO2008096375A2 (en) * | 2007-02-07 | 2008-08-14 | Decode Genetics Ehf. | Genetic variants contributing to risk of prostate cancer |
| WO2008130009A1 (ja) | 2007-04-17 | 2008-10-30 | Santen Pharmaceutical Co., Ltd. | 緑内障進行リスクの判定方法 |
| US8697360B2 (en) * | 2007-11-30 | 2014-04-15 | Decode Genetics Ehf. | Genetic variants on CHR 11Q and 6Q as markers for prostate and colorectal cancer predisposition |
| WO2009085196A1 (en) * | 2007-12-21 | 2009-07-09 | Wake Forest University Health Sciences | Methods and compositions for correlating genetic markers with prostate cancer risk |
| CN102144036B (zh) * | 2008-07-07 | 2014-07-16 | 解码遗传学私营有限责任公司 | 用于乳腺癌风险评估的遗传变型 |
| EP3216874A1 (en) | 2008-09-05 | 2017-09-13 | TOMA Biosciences, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| EP2347009A4 (en) * | 2008-10-14 | 2012-05-30 | Caris Mpi Inc | GENE AND GENE EXPRESSED TARGET PROTEINS FOR THE PRESENTATION OF BIOMARKERS AND SIGNATURES BY TUMOR TYPE |
| EP2451975A4 (en) * | 2009-05-08 | 2013-08-14 | Decode Genetics Ehf | GENETIC VARIANTS CONTRIBUTING TO A RISK OF PROSTATE CANCER |
| WO2011004404A1 (en) * | 2009-07-10 | 2011-01-13 | Decode Genetics Ehf | Genetic variants for predicting risk of glaucoma |
| US20120316218A1 (en) * | 2009-07-17 | 2012-12-13 | Glinsky Gennadi V | SMALL NON-CODING REGULARTORY RNA's and METHODS FOR THEIR USE |
| WO2011009089A1 (en) * | 2009-07-17 | 2011-01-20 | Ordway Research Institute, Inc. | SMALL NON-CODING REGULATORY RNAs AND METHODS FOR THEIR USE |
| AU2010315601A1 (en) | 2009-10-26 | 2012-05-10 | Abbott Laboratories | Diagnostic methods for determining prognosis of non-small cell lung cancer |
| CN102656458B (zh) | 2009-10-26 | 2016-10-19 | 雅培分子公司 | 用于测定非小细胞肺癌预后的诊断方法 |
| WO2012029080A1 (en) * | 2010-08-30 | 2012-03-08 | Decode Genetics Ehf | Sequence variants associated with prostate specific antigen levels |
| WO2012031207A2 (en) | 2010-09-03 | 2012-03-08 | Wake Forest University Health Sciences | Methods and compositions for correlating genetic markers with prostate cancer risk |
| US9309556B2 (en) | 2010-09-24 | 2016-04-12 | The Board Of Trustees Of The Leland Stanford Junior University | Direct capture, amplification and sequencing of target DNA using immobilized primers |
| US9534256B2 (en) | 2011-01-06 | 2017-01-03 | Wake Forest University Health Sciences | Methods and compositions for correlating genetic markers with risk of aggressive prostate cancer |
| EP3483285B1 (en) | 2011-02-09 | 2021-07-14 | Bio-Rad Laboratories, Inc. | Analysis of nucleic acids |
| CN102304567B (zh) * | 2011-04-29 | 2013-03-27 | 广州益善生物技术有限公司 | 一种染色体8q24区段多态性检测特异性引物和液相芯片 |
| WO2012178058A1 (en) * | 2011-06-22 | 2012-12-27 | Indiana University Research And Technology Corporation | Compositions for and methods of detecting, diagnosing and prognosing thymic cancer |
| WO2013065072A1 (en) * | 2011-10-30 | 2013-05-10 | Decode Genetics Ehf | Risk variants of prostate cancer |
| EP3024948B1 (en) | 2013-07-25 | 2020-01-15 | Bio-rad Laboratories, Inc. | Genetic assays for detecting viral recombination rate |
| JP6883584B2 (ja) * | 2015-08-27 | 2021-06-09 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | マルチオミック癌プロファイルを用いて機能的な患者固有の体細胞異常を識別するための統合された方法及びシステム |
| WO2017164699A1 (ko) * | 2016-03-24 | 2017-09-28 | 서울대학교병원 (분사무소) | 전립선암과 관련된 단일염기다형성 및 이를 이용한 유전 위험도 점수의 개발 |
| KR101944927B1 (ko) | 2016-03-24 | 2019-02-07 | 서울대학교산학협력단 | 전립선암과 관련된 단일염기다형성 및 이를 이용한 유전 위험도 점수의 개발 |
| CN106480211A (zh) * | 2016-11-24 | 2017-03-08 | 深圳市核子基因科技有限公司 | 一种用于检测睾丸癌易感性的试剂盒及其snp标志物 |
| CN110382718A (zh) * | 2017-02-01 | 2019-10-25 | 法迪亚股份有限公司 | 用于指示具有特定特征的个体中的前列腺癌的存在或不存在的方法 |
| TW202033760A (zh) * | 2018-11-28 | 2020-09-16 | 國立大學法人千葉大學 | 多因素遺傳疾病的基因檢測法、及檢測套件 |
| EP3963092A1 (en) * | 2019-05-02 | 2022-03-09 | Predictive Technology Group, Inc. | Somatic cancer driver mutations in endometriosis lesions contribute to secondary cancer risk |
| US20230119558A1 (en) * | 2020-03-06 | 2023-04-20 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Dna damage repair genes in cancer |
| KR102177218B1 (ko) * | 2020-04-24 | 2020-11-10 | 유니젠바이오 주식회사 | 머신러닝 기반 암진단 예측 장치 |
| KR102177222B1 (ko) * | 2020-04-24 | 2020-11-10 | 유니젠바이오 주식회사 | 머신러닝 기반 암진단 예측 시스템 |
| KR20250074712A (ko) | 2023-11-15 | 2025-05-28 | 주식회사 바스젠바이오 | 전립선암 발병의 위험도를 예측하기 위한 조성물 및 이를 이용한 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5384261A (en) * | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| AU785425B2 (en) * | 2001-03-30 | 2007-05-17 | Genetic Technologies Limited | Methods of genomic analysis |
| US20030170665A1 (en) * | 2001-08-04 | 2003-09-11 | Whitehead Institute For Biomedical Research | Haplotype map of the human genome and uses therefor |
| US20040023237A1 (en) * | 2001-11-26 | 2004-02-05 | Perelegen Sciences Inc. | Methods for genomic analysis |
| US20040146870A1 (en) * | 2003-01-27 | 2004-07-29 | Guochun Liao | Systems and methods for predicting specific genetic loci that affect phenotypic traits |
-
2007
- 2007-10-26 CA CA002667737A patent/CA2667737A1/en not_active Abandoned
- 2007-10-26 NZ NZ576591A patent/NZ576591A/en not_active IP Right Cessation
- 2007-10-26 CN CN200780046943A patent/CN101641451A/zh active Pending
- 2007-10-26 EP EP20070827611 patent/EP2089548A1/en not_active Withdrawn
- 2007-10-26 AU AU2007310412A patent/AU2007310412B2/en not_active Ceased
- 2007-10-26 JP JP2009534057A patent/JP5631000B2/ja not_active Expired - Fee Related
- 2007-10-26 MX MX2009004522A patent/MX2009004522A/es active IP Right Grant
- 2007-10-26 SG SG2011078417A patent/SG175680A1/en unknown
- 2007-10-26 US US12/442,254 patent/US20100129799A1/en not_active Abandoned
- 2007-10-26 BR BRPI0718322-4A2A patent/BRPI0718322A2/pt not_active IP Right Cessation
- 2007-10-26 WO PCT/IS2007/000019 patent/WO2008050356A1/en not_active Ceased
-
2009
- 2009-04-22 IL IL198305A patent/IL198305A0/en unknown
- 2009-05-07 ZA ZA2009/03173A patent/ZA200903173B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG175680A1 (en) | 2011-11-28 |
| JP5631000B2 (ja) | 2014-11-26 |
| ZA200903173B (en) | 2010-02-24 |
| NZ576591A (en) | 2012-04-27 |
| BRPI0718322A2 (pt) | 2013-11-26 |
| CN101641451A (zh) | 2010-02-03 |
| JP2010507388A (ja) | 2010-03-11 |
| AU2007310412A1 (en) | 2008-05-02 |
| EP2089548A1 (en) | 2009-08-19 |
| US20100129799A1 (en) | 2010-05-27 |
| AU2007310412B2 (en) | 2013-02-14 |
| MX2009004522A (es) | 2009-07-02 |
| WO2008050356A1 (en) | 2008-05-02 |
| IL198305A0 (en) | 2010-02-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2007310412B2 (en) | Cancer susceptibility variants on Chr8q24.21 | |
| US8865400B2 (en) | Genetic variants contributing to risk of prostate cancer | |
| US8580501B2 (en) | Genetic variants on chr 5p12 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment | |
| US20110117545A1 (en) | Genetic variants on chr2 and chr16 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment | |
| EP2329037A2 (en) | Genetic variants predictive of cancer risk | |
| CA2729931A1 (en) | Genetic variants predictive of cancer risk in humans | |
| AU2009269542A1 (en) | Genetic variants for breast cancer risk assessment | |
| US20110020320A1 (en) | Genetic Variants Contributing to Risk of Prostate Cancer | |
| US20140248615A1 (en) | Genetic variants on chr 11q and 6q as markers for prostate and colorectal cancer predisposition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20161026 |