CA2630617A1 - Compositions et procedes de modulation des canaux ioniques - Google Patents

Compositions et procedes de modulation des canaux ioniques Download PDF

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Publication number
CA2630617A1
CA2630617A1 CA002630617A CA2630617A CA2630617A1 CA 2630617 A1 CA2630617 A1 CA 2630617A1 CA 002630617 A CA002630617 A CA 002630617A CA 2630617 A CA2630617 A CA 2630617A CA 2630617 A1 CA2630617 A1 CA 2630617A1
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Canada
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group
tetrahydro
pyrrolo
isoquinoline
alkyl
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CA002630617A
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CA2630617C (fr
Inventor
Rahul Vohra
Joachim Demnitz
Philip K. Ahring
Zhonghong Gan
Nachhattarpal Gill
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Aros Pharma ApS
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Individual
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • C—CHEMISTRY; METALLURGY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
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CA2630617A 2005-11-23 2006-11-22 Compositions et procedes de modulation des canaux ioniques Expired - Fee Related CA2630617C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73960005P 2005-11-23 2005-11-23
US60/739,600 2005-11-23
PCT/CA2006/001897 WO2007059608A1 (fr) 2005-11-23 2006-11-22 Compositions et procedes de modulation des canaux ioniques

Publications (2)

Publication Number Publication Date
CA2630617A1 true CA2630617A1 (fr) 2007-05-31
CA2630617C CA2630617C (fr) 2014-03-25

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ID=38066867

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2630617A Expired - Fee Related CA2630617C (fr) 2005-11-23 2006-11-22 Compositions et procedes de modulation des canaux ioniques

Country Status (9)

Country Link
US (2) US7718641B2 (fr)
EP (1) EP1957486A4 (fr)
JP (1) JP2009516712A (fr)
KR (1) KR20080070749A (fr)
CN (1) CN101346375B (fr)
AU (1) AU2006317545B2 (fr)
BR (1) BRPI0618863A2 (fr)
CA (1) CA2630617C (fr)
WO (1) WO2007059608A1 (fr)

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AU4910500A (en) * 1999-05-19 2000-12-12 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
US8377691B2 (en) * 2006-01-26 2013-02-19 Integral Molecular, Inc. Lipoparticles comprising ion channels, methods of making and using the same
WO2008007131A2 (fr) * 2006-07-14 2008-01-17 Medical Research Council Traitement d'une maladie démyélinisante
WO2008144931A1 (fr) * 2007-05-30 2008-12-04 Painceptor Pharma Corporation Compositions et procédés pour la modulation des canaux ioniques
EP2853897A1 (fr) * 2008-05-08 2015-04-01 University Of Utah Research Foundation Récepteurs sensoriels de fatigue chronique et douleur et utilisations associées
NZ595775A (en) 2008-12-26 2013-07-26 Glenmark Pharmaceuticals Sa Fused imidazole derivatives as trpv3 antagonist
US9211313B2 (en) * 2011-01-14 2015-12-15 The Research Foundation Of State University Of New York Methods and compound to inhibit Ca2+ permeable cation conductance
JP5971657B2 (ja) 2011-04-20 2016-08-17 塩野義製薬株式会社 Ｔｒｐｖ４阻害活性を有する芳香族複素環誘導体
JO3154B1 (ar) * 2011-06-17 2017-09-20 Glaxosmithkline Llc عوامل مضادة لـ trpv4
WO2013146754A1 (fr) 2012-03-27 2013-10-03 塩野義製薬株式会社 Dérivé à noyau à cinq chaînons hétérocyclique aromatique ayant une activité inhibitrice de trpv4
WO2015021988A1 (fr) 2013-08-12 2015-02-19 Aros Pharma Aps Composés de pyrrolo-isoquinoline pour le traitement de la douleur associée à la cystite interstitielle/syndrome de la vessie douloureuse
KR102084185B1 (ko) * 2013-08-29 2020-03-04 주식회사 대웅제약 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법
JPWO2015046193A1 (ja) 2013-09-25 2017-03-09 塩野義製薬株式会社 Ｔｒｐｖ４阻害活性を有する芳香族複素環式アミン誘導体
WO2018151240A1 (fr) * 2017-02-17 2018-08-23 第一三共株式会社 COMPOSÉ 3,6,7,8-TÉTRAHYDROCYCLOPENTA[e]INDOLE
WO2018151239A1 (fr) * 2017-02-17 2018-08-23 第一三共株式会社 COMPOSÉ 3, 6-DIHYDRO-2H-FURO[2, 3-e]INDOLE
CN109364248B (zh) * 2018-10-16 2021-05-18 哈尔滨医科大学 ENaC及其抑制剂在预防、缓解和/或治疗动脉粥样硬化中的应用

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EP1957486A4 (fr) 2009-11-11
JP2009516712A (ja) 2009-04-23
CN101346375B (zh) 2013-04-10
WO2007059608A1 (fr) 2007-05-31
AU2006317545A1 (en) 2007-05-31
BRPI0618863A2 (pt) 2016-09-13
US7718641B2 (en) 2010-05-18
CN101346375A (zh) 2009-01-14
KR20080070749A (ko) 2008-07-30
US20070191418A1 (en) 2007-08-16
AU2006317545B2 (en) 2012-04-12
EP1957486A1 (fr) 2008-08-20
CA2630617C (fr) 2014-03-25
US20100197721A1 (en) 2010-08-05

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