CA2658463A1 - Methode efficace de reprogrammation nucleaire - Google Patents

Methode efficace de reprogrammation nucleaire Download PDF

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Publication number
CA2658463A1
CA2658463A1 CA002658463A CA2658463A CA2658463A1 CA 2658463 A1 CA2658463 A1 CA 2658463A1 CA 002658463 A CA002658463 A CA 002658463A CA 2658463 A CA2658463 A CA 2658463A CA 2658463 A1 CA2658463 A1 CA 2658463A1
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Prior art keywords
mir
mirna
cells
hsa
gene
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CA002658463A
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CA2658463C (fr
Inventor
Shinya Yamanaka
Michiyo Koyanagi
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Kyoto University
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Kyoto University
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Priority claimed from PCT/JP2008/059586 external-priority patent/WO2009075119A1/fr
Publication of CA2658463A1 publication Critical patent/CA2658463A1/fr
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Publication of CA2658463C publication Critical patent/CA2658463C/fr
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Abstract

L'invention concerne un procédé pour produire efficacement des cellules souches pluripotentes artificielles qui comprend l'étape consistant à procéder à une initialisation de noyaux au moyen d'un facteur d'initialisation de noyaux en présence d'un miARN, le miARN ayant les caractéristiques suivantes : (a) il est exprimé dans les cellules souches embryonnaires à un plus haut niveau que dans les cellules somatiques ; et (b) une efficacité d'initialisation de noyaux plus élevée a été établie en présence du miARN qu'en son absence.
CA2658463A 2007-12-10 2008-05-23 Methode efficace de reprogrammation nucleaire Active CA2658463C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99689307P 2007-12-10 2007-12-10
US60/996,893 2007-12-10
PCT/JP2008/059586 WO2009075119A1 (fr) 2007-12-10 2008-05-23 Procédé efficace d'initialisation de noyaux

Publications (2)

Publication Number Publication Date
CA2658463A1 true CA2658463A1 (fr) 2009-06-10
CA2658463C CA2658463C (fr) 2015-07-21

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CA2658463A Active CA2658463C (fr) 2007-12-10 2008-05-23 Methode efficace de reprogrammation nucleaire

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CA (1) CA2658463C (fr)

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CA2658463C (fr) 2015-07-21

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