CA2630087A1 - Formulations chimiotherapeutiques de trihydrochlorure de zosuquidar et cyclodextrines modifies - Google Patents
Formulations chimiotherapeutiques de trihydrochlorure de zosuquidar et cyclodextrines modifies Download PDFInfo
- Publication number
- CA2630087A1 CA2630087A1 CA002630087A CA2630087A CA2630087A1 CA 2630087 A1 CA2630087 A1 CA 2630087A1 CA 002630087 A CA002630087 A CA 002630087A CA 2630087 A CA2630087 A CA 2630087A CA 2630087 A1 CA2630087 A1 CA 2630087A1
- Authority
- CA
- Canada
- Prior art keywords
- zosuquidar
- sulfobutylcyclodextrin
- cyclodextrin
- stable
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- ZPFVQKPWGDRLHL-ZLYBXYBFSA-N zosuquidar trihydrochloride Chemical compound Cl.Cl.Cl.C([C@H](COC=1C2=CC=CN=C2C=CC=1)O)N(CC1)CCN1C1C2=CC=CC=C2[C@H]2C(F)(F)[C@H]2C2=CC=CC=C12 ZPFVQKPWGDRLHL-ZLYBXYBFSA-N 0.000 title description 5
- 229950005752 zosuquidar Drugs 0.000 claims abstract description 218
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- 238000000034 method Methods 0.000 claims abstract description 83
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Classifications
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69693905P | 2005-07-06 | 2005-07-06 | |
| US69693005P | 2005-07-06 | 2005-07-06 | |
| US69675605P | 2005-07-06 | 2005-07-06 | |
| US60/696,756 | 2005-07-06 | ||
| US60/696,930 | 2005-07-06 | ||
| US60/696,939 | 2005-07-06 | ||
| US11/418,324 | 2006-05-03 | ||
| US11/416,829 | 2006-05-03 | ||
| US11/418,400 | 2006-05-03 | ||
| US11/417,958 US20070010485A1 (en) | 2005-07-06 | 2006-05-03 | Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins |
| US11/416,571 | 2006-05-03 | ||
| US11/416,571 US20070010465A1 (en) | 2005-07-06 | 2006-05-03 | Zosuquidar, daunorubicin, and cytarabine for the treatment of cancer |
| US11/416,832 US20070010466A1 (en) | 2005-07-06 | 2006-05-03 | Zosuquidar, daunorubicin, and cytarabine for the treatment of cancer |
| US11/416,832 | 2006-05-03 | ||
| US11/416,833 US20070009531A1 (en) | 2005-07-06 | 2006-05-03 | Treatment of patients with cancer using a calicheamicin-antibody conjugate in combination with zosuquidar |
| US11/416,992 US20070009532A1 (en) | 2005-07-06 | 2006-05-03 | Treatment of patients with cancer using a calicheamicin-antibody conjugate in combination with zosuquidar |
| US11/418,324 US20070010486A1 (en) | 2005-07-06 | 2006-05-03 | Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins |
| US11/418,400 US20070010487A1 (en) | 2005-07-06 | 2006-05-03 | Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins |
| US11/416,833 | 2006-05-03 | ||
| US11/416,829 US20070010478A1 (en) | 2005-07-06 | 2006-05-03 | Zosuquidar, daunorubicin, and cytarabine for the treatment of cancer |
| US11/417,958 | 2006-05-03 | ||
| US11/416,992 | 2006-05-03 | ||
| PCT/US2006/026031 WO2007008496A1 (fr) | 2005-07-06 | 2006-06-30 | Formulations chimiotherapeutiques de trihydrochlorure de zosuquidar et cyclodextrines modifies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2630087A1 true CA2630087A1 (fr) | 2007-01-18 |
Family
ID=37637468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002630087A Abandoned CA2630087A1 (fr) | 2005-07-06 | 2006-06-30 | Formulations chimiotherapeutiques de trihydrochlorure de zosuquidar et cyclodextrines modifies |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1898957A1 (fr) |
| AU (1) | AU2006269498A1 (fr) |
| CA (1) | CA2630087A1 (fr) |
| WO (1) | WO2007008496A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090318560A1 (en) * | 2007-02-26 | 2009-12-24 | Wayne Parent | Formulations for cathepsin k inhibitors |
| CN103142499B (zh) * | 2013-03-21 | 2014-10-01 | 青岛正大海尔制药有限公司 | 一种依托泊苷颗粒 |
| CN112807281A (zh) * | 2019-10-31 | 2021-05-18 | 南京海维医药科技有限公司 | 包含血管紧张素ii的稳定组合物及其制备方法、使用方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5643909A (en) * | 1993-04-19 | 1997-07-01 | Syntex (U.S.A.) Inc. | 10,11-Methanodibenzosuberane derivatives |
-
2006
- 2006-06-30 AU AU2006269498A patent/AU2006269498A1/en not_active Abandoned
- 2006-06-30 EP EP06774486A patent/EP1898957A1/fr not_active Withdrawn
- 2006-06-30 WO PCT/US2006/026031 patent/WO2007008496A1/fr active Application Filing
- 2006-06-30 CA CA002630087A patent/CA2630087A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1898957A1 (fr) | 2008-03-19 |
| WO2007008496A1 (fr) | 2007-01-18 |
| AU2006269498A1 (en) | 2007-01-18 |
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