CA2653061A1 - Proteines stabilisees - Google Patents
Proteines stabilisees Download PDFInfo
- Publication number
- CA2653061A1 CA2653061A1 CA002653061A CA2653061A CA2653061A1 CA 2653061 A1 CA2653061 A1 CA 2653061A1 CA 002653061 A CA002653061 A CA 002653061A CA 2653061 A CA2653061 A CA 2653061A CA 2653061 A1 CA2653061 A1 CA 2653061A1
- Authority
- CA
- Canada
- Prior art keywords
- protein
- capped
- adenosine deaminase
- amino acid
- oxidizable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80541706P | 2006-06-21 | 2006-06-21 | |
US60/805,417 | 2006-06-21 | ||
US73801207A | 2007-04-20 | 2007-04-20 | |
US11/738,012 | 2007-04-20 | ||
PCT/US2007/069948 WO2007149686A2 (fr) | 2006-06-21 | 2007-05-30 | Protéines stabilisées |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2653061A1 true CA2653061A1 (fr) | 2007-12-27 |
Family
ID=38834219
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002653061A Abandoned CA2653061A1 (fr) | 2006-06-21 | 2007-05-30 | Proteines stabilisees |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2038424A2 (fr) |
JP (1) | JP2010500963A (fr) |
CA (1) | CA2653061A1 (fr) |
TW (1) | TW200817521A (fr) |
WO (1) | WO2007149686A2 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ580980A (en) | 2007-04-20 | 2012-04-27 | Sigma Tau Rare Diseases S A | Enzymatic anticancer therapy |
US8071741B2 (en) * | 2007-04-20 | 2011-12-06 | Defiante Farmaceutica, S.A. | Stable recombinant adenosine deaminase |
EP2344200A2 (fr) * | 2008-09-19 | 2011-07-20 | Nektar Therapeutics | Peptides thérapeutiques modifiés, procédés pour les préparer et les utiliser |
EP2341942A1 (fr) | 2008-09-19 | 2011-07-13 | Nektar Therapeutics | Conjugués polymères de peptides thérapeutiques |
ES2728225T3 (es) * | 2009-02-20 | 2019-10-23 | 2 Bbb Medicines B V | Sistema de administración de fármacos a base de glutatión |
US9121016B2 (en) * | 2011-09-09 | 2015-09-01 | Toyota Motor Engineering & Manufacturing North America, Inc. | Coatings containing polymer modified enzyme for stable self-cleaning of organic stains |
US8911986B2 (en) * | 2011-04-29 | 2014-12-16 | Toyota Motor Engineering & Manufacturing North America, Inc. | Coatings containing polymer modified enzyme for stable self-cleaning of organic stains |
PL3207130T3 (pl) | 2014-10-14 | 2020-02-28 | Halozyme, Inc. | Kompozycje deaminazy adenozyny 2 (ada2), jej warianty i sposoby ich zastosowania |
WO2021022198A1 (fr) * | 2019-08-01 | 2021-02-04 | Carnegie Mellon University (CMU) | Réglage de la solubilité de protéines par modification de surface polymère |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6207876B1 (en) * | 1998-04-28 | 2001-03-27 | Board Of Regents, The University Of Texas System | Adenosine deaminase deficient transgenic mice and methods for the use thereof |
US6946098B2 (en) * | 2001-08-10 | 2005-09-20 | Clearant, Inc. | Methods for sterilizing biological materials |
-
2007
- 2007-05-30 EP EP07797875A patent/EP2038424A2/fr not_active Withdrawn
- 2007-05-30 JP JP2009516623A patent/JP2010500963A/ja not_active Withdrawn
- 2007-05-30 CA CA002653061A patent/CA2653061A1/fr not_active Abandoned
- 2007-05-30 WO PCT/US2007/069948 patent/WO2007149686A2/fr active Application Filing
- 2007-06-12 TW TW096121115A patent/TW200817521A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO2007149686A3 (fr) | 2009-04-02 |
JP2010500963A (ja) | 2010-01-14 |
EP2038424A2 (fr) | 2009-03-25 |
WO2007149686A2 (fr) | 2007-12-27 |
TW200817521A (en) | 2008-04-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2653061A1 (fr) | Proteines stabilisees | |
Pasut et al. | PEGylation of proteins as tailored chemistry for optimized bioconjugates | |
EP2147116B1 (fr) | Adénosine désaminase recombinante stable | |
CN101198693B (zh) | 尿酸氧化酶的变体形式及其用途 | |
ES2255147T3 (es) | Arginina deiminasa derivada de mycoplasma arthritidis y conjugados de polimeros que la contienen. | |
AU2005224078B2 (en) | Methods for increasing protein polyethylene glycol (PEG) conjugation | |
JP2006321808A (ja) | 化学的に修飾されたヒト成長ホルモンコンジュゲート | |
WO2006110776A2 (fr) | Compositions a base de polymere et conjugues d'agents antimicrobiens | |
KR101408062B1 (ko) | L-아스파라기나아제 ⅱ 제조를 위한 재조합 숙주 | |
JP2006516263A (ja) | 化学修飾されたヒト成長ホルモンコンジュゲート | |
AU2009246851B2 (en) | Conjugates of a cholinesterase moiety and a polymer | |
US20030215436A1 (en) | Anitmicrobial polymer conjugates | |
RU2486246C2 (ru) | Стабильная рекомбинантная аденозиндеаминаза | |
US20050153416A1 (en) | Conjugates of the c domain of human gelatinase a and polyethylene glycol, methods of purification and uses thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |