CA2664631A1 - Quinoline derivatives for modulating dna methylation - Google Patents
Quinoline derivatives for modulating dna methylation Download PDFInfo
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- CA2664631A1 CA2664631A1 CA002664631A CA2664631A CA2664631A1 CA 2664631 A1 CA2664631 A1 CA 2664631A1 CA 002664631 A CA002664631 A CA 002664631A CA 2664631 A CA2664631 A CA 2664631A CA 2664631 A1 CA2664631 A1 CA 2664631A1
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- acid
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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| US91185007P | 2007-04-13 | 2007-04-13 | |
| US60/911,850 | 2007-04-13 | ||
| PCT/US2007/081321 WO2008046085A2 (en) | 2006-10-12 | 2007-10-12 | Quinoline derivatives for modulating dna methylation |
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| WO2012079079A1 (en) * | 2010-12-10 | 2012-06-14 | President And Fellows Of Harvard College | Production of induced pluripotent stem cells |
| US20140309257A1 (en) * | 2011-11-11 | 2014-10-16 | The Regents Of The University Of Colorado, A Body Corporate | Topoisomerase inhibitors and methods of making and use as therapeutic agents |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| EP2782584B1 (en) | 2011-11-23 | 2021-06-09 | TherapeuticsMD, Inc. | Natural combination hormone replacement formulations and therapies |
| WO2013086379A2 (en) * | 2011-12-08 | 2013-06-13 | Fundacion Sales | Methods and compositions for treating antiprogestin-resistant cancers |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| TWI693073B (zh) | 2012-12-21 | 2020-05-11 | 日商中外製藥股份有限公司 | 對ｇｐｃ３標的治療劑療法為有效之患者投與的ｇｐｃ３標的治療劑 |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
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| FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
| EP0549814B1 (en) | 1991-07-23 | 1997-06-18 | Fujitsu Limited | Mechanism for finely moving head |
| FR2705099B1 (fr) | 1993-05-12 | 1995-08-04 | Centre Nat Rech Scient | Oligonucléotides phosphorothioates triesters et procédé de préparation. |
| EP0786454A4 (en) | 1994-10-07 | 1998-01-07 | Zenyaku Kogyo Kk | THIOQUINOLONE DERIVATIVE |
| EE200200119A (et) * | 1999-09-21 | 2003-04-15 | Astrazeneca Ab | Kinasoliini derivaadid ja nende kasutamine ravimitena |
| US7378524B2 (en) * | 2003-04-11 | 2008-05-27 | Taigen Biotechnology Co., Ltd. | Aminoquinoline compounds |
| CA2567832A1 (en) * | 2004-06-04 | 2005-12-15 | Astrazeneca Ab | Quinazoline derivatives as erbb receptor tyrosine kinases |
| US7790746B2 (en) * | 2007-10-12 | 2010-09-07 | Supergen, Inc. | Quinoline derivatives for modulating DNA methylation |
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- 2007-10-12 JP JP2009532619A patent/JP2010506856A/ja active Pending
- 2007-10-12 US US11/871,762 patent/US20080175814A1/en not_active Abandoned
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- 2007-10-12 CA CA002664631A patent/CA2664631A1/en not_active Abandoned
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- 2007-10-12 EP EP10000636A patent/EP2174938A1/en not_active Withdrawn
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2009
- 2009-09-09 US US12/556,510 patent/US20100129320A1/en not_active Abandoned
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| US20080175814A1 (en) | 2008-07-24 |
| US20100129320A1 (en) | 2010-05-27 |
| EP2078008A2 (en) | 2009-07-15 |
| KR20090089854A (ko) | 2009-08-24 |
| WO2008046085A2 (en) | 2008-04-17 |
| EP2174938A1 (en) | 2010-04-14 |
| WO2008046085A3 (en) | 2008-06-05 |
| JP2010506856A (ja) | 2010-03-04 |
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