CA2639714A1 - Pcr elbow determination using quadratic test for curvature analysis of a double sigmoid - Google Patents

Pcr elbow determination using quadratic test for curvature analysis of a double sigmoid Download PDF

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Publication number
CA2639714A1
CA2639714A1 CA002639714A CA2639714A CA2639714A1 CA 2639714 A1 CA2639714 A1 CA 2639714A1 CA 002639714 A CA002639714 A CA 002639714A CA 2639714 A CA2639714 A CA 2639714A CA 2639714 A1 CA2639714 A1 CA 2639714A1
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CA
Canada
Prior art keywords
curve
data set
value
pcr
data
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002639714A
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English (en)
French (fr)
Inventor
Sane Aditya
Ronald T. Kurnik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2639714A1 publication Critical patent/CA2639714A1/en
Abandoned legal-status Critical Current

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    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
    • G06F17/10—Complex mathematical operations
    • G06F17/18—Complex mathematical operations for evaluating statistical data, e.g. average values, frequency distributions, probability functions, regression analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Data Mining & Analysis (AREA)
  • Computational Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mathematical Physics (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Databases & Information Systems (AREA)
  • Molecular Biology (AREA)
  • Software Systems (AREA)
  • Evolutionary Biology (AREA)
  • Algebra (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Probability & Statistics with Applications (AREA)
  • Operations Research (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Image Analysis (AREA)
CA002639714A 2007-09-25 2008-09-22 Pcr elbow determination using quadratic test for curvature analysis of a double sigmoid Abandoned CA2639714A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/861,188 US20090119020A1 (en) 2007-09-25 2007-09-25 Pcr elbow determination using quadratic test for curvature analysis of a double sigmoid
US11/861,188 2007-09-25

Publications (1)

Publication Number Publication Date
CA2639714A1 true CA2639714A1 (en) 2009-03-25

Family

ID=40475156

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002639714A Abandoned CA2639714A1 (en) 2007-09-25 2008-09-22 Pcr elbow determination using quadratic test for curvature analysis of a double sigmoid

Country Status (5)

Country Link
US (1) US20090119020A1 (enExample)
EP (1) EP2107470B1 (enExample)
JP (1) JP6009724B2 (enExample)
CN (1) CN101526476B (enExample)
CA (1) CA2639714A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8374795B2 (en) 2008-05-13 2013-02-12 Roche Molecular Systems, Inc. Systems and methods for step discontinuity removal in real-time PCR fluorescence data
US8219366B2 (en) * 2009-08-26 2012-07-10 Roche Molecular Sytems, Inc. Determination of elbow values for PCR for parabolic shaped curves
US11072821B2 (en) 2009-09-12 2021-07-27 Azure Vault Ltd. Identifying transition points in chemical reactions
CA2817220C (en) 2009-11-22 2015-10-20 Azure Vault Ltd. Automatic chemical assay classification
US8666673B2 (en) 2010-05-14 2014-03-04 Biomerieux, Inc Identification and/or characterization of a microbial agent using taxonomic hierarchical classification
US9988675B2 (en) 2011-03-15 2018-06-05 Azure Vault Ltd. Rate based identification of reaction points
US8738303B2 (en) * 2011-05-02 2014-05-27 Azure Vault Ltd. Identifying outliers among chemical assays
US8660968B2 (en) 2011-05-25 2014-02-25 Azure Vault Ltd. Remote chemical assay classification
US20130096845A1 (en) 2011-10-14 2013-04-18 Ze'ev Russak Cumulative differential chemical assay identification
US10475527B2 (en) 2012-03-22 2019-11-12 Biomerieux, Inc. Method and system for detection of microbial growth in a specimen container
US10176293B2 (en) * 2012-10-02 2019-01-08 Roche Molecular Systems, Inc. Universal method to determine real-time PCR cycle threshold values
US9607128B2 (en) 2013-12-30 2017-03-28 Roche Molecular Systems, Inc. Detection and correction of jumps in real-time PCR signals
US10519759B2 (en) 2014-04-24 2019-12-31 Conocophillips Company Growth functions for modeling oil production
JP7493300B2 (ja) * 2017-06-27 2024-05-31 東洋紡株式会社 解析用プログラムおよび解析装置
AU2018339207A1 (en) 2017-09-28 2020-04-16 Seegene, Inc. . Method and device for analyzing target analyte in sample
DE102020202363A1 (de) * 2020-02-25 2021-08-26 Robert Bosch Gesellschaft mit beschränkter Haftung Verfahren und Vorrichtung zur Durchführung eines qPCR-Verfahrens
CN115312123A (zh) * 2021-05-07 2022-11-08 台达电子工业股份有限公司 数据预筛方法及其数据预筛装置
EP4421814A4 (en) 2021-10-21 2025-11-12 Seegene Inc APPROVAL AND METHOD FOR READING A POSITIVE/NEGATIVE RESULT WITH RESPECT TO A TARGET TEST SUBSTANCE IN A SAMPLE
CN114339768B (zh) * 2021-12-24 2024-11-22 观源(上海)科技有限公司 一种usim卡抗侧信道攻击能力评估方法及其系统
US20250336479A1 (en) 2022-07-29 2025-10-30 Seegene, Inc Apparatus and method for providing interface for setting threshold value of parameter
WO2024128878A1 (ko) 2022-12-15 2024-06-20 주식회사 씨젠 형광 데이터의 분석 알고리즘에 대한 성능 비교 결과를 디스플레이하는 장치 및 방법
CN116473512B (zh) * 2023-03-22 2024-05-03 上海交通大学 一种动物循环系统中外泌体的监测装置及监测方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69739357D1 (de) 1996-06-04 2009-05-28 Univ Utah Res Found Überwachung der hybridisierung während pcr
ES2215230T3 (es) 1996-06-04 2004-10-01 University Of Utah Research Foundation Sistema y metodo para llevar a cabo y supervisar reacciones de cadena de polimerasa.
US7228237B2 (en) * 2002-02-07 2007-06-05 Applera Corporation Automatic threshold setting and baseline determination for real-time PCR
ES2301754T3 (es) * 2002-02-12 2008-07-01 University Of Utah Research Foundation Analisis de pruebas multiples de amplificaciones de acidos nucleicos en tiempo real.
US20060009916A1 (en) * 2004-07-06 2006-01-12 Xitong Li Quantitative PCR data analysis system (QDAS)
JP5091122B2 (ja) * 2005-05-13 2012-12-05 バイオ−ラッド ラボラトリーズ，インコーポレイティド 統計的線形データの同定
EP3168766B1 (en) * 2005-09-20 2023-08-16 University of Utah Research Foundation Genotyping method for a plurality of samples
EP1798650A1 (en) * 2005-12-19 2007-06-20 Roche Diagnostics GmbH Analytical method and instrument
US7680868B2 (en) * 2005-12-20 2010-03-16 Roche Molecular Systems, Inc. PCR elbow determination by use of a double sigmoid function curve fit with the Levenburg-Marquardt algorithm and normalization
US7844403B2 (en) * 2005-12-20 2010-11-30 Roche Molecular Systems, Inc. Temperature step correction with double sigmoid Levenberg-Marquardt and robust linear regression
US7668663B2 (en) * 2005-12-20 2010-02-23 Roche Molecular Systems, Inc. Levenberg-Marquardt outlier spike removal method
EP1804172B1 (en) * 2005-12-20 2021-08-11 Roche Diagnostics GmbH PCR elbow determination using curvature analysis of a double sigmoid

Also Published As

Publication number Publication date
HK1133697A1 (en) 2010-04-01
US20090119020A1 (en) 2009-05-07
EP2107470A2 (en) 2009-10-07
JP2009080811A (ja) 2009-04-16
EP2107470A3 (en) 2017-09-06
JP6009724B2 (ja) 2016-10-19
CN101526476B (zh) 2013-11-13
CN101526476A (zh) 2009-09-09
EP2107470B1 (en) 2023-08-30

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130816

FZDE Discontinued

Effective date: 20210303