CA2655381C - Compositions of glycopyrronium salt for inhalation - Google Patents
Compositions of glycopyrronium salt for inhalation Download PDFInfo
- Publication number
- CA2655381C CA2655381C CA2655381A CA2655381A CA2655381C CA 2655381 C CA2655381 C CA 2655381C CA 2655381 A CA2655381 A CA 2655381A CA 2655381 A CA2655381 A CA 2655381A CA 2655381 C CA2655381 C CA 2655381C
- Authority
- CA
- Canada
- Prior art keywords
- process according
- glycopyrronium
- adherent agent
- micronised
- glycopyrronium salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 70
- ANGKOCUUWGHLCE-HKUYNNGSSA-N [(3s)-1,1-dimethylpyrrolidin-1-ium-3-yl] (2r)-2-cyclopentyl-2-hydroxy-2-phenylacetate Chemical group C1[N+](C)(C)CC[C@@H]1OC(=O)[C@](O)(C=1C=CC=CC=1)C1CCCC1 ANGKOCUUWGHLCE-HKUYNNGSSA-N 0.000 title claims abstract description 58
- 239000002245 particle Substances 0.000 claims abstract description 60
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 56
- 230000000181 anti-adherent effect Effects 0.000 claims abstract description 54
- 239000003911 antiadherent Substances 0.000 claims abstract description 54
- 239000000843 powder Substances 0.000 claims abstract description 43
- 238000009472 formulation Methods 0.000 claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 24
- 238000004519 manufacturing process Methods 0.000 claims abstract description 9
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 40
- 229960002462 glycopyrronium bromide Drugs 0.000 claims description 20
- 235000019359 magnesium stearate Nutrition 0.000 claims description 20
- ANGKOCUUWGHLCE-UHFFFAOYSA-N 2-cyclopentyl-2-hydroxy-2-phenylacetic acid (1,1-dimethyl-3-pyrrolidin-1-iumyl) ester Chemical group C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 ANGKOCUUWGHLCE-UHFFFAOYSA-N 0.000 claims description 14
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- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
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- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims description 6
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 13
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- VPNYRYCIDCJBOM-UHFFFAOYSA-M Glycopyrronium bromide Chemical compound [Br-].C1[N+](C)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 VPNYRYCIDCJBOM-UHFFFAOYSA-M 0.000 description 9
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- 239000002775 capsule Substances 0.000 description 6
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- A61P11/08—Bronchodilators
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
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- Pain & Pain Management (AREA)
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| GB0613161.9 | 2006-06-30 | ||
| GBGB0613161.9A GB0613161D0 (en) | 2006-06-30 | 2006-06-30 | Organic Compounds |
| PCT/EP2007/005744 WO2008000482A1 (en) | 2006-06-30 | 2007-06-28 | Compositions of glycopyrronium salt for inhalation |
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| CA2655381A1 CA2655381A1 (en) | 2008-01-03 |
| CA2655381C true CA2655381C (en) | 2014-10-21 |
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| CA2655381A Active CA2655381C (en) | 2006-06-30 | 2007-06-28 | Compositions of glycopyrronium salt for inhalation |
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| PT (1) | PT2037879E (enExample) |
| RU (1) | RU2453302C2 (enExample) |
| WO (1) | WO2008000482A1 (enExample) |
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| GB201415381D0 (en) * | 2014-08-29 | 2014-10-15 | Algipharma As | Inhalable powder formulations of alginate oligomers |
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| CN105412049B (zh) * | 2014-09-16 | 2020-01-07 | 四川海思科制药有限公司 | 一种干粉吸入剂用药物组合物及其制备方法 |
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| MA48620A (fr) * | 2017-05-11 | 2021-04-28 | Chiesi Farm Spa | Procédé de préparation d'une formulation de poudre sèche contenant un anticholinergique, un corticostéroïde et un bêta-adrénergique |
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| CN109200034A (zh) * | 2017-06-30 | 2019-01-15 | 正大天晴药业集团股份有限公司 | 一种可吸入干粉形式的组合物及其制备方法 |
| CN111971034A (zh) * | 2018-07-26 | 2020-11-20 | 四川海思科制药有限公司 | 一种含格隆铵盐的气雾剂药物组合物及其制备方法与应用 |
| CN116173025A (zh) * | 2018-07-26 | 2023-05-30 | 四川海思科制药有限公司 | 一种含格隆铵盐及茚达特罗盐的气雾剂药物组合物及其制备方法与应用 |
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| CN109745565B (zh) * | 2019-01-28 | 2021-05-18 | 上海方予健康医药科技有限公司 | 一种用于吸入的干粉组合物及其制备方法 |
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| CN116194087B (zh) * | 2020-01-15 | 2025-07-11 | 四川海思科制药有限公司 | 一种含茚达特罗的吸入气雾剂药物组合物及其制备方法 |
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| GB0326632D0 (en) | 2003-11-14 | 2003-12-17 | Jagotec Ag | Dry powder formulations |
| GB0409703D0 (en) | 2004-04-30 | 2004-06-02 | Vectura Ltd | Pharmaceutical compositions |
| GB0410399D0 (en) | 2004-05-10 | 2004-06-16 | Arakis Ltd | The treatment of respiratory disease |
| GB0525254D0 (en) | 2005-12-12 | 2006-01-18 | Jagotec Ag | Powder compositions for inhalation |
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| AU2007264000A1 (en) | 2008-01-03 |
| KR20090023650A (ko) | 2009-03-05 |
| EP2037879A1 (en) | 2009-03-25 |
| BRPI0713777B1 (pt) | 2019-08-27 |
| CA2655381A1 (en) | 2008-01-03 |
| JP2009541393A (ja) | 2009-11-26 |
| US20090209502A1 (en) | 2009-08-20 |
| PT2037879E (pt) | 2013-08-27 |
| BRPI0713777A2 (pt) | 2012-10-30 |
| JP5266213B2 (ja) | 2013-08-21 |
| CN101484134B (zh) | 2012-08-08 |
| CN101484134A (zh) | 2009-07-15 |
| US20160081934A1 (en) | 2016-03-24 |
| FR13C0059I1 (fr) | 2013-12-13 |
| PL2037879T3 (pl) | 2013-09-30 |
| MX2008016356A (es) | 2009-01-16 |
| US20150224194A1 (en) | 2015-08-13 |
| US10314784B2 (en) | 2019-06-11 |
| KR101400579B1 (ko) | 2014-05-28 |
| AU2007264000B2 (en) | 2011-06-09 |
| RU2453302C2 (ru) | 2012-06-20 |
| WO2008000482A1 (en) | 2008-01-03 |
| US20120065174A1 (en) | 2012-03-15 |
| BRPI0713777B8 (pt) | 2021-05-25 |
| EP2037879B1 (en) | 2013-05-15 |
| ES2424754T3 (es) | 2013-10-08 |
| GB0613161D0 (en) | 2006-08-09 |
| RU2009102934A (ru) | 2010-08-10 |
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