CA2626005A1 - Inositol derivatives and their uses in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence - Google Patents

Inositol derivatives and their uses in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence Download PDF

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Publication number
CA2626005A1
CA2626005A1 CA002626005A CA2626005A CA2626005A1 CA 2626005 A1 CA2626005 A1 CA 2626005A1 CA 002626005 A CA002626005 A CA 002626005A CA 2626005 A CA2626005 A CA 2626005A CA 2626005 A1 CA2626005 A1 CA 2626005A1
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Prior art keywords
alkyl
hydroxyl
pharmaceutical composition
halo
pharmaceutically acceptable
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Abandoned
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CA002626005A
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English (en)
French (fr)
Inventor
Antonio Cruz
Linda Kurdydyk
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Waratah Pharmaceuticals Inc
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Individual
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Publication of CA2626005A1 publication Critical patent/CA2626005A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/26—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing rings other than aromatic rings
    • C07C55/28—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms containing rings other than aromatic rings monocyclic
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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    • C07C43/00—Ethers; Compounds having groups, groups or groups
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Neurology (AREA)
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  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
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  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
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  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
CA002626005A 2005-10-13 2006-10-13 Inositol derivatives and their uses in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence Abandoned CA2626005A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72563405P 2005-10-13 2005-10-13
US60/725,634 2005-10-13
PCT/IB2006/004181 WO2007119108A2 (en) 2005-10-13 2006-10-13 Inositol derivatives and their uses in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence

Publications (1)

Publication Number Publication Date
CA2626005A1 true CA2626005A1 (en) 2007-10-25

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ID=37942269

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002626005A Abandoned CA2626005A1 (en) 2005-10-13 2006-10-13 Inositol derivatives and their uses in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence

Country Status (5)

Country Link
US (4) US20070111970A1 (enExample)
EP (1) EP1940373B8 (enExample)
JP (2) JP2009511568A (enExample)
CA (1) CA2626005A1 (enExample)
WO (2) WO2007119108A2 (enExample)

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US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
EP1940373B8 (en) * 2005-10-13 2015-06-24 Waratah Pharmaceuticals, Inc. 1-fluoro-1-deoxy-scyllo-inositol for the treatment of alzheimer's disease
US20100173960A1 (en) * 2006-09-21 2010-07-08 Antonio Cruz The Combination of a Cyclohexanehexol and a NSAID for the Treatment of Neurodegenerative Diseases
EP2091566A4 (en) * 2006-11-24 2011-07-06 Waratah Pharmaceuticals Inc COMBINATION THERAPIES AGAINST ALZHEIMER DISEASE AND SIMILAR ILLNESSES
AU2013248197B2 (en) * 2008-03-21 2016-05-12 The General Hospital Corporation Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders
EP2268647B1 (en) 2008-03-21 2017-01-25 The General Hospital Corporation Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders
KR101021078B1 (ko) 2008-07-22 2011-03-14 포항공과대학교 산학협력단 이노시톨 또는 트리할로스 유도체 및 이를 함유하는 퇴행성뇌신경계 질환 치료용 약학 조성물
AU2009279400A1 (en) 2008-08-08 2010-02-11 University Of Florida Research Foundation, Inc. Lipid compounds for supression of tumorigenesis
US20100279997A1 (en) * 2009-05-04 2010-11-04 Lindsay Burns Barbier Analgesic that binds filamin a
GB0920985D0 (en) * 2009-11-30 2010-01-13 Queen Mary & Westfield College Novel inositol phosphate derivatives
US8394858B2 (en) 2009-12-03 2013-03-12 Novartis Ag Cyclohexane derivatives and uses thereof
WO2011100670A1 (en) * 2010-02-15 2011-08-18 Abbott Laboratories Process for the preparation of scyllo-inositol
EP2390245A1 (en) * 2010-05-26 2011-11-30 Nabriva Therapeutics AG Enantiomerically pure amines
US9320793B2 (en) * 2010-07-14 2016-04-26 Acumen Pharmaceuticals, Inc. Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42
BR112013009072A2 (pt) 2010-10-13 2016-07-19 Elan Pharm Inc processo de síntese de scyllitol e compostos relacionados
FR2989088B1 (fr) * 2012-04-04 2014-08-29 Univ Lorraine Radiotraceur pour la maladie d'alzheimer
WO2014012054A1 (en) 2012-07-13 2014-01-16 Pain Therapeutics, Inc. Alzheimer's disease assay in a living patent
GB201312499D0 (en) * 2013-07-12 2013-08-28 Isis Innovation Therapeutic compounds
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US20070111970A1 (en) 2007-05-17
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