CA2662535A1 - Method for reducing or alleviating inflammation in the digestive tract - Google Patents
Method for reducing or alleviating inflammation in the digestive tract Download PDFInfo
- Publication number
- CA2662535A1 CA2662535A1 CA002662535A CA2662535A CA2662535A1 CA 2662535 A1 CA2662535 A1 CA 2662535A1 CA 002662535 A CA002662535 A CA 002662535A CA 2662535 A CA2662535 A CA 2662535A CA 2662535 A1 CA2662535 A1 CA 2662535A1
- Authority
- CA
- Canada
- Prior art keywords
- carboxy
- ethylamino
- imidazol
- ace2
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 230000004054 inflammatory process Effects 0.000 title claims abstract description 33
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 32
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- 102000053723 Angiotensin-converting enzyme 2 Human genes 0.000 claims abstract description 161
- 108090000975 Angiotensin-converting enzyme 2 Proteins 0.000 claims abstract description 160
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- 208000027866 inflammatory disease Diseases 0.000 claims abstract description 21
- 208000037273 Pathologic Processes Diseases 0.000 claims abstract description 4
- 230000009054 pathological process Effects 0.000 claims abstract description 4
- NTCCRGGIJNDEAB-IRXDYDNUSA-N MLN-4760 Chemical compound CC(C)C[C@@H](C(O)=O)N[C@H](C(O)=O)CC1=CN=CN1CC1=CC(Cl)=CC(Cl)=C1 NTCCRGGIJNDEAB-IRXDYDNUSA-N 0.000 claims description 95
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 91
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- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 68
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 67
- 239000003814 drug Substances 0.000 claims description 66
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- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 claims description 4
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- 125000000304 alkynyl group Chemical group 0.000 claims description 4
- IPOKCKJONYRRHP-FMQUCBEESA-N balsalazide Chemical compound C1=CC(C(=O)NCCC(=O)O)=CC=C1\N=N\C1=CC=C(O)C(C(O)=O)=C1 IPOKCKJONYRRHP-FMQUCBEESA-N 0.000 claims description 4
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
- 229920001664 tyloxapol Polymers 0.000 description 1
- 229960004224 tyloxapol Drugs 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
- 230000003639 vasoconstrictive effect Effects 0.000 description 1
- 238000003041 virtual screening Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000004018 waxing Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82507506P | 2006-09-08 | 2006-09-08 | |
| US60/825,075 | 2006-09-08 | ||
| US82780706P | 2006-10-02 | 2006-10-02 | |
| US60/827,807 | 2006-10-02 | ||
| PCT/US2007/077857 WO2008031014A1 (en) | 2006-09-08 | 2007-09-07 | Method for reducing or alleviating inflammation in the digestive tract |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2662535A1 true CA2662535A1 (en) | 2008-03-13 |
Family
ID=38670723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002662535A Abandoned CA2662535A1 (en) | 2006-09-08 | 2007-09-07 | Method for reducing or alleviating inflammation in the digestive tract |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20080234345A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2059234B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010502736A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101568331A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE531362T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007292247A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2662535A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2059234T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2376493T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL197362A0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008031014A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2095819A1 (en) * | 2008-02-28 | 2009-09-02 | Maastricht University | N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors |
| US20100035848A1 (en) * | 2008-03-10 | 2010-02-11 | Stephen Richard Donahue | Therapy for disorders of the proximal digestive tract |
| US20100204286A1 (en) * | 2009-02-12 | 2010-08-12 | Donahue Stephen R | Method for reducing gastrointestinal adverse effects of cytotoxic agents |
| WO2011108638A1 (ja) * | 2010-03-04 | 2011-09-09 | 大日本住友製薬株式会社 | 炎症性腸疾患用薬剤 |
| WO2011112828A1 (en) | 2010-03-12 | 2011-09-15 | Omeros Corporation | Pde10 inhibitors and related compositions and methods |
| NZ716494A (en) | 2014-04-28 | 2017-07-28 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
| NZ630803A (en) | 2014-04-28 | 2016-03-31 | Omeros Corp | Optically active pde10 inhibitor |
| MA41271A (fr) * | 2014-12-26 | 2017-10-31 | Celgene Alpine Invest Company Ii Llc | Méthodes d'utilisation d'oligonucléotides antisens ciblant smad7 |
| BR112017022936A2 (pt) | 2015-04-24 | 2018-07-17 | Omeros Corp | inibidores da pde10 e composições e métodos relacionados |
| WO2017079678A1 (en) | 2015-11-04 | 2017-05-11 | Omeros Corporation | Solid state forms of a pde10 inhibitor |
| GB202116266D0 (en) * | 2021-11-11 | 2021-12-29 | Bicycletx Ltd | Novel use |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6194556B1 (en) * | 1997-12-11 | 2001-02-27 | Millennium Pharmaceuticals, Inc. | Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therfor |
| EP1183019A2 (en) * | 1999-04-30 | 2002-03-06 | Millennium Pharmaceuticals, Inc. | Ace-2 inhibiting compounds and methods of use thereof |
| US7045532B2 (en) | 1999-04-30 | 2006-05-16 | Millennium Pharmaceuticals, Inc. | ACE-2 modulating compounds and methods of use thereof |
| US6900033B2 (en) * | 2001-06-04 | 2005-05-31 | Human Genome Sciences, Inc. | Methods and compositions for modulating ACE-2 activity |
| GB0203061D0 (en) | 2002-02-08 | 2002-03-27 | Novartis Ag | Organic compounds |
| AR041386A1 (es) * | 2002-09-24 | 2005-05-18 | Combinatorx Inc | Metodos y reactivos para el tratamiento de enfermedades y trastornos asociados con niveles aumentados de citoquinas proinflamatorias |
| WO2004073614A2 (en) * | 2003-02-14 | 2004-09-02 | Combinatorx, Incorporated | Combination therapy for the treatment of immunoinflammatory disorders |
| US20050203168A1 (en) * | 2004-03-11 | 2005-09-15 | The Regents Of The University Of Michigan | Angiotensin converting enzyme inhibitor use for treatment and prevention of gastrointestinal disorders |
| US7842709B2 (en) * | 2006-09-08 | 2010-11-30 | Ore Pharmaceuticals Inc. | Method for treating inflammatory diseases of the digestive tract |
-
2007
- 2007-09-07 EP EP07814746A patent/EP2059234B1/en not_active Not-in-force
- 2007-09-07 US US11/851,694 patent/US20080234345A1/en not_active Abandoned
- 2007-09-07 AU AU2007292247A patent/AU2007292247A1/en not_active Abandoned
- 2007-09-07 ES ES07814746T patent/ES2376493T3/es active Active
- 2007-09-07 CN CNA2007800394181A patent/CN101568331A/zh active Pending
- 2007-09-07 JP JP2009527579A patent/JP2010502736A/ja active Pending
- 2007-09-07 WO PCT/US2007/077857 patent/WO2008031014A1/en not_active Ceased
- 2007-09-07 DK DK07814746.9T patent/DK2059234T3/da active
- 2007-09-07 CA CA002662535A patent/CA2662535A1/en not_active Abandoned
- 2007-09-07 AT AT07814746T patent/ATE531362T1/de active
-
2009
- 2009-03-03 IL IL197362A patent/IL197362A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2376493T3 (es) | 2012-03-14 |
| DK2059234T3 (da) | 2011-11-28 |
| IL197362A0 (en) | 2009-12-24 |
| WO2008031014A1 (en) | 2008-03-13 |
| ATE531362T1 (de) | 2011-11-15 |
| AU2007292247A1 (en) | 2008-03-13 |
| EP2059234B1 (en) | 2011-11-02 |
| JP2010502736A (ja) | 2010-01-28 |
| US20080234345A1 (en) | 2008-09-25 |
| CN101568331A (zh) | 2009-10-28 |
| EP2059234A1 (en) | 2009-05-20 |
| AU2007292247A2 (en) | 2009-03-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20130909 |
|
| FZDE | Discontinued |
Effective date: 20130909 |