CA2657302A1 - Modified tgf-.beta. superfamily proteins - Google Patents

Modified tgf-.beta. superfamily proteins Download PDF

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Publication number
CA2657302A1
CA2657302A1 CA002657302A CA2657302A CA2657302A1 CA 2657302 A1 CA2657302 A1 CA 2657302A1 CA 002657302 A CA002657302 A CA 002657302A CA 2657302 A CA2657302 A CA 2657302A CA 2657302 A1 CA2657302 A1 CA 2657302A1
Authority
CA
Canada
Prior art keywords
tgf
protein
beta
proteins
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002657302A
Other languages
English (en)
French (fr)
Inventor
Hermann Oppermann
Mei-Sheng Tai
John Mccartney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MARIEL THERAPEUTICS Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2657302A1 publication Critical patent/CA2657302A1/en
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002657302A 1998-10-07 1999-10-07 Modified tgf-.beta. superfamily proteins Abandoned CA2657302A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10341898P 1998-10-07 1998-10-07
US60/103,418 1998-10-07
US37533399A 1999-08-16 1999-08-16
US09/375,333 1999-08-16
CA002345024A CA2345024C (en) 1998-10-07 1999-10-07 Modified tgf-.beta. superfamily proteins

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002345024A Division CA2345024C (en) 1998-10-07 1999-10-07 Modified tgf-.beta. superfamily proteins

Publications (1)

Publication Number Publication Date
CA2657302A1 true CA2657302A1 (en) 2000-04-13

Family

ID=26800442

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002345024A Expired - Fee Related CA2345024C (en) 1998-10-07 1999-10-07 Modified tgf-.beta. superfamily proteins
CA002657302A Abandoned CA2657302A1 (en) 1998-10-07 1999-10-07 Modified tgf-.beta. superfamily proteins

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002345024A Expired - Fee Related CA2345024C (en) 1998-10-07 1999-10-07 Modified tgf-.beta. superfamily proteins

Country Status (6)

Country Link
US (2) US20050250936A1 (enExample)
EP (2) EP2128260A3 (enExample)
JP (6) JP3762222B2 (enExample)
AU (1) AU1103900A (enExample)
CA (2) CA2345024C (enExample)
WO (1) WO2000020449A2 (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60025830T2 (de) * 1999-07-21 2006-11-02 University Of Southern California, Los Angeles Fusions-polypeptide zur gewebegeneration und wundheilung zur gezielten matrixanwendung
US7141392B2 (en) 2001-01-09 2006-11-28 Queen Mary And Westfield College Latent fusion protein
US6942853B2 (en) * 2001-01-09 2005-09-13 Queen Mary And Westfield College Latent fusion protein
JP2002306163A (ja) * 2001-04-11 2002-10-22 Chemo Sero Therapeut Res Inst 大腸菌を宿主とする遺伝子組換えヒトトロンビンの調製方法
FI116827B (fi) 2001-08-24 2006-03-15 Univ Zuerich Luun morfogeneettisen proteiinin deleetiomutantti, sitä sisältävä farmaseuttinen koostumus ja sen käyttö
US8192735B2 (en) 2004-04-13 2012-06-05 St Vincent's Hospital Sydney Limited Method for modulating appetite
US20090042780A1 (en) * 2004-05-20 2009-02-12 Acceleron Pharma Inc Modified TGF-Beta Superfamily Polypeptides and Related Methods
US7795389B2 (en) 2004-09-28 2010-09-14 The Board Of Regents Of The University Of Texas System Antagonizing TGF-beta activity with various ectodomains TGF-beta receptors used in combination or as fusion proteins
US20080199443A1 (en) * 2005-06-09 2008-08-21 The Govt. Of The U.S.A. As Represented By The Secretary, Dept. Of Health And Human Services Bone Morphogenetic Variants, Compositions and Methods of Treatment
ATE514712T1 (de) 2005-12-26 2011-07-15 Yantai Zhenghai Bio Technology Co Ltd Aktivierte collagen-gerüstmaterialien und ihre speziellen kondensierten aktiven restorationsfaktoren
WO2008051526A2 (en) * 2006-10-23 2008-05-02 Stryker Corporation Bone morphogenetic proteins
EP2120859B1 (en) 2006-12-21 2013-11-20 Stryker Corporation Sustained-release formulations comprising bmp-7 crystals
WO2010090523A1 (en) * 2009-02-06 2010-08-12 Pepscan Systems B.V. Truncated cystine-knot proteins
CN102369016A (zh) 2009-02-12 2012-03-07 史赛克公司 用于治疗系统性病症和疾病的包含TGF-β超家族成员的蛋白质的外周施用
AU2010213591B2 (en) 2009-02-12 2013-11-21 Stryker Corporation Compositions and methods for minimally-invasive systemic delivery of proteins including TGF-beta superfamily members
WO2010110974A1 (en) 2009-03-24 2010-09-30 Stryker Corporation Methods and compositions for tissue engineering
US20110224138A1 (en) 2009-09-09 2011-09-15 Julie Krop Methods for treating pain induced by injuries and diseases of an articular joint
WO2011035094A1 (en) 2009-09-17 2011-03-24 Stryker Corporation Buffers for controlling the ph of bone morphogenetic proteins
CA2785038A1 (en) 2009-12-22 2011-07-21 Stryker Corporation Bmp-7 variants with reduced immunogenicity
US8592364B2 (en) * 2010-02-11 2013-11-26 Ecole Polytechnique Federale de Lausanne (“EPFL”) CCR7 ligand delivery and co-delivery in immunotherapy
US11078248B2 (en) 2010-03-19 2021-08-03 Lifenet Health BMP peptides and methods of use
CA2794167A1 (en) 2010-03-24 2011-09-29 Lifenet Health Bmp-7 peptides & methods of use
CN108117586A (zh) 2010-08-10 2018-06-05 洛桑聚合联合学院 红细胞结合性治疗剂
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
AU2011292810B2 (en) * 2010-08-20 2015-04-30 Wyeth Llc Designer osteogenic proteins
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
US9856305B2 (en) 2010-08-20 2018-01-02 Wyeth Llc Designer osteogenic proteins
KR20150010699A (ko) 2012-02-15 2015-01-28 에꼴 뽈리떼끄닉 뻬데랄 드 로잔느 (으뻬에프엘) 적혈구 결합요법
CN105073133B (zh) 2012-12-21 2021-04-20 Aveo制药公司 抗gdf15抗体
EP2981822B1 (en) 2013-05-06 2020-09-02 Scholar Rock, Inc. Compositions and methods for growth factor modulation
AU2015233084B2 (en) 2014-02-21 2020-12-17 Anokion Sa Glycotargeting therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
AU2016311298A1 (en) 2015-08-25 2018-02-08 Histide Ag Compounds for inducing tissue formation and uses thereof
EP3341397B1 (en) * 2015-08-25 2024-12-18 Histide AG Compounds for inducing tissue formation and uses thereof
CN109415425A (zh) 2016-05-31 2019-03-01 财团法人牧岩生命科学研究所 TGF-β超家族的AB6家族设计配体
US11253579B2 (en) 2017-06-16 2022-02-22 The University Of Chicago Compositions and methods for inducing immune tolerance
CN112384239A (zh) 2018-05-09 2021-02-19 芝加哥大学 影响免疫耐受的组合物和方法
EP3878856B1 (en) 2018-11-05 2025-06-18 Ajinomoto Co., Inc. Method for producing refolded protein by using flow microreactor, and protein refolding apparatus
CN115128147B (zh) * 2021-03-29 2025-02-11 盛禾(中国)生物制药有限公司 一种融合蛋白样品的快速分析方法
EP4648790A1 (en) * 2023-01-12 2025-11-19 Regeneron Pharmaceuticals, Inc. Compositions and methods for targeted delivery of tgfbeta

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985002198A1 (en) * 1983-11-01 1985-05-23 Amgen Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides
ZA874681B (en) 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US4877864A (en) 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
US5108922A (en) 1986-07-01 1992-04-28 Genetics Institute, Inc. DNA sequences encoding BMP-1 products
US5106748A (en) 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5013649A (en) 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5155058A (en) 1986-11-07 1992-10-13 Canon Kabushiki Kaisha Method of making semiconductor memory device
US5221620A (en) * 1987-10-06 1993-06-22 Oncogen Cloning and expression of transforming growth factor β2
EP0372005A4 (en) * 1987-10-30 1990-06-26 Oncogen EXPRESSION SYSTEMS FOR THE PREPARATION OF POLYPEPTIDES IN PROKARYOTIC CELLS.
US5011691A (en) 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5258494A (en) 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US4968590A (en) 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5250302A (en) 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
US5002965A (en) 1989-05-09 1991-03-26 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Use of ginkgolides to prevent reperfusion injury in organ transplantation
DK0448704T3 (da) 1989-10-17 1999-04-06 Stryker Corp Osteogene anordninger
CA2070393A1 (en) * 1989-10-18 1991-04-19 Charles M. Cohen Biosynthetic constructs of tgf-beta
GB8927546D0 (en) 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
AU659412B2 (en) * 1990-06-25 1995-05-18 Osi Pharmaceuticals, Inc. Tissue-derived tumor growth inhibitors
JP3627985B2 (ja) 1991-03-11 2005-03-09 キュリス インコーポレイテッド タンパク質により誘導される形態形成
DE69233022T2 (de) * 1991-11-04 2004-02-12 Genetics Institute, LLC, Cambridge Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
US5807713A (en) * 1992-02-12 1998-09-15 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung DNA encoding growth/differentiation factor
DK1167384T3 (da) 1992-10-28 2007-04-10 Genentech Inc Vaskular endotheliel cellevækstfaktor antagonister
EP1439190A1 (en) 1993-01-12 2004-07-21 The Johns Hopkins University School Of Medicine Growth differentiation factor-5
CA2124422A1 (en) * 1993-05-27 1994-11-28 Yukio Fujisawa Heterodimers of tgf-.beta. superfamily
AU697625B2 (en) 1993-07-09 1998-10-15 Johns Hopkins University School Of Medicine, The Growth differentiation factor-6
US5399677A (en) 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
JP3717930B2 (ja) 1993-12-07 2005-11-16 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Bmp−12、bmp−13およびそれらの腱誘導組成物
TW459044B (en) * 1994-07-01 2001-10-11 Bioph Biotech Entw Pharm Gmbh Protein MP-121 of the TGF-β-like family
US5800811A (en) * 1995-06-06 1998-09-01 Hall; Frederick L. Artificial skin prepared from coclagen matrix containing transforming growth factor-β having a collagen binding site
US6352972B1 (en) * 1995-06-06 2002-03-05 Marcel E. Nimni Bone morphogenetic proteins and their use in bone growth
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US5932716A (en) 1995-07-26 1999-08-03 Creative Biomolecules, Inc. Morphogen-responsive regulatory elements
US6677432B1 (en) * 1998-10-07 2004-01-13 Stryker Corporation Mutations of the C-terminal portion of TGF-β superfamily proteins
US8750953B2 (en) 2008-02-19 2014-06-10 Covidien Lp Methods and systems for alerting practitioners to physiological conditions
JP2011519049A (ja) 2008-04-29 2011-06-30 イミューンエクサイト インコーポレイテッド 免疫調節組成物およびその使用方法
RU2510423C2 (ru) 2009-08-31 2014-03-27 Ниппон Стил Корпорейшн Высокопрочная гальванизированная листовая сталь и способ ее изготовления
US9201968B2 (en) 2011-08-29 2015-12-01 Massachusetts Institute Of Technology System and method for finding mood-dependent top selling/rated lists
US9107654B2 (en) 2012-01-05 2015-08-18 Cook Medical Technologies Llc Attachment device for tissue approximation and retraction

Also Published As

Publication number Publication date
EP1117805A2 (en) 2001-07-25
WO2000020449A3 (en) 2000-10-12
JP2010180241A (ja) 2010-08-19
US20120122778A1 (en) 2012-05-17
AU1103900A (en) 2000-04-26
JP2005320339A (ja) 2005-11-17
JP2013014606A (ja) 2013-01-24
JP2016056185A (ja) 2016-04-21
JP2008231125A (ja) 2008-10-02
JP3762222B2 (ja) 2006-04-05
CA2345024C (en) 2009-05-19
WO2000020449A9 (en) 2002-08-22
WO2000020449A2 (en) 2000-04-13
CA2345024A1 (en) 2000-04-13
EP2128260A2 (en) 2009-12-02
JP2003535019A (ja) 2003-11-25
US20050250936A1 (en) 2005-11-10
EP2128260A3 (en) 2010-06-16
US8518411B2 (en) 2013-08-27

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20170825