CA2661332A1

CA2661332A1 - Compositions et procedes pour le diagnostic et le traitement du diabete de type 2

Compositions et procedes pour le diagnostic et le traitement du diabete de type 2 Download PDF

Info

Publication number: CA2661332A1
Authority: CA; Canada
Prior art keywords: diabetes; subject; type; diabetic condition; dbmarkers
Prior art date: 2006-09-01
Legal status : Abandoned

Application number

CA002661332A

Other languages

English (en)

Inventor

Cohava Gelber

Liping Liu

Current Assignee

American Type Culture Collection ATCC

Original Assignee

Individual

Priority date

2006-09-01

Filing date

2007-03-28

Publication date

2008-03-13

2007-03-28 Application filed by Individual filed Critical Individual

2008-03-13 Publication of CA2661332A1 publication Critical patent/CA2661332A1/fr

Status Abandoned legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims abstract description 189
238000011282 treatment Methods 0.000 title claims abstract description 60
208000001072 type 2 diabetes mellitus Diseases 0.000 title claims description 153
238000003745 diagnosis Methods 0.000 title abstract description 11
239000000203 mixture Substances 0.000 title description 38
206010012601 diabetes mellitus Diseases 0.000 claims abstract description 232
108090000623 proteins and genes Proteins 0.000 claims description 220
206010018429 Glucose tolerance impaired Diseases 0.000 claims description 181
102000004169 proteins and genes Human genes 0.000 claims description 169
210000002966 serum Anatomy 0.000 claims description 82
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 74
230000014509 gene expression Effects 0.000 claims description 68
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 51
239000008103 glucose Substances 0.000 claims description 49
239000002207 metabolite Substances 0.000 claims description 42
239000003795 chemical substances by application Substances 0.000 claims description 41
108090000765 processed proteins & peptides Proteins 0.000 claims description 39
238000003556 assay Methods 0.000 claims description 36
238000001514 detection method Methods 0.000 claims description 36
229940125396 insulin Drugs 0.000 claims description 36
108090001061 Insulin Proteins 0.000 claims description 35
102000004877 Insulin Human genes 0.000 claims description 35
210000004369 blood Anatomy 0.000 claims description 33
239000008280 blood Substances 0.000 claims description 33
238000004422 calculation algorithm Methods 0.000 claims description 31
238000000672 surface-enhanced laser desorption--ionisation Methods 0.000 claims description 28
239000008194 pharmaceutical composition Substances 0.000 claims description 25
239000012634 fragment Substances 0.000 claims description 20
210000001519 tissue Anatomy 0.000 claims description 18
210000002381 plasma Anatomy 0.000 claims description 17
230000007423 decrease Effects 0.000 claims description 15
239000003153 chemical reaction reagent Substances 0.000 claims description 14
230000006872 improvement Effects 0.000 claims description 14
230000009467 reduction Effects 0.000 claims description 14
208000024172 Cardiovascular disease Diseases 0.000 claims description 13
238000003491 array Methods 0.000 claims description 13
238000005516 engineering process Methods 0.000 claims description 13
230000035488 systolic blood pressure Effects 0.000 claims description 12
238000002965 ELISA Methods 0.000 claims description 11
230000035487 diastolic blood pressure Effects 0.000 claims description 11
239000012530 fluid Substances 0.000 claims description 11
238000011269 treatment regimen Methods 0.000 claims description 11
239000003937 drug carrier Substances 0.000 claims description 10
239000003112 inhibitor Substances 0.000 claims description 10
150000001413 amino acids Chemical group 0.000 claims description 9
238000003752 polymerase chain reaction Methods 0.000 claims description 9
210000002700 urine Anatomy 0.000 claims description 9
239000003085 diluting agent Substances 0.000 claims description 8
206010003445 Ascites Diseases 0.000 claims description 7
108091034117 Oligonucleotide Proteins 0.000 claims description 7
238000001574 biopsy Methods 0.000 claims description 7
210000001185 bone marrow Anatomy 0.000 claims description 7
235000015872 dietary supplement Nutrition 0.000 claims description 7
210000003722 extracellular fluid Anatomy 0.000 claims description 7
238000011331 genomic analysis Methods 0.000 claims description 7
238000001114 immunoprecipitation Methods 0.000 claims description 7
238000004895 liquid chromatography mass spectrometry Methods 0.000 claims description 7
238000007410 oral glucose tolerance test Methods 0.000 claims description 7
210000001819 pancreatic juice Anatomy 0.000 claims description 7
210000003296 saliva Anatomy 0.000 claims description 7
210000001138 tear Anatomy 0.000 claims description 7
238000000636 Northern blotting Methods 0.000 claims description 6
206010036790 Productive cough Diseases 0.000 claims description 6
239000000556 agonist Substances 0.000 claims description 6
238000010166 immunofluorescence Methods 0.000 claims description 6
238000010208 microarray analysis Methods 0.000 claims description 6
238000012544 monitoring process Methods 0.000 claims description 6
210000003802 sputum Anatomy 0.000 claims description 6
208000024794 sputum Diseases 0.000 claims description 6
238000011477 surgical intervention Methods 0.000 claims description 6
108091023037 Aptamer Proteins 0.000 claims description 5
208000001647 Renal Insufficiency Diseases 0.000 claims description 5
238000002105 Southern blotting Methods 0.000 claims description 5
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 5
125000000539 amino acid group Chemical group 0.000 claims description 5
238000003119 immunoblot Methods 0.000 claims description 5
201000006370 kidney failure Diseases 0.000 claims description 5
208000000044 Amnesia Diseases 0.000 claims description 4
201000004569 Blindness Diseases 0.000 claims description 4
208000026139 Memory disease Diseases 0.000 claims description 4
230000000984 immunochemical effect Effects 0.000 claims description 4
230000006984 memory degeneration Effects 0.000 claims description 4
208000023060 memory loss Diseases 0.000 claims description 4
201000001119 neuropathy Diseases 0.000 claims description 4
230000007823 neuropathy Effects 0.000 claims description 4
208000033808 peripheral neuropathy Diseases 0.000 claims description 4
GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 claims description 4
238000003127 radioimmunoassay Methods 0.000 claims description 4
238000003753 real-time PCR Methods 0.000 claims description 4
206010003840 Autonomic nervous system imbalance Diseases 0.000 claims description 3
229940123208 Biguanide Drugs 0.000 claims description 3
206010010071 Coma Diseases 0.000 claims description 3
101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 claims description 3
229940122199 Insulin secretagogue Drugs 0.000 claims description 3
102000019280 Pancreatic lipases Human genes 0.000 claims description 3
108050006759 Pancreatic lipases Proteins 0.000 claims description 3
108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 claims description 3
208000017442 Retinal disease Diseases 0.000 claims description 3
206010038923 Retinopathy Diseases 0.000 claims description 3
229940100389 Sulfonylurea Drugs 0.000 claims description 3
150000004283 biguanides Chemical class 0.000 claims description 3
230000003345 hyperglycaemic effect Effects 0.000 claims description 3
230000002727 hyperosmolar Effects 0.000 claims description 3
208000017169 kidney disease Diseases 0.000 claims description 3
238000001294 liquid chromatography-tandem mass spectrometry Methods 0.000 claims description 3
238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims description 3
229940116369 pancreatic lipase Drugs 0.000 claims description 3
239000003614 peroxisome proliferator Substances 0.000 claims description 2
102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 claims 1
102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 claims 1
239000000090 biomarker Substances 0.000 abstract description 26
239000003814 drug Substances 0.000 abstract description 21
230000001965 increasing effect Effects 0.000 abstract description 10
230000002265 prevention Effects 0.000 abstract description 5
238000002560 therapeutic procedure Methods 0.000 abstract description 5
238000004393 prognosis Methods 0.000 abstract description 4
235000018102 proteins Nutrition 0.000 description 157
239000000523 sample Substances 0.000 description 84
238000012360 testing method Methods 0.000 description 83
150000007523 nucleic acids Chemical group 0.000 description 52
210000004027 cell Anatomy 0.000 description 48
102000039446 nucleic acids Human genes 0.000 description 47
108020004707 nucleic acids Proteins 0.000 description 47
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 46
229960001031 glucose Drugs 0.000 description 46
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 40
201000010099 disease Diseases 0.000 description 39
238000004458 analytical method Methods 0.000 description 36
241000700159 Rattus Species 0.000 description 34
239000002299 complementary DNA Substances 0.000 description 29
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 28
239000000284 extract Substances 0.000 description 26
102000004196 processed proteins & peptides Human genes 0.000 description 26
239000000499 gel Substances 0.000 description 25
239000000872 buffer Substances 0.000 description 21
-1 Cy3 and Cy5' Substances 0.000 description 18
239000000427 antigen Substances 0.000 description 18
108091007433 antigens Proteins 0.000 description 17
102000036639 antigens Human genes 0.000 description 17
229920001184 polypeptide Polymers 0.000 description 17
230000035945 sensitivity Effects 0.000 description 16
238000005259 measurement Methods 0.000 description 15
102000054765 polymorphisms of proteins Human genes 0.000 description 15
239000007787 solid Substances 0.000 description 15
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 14
238000006243 chemical reaction Methods 0.000 description 14
238000009472 formulation Methods 0.000 description 14
208000024891 symptom Diseases 0.000 description 14
208000002705 Glucose Intolerance Diseases 0.000 description 13
239000000463 material Substances 0.000 description 13
201000009104 prediabetes syndrome Diseases 0.000 description 13
239000012491 analyte Substances 0.000 description 12
230000027455 binding Effects 0.000 description 12
210000001165 lymph node Anatomy 0.000 description 12
239000012071 phase Substances 0.000 description 12
239000002243 precursor Substances 0.000 description 12
108010056891 Calnexin Proteins 0.000 description 11
102100021868 Calnexin Human genes 0.000 description 11
229940024606 amino acid Drugs 0.000 description 11
239000011324 bead Substances 0.000 description 11
230000008859 change Effects 0.000 description 11
150000001875 compounds Chemical class 0.000 description 11
230000000875 corresponding effect Effects 0.000 description 11
230000000694 effects Effects 0.000 description 11
210000000496 pancreas Anatomy 0.000 description 11
230000008569 process Effects 0.000 description 11
150000003839 salts Chemical class 0.000 description 11
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
239000006144 Dulbecco’s modiﬁed Eagle's medium Substances 0.000 description 10
102000015779 HDL Lipoproteins Human genes 0.000 description 10
108091005461 Nucleic proteins Chemical group 0.000 description 10
239000002253 acid Substances 0.000 description 10
235000012000 cholesterol Nutrition 0.000 description 10
230000004927 fusion Effects 0.000 description 10
210000004185 liver Anatomy 0.000 description 10
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 10
102000004190 Enzymes Human genes 0.000 description 9
108090000790 Enzymes Proteins 0.000 description 9
108010010234 HDL Lipoproteins Proteins 0.000 description 9
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
229940079593 drug Drugs 0.000 description 9
229940088598 enzyme Drugs 0.000 description 9
230000036541 health Effects 0.000 description 9
230000000521 hyperimmunizing effect Effects 0.000 description 9
210000004698 lymphocyte Anatomy 0.000 description 9
239000003001 serine protease inhibitor Substances 0.000 description 9
102100027211 Albumin Human genes 0.000 description 8
108010088751 Albumins Proteins 0.000 description 8
108010040923 D3 peptide Proteins 0.000 description 8
101001077660 Homo sapiens Serine protease inhibitor Kazal-type 1 Proteins 0.000 description 8
241000283973 Oryctolagus cuniculus Species 0.000 description 8
102100025144 Serine protease inhibitor Kazal-type 1 Human genes 0.000 description 8
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
235000001014 amino acid Nutrition 0.000 description 8
210000002472 endoplasmic reticulum Anatomy 0.000 description 8
238000002474 experimental method Methods 0.000 description 8
235000019197 fats Nutrition 0.000 description 8
210000002216 heart Anatomy 0.000 description 8
210000004408 hybridoma Anatomy 0.000 description 8
239000003550 marker Substances 0.000 description 8
238000004949 mass spectrometry Methods 0.000 description 8
230000035772 mutation Effects 0.000 description 8
239000000137 peptide hydrolase inhibitor Substances 0.000 description 8
239000013074 reference sample Substances 0.000 description 8
239000000243 solution Substances 0.000 description 8
239000000758 substrate Substances 0.000 description 8
230000001225 therapeutic effect Effects 0.000 description 8
238000001262 western blot Methods 0.000 description 8
108091006146 Channels Proteins 0.000 description 7
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
241001465754 Metazoa Species 0.000 description 7
239000013543 active substance Substances 0.000 description 7
238000011161 development Methods 0.000 description 7
230000018109 developmental process Effects 0.000 description 7
239000000975 dye Substances 0.000 description 7
238000005194 fractionation Methods 0.000 description 7
238000012417 linear regression Methods 0.000 description 7
238000002493 microarray Methods 0.000 description 7
229920000136 polysorbate Polymers 0.000 description 7
238000003757 reverse transcription PCR Methods 0.000 description 7
238000000926 separation method Methods 0.000 description 7
239000000725 suspension Substances 0.000 description 7
102100025277 C-X-C motif chemokine 13 Human genes 0.000 description 6
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
108090000288 Glycoproteins Chemical group 0.000 description 6
102000003886 Glycoproteins Human genes 0.000 description 6
101000616112 Homo sapiens Stress-associated endoplasmic reticulum protein 1 Proteins 0.000 description 6
206010020772 Hypertension Diseases 0.000 description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
229940122055 Serine protease inhibitor Drugs 0.000 description 6
101710102218 Serine protease inhibitor Proteins 0.000 description 6
102100021813 Stress-associated endoplasmic reticulum protein 1 Human genes 0.000 description 6
230000004075 alteration Effects 0.000 description 6
239000002585 base Substances 0.000 description 6
239000000969 carrier Substances 0.000 description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
235000018417 cysteine Nutrition 0.000 description 6
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 6
238000002347 injection Methods 0.000 description 6
239000007924 injection Substances 0.000 description 6
239000007788 liquid Substances 0.000 description 6
239000007791 liquid phase Substances 0.000 description 6
239000011159 matrix material Substances 0.000 description 6
229920001223 polyethylene glycol Polymers 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
102000005962 receptors Human genes 0.000 description 6
108020003175 receptors Proteins 0.000 description 6
238000007920 subcutaneous administration Methods 0.000 description 6
208000011580 syndromic disease Diseases 0.000 description 6
108091003079 Bovine Serum Albumin Proteins 0.000 description 5
102000001534 GDP dissociation inhibitor Human genes 0.000 description 5
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
108010092964 Guanine Nucleotide Dissociation Inhibitors Proteins 0.000 description 5
108010001336 Horseradish Peroxidase Proteins 0.000 description 5
108090000364 Ligases Proteins 0.000 description 5
102000003960 Ligases Human genes 0.000 description 5
208000008589 Obesity Diseases 0.000 description 5
108010074467 Pancreatitis-Associated Proteins Proteins 0.000 description 5
102000008080 Pancreatitis-Associated Proteins Human genes 0.000 description 5
239000002202 Polyethylene glycol Substances 0.000 description 5
108010029485 Protein Isoforms Chemical group 0.000 description 5
102000001708 Protein Isoforms Human genes 0.000 description 5
102100034207 Protein argonaute-2 Human genes 0.000 description 5
108010073443 Ribi adjuvant Proteins 0.000 description 5
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
102100039172 Trefoil factor 2 Human genes 0.000 description 5
102100026390 Tribbles homolog 3 Human genes 0.000 description 5
230000001143 conditioned effect Effects 0.000 description 5
239000000470 constituent Substances 0.000 description 5
230000001419 dependent effect Effects 0.000 description 5
235000005911 diet Nutrition 0.000 description 5
230000037213 diet Effects 0.000 description 5
238000010790 dilution Methods 0.000 description 5
239000012895 dilution Substances 0.000 description 5
238000001962 electrophoresis Methods 0.000 description 5
238000000556 factor analysis Methods 0.000 description 5
239000012091 fetal bovine serum Substances 0.000 description 5
230000004153 glucose metabolism Effects 0.000 description 5
238000003018 immunoassay Methods 0.000 description 5
238000001990 intravenous administration Methods 0.000 description 5
239000003446 ligand Substances 0.000 description 5
239000012528 membrane Substances 0.000 description 5
230000002438 mitochondrial effect Effects 0.000 description 5
239000003921 oil Substances 0.000 description 5
235000019198 oils Nutrition 0.000 description 5
239000008188 pellet Substances 0.000 description 5
238000012545 processing Methods 0.000 description 5
235000019624 protein content Nutrition 0.000 description 5
238000012216 screening Methods 0.000 description 5
238000003196 serial analysis of gene expression Methods 0.000 description 5
230000019491 signal transduction Effects 0.000 description 5
238000001228 spectrum Methods 0.000 description 5
239000006228 supernatant Substances 0.000 description 5
239000003826 tablet Substances 0.000 description 5
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
108091032973 (ribonucleotides)n+m Proteins 0.000 description 4
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
101150098822 CD53 gene Proteins 0.000 description 4
108010012236 Chemokines Proteins 0.000 description 4
102000019034 Chemokines Human genes 0.000 description 4
108010073791 Glycine amidinotransferase Proteins 0.000 description 4
102100040870 Glycine amidinotransferase, mitochondrial Human genes 0.000 description 4
101001139146 Homo sapiens Krueppel-like factor 2 Proteins 0.000 description 4
102000006496 Immunoglobulin Heavy Chains Human genes 0.000 description 4
108010019476 Immunoglobulin Heavy Chains Proteins 0.000 description 4
102000004310 Ion Channels Human genes 0.000 description 4
108090000862 Ion Channels Proteins 0.000 description 4
102100020675 Krueppel-like factor 2 Human genes 0.000 description 4
208000001145 Metabolic Syndrome Diseases 0.000 description 4
206010033307 Overweight Diseases 0.000 description 4
229940122344 Peptidase inhibitor Drugs 0.000 description 4
206010035226 Plasma cell myeloma Diseases 0.000 description 4
102100024447 Prostaglandin E2 receptor EP3 subtype Human genes 0.000 description 4
102100022564 Protein NipSnap homolog 2 Human genes 0.000 description 4
101710092885 Protein NipSnap homolog 2 Proteins 0.000 description 4
101150004107 REG3A gene Proteins 0.000 description 4
102000006382 Ribonucleases Human genes 0.000 description 4
108010083644 Ribonucleases Proteins 0.000 description 4
241000283984 Rodentia Species 0.000 description 4
102100029665 Serine/arginine-rich splicing factor 3 Human genes 0.000 description 4
101710120037 Toxin CcdB Proteins 0.000 description 4
101150007732 Trib3 gene Proteins 0.000 description 4
108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 4
201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 4
239000004480 active ingredient Substances 0.000 description 4
125000003275 alpha amino acid group Chemical group 0.000 description 4
125000000129 anionic group Chemical group 0.000 description 4
239000012472 biological sample Substances 0.000 description 4
150000001720 carbohydrates Chemical class 0.000 description 4
235000014633 carbohydrates Nutrition 0.000 description 4
238000007405 data analysis Methods 0.000 description 4
238000009826 distribution Methods 0.000 description 4
239000000839 emulsion Substances 0.000 description 4
238000010195 expression analysis Methods 0.000 description 4
230000006870 function Effects 0.000 description 4
125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 4
230000002209 hydrophobic effect Effects 0.000 description 4
201000001421 hyperglycemia Diseases 0.000 description 4
239000002502 liposome Substances 0.000 description 4
238000011068 loading method Methods 0.000 description 4
238000007477 logistic regression Methods 0.000 description 4
238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 4
201000000050 myeloid neoplasm Diseases 0.000 description 4
239000013642 negative control Substances 0.000 description 4
238000010606 normalization Methods 0.000 description 4
235000020824 obesity Nutrition 0.000 description 4
229920001542 oligosaccharide Polymers 0.000 description 4
150000002482 oligosaccharides Chemical class 0.000 description 4
230000008520 organization Effects 0.000 description 4
230000037361 pathway Effects 0.000 description 4
230000037081 physical activity Effects 0.000 description 4
229920000642 polymer Polymers 0.000 description 4
239000013641 positive control Substances 0.000 description 4
238000011552 rat model Methods 0.000 description 4
230000009257 reactivity Effects 0.000 description 4
230000001172 regenerating effect Effects 0.000 description 4
239000011780 sodium chloride Substances 0.000 description 4
239000002904 solvent Substances 0.000 description 4
239000003381 stabilizer Substances 0.000 description 4
239000005720 sucrose Substances 0.000 description 4
230000032258 transport Effects 0.000 description 4
238000011277 treatment modality Methods 0.000 description 4
102000003298 tumor necrosis factor receptor Human genes 0.000 description 4
102100025230 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial Human genes 0.000 description 3
238000004780 2D liquid chromatography Methods 0.000 description 3
108010027122 ADP-ribosyl Cyclase 1 Proteins 0.000 description 3
102000018667 ADP-ribosyl Cyclase 1 Human genes 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
229920000936 Agarose Polymers 0.000 description 3
102100022749 Aminopeptidase N Human genes 0.000 description 3
239000004382 Amylase Substances 0.000 description 3
102000013142 Amylases Human genes 0.000 description 3
108010065511 Amylases Proteins 0.000 description 3
102100029844 B box and SPRY domain-containing protein Human genes 0.000 description 3
101150055319 BSPRY gene Proteins 0.000 description 3
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
102100028252 Brain acid soluble protein 1 Human genes 0.000 description 3
101710098309 C-X-C motif chemokine 13 Proteins 0.000 description 3
101150081010 CCKAR gene Proteins 0.000 description 3
101150002659 CD38 gene Proteins 0.000 description 3
101001110283 Canis lupus familiaris Ras-related C3 botulinum toxin substrate 1 Proteins 0.000 description 3
241000283707 Capra Species 0.000 description 3
108010089335 Cholecystokinin A Receptor Proteins 0.000 description 3
102100034927 Cholecystokinin receptor type A Human genes 0.000 description 3
102100034976 Cystathionine beta-synthase Human genes 0.000 description 3
108010073644 Cystathionine beta-synthase Proteins 0.000 description 3
102000005889 Cysteine-Rich Protein 61 Human genes 0.000 description 3
108010019961 Cysteine-Rich Protein 61 Proteins 0.000 description 3
108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 description 3
102000003849 Cytochrome P450 Human genes 0.000 description 3
102100026234 Cytokine receptor common subunit gamma Human genes 0.000 description 3
101150017921 DDIT3 gene Proteins 0.000 description 3
108020004414 DNA Proteins 0.000 description 3
208000002249 Diabetes Complications Diseases 0.000 description 3
238000009007 Diagnostic Kit Methods 0.000 description 3
239000001856 Ethyl cellulose Substances 0.000 description 3
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 3
101150107205 FCGR2 gene Proteins 0.000 description 3
102000009109 Fc receptors Human genes 0.000 description 3
108010087819 Fc receptors Proteins 0.000 description 3
101150019273 GATM gene Proteins 0.000 description 3
101150045568 GNMT gene Proteins 0.000 description 3
102100024412 GTPase IMAP family member 4 Human genes 0.000 description 3
101150078395 Gimap4 gene Proteins 0.000 description 3
101150034593 Gjb2 gene Proteins 0.000 description 3
102100025961 Glutaminase liver isoform, mitochondrial Human genes 0.000 description 3
239000004471 Glycine Substances 0.000 description 3
229920002907 Guar gum Polymers 0.000 description 3
101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 description 3
101000864323 Homo sapiens B box and SPRY domain-containing protein Proteins 0.000 description 3
101000935689 Homo sapiens Brain acid soluble protein 1 Proteins 0.000 description 3
101000858064 Homo sapiens C-X-C motif chemokine 13 Proteins 0.000 description 3
101001055227 Homo sapiens Cytokine receptor common subunit gamma Proteins 0.000 description 3
101000833375 Homo sapiens GTPase IMAP family member 4 Proteins 0.000 description 3
101000579894 Homo sapiens Leucine-rich repeat-containing protein 39 Proteins 0.000 description 3
101001023359 Homo sapiens Lung adenoma susceptibility protein 2 Proteins 0.000 description 3
101000734579 Homo sapiens Phosphoenolpyruvate carboxykinase [GTP], mitochondrial Proteins 0.000 description 3
101001117517 Homo sapiens Prostaglandin E2 receptor EP3 subtype Proteins 0.000 description 3
101000686246 Homo sapiens Ras-related protein R-Ras Proteins 0.000 description 3
101000581815 Homo sapiens Regenerating islet-derived protein 3-alpha Proteins 0.000 description 3
101000837987 Homo sapiens Tandem C2 domains nuclear protein Proteins 0.000 description 3
101000744745 Homo sapiens YTH domain-containing family protein 2 Proteins 0.000 description 3
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 3
101150009635 IGFBP3 gene Proteins 0.000 description 3
206010022489 Insulin Resistance Diseases 0.000 description 3
102000004374 Insulin-like growth factor binding protein 3 Human genes 0.000 description 3
102100027494 Leucine-rich repeat-containing protein 39 Human genes 0.000 description 3
102100035138 Lung adenoma susceptibility protein 2 Human genes 0.000 description 3
241000124008 Mammalia Species 0.000 description 3
241000699666 Mus <mouse, genus> Species 0.000 description 3
101000709097 Mus musculus Schlafen family member 8 Proteins 0.000 description 3
101100096430 Mus musculus Serpini2 gene Proteins 0.000 description 3
241000699670 Mus sp. Species 0.000 description 3
238000005481 NMR spectroscopy Methods 0.000 description 3
229910019142 PO4 Inorganic materials 0.000 description 3
101150071454 PTPRC gene Proteins 0.000 description 3
108020002230 Pancreatic Ribonuclease Proteins 0.000 description 3
102000005891 Pancreatic ribonuclease Human genes 0.000 description 3
101150078768 Pdk4 gene Proteins 0.000 description 3
102100034792 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial Human genes 0.000 description 3
229920000954 Polyglycolide Polymers 0.000 description 3
229940124158 Protease/peptidase inhibitor Drugs 0.000 description 3
101710150593 Protein beta Proteins 0.000 description 3
102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 3
108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 3
102000000033 Purinergic Receptors Human genes 0.000 description 3
108010080192 Purinergic Receptors Proteins 0.000 description 3
101150026799 QSOX1 gene Proteins 0.000 description 3
101150030456 RNASE4 gene Proteins 0.000 description 3
101150007156 Rab8b gene Proteins 0.000 description 3
102100024683 Ras-related protein R-Ras Human genes 0.000 description 3
102100027336 Regenerating islet-derived protein 3-alpha Human genes 0.000 description 3
102000004285 Ribosomal Protein L3 Human genes 0.000 description 3
108090000894 Ribosomal Protein L3 Proteins 0.000 description 3
102000013674 S-100 Human genes 0.000 description 3
108700021018 S100 Proteins 0.000 description 3
108091006207 SLC-Transporter Proteins 0.000 description 3
102000037054 SLC-Transporter Human genes 0.000 description 3
101150019148 Slc7a3 gene Proteins 0.000 description 3
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
229920002125 Sokalan® Polymers 0.000 description 3
229930006000 Sucrose Natural products 0.000 description 3
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
102100028544 Tandem C2 domains nuclear protein Human genes 0.000 description 3
108010077674 Tetraspanin 25 Proteins 0.000 description 3
102000010430 Tetraspanin 25 Human genes 0.000 description 3
108010088411 Trefoil Factor-2 Proteins 0.000 description 3
101710114562 Trypsin V-A Proteins 0.000 description 3
102100039644 YTH domain-containing family protein 2 Human genes 0.000 description 3
230000005856 abnormality Effects 0.000 description 3
238000002835 absorbance Methods 0.000 description 3
239000000654 additive Substances 0.000 description 3
235000019418 amylase Nutrition 0.000 description 3
210000003484 anatomy Anatomy 0.000 description 3
238000010171 animal model Methods 0.000 description 3
238000005349 anion exchange Methods 0.000 description 3
210000000612 antigen-presenting cell Anatomy 0.000 description 3
238000013459 approach Methods 0.000 description 3
101150014732 asnS gene Proteins 0.000 description 3
230000008901 benefit Effects 0.000 description 3
230000036772 blood pressure Effects 0.000 description 3
210000001124 body fluid Anatomy 0.000 description 3
239000002775 capsule Substances 0.000 description 3
229960001631 carbomer Drugs 0.000 description 3
150000001768 cations Chemical class 0.000 description 3
239000006285 cell suspension Substances 0.000 description 3
102000004361 claudin 10 Human genes 0.000 description 3
108090000999 claudin 10 Proteins 0.000 description 3
238000000576 coating method Methods 0.000 description 3
229940075614 colloidal silicon dioxide Drugs 0.000 description 3
238000013270 controlled release Methods 0.000 description 3
208000029078 coronary artery disease Diseases 0.000 description 3
230000002596 correlated effect Effects 0.000 description 3
230000006378 damage Effects 0.000 description 3
230000034994 death Effects 0.000 description 3
231100000517 death Toxicity 0.000 description 3
230000007812 deficiency Effects 0.000 description 3
238000002405 diagnostic procedure Methods 0.000 description 3
230000029087 digestion Effects 0.000 description 3
235000019325 ethyl cellulose Nutrition 0.000 description 3
229920001249 ethyl cellulose Polymers 0.000 description 3
230000001747 exhibiting effect Effects 0.000 description 3
238000000605 extraction Methods 0.000 description 3
102000013361 fetuin Human genes 0.000 description 3
108060002885 fetuin Proteins 0.000 description 3
229960004580 glibenclamide Drugs 0.000 description 3
ZJJXGWJIGJFDTL-UHFFFAOYSA-N glipizide Chemical compound C1=NC(C)=CN=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZJJXGWJIGJFDTL-UHFFFAOYSA-N 0.000 description 3
ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 description 3
239000008187 granular material Substances 0.000 description 3
239000000665 guar gum Substances 0.000 description 3
235000010417 guar gum Nutrition 0.000 description 3
229960002154 guar gum Drugs 0.000 description 3
238000009396 hybridization Methods 0.000 description 3
239000001863 hydroxypropyl cellulose Substances 0.000 description 3
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 3
239000007943 implant Substances 0.000 description 3
238000011534 incubation Methods 0.000 description 3
150000002632 lipids Chemical class 0.000 description 3
230000004060 metabolic process Effects 0.000 description 3
XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 3
229960003105 metformin Drugs 0.000 description 3
238000002156 mixing Methods 0.000 description 3
WYZDCUGWXKHESN-UHFFFAOYSA-N n-benzyl-n-methyl-1-phenylmethanamine Chemical compound C=1C=CC=CC=1CN(C)CC1=CC=CC=C1 WYZDCUGWXKHESN-UHFFFAOYSA-N 0.000 description 3
210000000056 organ Anatomy 0.000 description 3
230000036961 partial effect Effects 0.000 description 3
239000000546 pharmaceutical excipient Substances 0.000 description 3
235000021317 phosphate Nutrition 0.000 description 3
230000026731 phosphorylation Effects 0.000 description 3
238000006366 phosphorylation reaction Methods 0.000 description 3
230000035479 physiological effects, processes and functions Effects 0.000 description 3
229920000747 poly(lactic acid) Polymers 0.000 description 3
229920002401 polyacrylamide Polymers 0.000 description 3
239000004633 polyglycolic acid Substances 0.000 description 3
239000004626 polylactic acid Substances 0.000 description 3
239000000047 product Substances 0.000 description 3
230000000069 prophylactic effect Effects 0.000 description 3
230000004044 response Effects 0.000 description 3
108091008146 restriction endonucleases Proteins 0.000 description 3
238000010839 reverse transcription Methods 0.000 description 3
230000003248 secreting effect Effects 0.000 description 3
210000004739 secretory vesicle Anatomy 0.000 description 3
230000035939 shock Effects 0.000 description 3
239000002002 slurry Substances 0.000 description 3
235000019333 sodium laurylsulphate Nutrition 0.000 description 3
238000004611 spectroscopical analysis Methods 0.000 description 3
239000000126 substance Substances 0.000 description 3
229940124597 therapeutic agent Drugs 0.000 description 3
230000000699 topical effect Effects 0.000 description 3
150000003626 triacylglycerols Chemical class 0.000 description 3
238000000539 two dimensional gel electrophoresis Methods 0.000 description 3
239000003981 vehicle Substances 0.000 description 3
XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 description 2
108091064702 1 family Proteins 0.000 description 2
102100037429 17-beta-hydroxysteroid dehydrogenase 13 Human genes 0.000 description 2
101150058497 ANPEP gene Proteins 0.000 description 2
101150063992 APOC2 gene Proteins 0.000 description 2
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
102100036661 Acylphosphatase-2 Human genes 0.000 description 2
108010071619 Apolipoproteins Proteins 0.000 description 2
102000007592 Apolipoproteins Human genes 0.000 description 2
239000004475 Arginine Substances 0.000 description 2
102100023927 Asparagine synthetase [glutamine-hydrolyzing] Human genes 0.000 description 2
108010070255 Aspartate-ammonia ligase Proteins 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
101001074429 Bacillus subtilis (strain 168) Polyketide biosynthesis acyltransferase homolog PksD Proteins 0.000 description 2
101000936617 Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) Polyketide biosynthesis acyltransferase homolog BaeD Proteins 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
108010015087 Basic Amino Acid Transport Systems Proteins 0.000 description 2
102000001733 Basic Amino Acid Transport Systems Human genes 0.000 description 2
101150023803 Bhlha15 gene Proteins 0.000 description 2
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
108010074051 C-Reactive Protein Proteins 0.000 description 2
101710186200 CCAAT/enhancer-binding protein Proteins 0.000 description 2
101150042405 CCN1 gene Proteins 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
102000005701 Calcium-Binding Proteins Human genes 0.000 description 2
108010045403 Calcium-Binding Proteins Proteins 0.000 description 2
241000282472 Canis lupus familiaris Species 0.000 description 2
102100034357 Casein kinase I isoform alpha Human genes 0.000 description 2
101150080342 Cebpg gene Proteins 0.000 description 2
102000008186 Collagen Human genes 0.000 description 2
108010035532 Collagen Proteins 0.000 description 2
102100023699 Collagen and calcium-binding EGF domain-containing protein 1 Human genes 0.000 description 2
206010010099 Combined immunodeficiency Diseases 0.000 description 2
108090000044 Complement Factor I Proteins 0.000 description 2
102100035431 Complement factor I Human genes 0.000 description 2
102000010970 Connexin Human genes 0.000 description 2
108050001175 Connexin Proteins 0.000 description 2
101150045176 Cyp2d26 gene Proteins 0.000 description 2
102100028007 Cystatin-SA Human genes 0.000 description 2
101710144510 Cysteine proteinase inhibitor Proteins 0.000 description 2
102100021246 DDIT3 upstream open reading frame protein Human genes 0.000 description 2
102100025012 Dipeptidyl peptidase 4 Human genes 0.000 description 2
108010049003 Fibrinogen Proteins 0.000 description 2
102000008946 Fibrinogen Human genes 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
101710184005 Glutaminase 2 Proteins 0.000 description 2
108010088390 Glycine N-Methyltransferase Proteins 0.000 description 2
102000008764 Glycine N-methyltransferase Human genes 0.000 description 2
108010023302 HDL Cholesterol Proteins 0.000 description 2
108010042283 HSP40 Heat-Shock Proteins Proteins 0.000 description 2
102000004447 HSP40 Heat-Shock Proteins Human genes 0.000 description 2
108010004889 Heat-Shock Proteins Proteins 0.000 description 2
102000002812 Heat-Shock Proteins Human genes 0.000 description 2
241000282412 Homo Species 0.000 description 2
101000806241 Homo sapiens 17-beta-hydroxysteroid dehydrogenase 13 Proteins 0.000 description 2
101001077332 Homo sapiens 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial Proteins 0.000 description 2
101000929554 Homo sapiens Acylphosphatase-2 Proteins 0.000 description 2
101000994700 Homo sapiens Casein kinase I isoform alpha Proteins 0.000 description 2
101000978341 Homo sapiens Collagen and calcium-binding EGF domain-containing protein 1 Proteins 0.000 description 2
101000861454 Homo sapiens Protein c-Fos Proteins 0.000 description 2
101000692973 Homo sapiens RING finger protein 145 Proteins 0.000 description 2
101001132575 Homo sapiens Ras-related protein Rab-8B Proteins 0.000 description 2
101000587434 Homo sapiens Serine/arginine-rich splicing factor 3 Proteins 0.000 description 2
101000851528 Homo sapiens Transmembrane emp24 domain-containing protein 6 Proteins 0.000 description 2
101000637932 Homo sapiens Transmembrane protein 125 Proteins 0.000 description 2
101000889450 Homo sapiens Trefoil factor 2 Proteins 0.000 description 2
101000734339 Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Proteins 0.000 description 2
108060003951 Immunoglobulin Proteins 0.000 description 2
108010057186 Insulin Glargine Proteins 0.000 description 2
108010065920 Insulin Lispro Proteins 0.000 description 2
COCFEDIXXNGUNL-RFKWWTKHSA-N Insulin glargine Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(=O)NCC(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 COCFEDIXXNGUNL-RFKWWTKHSA-N 0.000 description 2
108090000965 Insulin-like growth factor binding protein 3 Proteins 0.000 description 2
102100022708 Insulin-like growth factor-binding protein 3 Human genes 0.000 description 2
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
108010028554 LDL Cholesterol Proteins 0.000 description 2
108010007622 LDL Lipoproteins Proteins 0.000 description 2
102000007330 LDL Lipoproteins Human genes 0.000 description 2
102000052922 Large Neutral Amino Acid-Transporter 1 Human genes 0.000 description 2
102000017095 Leukocyte Common Antigens Human genes 0.000 description 2
108010013709 Leukocyte Common Antigens Proteins 0.000 description 2
102000004086 Ligand-Gated Ion Channels Human genes 0.000 description 2
108090000543 Ligand-Gated Ion Channels Proteins 0.000 description 2
102000005431 Molecular Chaperones Human genes 0.000 description 2
108010006519 Molecular Chaperones Proteins 0.000 description 2
241001529936 Murinae Species 0.000 description 2
101100125779 Mus musculus Ighm gene Proteins 0.000 description 2
101100180429 Mus musculus Klk1b3 gene Proteins 0.000 description 2
101100186483 Mus musculus Nat8b-ps gene Proteins 0.000 description 2
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
238000004497 NIR spectroscopy Methods 0.000 description 2
102000005238 NM23 Nucleoside Diphosphate Kinases Human genes 0.000 description 2
108010081372 NM23 Nucleoside Diphosphate Kinases Proteins 0.000 description 2
101150065592 NME2 gene Proteins 0.000 description 2
101150038811 Nat8f2 gene Proteins 0.000 description 2
102100021133 Nuclear protein 1 Human genes 0.000 description 2
101710170054 Nuclear protein 1 Proteins 0.000 description 2
101150077540 P2rx1 gene Proteins 0.000 description 2
238000002944 PCR assay Methods 0.000 description 2
101150053131 PTGER3 gene Proteins 0.000 description 2
239000002033 PVDF binder Substances 0.000 description 2
102000035195 Peptidases Human genes 0.000 description 2
108091005804 Peptidases Proteins 0.000 description 2
102000005877 Peptide Initiation Factors Human genes 0.000 description 2
108010044843 Peptide Initiation Factors Proteins 0.000 description 2
102100038831 Peroxisome proliferator-activated receptor alpha Human genes 0.000 description 2
102100026187 Placenta-specific gene 8 protein Human genes 0.000 description 2
101710146232 Placenta-specific gene 8 protein Proteins 0.000 description 2
229920001710 Polyorthoester Polymers 0.000 description 2
239000004793 Polystyrene Substances 0.000 description 2
102100026126 Proline-tRNA ligase Human genes 0.000 description 2
102100027584 Protein c-Fos Human genes 0.000 description 2
102100026364 RING finger protein 145 Human genes 0.000 description 2
102100033959 Ras-related protein Rab-8B Human genes 0.000 description 2
241000700157 Rattus norvegicus Species 0.000 description 2
101100496425 Rattus norvegicus Cml1 gene Proteins 0.000 description 2
101100453992 Rattus norvegicus Ngfg gene Proteins 0.000 description 2
102100026115 S-adenosylmethionine synthase isoform type-1 Human genes 0.000 description 2
108091006232 SLC7A5 Proteins 0.000 description 2
101710123508 Serine/arginine-rich splicing factor 3 Proteins 0.000 description 2
102000008847 Serpin Human genes 0.000 description 2
108050000761 Serpin Proteins 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
102100034371 Sulfhydryl oxidase 1 Human genes 0.000 description 2
101710159725 Sulfhydryl oxidase 1 Proteins 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
101150115851 Tff2 gene Proteins 0.000 description 2
101710137710 Thioesterase 1/protease 1/lysophospholipase L1 Proteins 0.000 description 2
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
108010057666 Transcription Factor CHOP Proteins 0.000 description 2
102100036765 Transmembrane emp24 domain-containing protein 6 Human genes 0.000 description 2
102100032074 Transmembrane protein 125 Human genes 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
102100039066 Very low-density lipoprotein receptor Human genes 0.000 description 2
101710177612 Very low-density lipoprotein receptor Proteins 0.000 description 2
101150115477 Vldlr gene Proteins 0.000 description 2
102100034825 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Human genes 0.000 description 2
229960002632 acarbose Drugs 0.000 description 2
XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 description 2
230000002378 acidificating effect Effects 0.000 description 2
230000009471 action Effects 0.000 description 2
230000001476 alcoholic effect Effects 0.000 description 2
102000012005 alpha-2-HS-Glycoprotein Human genes 0.000 description 2
108010075843 alpha-2-HS-Glycoprotein Proteins 0.000 description 2
238000004873 anchoring Methods 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
239000002220 antihypertensive agent Substances 0.000 description 2
229940127088 antihypertensive drug Drugs 0.000 description 2
239000003963 antioxidant agent Substances 0.000 description 2
235000006708 antioxidants Nutrition 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
235000009697 arginine Nutrition 0.000 description 2
235000010323 ascorbic acid Nutrition 0.000 description 2
229960005070 ascorbic acid Drugs 0.000 description 2
239000011668 ascorbic acid Substances 0.000 description 2
239000011230 binding agent Substances 0.000 description 2
229920002988 biodegradable polymer Polymers 0.000 description 2
239000004621 biodegradable polymer Substances 0.000 description 2
239000013060 biological fluid Substances 0.000 description 2
230000008512 biological response Effects 0.000 description 2
229960002685 biotin Drugs 0.000 description 2
235000020958 biotin Nutrition 0.000 description 2
239000011616 biotin Substances 0.000 description 2
230000037396 body weight Effects 0.000 description 2
239000011575 calcium Substances 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
238000004364 calculation method Methods 0.000 description 2
125000002091 cationic group Chemical group 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
238000012512 characterization method Methods 0.000 description 2
230000002113 chemopreventative effect Effects 0.000 description 2
238000011098 chromatofocusing Methods 0.000 description 2
230000001684 chronic effect Effects 0.000 description 2
238000007635 classification algorithm Methods 0.000 description 2
238000010367 cloning Methods 0.000 description 2
239000005515 coenzyme Substances 0.000 description 2
235000017471 coenzyme Q10 Nutrition 0.000 description 2
229920001436 collagen Polymers 0.000 description 2
239000013068 control sample Substances 0.000 description 2
229920001577 copolymer Polymers 0.000 description 2
DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
239000012228 culture supernatant Substances 0.000 description 2
239000002852 cysteine proteinase inhibitor Substances 0.000 description 2
230000003247 decreasing effect Effects 0.000 description 2
239000007933 dermal patch Substances 0.000 description 2
239000008121 dextrose Substances 0.000 description 2
FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 description 2
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 2
101150034816 dnajc3 gene Proteins 0.000 description 2
230000004064 dysfunction Effects 0.000 description 2
235000013399 edible fruits Nutrition 0.000 description 2
239000003480 eluent Substances 0.000 description 2
238000010828 elution Methods 0.000 description 2
239000003995 emulsifying agent Substances 0.000 description 2
229960004667 ethyl cellulose Drugs 0.000 description 2
238000011156 evaluation Methods 0.000 description 2
229940012952 fibrinogen Drugs 0.000 description 2
GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
239000007850 fluorescent dye Substances 0.000 description 2
235000003599 food sweetener Nutrition 0.000 description 2
210000003976 gap junction Anatomy 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
239000008273 gelatin Substances 0.000 description 2
229940014259 gelatin Drugs 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
230000002068 genetic effect Effects 0.000 description 2
210000003731 gingival crevicular fluid Anatomy 0.000 description 2
229960001381 glipizide Drugs 0.000 description 2
101150020260 gls2 gene Proteins 0.000 description 2
108010092115 glutamyl-prolyl-tRNA synthetase Proteins 0.000 description 2
230000002641 glycemic effect Effects 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
239000003102 growth factor Substances 0.000 description 2
229940121372 histone deacetylase inhibitor Drugs 0.000 description 2
239000003276 histone deacetylase inhibitor Substances 0.000 description 2
238000000265 homogenisation Methods 0.000 description 2
WNRQPCUGRUFHED-DETKDSODSA-N humalog Chemical compound C([C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(O)=O)C1=CC=C(O)C=C1.C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 WNRQPCUGRUFHED-DETKDSODSA-N 0.000 description 2
229940071676 hydroxypropylcellulose Drugs 0.000 description 2
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
230000001900 immune effect Effects 0.000 description 2
230000008105 immune reaction Effects 0.000 description 2
230000028993 immune response Effects 0.000 description 2
230000003053 immunization Effects 0.000 description 2
238000002649 immunization Methods 0.000 description 2
102000018358 immunoglobulin Human genes 0.000 description 2
238000000338 in vitro Methods 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
238000011221 initial treatment Methods 0.000 description 2
230000000977 initiatory effect Effects 0.000 description 2
238000007918 intramuscular administration Methods 0.000 description 2
238000007912 intraperitoneal administration Methods 0.000 description 2
150000002500 ions Chemical class 0.000 description 2
230000002427 irreversible effect Effects 0.000 description 2
239000004816 latex Substances 0.000 description 2
229920000126 latex Polymers 0.000 description 2
230000000670 limiting effect Effects 0.000 description 2
AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 2
238000004811 liquid chromatography Methods 0.000 description 2
239000012160 loading buffer Substances 0.000 description 2
230000007774 longterm Effects 0.000 description 2
239000000314 lubricant Substances 0.000 description 2
230000001926 lymphatic effect Effects 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
238000007726 management method Methods 0.000 description 2
235000012054 meals Nutrition 0.000 description 2
230000007246 mechanism Effects 0.000 description 2
239000002609 medium Substances 0.000 description 2
108020004999 messenger RNA Proteins 0.000 description 2
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
230000004048 modification Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
210000003205 muscle Anatomy 0.000 description 2
230000000955 neuroendocrine Effects 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
239000000346 nonvolatile oil Substances 0.000 description 2
239000002773 nucleotide Substances 0.000 description 2
125000003729 nucleotide group Chemical group 0.000 description 2
RNVCVTLRINQCPJ-UHFFFAOYSA-N o-toluidine Chemical compound CC1=CC=CC=C1N RNVCVTLRINQCPJ-UHFFFAOYSA-N 0.000 description 2
210000004923 pancreatic tissue Anatomy 0.000 description 2
239000002245 particle Substances 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
239000010452 phosphate Substances 0.000 description 2
239000006187 pill Substances 0.000 description 2
239000004014 plasticizer Substances 0.000 description 2
229920002223 polystyrene Polymers 0.000 description 2
229920002981 polyvinylidene fluoride Polymers 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
230000004481 post-translational protein modification Effects 0.000 description 2
239000000843 powder Substances 0.000 description 2
230000035935 pregnancy Effects 0.000 description 2
238000011002 quantification Methods 0.000 description 2
230000002829 reductive effect Effects 0.000 description 2
230000008929 regeneration Effects 0.000 description 2
238000011069 regeneration method Methods 0.000 description 2
238000011160 research Methods 0.000 description 2
230000000717 retained effect Effects 0.000 description 2
238000004007 reversed phase HPLC Methods 0.000 description 2
230000002441 reversible effect Effects 0.000 description 2
238000010079 rubber tapping Methods 0.000 description 2
239000012723 sample buffer Substances 0.000 description 2
238000012163 sequencing technique Methods 0.000 description 2
230000011664 signaling Effects 0.000 description 2
230000009870 specific binding Effects 0.000 description 2
238000009987 spinning Methods 0.000 description 2
238000010186 staining Methods 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
229940032147 starch Drugs 0.000 description 2
238000007619 statistical method Methods 0.000 description 2
235000000346 sugar Nutrition 0.000 description 2
239000004094 surface-active agent Substances 0.000 description 2
238000013268 sustained release Methods 0.000 description 2
239000012730 sustained-release form Substances 0.000 description 2
239000003765 sweetening agent Substances 0.000 description 2
238000004885 tandem mass spectrometry Methods 0.000 description 2
230000008685 targeting Effects 0.000 description 2
230000037317 transdermal delivery Effects 0.000 description 2
230000026683 transduction Effects 0.000 description 2
238000010361 transduction Methods 0.000 description 2
229960001641 troglitazone Drugs 0.000 description 2
GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 2
238000000870 ultraviolet spectroscopy Methods 0.000 description 2
239000002691 unilamellar liposome Substances 0.000 description 2
235000013311 vegetables Nutrition 0.000 description 2
230000035899 viability Effects 0.000 description 2
230000003612 virological effect Effects 0.000 description 2
238000012800 visualization Methods 0.000 description 2
239000011534 wash buffer Substances 0.000 description 2
208000016261 weight loss Diseases 0.000 description 2
NWGZOALPWZDXNG-LURJTMIESA-N (2s)-5-(diaminomethylideneamino)-2-(dimethylamino)pentanoic acid Chemical compound CN(C)[C@H](C(O)=O)CCCNC(N)=N NWGZOALPWZDXNG-LURJTMIESA-N 0.000 description 1
QGKMIGUHVLGJBR-UHFFFAOYSA-M (4z)-1-(3-methylbutyl)-4-[[1-(3-methylbutyl)quinolin-1-ium-4-yl]methylidene]quinoline;iodide Chemical compound [I-].C12=CC=CC=C2N(CCC(C)C)C=CC1=CC1=CC=[N+](CCC(C)C)C2=CC=CC=C12 QGKMIGUHVLGJBR-UHFFFAOYSA-M 0.000 description 1
BOVGTQGAOIONJV-BETUJISGSA-N 1-[(3ar,6as)-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-2-yl]-3-(4-methylphenyl)sulfonylurea Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1C[C@H]2CCC[C@H]2C1 BOVGTQGAOIONJV-BETUJISGSA-N 0.000 description 1
KVUXYQHEESDGIJ-UHFFFAOYSA-N 10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-3,16-diol Chemical compound C1CC2CC(O)CCC2(C)C2C1C1CC(O)CC1(C)CC2 KVUXYQHEESDGIJ-UHFFFAOYSA-N 0.000 description 1
JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 description 1
BSKHPKMHTQYZBB-UHFFFAOYSA-N 2-methylpyridine Chemical class CC1=CC=CC=N1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 description 1
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
TVZGACDUOSZQKY-LBPRGKRZSA-N 4-aminofolic acid Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 TVZGACDUOSZQKY-LBPRGKRZSA-N 0.000 description 1
108010029607 4-nitrophenyl-alpha-glucosidase Proteins 0.000 description 1
HCEQQASHRRPQFE-UHFFFAOYSA-N 5-chloro-n-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide;3-(diaminomethylidene)-1,1-dimethylguanidine;hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N.COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 HCEQQASHRRPQFE-UHFFFAOYSA-N 0.000 description 1
GEDJUAKXFJRZSG-UHFFFAOYSA-N 7-[3-[(3-acetylphenoxy)methyl]-1,5-dimethylpyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1H-indole-2-carboxylic acid Chemical compound CC(=O)c1cccc(OCc2nn(C)c(C)c2-c2cccc3c(CCCOc4cccc5ccccc45)c([nH]c23)C(O)=O)c1 GEDJUAKXFJRZSG-UHFFFAOYSA-N 0.000 description 1
102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 description 1
101150106303 AHSG gene Proteins 0.000 description 1
101150001527 APOC3 gene Proteins 0.000 description 1
208000004611 Abdominal Obesity Diseases 0.000 description 1
240000005020 Acaciella glauca Species 0.000 description 1
244000202285 Acrocomia mexicana Species 0.000 description 1
235000003625 Acrocomia mexicana Nutrition 0.000 description 1
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
102100025851 Acyl-coenzyme A thioesterase 2, mitochondrial Human genes 0.000 description 1
102000002260 Alkaline Phosphatase Human genes 0.000 description 1
108020004774 Alkaline Phosphatase Proteins 0.000 description 1
240000002234 Allium sativum Species 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
102100031972 Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase Human genes 0.000 description 1
101710163570 Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase Proteins 0.000 description 1
241000428352 Amma Species 0.000 description 1
102100034613 Annexin A2 Human genes 0.000 description 1
108090000668 Annexin A2 Proteins 0.000 description 1
108020000948 Antisense Oligonucleotides Proteins 0.000 description 1
101150104773 Apoh gene Proteins 0.000 description 1
108010024284 Apolipoprotein C-II Proteins 0.000 description 1
102100039998 Apolipoprotein C-II Human genes 0.000 description 1
102100029470 Apolipoprotein E Human genes 0.000 description 1
101710095339 Apolipoprotein E Proteins 0.000 description 1
101100316026 Arabidopsis thaliana UGGT gene Proteins 0.000 description 1
200000000007 Arterial disease Diseases 0.000 description 1
206010003211 Arteriosclerosis coronary artery Diseases 0.000 description 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
108010011485 Aspartame Proteins 0.000 description 1
201000001320 Atherosclerosis Diseases 0.000 description 1
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
108010039209 Blood Coagulation Factors Proteins 0.000 description 1
102000015081 Blood Coagulation Factors Human genes 0.000 description 1
102000004506 Blood Proteins Human genes 0.000 description 1
108010017384 Blood Proteins Proteins 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
101001091591 Bos taurus Kininogen-1 Proteins 0.000 description 1
206010006187 Breast cancer Diseases 0.000 description 1
208000026310 Breast neoplasm Diseases 0.000 description 1
239000004255 Butylated hydroxyanisole Substances 0.000 description 1
102100021935 C-C motif chemokine 26 Human genes 0.000 description 1
102100032752 C-reactive protein Human genes 0.000 description 1
102100037675 CCAAT/enhancer-binding protein gamma Human genes 0.000 description 1
101001122179 Caenorhabditis elegans Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial Proteins 0.000 description 1
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
206010007559 Cardiac failure congestive Diseases 0.000 description 1
108010078791 Carrier Proteins Proteins 0.000 description 1
102000008122 Casein Kinase I Human genes 0.000 description 1
108010049812 Casein Kinase I Proteins 0.000 description 1
102100021391 Cationic amino acid transporter 3 Human genes 0.000 description 1
206010065941 Central obesity Diseases 0.000 description 1
VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
102000017589 Chromo domains Human genes 0.000 description 1
108050005811 Chromo domains Proteins 0.000 description 1
102100031265 Chromodomain-helicase-DNA-binding protein 2 Human genes 0.000 description 1
101710170295 Chromodomain-helicase-DNA-binding protein 2 Proteins 0.000 description 1
102100021615 Class A basic helix-loop-helix protein 15 Human genes 0.000 description 1
102000005870 Coenzyme A Ligases Human genes 0.000 description 1
208000035473 Communicable disease Diseases 0.000 description 1
102000008929 Complement component C9 Human genes 0.000 description 1
108050000891 Complement component C9 Proteins 0.000 description 1
102100034622 Complement factor B Human genes 0.000 description 1
229920002261 Corn starch Polymers 0.000 description 1
229920002785 Croscarmellose sodium Polymers 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
230000004544 DNA amplification Effects 0.000 description 1
230000005778 DNA damage Effects 0.000 description 1
231100000277 DNA damage Toxicity 0.000 description 1
230000004568 DNA-binding Effects 0.000 description 1
101150001407 Ddah1 gene Proteins 0.000 description 1
101710088194 Dehydrogenase Proteins 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
208000007342 Diabetic Nephropathies Diseases 0.000 description 1
206010012689 Diabetic retinopathy Diseases 0.000 description 1
102000016503 Dimethylarginine dimethylaminohydrolases Human genes 0.000 description 1
206010061818 Disease progression Diseases 0.000 description 1
102100031681 DnaJ homolog subfamily C member 3 Human genes 0.000 description 1
238000012286 ELISA Assay Methods 0.000 description 1
LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
102100023882 Endoribonuclease ZC3H12A Human genes 0.000 description 1
101710112715 Endoribonuclease ZC3H12A Proteins 0.000 description 1
241000283073 Equus caballus Species 0.000 description 1
241000588724 Escherichia coli Species 0.000 description 1
101000658547 Escherichia coli (strain K12) Type I restriction enzyme EcoKI endonuclease subunit Proteins 0.000 description 1
101000658543 Escherichia coli Type I restriction enzyme EcoAI endonuclease subunit Proteins 0.000 description 1
101000658546 Escherichia coli Type I restriction enzyme EcoEI endonuclease subunit Proteins 0.000 description 1
101000658530 Escherichia coli Type I restriction enzyme EcoR124II endonuclease subunit Proteins 0.000 description 1
101000658540 Escherichia coli Type I restriction enzyme EcoprrI endonuclease subunit Proteins 0.000 description 1
102100029602 Eukaryotic translation initiation factor 4B Human genes 0.000 description 1
101710092092 Eukaryotic translation initiation factor 4B Proteins 0.000 description 1
108010011459 Exenatide Proteins 0.000 description 1
HTQBXNHDCUEHJF-XWLPCZSASA-N Exenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 HTQBXNHDCUEHJF-XWLPCZSASA-N 0.000 description 1
108010043222 Exubera Proteins 0.000 description 1
101150088232 FETUB gene Proteins 0.000 description 1
101150048676 FUT1 gene Proteins 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
102100028044 Fetuin-B Human genes 0.000 description 1
108010086121 Fetuin-B Proteins 0.000 description 1
108010019236 Fucosyltransferases Proteins 0.000 description 1
102000006471 Fucosyltransferases Human genes 0.000 description 1
241000233866 Fungi Species 0.000 description 1
102100039835 Galactoside alpha-(1,2)-fucosyltransferase 1 Human genes 0.000 description 1
IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
FAEKWTJYAYMJKF-QHCPKHFHSA-N GlucoNorm Chemical compound C1=C(C(O)=O)C(OCC)=CC(CC(=O)N[C@@H](CC(C)C)C=2C(=CC=CC=2)N2CCCCC2)=C1 FAEKWTJYAYMJKF-QHCPKHFHSA-N 0.000 description 1
108010050375 Glucose 1-Dehydrogenase Proteins 0.000 description 1
239000004366 Glucose oxidase Substances 0.000 description 1
108010015776 Glucose oxidase Proteins 0.000 description 1
108010056771 Glucosidases Proteins 0.000 description 1
102000004366 Glucosidases Human genes 0.000 description 1
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
102000017011 Glycated Hemoglobin A Human genes 0.000 description 1
108010014663 Glycated Hemoglobin A Proteins 0.000 description 1
108030000900 Glycine C-acetyltransferases Proteins 0.000 description 1
108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
102000004144 Green Fluorescent Proteins Human genes 0.000 description 1
101000658545 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Type I restriction enyme HindI endonuclease subunit Proteins 0.000 description 1
102100025255 Haptoglobin Human genes 0.000 description 1
108050005077 Haptoglobin Proteins 0.000 description 1
206010019280 Heart failures Diseases 0.000 description 1
102000013271 Hemopexin Human genes 0.000 description 1
108010026027 Hemopexin Proteins 0.000 description 1
102000005548 Hexokinase Human genes 0.000 description 1
108700040460 Hexokinases Proteins 0.000 description 1
101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 description 1
101000720371 Homo sapiens Acyl-coenzyme A thioesterase 2, mitochondrial Proteins 0.000 description 1
101000678026 Homo sapiens Alpha-1-antichymotrypsin Proteins 0.000 description 1
101000897493 Homo sapiens C-C motif chemokine 26 Proteins 0.000 description 1
101000880590 Homo sapiens CCAAT/enhancer-binding protein gamma Proteins 0.000 description 1
101000894420 Homo sapiens Cationic amino acid transporter 3 Proteins 0.000 description 1
101000971300 Homo sapiens Class A basic helix-loop-helix protein 15 Proteins 0.000 description 1
101000710032 Homo sapiens Complement factor B Proteins 0.000 description 1
101000845898 Homo sapiens DnaJ homolog subfamily C member 3 Proteins 0.000 description 1
101000856993 Homo sapiens Glutaminase liver isoform, mitochondrial Proteins 0.000 description 1
101000609413 Homo sapiens Inter-alpha-trypsin inhibitor heavy chain H4 Proteins 0.000 description 1
101001122174 Homo sapiens Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial Proteins 0.000 description 1
101000950648 Homo sapiens Malectin Proteins 0.000 description 1
101000959028 Homo sapiens Mitochondrial 10-formyltetrahydrofolate dehydrogenase Proteins 0.000 description 1
101001055594 Homo sapiens S-adenosylmethionine synthase isoform type-1 Proteins 0.000 description 1
101000685001 Homo sapiens Stromal cell-derived factor 2-like protein 1 Proteins 0.000 description 1
101000712600 Homo sapiens Thyroid hormone receptor beta Proteins 0.000 description 1
101000766345 Homo sapiens Tribbles homolog 3 Proteins 0.000 description 1
101000777134 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 43 Proteins 0.000 description 1
101000708573 Homo sapiens Y+L amino acid transporter 2 Proteins 0.000 description 1
101000802375 Homo sapiens Zinc transporter 2 Proteins 0.000 description 1
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
206010060378 Hyperinsulinaemia Diseases 0.000 description 1
UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
206010061598 Immunodeficiency Diseases 0.000 description 1
208000029462 Immunodeficiency disease Diseases 0.000 description 1
206010056997 Impaired fasting glucose Diseases 0.000 description 1
101710134930 Import motor subunit, mitochondrial Proteins 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
108010089308 Insulin Detemir Proteins 0.000 description 1
108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
102000014429 Insulin-like growth factor Human genes 0.000 description 1
102100039457 Inter-alpha-trypsin inhibitor heavy chain H4 Human genes 0.000 description 1
102000015696 Interleukins Human genes 0.000 description 1
108010063738 Interleukins Proteins 0.000 description 1
108010077861 Kininogens Proteins 0.000 description 1
102000010631 Kininogens Human genes 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
229930064664 L-arginine Natural products 0.000 description 1
235000014852 L-arginine Nutrition 0.000 description 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
238000008214 LDL Cholesterol Methods 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
241000283986 Lepus Species 0.000 description 1
240000007472 Leucaena leucocephala Species 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
102100027064 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial Human genes 0.000 description 1
YSDQQAXHVYUZIW-QCIJIYAXSA-N Liraglutide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 YSDQQAXHVYUZIW-QCIJIYAXSA-N 0.000 description 1
108010019598 Liraglutide Proteins 0.000 description 1
108010011449 Long-chain-fatty-acid-CoA ligase Proteins 0.000 description 1
101150068825 MAT1A gene Proteins 0.000 description 1
206010054805 Macroangiopathy Diseases 0.000 description 1
102100037750 Malectin Human genes 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
102000012750 Membrane Glycoproteins Human genes 0.000 description 1
108010090054 Membrane Glycoproteins Proteins 0.000 description 1
102000018697 Membrane Proteins Human genes 0.000 description 1
108010052285 Membrane Proteins Proteins 0.000 description 1
244000246386 Mentha pulegium Species 0.000 description 1
235000016257 Mentha pulegium Nutrition 0.000 description 1
235000004357 Mentha x piperita Nutrition 0.000 description 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
101000658548 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) Putative type I restriction enzyme MjaIXP endonuclease subunit Proteins 0.000 description 1
101000658542 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) Putative type I restriction enzyme MjaVIIIP endonuclease subunit Proteins 0.000 description 1
101000658529 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) Putative type I restriction enzyme MjaVIIP endonuclease subunit Proteins 0.000 description 1
108010007784 Methionine adenosyltransferase Proteins 0.000 description 1
102000007357 Methionine adenosyltransferase Human genes 0.000 description 1
108060004795 Methyltransferase Proteins 0.000 description 1
206010027525 Microalbuminuria Diseases 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
IBAQFPQHRJAVAV-ULAWRXDQSA-N Miglitol Chemical compound OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO IBAQFPQHRJAVAV-ULAWRXDQSA-N 0.000 description 1
102100039076 Mitochondrial 10-formyltetrahydrofolate dehydrogenase Human genes 0.000 description 1
108010074633 Mixed Function Oxygenases Proteins 0.000 description 1
102000008109 Mixed Function Oxygenases Human genes 0.000 description 1
229920000881 Modified starch Polymers 0.000 description 1
IRLWJILLXJGJTD-UHFFFAOYSA-N Muraglitazar Chemical compound C1=CC(OC)=CC=C1OC(=O)N(CC(O)=O)CC(C=C1)=CC=C1OCCC1=C(C)OC(C=2C=CC=CC=2)=N1 IRLWJILLXJGJTD-UHFFFAOYSA-N 0.000 description 1
241000699660 Mus musculus Species 0.000 description 1
101100203797 Mus musculus Spinkl gene Proteins 0.000 description 1
102100035854 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Human genes 0.000 description 1
108050006009 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Proteins 0.000 description 1
239000000020 Nitrocellulose Substances 0.000 description 1
108020004711 Nucleic Acid Probes Proteins 0.000 description 1
108091028043 Nucleic acid sequence Proteins 0.000 description 1
239000004677 Nylon Substances 0.000 description 1
REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 1
101000989950 Otolemur crassicaudatus Hemoglobin subunit alpha-A Proteins 0.000 description 1
102000004316 Oxidoreductases Human genes 0.000 description 1
108090000854 Oxidoreductases Proteins 0.000 description 1
238000012408 PCR amplification Methods 0.000 description 1
102100037878 Pancreas transcription factor 1 subunit alpha Human genes 0.000 description 1
101710161360 Pancreas transcription factor 1 subunit alpha Proteins 0.000 description 1
108010067035 Pancrelipase Proteins 0.000 description 1
235000019483 Peanut oil Nutrition 0.000 description 1
102000007079 Peptide Fragments Human genes 0.000 description 1
208000037581 Persistent Infection Diseases 0.000 description 1
108010069013 Phenylalanine Hydroxylase Proteins 0.000 description 1
102100038223 Phenylalanine-4-hydroxylase Human genes 0.000 description 1
102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
108010004729 Phycoerythrin Proteins 0.000 description 1
241000276498 Pollachius virens Species 0.000 description 1
229920002732 Polyanhydride Polymers 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
102100034569 Pregnancy zone protein Human genes 0.000 description 1
101710195143 Pregnancy zone protein Proteins 0.000 description 1
101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 1
101710125002 Prostaglandin E2 receptor EP3 subtype Proteins 0.000 description 1
239000004365 Protease Substances 0.000 description 1
101710132686 Protein L3 Proteins 0.000 description 1
102000002727 Protein Tyrosine Phosphatase Human genes 0.000 description 1
101710192597 Protein map Proteins 0.000 description 1
108010026552 Proteome Proteins 0.000 description 1
102100027378 Prothrombin Human genes 0.000 description 1
108010094028 Prothrombin Proteins 0.000 description 1
102000053067 Pyruvate Dehydrogenase Acetyl-Transferring Kinase Human genes 0.000 description 1
102000015097 RNA Splicing Factors Human genes 0.000 description 1
108010039259 RNA Splicing Factors Proteins 0.000 description 1
238000011529 RT qPCR Methods 0.000 description 1
238000010240 RT-PCR analysis Methods 0.000 description 1
238000001069 Raman spectroscopy Methods 0.000 description 1
101000701855 Rattus norvegicus Serine protease inhibitor A3M Proteins 0.000 description 1
101001006906 Rattus norvegicus T-kininogen 1 Proteins 0.000 description 1
101710136899 Replication enhancer protein Proteins 0.000 description 1
YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 description 1
101710186154 S-adenosylmethionine synthase 1 Proteins 0.000 description 1
101710167538 S-adenosylmethionine synthase isoform type-1 Proteins 0.000 description 1
101100033898 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) RGD1 gene Proteins 0.000 description 1
101710187074 Serine proteinase inhibitor Proteins 0.000 description 1
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
101150044140 Slc7a5 gene Proteins 0.000 description 1
108020004459 Small interfering RNA Proteins 0.000 description 1
DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
101150001066 Spink1 gene Proteins 0.000 description 1
101001042773 Staphylococcus aureus (strain COL) Type I restriction enzyme SauCOLORF180P endonuclease subunit Proteins 0.000 description 1
101000838760 Staphylococcus aureus (strain MRSA252) Type I restriction enzyme SauMRSORF196P endonuclease subunit Proteins 0.000 description 1
101000838761 Staphylococcus aureus (strain MSSA476) Type I restriction enzyme SauMSSORF170P endonuclease subunit Proteins 0.000 description 1
101000838758 Staphylococcus aureus (strain MW2) Type I restriction enzyme SauMW2ORF169P endonuclease subunit Proteins 0.000 description 1
101001042566 Staphylococcus aureus (strain Mu50 / ATCC 700699) Type I restriction enzyme SauMu50ORF195P endonuclease subunit Proteins 0.000 description 1
101000838763 Staphylococcus aureus (strain N315) Type I restriction enzyme SauN315I endonuclease subunit Proteins 0.000 description 1
101000838759 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) Type I restriction enzyme SepRPIP endonuclease subunit Proteins 0.000 description 1
101000838756 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) Type I restriction enzyme SsaAORF53P endonuclease subunit Proteins 0.000 description 1
238000012896 Statistical algorithm Methods 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
108010090804 Streptavidin Proteins 0.000 description 1
102100023183 Stromal cell-derived factor 2-like protein 1 Human genes 0.000 description 1
238000000692 Student's t-test Methods 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
235000019486 Sunflower oil Nutrition 0.000 description 1
210000001744 T-lymphocyte Anatomy 0.000 description 1
108700031126 Tetraspanins Proteins 0.000 description 1
102000043977 Tetraspanins Human genes 0.000 description 1
229940123464 Thiazolidinedione Drugs 0.000 description 1
208000037063 Thinness Diseases 0.000 description 1
206010043458 Thirst Diseases 0.000 description 1
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
239000004473 Threonine Substances 0.000 description 1
108090000190 Thrombin Proteins 0.000 description 1
102100033451 Thyroid hormone receptor beta Human genes 0.000 description 1
102000040945 Transcription factor Human genes 0.000 description 1
108091023040 Transcription factor Proteins 0.000 description 1
102000004338 Transferrin Human genes 0.000 description 1
108090000901 Transferrin Proteins 0.000 description 1
101710154711 Tribbles Proteins 0.000 description 1
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 1
DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 1
108090000631 Trypsin Proteins 0.000 description 1
102000004142 Trypsin Human genes 0.000 description 1
206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
102100040363 UDP-glucose:glycoprotein glucosyltransferase 1 Human genes 0.000 description 1
108090000848 Ubiquitin Proteins 0.000 description 1
102000044159 Ubiquitin Human genes 0.000 description 1
102100031311 Ubiquitin carboxyl-terminal hydrolase 43 Human genes 0.000 description 1
102000021911 Ubiquitin-like domains Human genes 0.000 description 1
108091012462 Ubiquitin-like domains Proteins 0.000 description 1
241000700605 Viruses Species 0.000 description 1
206010047513 Vision blurred Diseases 0.000 description 1
102000050760 Vitamin D-binding protein Human genes 0.000 description 1
101710179590 Vitamin D-binding protein Proteins 0.000 description 1
FZNCGRZWXLXZSZ-CIQUZCHMSA-N Voglibose Chemical compound OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O FZNCGRZWXLXZSZ-CIQUZCHMSA-N 0.000 description 1
102100032803 Y+L amino acid transporter 2 Human genes 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
102100034994 Zinc transporter 2 Human genes 0.000 description 1
108091006550 Zinc transporters Proteins 0.000 description 1
101710159466 [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial Proteins 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
239000003070 absorption delaying agent Substances 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
150000001242 acetic acid derivatives Chemical class 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
150000001252 acrylic acid derivatives Chemical class 0.000 description 1
230000001154 acute effect Effects 0.000 description 1
239000002313 adhesive film Substances 0.000 description 1
210000000577 adipose tissue Anatomy 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
239000011543 agarose gel Substances 0.000 description 1
238000000246 agarose gel electrophoresis Methods 0.000 description 1
238000005054 agglomeration Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
150000001299 aldehydes Chemical class 0.000 description 1
IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
239000000783 alginic acid Substances 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
229960001126 alginic acid Drugs 0.000 description 1
150000004781 alginic acids Chemical class 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
229910052784 alkaline earth metal Inorganic materials 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
108020004134 amidinotransferase Proteins 0.000 description 1
102000006614 amidinotransferase Human genes 0.000 description 1
229960003896 aminopterin Drugs 0.000 description 1
230000003321 amplification Effects 0.000 description 1
238000000540 analysis of variance Methods 0.000 description 1
238000002399 angioplasty Methods 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
229940127003 anti-diabetic drug Drugs 0.000 description 1
239000003472 antidiabetic agent Substances 0.000 description 1
229940019748 antifibrinolytic proteinase inhibitors Drugs 0.000 description 1
239000003429 antifungal agent Substances 0.000 description 1
229940121375 antifungal agent Drugs 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
239000000074 antisense oligonucleotide Substances 0.000 description 1
238000012230 antisense oligonucleotides Methods 0.000 description 1
RCHHVVGSTHAVPF-ZPHPLDECSA-N apidra Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3N=CNC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CNC=N1 RCHHVVGSTHAVPF-ZPHPLDECSA-N 0.000 description 1
239000008365 aqueous carrier Substances 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
238000000149 argon plasma sintering Methods 0.000 description 1
230000004872 arterial blood pressure Effects 0.000 description 1
208000028922 artery disease Diseases 0.000 description 1
238000013528 artificial neural network Methods 0.000 description 1
235000009582 asparagine Nutrition 0.000 description 1
229960001230 asparagine Drugs 0.000 description 1
125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 1
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
239000000605 aspartame Substances 0.000 description 1
235000010357 aspartame Nutrition 0.000 description 1
229960003438 aspartame Drugs 0.000 description 1
235000003704 aspartic acid Nutrition 0.000 description 1
208000006673 asthma Diseases 0.000 description 1
YDGMGEXADBMOMJ-UHFFFAOYSA-N asymmetrical dimethylarginine Natural products CN(C)C(N)=NCCCC(N)C(O)=O YDGMGEXADBMOMJ-UHFFFAOYSA-N 0.000 description 1
230000000923 atherogenic effect Effects 0.000 description 1
230000001363 autoimmune Effects 0.000 description 1
229940054739 avandamet Drugs 0.000 description 1
238000003705 background correction Methods 0.000 description 1
210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 1
230000006399 behavior Effects 0.000 description 1
230000003542 behavioural effect Effects 0.000 description 1
JUHORIMYRDESRB-UHFFFAOYSA-N benzathine Chemical class C=1C=CC=CC=1CNCCNCC1=CC=CC=C1 JUHORIMYRDESRB-UHFFFAOYSA-N 0.000 description 1
229940077388 benzenesulfonate Drugs 0.000 description 1
SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
235000019445 benzyl alcohol Nutrition 0.000 description 1
235000021028 berry Nutrition 0.000 description 1
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
238000002011 beta-particle spectroscopy Methods 0.000 description 1
AFYNADDZULBEJA-UHFFFAOYSA-N bicinchoninic acid Chemical compound C1=CC=CC2=NC(C=3C=C(C4=CC=CC=C4N=3)C(=O)O)=CC(C(O)=O)=C21 AFYNADDZULBEJA-UHFFFAOYSA-N 0.000 description 1
239000003613 bile acid Substances 0.000 description 1
229920000249 biocompatible polymer Polymers 0.000 description 1
239000012620 biological material Substances 0.000 description 1
230000007321 biological mechanism Effects 0.000 description 1
230000033228 biological regulation Effects 0.000 description 1
229920001400 block copolymer Polymers 0.000 description 1
239000003114 blood coagulation factor Substances 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
230000003139 buffering effect Effects 0.000 description 1
DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 1
235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
229940043253 butylated hydroxyanisole Drugs 0.000 description 1
CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
210000004900 c-terminal fragment Anatomy 0.000 description 1
210000004899 c-terminal region Anatomy 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
238000005251 capillar electrophoresis Methods 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
235000011089 carbon dioxide Nutrition 0.000 description 1
239000011545 carbonate/bicarbonate buffer Substances 0.000 description 1
HFNQLYDPNAZRCH-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O.OC(O)=O HFNQLYDPNAZRCH-UHFFFAOYSA-N 0.000 description 1
150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
230000021164 cell adhesion Effects 0.000 description 1
239000006143 cell culture medium Substances 0.000 description 1
230000024245 cell differentiation Effects 0.000 description 1
230000003915 cell function Effects 0.000 description 1
230000012292 cell migration Effects 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
208000026106 cerebrovascular disease Diseases 0.000 description 1
230000005465 channeling Effects 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
239000011651 chromium Substances 0.000 description 1
229910052804 chromium Inorganic materials 0.000 description 1
235000012721 chromium Nutrition 0.000 description 1
150000001860 citric acid derivatives Chemical class 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
238000013329 compounding Methods 0.000 description 1
208000012696 congenital leptin deficiency Diseases 0.000 description 1
238000010276 construction Methods 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
238000002586 coronary angiography Methods 0.000 description 1
208000026758 coronary atherosclerosis Diseases 0.000 description 1
229940109239 creatinine Drugs 0.000 description 1
229960001681 croscarmellose sodium Drugs 0.000 description 1
229960000913 crospovidone Drugs 0.000 description 1
235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
238000013211 curve analysis Methods 0.000 description 1
210000005220 cytoplasmic tail Anatomy 0.000 description 1
238000003066 decision tree Methods 0.000 description 1
230000002950 deficient Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
239000008367 deionised water Substances 0.000 description 1
229910021641 deionized water Inorganic materials 0.000 description 1
230000002939 deleterious effect Effects 0.000 description 1
238000012217 deletion Methods 0.000 description 1
230000037430 deletion Effects 0.000 description 1
230000008021 deposition Effects 0.000 description 1
238000013461 design Methods 0.000 description 1
239000003599 detergent Substances 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
208000033679 diabetic kidney disease Diseases 0.000 description 1
238000010586 diagram Methods 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
VLYUGYAKYZETRF-UHFFFAOYSA-N dihydrolipoamide Chemical compound NC(=O)CCCCC(S)CCS VLYUGYAKYZETRF-UHFFFAOYSA-N 0.000 description 1
239000012470 diluted sample Substances 0.000 description 1
238000007865 diluting Methods 0.000 description 1
108010048054 dimethylargininase Proteins 0.000 description 1
231100000676 disease causative agent Toxicity 0.000 description 1
230000005750 disease progression Effects 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
239000002612 dispersion medium Substances 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
238000002651 drug therapy Methods 0.000 description 1
238000013399 early diagnosis Methods 0.000 description 1
230000002526 effect on cardiovascular system Effects 0.000 description 1
238000011984 electrochemiluminescence immunoassay Methods 0.000 description 1
239000003792 electrolyte Substances 0.000 description 1
239000003623 enhancer Substances 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
238000001952 enzyme assay Methods 0.000 description 1
HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 description 1
150000002169 ethanolamines Chemical class 0.000 description 1
LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
229940093471 ethyl oleate Drugs 0.000 description 1
239000005038 ethylene vinyl acetate Substances 0.000 description 1
230000029142 excretion Effects 0.000 description 1
229960001519 exenatide Drugs 0.000 description 1
239000013604 expression vector Substances 0.000 description 1
210000003414 extremity Anatomy 0.000 description 1
229940012151 exubera Drugs 0.000 description 1
210000001508 eye Anatomy 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical compound [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 description 1
239000000835 fiber Substances 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
238000012921 fluorescence analysis Methods 0.000 description 1
238000005187 foaming Methods 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
108010079306 galactoside 2-alpha-L-fucosyltransferase Proteins 0.000 description 1
108010067742 gamma nerve growth factor Proteins 0.000 description 1
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
235000004611 garlic Nutrition 0.000 description 1
238000004817 gas chromatography Methods 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
238000001502 gel electrophoresis Methods 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
208000004104 gestational diabetes Diseases 0.000 description 1
239000011521 glass Substances 0.000 description 1
229960000346 gliclazide Drugs 0.000 description 1
229960004346 glimepiride Drugs 0.000 description 1
WIGIZIANZCJQQY-RUCARUNLSA-N glimepiride Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)N[C@@H]2CC[C@@H](C)CC2)C=C1 WIGIZIANZCJQQY-RUCARUNLSA-N 0.000 description 1
208000005017 glioblastoma Diseases 0.000 description 1
230000004110 gluconeogenesis Effects 0.000 description 1
230000014101 glucose homeostasis Effects 0.000 description 1
229940116332 glucose oxidase Drugs 0.000 description 1
235000019420 glucose oxidase Nutrition 0.000 description 1
229940112611 glucovance Drugs 0.000 description 1
229940097043 glucuronic acid Drugs 0.000 description 1
235000013922 glutamic acid Nutrition 0.000 description 1
239000004220 glutamic acid Substances 0.000 description 1
230000013595 glycosylation Effects 0.000 description 1
238000006206 glycosylation reaction Methods 0.000 description 1
239000005090 green fluorescent protein Substances 0.000 description 1
230000012010 growth Effects 0.000 description 1
102000028718 growth factor binding proteins Human genes 0.000 description 1
108091009353 growth factor binding proteins Proteins 0.000 description 1
230000003862 health status Effects 0.000 description 1
238000005534 hematocrit Methods 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
235000001050 hortel pimenta Nutrition 0.000 description 1
229940038661 humalog Drugs 0.000 description 1
102000048695 human SERPINA3 Human genes 0.000 description 1
235000003642 hunger Nutrition 0.000 description 1
239000000017 hydrogel Substances 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
230000003451 hyperinsulinaemic effect Effects 0.000 description 1
201000008980 hyperinsulinism Diseases 0.000 description 1
238000003384 imaging method Methods 0.000 description 1
229940042743 immune sera Drugs 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
230000007813 immunodeficiency Effects 0.000 description 1
230000016784 immunoglobulin production Effects 0.000 description 1
238000013198 immunometric assay Methods 0.000 description 1
230000001771 impaired effect Effects 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
239000003701 inert diluent Substances 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
238000001802 infusion Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000007641 inkjet printing Methods 0.000 description 1
150000007529 inorganic bases Chemical class 0.000 description 1
229960003948 insulin detemir Drugs 0.000 description 1
229960002869 insulin glargine Drugs 0.000 description 1
108700039926 insulin glulisine Proteins 0.000 description 1
229960000696 insulin glulisine Drugs 0.000 description 1
229960002068 insulin lispro Drugs 0.000 description 1
230000003914 insulin secretion Effects 0.000 description 1
230000004155 insulin signaling pathway Effects 0.000 description 1
108010093564 inter-alpha-inhibitor Proteins 0.000 description 1
230000003993 interaction Effects 0.000 description 1
238000001361 intraarterial administration Methods 0.000 description 1
238000007913 intrathecal administration Methods 0.000 description 1
239000007951 isotonicity adjuster Substances 0.000 description 1
238000012804 iterative process Methods 0.000 description 1
238000003064 k means clustering Methods 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
238000000021 kinase assay Methods 0.000 description 1
238000009533 lab test Methods 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229940060975 lantus Drugs 0.000 description 1
210000000265 leukocyte Anatomy 0.000 description 1
UGOZVNFCFYTPAZ-IOXYNQHNSA-N levemir Chemical compound CCCCCCCCCCCCCC(=O)NCCCC[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=2N=CNC=2)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=2N=CNC=2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=2C=CC=CC=2)C(C)C)CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(C)C)CSSC[C@H](NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC2=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H](CSSC1)C(=O)N[C@@H](CC(N)=O)C(O)=O)CC1=CC=C(O)C=C1 UGOZVNFCFYTPAZ-IOXYNQHNSA-N 0.000 description 1
238000011542 limb amputation Methods 0.000 description 1
230000037356 lipid metabolism Effects 0.000 description 1
235000019136 lipoic acid Nutrition 0.000 description 1
239000012669 liquid formulation Substances 0.000 description 1
229960002701 liraglutide Drugs 0.000 description 1
229910003002 lithium salt Inorganic materials 0.000 description 1
159000000002 lithium salts Chemical class 0.000 description 1
210000005229 liver cell Anatomy 0.000 description 1
210000005228 liver tissue Anatomy 0.000 description 1
230000033001 locomotion Effects 0.000 description 1
239000012139 lysis buffer Substances 0.000 description 1
239000000395 magnesium oxide Substances 0.000 description 1
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
230000005291 magnetic effect Effects 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000000873 masking effect Effects 0.000 description 1
238000013178 mathematical model Methods 0.000 description 1
238000010339 medical test Methods 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
229940054183 metaglip Drugs 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
229940035732 metformin and rosiglitazone Drugs 0.000 description 1
STZCRXQWRGQSJD-GEEYTBSJSA-M methyl orange Chemical compound [Na+].C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-GEEYTBSJSA-M 0.000 description 1
229940012189 methyl orange Drugs 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
229960001047 methyl salicylate Drugs 0.000 description 1
238000012775 microarray technology Methods 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
239000004005 microsphere Substances 0.000 description 1
230000027939 micturition Effects 0.000 description 1
229960001110 miglitol Drugs 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
230000004065 mitochondrial dysfunction Effects 0.000 description 1
208000001022 morbid obesity Diseases 0.000 description 1
230000008450 motivation Effects 0.000 description 1
208000010125 myocardial infarction Diseases 0.000 description 1
210000004457 myocytus nodalis Anatomy 0.000 description 1
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
229960000698 nateglinide Drugs 0.000 description 1
OELFLUMRDSZNSF-BRWVUGGUSA-N nateglinide Chemical compound C1C[C@@H](C(C)C)CC[C@@H]1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-BRWVUGGUSA-N 0.000 description 1
210000000822 natural killer cell Anatomy 0.000 description 1
238000004848 nephelometry Methods 0.000 description 1
PKWDZWYVIHVNKS-UHFFFAOYSA-N netoglitazone Chemical compound FC1=CC=CC=C1COC1=CC=C(C=C(CC2C(NC(=O)S2)=O)C=C2)C2=C1 PKWDZWYVIHVNKS-UHFFFAOYSA-N 0.000 description 1
229950001628 netoglitazone Drugs 0.000 description 1
229920001220 nitrocellulos Polymers 0.000 description 1
239000012457 nonaqueous media Substances 0.000 description 1
239000002687 nonaqueous vehicle Substances 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
230000001019 normoglycemic effect Effects 0.000 description 1
238000003199 nucleic acid amplification method Methods 0.000 description 1
239000002853 nucleic acid probe Substances 0.000 description 1
229920001778 nylon Polymers 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000002674 ointment Substances 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
229940012843 omega-3 fatty acid Drugs 0.000 description 1
235000020660 omega-3 fatty acid Nutrition 0.000 description 1
239000006014 omega-3 oil Substances 0.000 description 1
238000005457 optimization Methods 0.000 description 1
230000008816 organ damage Effects 0.000 description 1
210000004789 organ system Anatomy 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
150000002895 organic esters Chemical class 0.000 description 1
AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 description 1
229960001243 orlistat Drugs 0.000 description 1
201000008968 osteosarcoma Diseases 0.000 description 1
229940062190 pancreas extract Drugs 0.000 description 1
230000004203 pancreatic function Effects 0.000 description 1
230000005298 paramagnetic effect Effects 0.000 description 1
238000005192 partition Methods 0.000 description 1
230000032696 parturition Effects 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
230000007170 pathology Effects 0.000 description 1
230000007310 pathophysiology Effects 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
208000030613 peripheral artery disease Diseases 0.000 description 1
210000001428 peripheral nervous system Anatomy 0.000 description 1
210000002824 peroxisome Anatomy 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
239000008024 pharmaceutical diluent Substances 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
150000008105 phosphatidylcholines Chemical class 0.000 description 1
229930029653 phosphoenolpyruvate Natural products 0.000 description 1
DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 description 1
150000003904 phospholipids Chemical class 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
238000000206 photolithography Methods 0.000 description 1
HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920001983 poloxamer Polymers 0.000 description 1
229920001993 poloxamer 188 Polymers 0.000 description 1
229920001987 poloxamine Polymers 0.000 description 1
229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
229920001610 polycaprolactone Polymers 0.000 description 1
229920002721 polycyanoacrylate Polymers 0.000 description 1
229920000656 polylysine Polymers 0.000 description 1
229920000193 polymethacrylate Polymers 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920006324 polyoxymethylene Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
150000004804 polysaccharides Chemical class 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000017924 poor diet Nutrition 0.000 description 1
238000010149 post-hoc-test Methods 0.000 description 1
230000000291 postprandial effect Effects 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
229920001592 potato starch Polymers 0.000 description 1
229940069328 povidone Drugs 0.000 description 1
235000008476 powdered milk Nutrition 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000003449 preventive effect Effects 0.000 description 1
230000009862 primary prevention Effects 0.000 description 1
230000037452 priming Effects 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
235000019833 protease Nutrition 0.000 description 1
235000019419 proteases Nutrition 0.000 description 1
230000004224 protection Effects 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000003498 protein array Methods 0.000 description 1
238000000159 protein binding assay Methods 0.000 description 1
238000000751 protein extraction Methods 0.000 description 1
230000012846 protein folding Effects 0.000 description 1
239000012474 protein marker Substances 0.000 description 1
230000022558 protein metabolic process Effects 0.000 description 1
108020000494 protein-tyrosine phosphatase Proteins 0.000 description 1
229940039716 prothrombin Drugs 0.000 description 1
150000003222 pyridines Chemical class 0.000 description 1
238000000197 pyrolysis Methods 0.000 description 1
238000003908 quality control method Methods 0.000 description 1
239000002096 quantum dot Substances 0.000 description 1
150000003254 radicals Chemical class 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
238000005514 radiochemical analysis Methods 0.000 description 1
108700042226 ras Genes Proteins 0.000 description 1
230000000306 recurrent effect Effects 0.000 description 1
235000003499 redwood Nutrition 0.000 description 1
230000007980 regulation of cell activation Effects 0.000 description 1
230000023252 regulation of cell development Effects 0.000 description 1
230000021014 regulation of cell growth Effects 0.000 description 1
230000024122 regulation of cell motility Effects 0.000 description 1
230000026267 regulation of growth Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
229960002354 repaglinide Drugs 0.000 description 1
230000000284 resting effect Effects 0.000 description 1
238000012502 risk assessment Methods 0.000 description 1
SUFUKZSWUHZXAV-BTJKTKAUSA-N rosiglitazone maleate Chemical compound [H+].[H+].[O-]C(=O)\C=C/C([O-])=O.C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O SUFUKZSWUHZXAV-BTJKTKAUSA-N 0.000 description 1
101150073388 rpl3 gene Proteins 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
230000007017 scission Effects 0.000 description 1
238000013077 scoring method Methods 0.000 description 1
238000005204 segregation Methods 0.000 description 1
239000006152 selective media Substances 0.000 description 1
238000002864 sequence alignment Methods 0.000 description 1
238000010008 shearing Methods 0.000 description 1
150000004756 silanes Chemical class 0.000 description 1
229920000260 silastic Polymers 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
229960001866 silicon dioxide Drugs 0.000 description 1
229920002379 silicone rubber Polymers 0.000 description 1
239000004945 silicone rubber Substances 0.000 description 1
210000003491 skin Anatomy 0.000 description 1
230000000391 smoking effect Effects 0.000 description 1
210000000329 smooth muscle myocyte Anatomy 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
229940001584 sodium metabisulfite Drugs 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000008109 sodium starch glycolate Substances 0.000 description 1
229920003109 sodium starch glycolate Polymers 0.000 description 1
229940079832 sodium starch glycolate Drugs 0.000 description 1
239000002594 sorbent Substances 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
241000894007 species Species 0.000 description 1
230000003595 spectral effect Effects 0.000 description 1
238000010183 spectrum analysis Methods 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
230000003393 splenic effect Effects 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
210000000130 stem cell Anatomy 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000013517 stratification Methods 0.000 description 1
210000002536 stromal cell Anatomy 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1
238000012706 support-vector machine Methods 0.000 description 1
230000001629 suppression Effects 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000009897 systematic effect Effects 0.000 description 1
238000012353 t test Methods 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
CXGTZJYQWSUFET-IBGZPJMESA-N tesaglitazar Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OCCC1=CC=C(OS(C)(=O)=O)C=C1 CXGTZJYQWSUFET-IBGZPJMESA-N 0.000 description 1
229950004704 tesaglitazar Drugs 0.000 description 1
150000001467 thiazolidinediones Chemical class 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
229960002663 thioctic acid Drugs 0.000 description 1
229960004072 thrombin Drugs 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
239000012581 transferrin Substances 0.000 description 1
230000009466 transformation Effects 0.000 description 1
230000014621 translational initiation Effects 0.000 description 1
102000027257 transmembrane receptors Human genes 0.000 description 1
108091008578 transmembrane receptors Proteins 0.000 description 1
239000001069 triethyl citrate Substances 0.000 description 1
VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
235000013769 triethyl citrate Nutrition 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
239000002753 trypsin inhibitor Substances 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
206010048828 underweight Diseases 0.000 description 1
241001515965 unidentified phage Species 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
239000013598 vector Substances 0.000 description 1
235000001366 vegetable intake Nutrition 0.000 description 1
SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1
230000000007 visual effect Effects 0.000 description 1
MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
229960001729 voglibose Drugs 0.000 description 1
235000012431 wafers Nutrition 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000008215 water for injection Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1
230000004580 weight loss Effects 0.000 description 1
239000013585 weight reducing agent Substances 0.000 description 1
230000029663 wound healing Effects 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
230000003820 β-cell dysfunction Effects 0.000 description 1