CA2629155A1 - Materials and methods for abcb1 polymorphic variant screening, diagnosis, and treatment - Google Patents

Materials and methods for abcb1 polymorphic variant screening, diagnosis, and treatment Download PDF

Info

Publication number
CA2629155A1
CA2629155A1 CA002629155A CA2629155A CA2629155A1 CA 2629155 A1 CA2629155 A1 CA 2629155A1 CA 002629155 A CA002629155 A CA 002629155A CA 2629155 A CA2629155 A CA 2629155A CA 2629155 A1 CA2629155 A1 CA 2629155A1
Authority
CA
Canada
Prior art keywords
polymorphism
seq
combination
drug
polymorphic variant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002629155A
Other languages
English (en)
French (fr)
Inventor
William D. Figg
Alexander Sparreboom
Tristan M. Sissung
Richard L. Piekarz
Susan E. Bates
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2629155A1 publication Critical patent/CA2629155A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA002629155A 2005-11-10 2006-11-09 Materials and methods for abcb1 polymorphic variant screening, diagnosis, and treatment Abandoned CA2629155A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73608305P 2005-11-10 2005-11-10
US60/736,083 2005-11-10
PCT/US2006/043656 WO2007058896A2 (en) 2005-11-10 2006-11-09 Materials and methods for abcb1 polymorphic variant screening, diagnosis, and treatment

Publications (1)

Publication Number Publication Date
CA2629155A1 true CA2629155A1 (en) 2007-05-24

Family

ID=38049148

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002629155A Abandoned CA2629155A1 (en) 2005-11-10 2006-11-09 Materials and methods for abcb1 polymorphic variant screening, diagnosis, and treatment

Country Status (6)

Country Link
US (1) US20090325156A1 (https=)
EP (1) EP1957673A2 (https=)
JP (1) JP2009515524A (https=)
AU (1) AU2006315760A1 (https=)
CA (1) CA2629155A1 (https=)
WO (1) WO2007058896A2 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007145704A2 (en) 2006-04-24 2007-12-21 Gloucester Pharmaceuticals Gemcitabine combination therapy
US8957027B2 (en) 2006-06-08 2015-02-17 Celgene Corporation Deacetylase inhibitor therapy
ATE490344T1 (de) * 2006-07-14 2010-12-15 Govt Of The Usa As Represented By The Secretary Of The Dept Of Health And Human Services Abcbi-genotypisierung zur vorhersage der mikrotubuli-stabilisatorwirkstoffinduzierten toxizität
WO2008083288A2 (en) * 2006-12-29 2008-07-10 Gloucester Pharmaceuticals Purifiction of romidepsin
EP2140033B1 (en) 2007-03-28 2012-10-10 Signal Diagnostics System and method for high resolution analysis of nucleic acids to detect sequence variations
US10669574B2 (en) 2008-11-18 2020-06-02 XCR Diagnostics, Inc. DNA amplification technology
SG10201505475XA (en) 2010-07-12 2015-09-29 Celgene Corp Romidepsin solid forms and uses thereof
US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
US20140349862A1 (en) * 2011-05-30 2014-11-27 Vuong Ngoc Trieu Methods and compositions for therapeutic drug monitoring and dosing by point of care pharmacokinetic profiling
WO2012166795A1 (en) * 2011-05-30 2012-12-06 String Therapeutics Inc. Methods and compositions for therapeutic drug monitoring and dosing by point-of-care pharmacokinetic profiling
AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
AU2013202507B9 (en) 2012-11-14 2015-08-13 Celgene Corporation Inhibition of drug resistant cancer cells
RU2016117929A (ru) * 2013-10-09 2017-11-15 Флюоресентрик, Инк. Мультиплексные зонды
NZ630311A (en) 2013-12-27 2016-03-31 Celgene Corp Romidepsin formulations and uses thereof
CN105886599A (zh) * 2014-10-20 2016-08-24 江苏所罗门兄弟医学科技有限公司 一种用于ABCB1基因分型的ARMS-qPCR检测试剂盒及检测方法
CN108060230A (zh) * 2018-02-07 2018-05-22 山东德诺生物科技有限公司 用于检测rs1045642的引物探针组及其应用
CN110643699B (zh) * 2019-10-16 2020-12-01 成都仕康美生物科技有限公司 一种环孢素a代谢基因检测试剂盒及其应用方法
CN112980943B (zh) * 2021-03-31 2022-02-08 山东英盛生物技术有限公司 一种用于检测他克莫司精准用药的方法及引物、pcr试剂和试剂盒

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2002329A3 (cs) * 1999-07-30 2002-07-17 Epidauros Biotechnologie Aktiengesellschaft Polymorfismy v lidském genu MDR-1 a jejich pouľití v diagnostických a terapeutických aplikacích
US20040115627A1 (en) * 2000-04-12 2004-06-17 Judy Raucy Compositions and methods for induction of proteins involved in xenobiotic metabolism
ATE381626T1 (de) * 2000-04-13 2008-01-15 Univ Georgetown Genetische diagnose zur feststellung von qt- verlängerungen als unerwünschte reaktion auf arzneimittel
AU2002328945A1 (en) * 2001-07-23 2003-02-24 Epidauros Biotechnologie Ag Methods for improved treatment of cancer with irinotecan based on mrp1
JP2006511218A (ja) * 2002-12-21 2006-04-06 ファイザー・プロダクツ・インク 薬物誘発性不整脈に関連する方法および組成物

Also Published As

Publication number Publication date
EP1957673A2 (en) 2008-08-20
WO2007058896A2 (en) 2007-05-24
WO2007058896A3 (en) 2007-10-04
JP2009515524A (ja) 2009-04-16
US20090325156A1 (en) 2009-12-31
AU2006315760A1 (en) 2007-05-24

Similar Documents

Publication Publication Date Title
US20090325156A1 (en) Materials and methods for abcb1 polymorphic variant screening, diagnosis, and treatment
US10865449B2 (en) Method of identifying disease risk factors
Souto et al. Genome-wide linkage analysis of von Willebrand factor plasma levels: results from the GAIT project
US7879551B2 (en) Methods and materials for identifying polymorphic variants, diagnosing susceptibilities, and treating disease
US8846315B2 (en) Disease risk factors and methods of use
Robles-Osorio et al. Genetic heterogeneity of autosomal dominant hypercholesterolemia in Mexico
US20040203034A1 (en) Optimization of cancer treatment with irinotecan
US20090017452A1 (en) Methods and compositions relating to the pharmacogenetics of different gene variants
US20080293048A1 (en) Methods and kits based on ugt1a7 promoter polymorphism
EP1029079B1 (en) Diagnostics and therapeutics for chronic obstructive airway disease
US7807350B2 (en) Methods for predicting irinotecan toxicity
WO2006124646A2 (en) Methods and compostions relating to the pharmacogenetics of different gene variants in the context of irinotecan-based therapies
US20090247475A1 (en) Methods and compositions relating to pharmacogenetics of different gene variants in the context of irinotecan-based therapies
WO2010111595A2 (en) Markers related to age-related macular degeneration and uses therefor
AU2013202634B2 (en) Method of identifying disease risk factors
JP2002360275A (ja) 心臓血管疾患に関連する方法、組成物およびキット
US20050064429A1 (en) Method for diagnosing and treating predisposition for accelerated autosomal dominant polycystic kidney disease
WO2006136791A1 (en) Polymorphisms and haplotypes in p2x7 gene and their use in determining susceptibility for atherosclerosis-mediated diseases
HK1153511B (en) Method of identifying alzheimer's disease risk factors
WO2006084133A2 (en) Methods for dosing l-thyroxine
HK1198051A (en) Anti-alzheimer's disease treatment of subjects identified by detecting the presence of a genetic variant in the tomm40 gene at rs10524523

Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20121109