CA2661814A1 - Recombinant hcv e2 glycoprotein - Google Patents
Recombinant hcv e2 glycoprotein Download PDFInfo
- Publication number
- CA2661814A1 CA2661814A1 CA002661814A CA2661814A CA2661814A1 CA 2661814 A1 CA2661814 A1 CA 2661814A1 CA 002661814 A CA002661814 A CA 002661814A CA 2661814 A CA2661814 A CA 2661814A CA 2661814 A1 CA2661814 A1 CA 2661814A1
- Authority
- CA
- Canada
- Prior art keywords
- hcv
- glycoprotein
- modified
- variable region
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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Applications Claiming Priority (7)
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| AU2006904635 | 2006-08-25 | ||
| AU2006904635A AU2006904635A0 (en) | 2006-08-25 | Recombinant E2 Envelope Glycoprotein for Improved Treatment of HCV virus | |
| AU2006906090A AU2006906090A0 (en) | 2006-11-01 | Recombinant HCV E2 Glycoprotein for use in HCV Vaccine Treatment | |
| AU2006906090 | 2006-11-01 | ||
| AU2006906282 | 2006-11-10 | ||
| AU2006906282A AU2006906282A0 (en) | 2006-11-10 | Recombinant HCV E2 Glycoprotein for use in HCV Vaccine Treatment | |
| PCT/AU2007/001221 WO2008022401A1 (en) | 2006-08-25 | 2007-08-24 | Recombinant hcv e2 glycoprotein |
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| CA2661814A1 true CA2661814A1 (en) | 2008-02-28 |
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| KR101500017B1 (ko) * | 2006-08-25 | 2015-03-09 | 더 맥파레인 버넷 인스티튜트 포 메디칼 리서치 앤드 퍼블릭 헬스 리미티드 | 재조합 ｈｃｖ ｅ2 당단백질 |
| US9758794B2 (en) | 2008-04-22 | 2017-09-12 | Rutgers, The State University Of New Jersey | HCV E2 construct compositions and methods |
| US20110091495A1 (en) * | 2008-04-22 | 2011-04-21 | Rutgers, The State University Of New Jersey | Hcv e2 construct compositions and methods |
| WO2009146902A1 (en) * | 2008-06-03 | 2009-12-10 | Okairòs Ag | A vaccine for the prevention and therapy of hcv infections |
| CA2658714A1 (en) * | 2009-03-17 | 2010-09-17 | Thomas Krey | Hcv-derived polypeptides and uses thereof |
| CN102199613A (zh) * | 2010-03-25 | 2011-09-28 | 国立大学法人东京大学 | 感染性丙型肝炎病毒高生产hcv突变体及其应用 |
| US9079950B2 (en) | 2010-08-04 | 2015-07-14 | The Macfarlane Burnet Institute For Medical Research And Public Health Ltd | Modified Hepatitis C virus proteins |
| EP2643015B1 (en) | 2010-11-26 | 2019-08-21 | The Macfarlane Burnet Institute For Medical Research And Public Health Ltd | Compositions and methods |
| WO2013033319A2 (en) * | 2011-08-30 | 2013-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | A cluster of neutralizing antibodies to hepatitis c virus |
| CN103102394B (zh) * | 2013-02-27 | 2014-06-25 | 北京大学人民医院 | 丙型肝炎病毒b细胞表位肽puhi49及其应用 |
| CN110049993A (zh) | 2016-09-29 | 2019-07-23 | 麦克法兰布奈特医疗研究与公共健康研究所有限公司 | 组装的糖蛋白 |
| US11008368B2 (en) * | 2019-07-26 | 2021-05-18 | The Scripps Research Institute | Engineered HCV E2 immunogens and related vaccine compositions |
| AU2021270053A1 (en) * | 2020-05-11 | 2022-12-15 | Chancellor, Masters And Scholars Of The University Of Oxford | A Hepatitis C nucleic acid vaccine encoding a variable domain deleted E2 polypeptide |
| CN112730851B (zh) * | 2021-03-31 | 2021-06-22 | 南京立顶医疗科技有限公司 | 一种高灵敏SARS-CoV-2中和抗体的检测方法、检测试剂盒 |
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| ES2176342T5 (es) | 1994-10-21 | 2010-02-09 | Innogenetics N.V. | Secuencias del genotipo 7 del virus de la hepatitis c y su utilizacion como agentes profilacticos, terapeuticos y de diagnosticos. |
| JP2002528140A (ja) * | 1998-11-05 | 2002-09-03 | ザ ボード オブ トラスティーズ オブ リーランド スタンフォード ジュニア ユニバーシティ | ヒトｐａｎ−ｈｃｖヒトモノクローナル抗体 |
| AU7602800A (en) * | 1999-09-23 | 2001-04-24 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Hepatitis c virus envelope two protein (e2) which lacks all or part of the hypervariable region one (hvr1), corresponding nucleic acids, chimeric viruses and uses thereof |
| EP1326625A4 (en) | 2000-09-13 | 2005-05-04 | Hawaii Biotech Inc | IMMUNOGENIC COMPOSITION OF HEPATITIS C AND METHODS OF USING THE SAME |
| RU2274643C2 (ru) * | 2001-04-24 | 2006-04-20 | Иннодженетикс Н.В. | Выделенный оболочечный белок hcv, способ его получения и лекарство, вакцина, фармацевтическая композиция (варианты) его содержащие |
| IL145440A0 (en) * | 2001-09-13 | 2002-06-30 | Xtl Biopharmaceuticals Ltd | Synthetic hcv envelope proteins and their use for vaccination |
| EP1716250B1 (en) * | 2004-01-07 | 2015-08-05 | Third Wave Technologies, Inc. | Determination of hepatitis c virus genotype |
| KR101500017B1 (ko) * | 2006-08-25 | 2015-03-09 | 더 맥파레인 버넷 인스티튜트 포 메디칼 리서치 앤드 퍼블릭 헬스 리미티드 | 재조합 ｈｃｖ ｅ2 당단백질 |
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| AU2007288129B2 (en) | 2013-03-07 |
| EP2061805A1 (en) | 2009-05-27 |
| US8535686B2 (en) | 2013-09-17 |
| CN101563362B (zh) | 2015-02-11 |
| EP2061805A4 (en) | 2010-08-04 |
| JP2014240427A (ja) | 2014-12-25 |
| KR20090053930A (ko) | 2009-05-28 |
| AU2007288129A1 (en) | 2008-02-28 |
| CN101563362A (zh) | 2009-10-21 |
| US9598467B2 (en) | 2017-03-21 |
| WO2008022401A1 (en) | 2008-02-28 |
| EP2061805B1 (en) | 2020-02-12 |
| JP5999524B2 (ja) | 2016-09-28 |
| US20110014209A1 (en) | 2011-01-20 |
| JP2010501594A (ja) | 2010-01-21 |
| KR101500017B1 (ko) | 2015-03-09 |
| US20140120127A1 (en) | 2014-05-01 |
| JP5674310B2 (ja) | 2015-02-25 |
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