CA2629814C - Bisamide inhibitors of hedgehog signaling - Google Patents

Bisamide inhibitors of hedgehog signaling Download PDF

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Publication number
CA2629814C
CA2629814C CA2629814A CA2629814A CA2629814C CA 2629814 C CA2629814 C CA 2629814C CA 2629814 A CA2629814 A CA 2629814A CA 2629814 A CA2629814 A CA 2629814A CA 2629814 C CA2629814 C CA 2629814C
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Canada
Prior art keywords
chloro
nicotinamide
alkyl
phenyl
methyl
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CA2629814A
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English (en)
French (fr)
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CA2629814A1 (en
Inventor
Richard A. Goldsmith
Daniel P. Sutherlin
Kirk D. Robarge
Alan G. Olivero
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Genentech Inc
Curis Inc
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Genentech Inc
Curis Inc
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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