CA2625473A1 - Compounds and methods for peptide ribonucleic acid condensate particles for rna therapeutics - Google Patents
Compounds and methods for peptide ribonucleic acid condensate particles for rna therapeutics Download PDFInfo
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- CA2625473A1 CA2625473A1 CA002625473A CA2625473A CA2625473A1 CA 2625473 A1 CA2625473 A1 CA 2625473A1 CA 002625473 A CA002625473 A CA 002625473A CA 2625473 A CA2625473 A CA 2625473A CA 2625473 A1 CA2625473 A1 CA 2625473A1
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- compound
- peptide
- sirna
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
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- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
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- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72721605P | 2005-10-14 | 2005-10-14 | |
| US60/727,216 | 2005-10-14 | ||
| US73366405P | 2005-11-04 | 2005-11-04 | |
| US60/733,664 | 2005-11-04 | ||
| US82587806P | 2006-09-15 | 2006-09-15 | |
| US60/825,878 | 2006-09-15 | ||
| PCT/US2006/040174 WO2007047482A2 (en) | 2005-10-14 | 2006-10-13 | Compounds and methods for peptide ribonucleic acid condensate particles for rna therapeutics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2625473A1 true CA2625473A1 (en) | 2007-04-26 |
Family
ID=37963128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002625473A Abandoned CA2625473A1 (en) | 2005-10-14 | 2006-10-13 | Compounds and methods for peptide ribonucleic acid condensate particles for rna therapeutics |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20100129460A1 (enExample) |
| EP (1) | EP1934360A2 (enExample) |
| JP (3) | JP5536334B2 (enExample) |
| KR (1) | KR20080061397A (enExample) |
| CN (1) | CN101331231B (enExample) |
| AU (1) | AU2006304291A1 (enExample) |
| CA (1) | CA2625473A1 (enExample) |
| MX (1) | MX2008004899A (enExample) |
| WO (1) | WO2007047482A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR069704A1 (es) | 2007-12-18 | 2010-02-10 | Alcon Res Ltd | Sistema de administracion de rnai de interferencia y usos del mismo |
| US9089610B2 (en) * | 2008-08-19 | 2015-07-28 | Nektar Therapeutics | Complexes of small-interfering nucleic acids |
| WO2010059829A2 (en) * | 2008-11-19 | 2010-05-27 | Mdrna, Inc. | Compositions and methods for triggered release rna therapeutics |
| WO2013020986A1 (de) | 2011-08-08 | 2013-02-14 | Universität Regensburg | Polyanion-nanokomplexe für therapeutische anwendungen |
| EP2623978A1 (en) | 2012-02-03 | 2013-08-07 | Charité - Universitätsmedizin Berlin | CD8+ T-cell subsets as markers for prediction of delayed fracture healing |
| US20140335192A1 (en) * | 2013-05-09 | 2014-11-13 | Kipperman, RM, Ch 7 BK Trustee for Traversa Therap | Delivery of rna interfering agents |
| AU2016335158A1 (en) * | 2015-10-05 | 2018-04-12 | Devgen Nv | Methods of preserving the biological activity of ribonucleic acids |
| EP4005634A4 (en) * | 2019-07-24 | 2023-11-08 | Tohoku University | Chimeric molecule, pharmaceutical composition, method for cleaving target nucleic acid, and kit for target nucleic acid cleavage or diagnosis |
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| GB9218164D0 (en) * | 1992-08-26 | 1992-10-14 | Applied Research Systems | Virus and substances related thereto |
| US5679559A (en) * | 1996-07-03 | 1997-10-21 | University Of Utah Research Foundation | Cationic polymer and lipoprotein-containing system for gene delivery |
| AU2281201A (en) * | 1999-12-29 | 2001-07-09 | A. James Mixson | Histidine copolymer and methods for using same |
| AU2850001A (en) * | 2000-02-07 | 2001-08-20 | Transgene S.A. | Non-naturally occurring nucleic acid compositions, their use for the preparationof formulations useful for transfecting nucleic acid into cells and applicati ons |
| WO2001095946A2 (en) * | 2000-06-14 | 2001-12-20 | Transgene S.A. | Combination product for carrying out a cytotoxic treatment in a mammal |
| WO2002027031A2 (en) * | 2000-09-28 | 2002-04-04 | Cellomics, Inc. | Methods and reagents for live-cell gene expression quantification |
| JP2004035409A (ja) * | 2002-05-15 | 2004-02-05 | Geneshuttle Biopharm Inc | ベクターとしての使用のための新規融合タンパク質 |
| US20040019008A1 (en) * | 2002-05-28 | 2004-01-29 | Lewis David L. | Compositions and processes using siRNA, amphipathic compounds and polycations |
| US20030224055A1 (en) * | 2002-05-28 | 2003-12-04 | Lewis David L. | Compositions and processes for inhibiting gene expression using polynucleotides |
| FR2841137B1 (fr) * | 2002-06-20 | 2004-08-13 | Bioalliance Pharma | Systeme de vectorisation comprenant des nanoparticules de taille homogene d'au moins un polymere et d'au moins un polysaccharide charge positivement |
| WO2004028471A2 (en) * | 2002-09-28 | 2004-04-08 | Massachusetts Institute Of Technology | Influenza therapeutic |
| AU2003219576A1 (en) * | 2003-04-03 | 2004-10-25 | Korea Advanced Institute Of Science And Technology | Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof |
| US20050136437A1 (en) * | 2003-08-25 | 2005-06-23 | Nastech Pharmaceutical Company Inc. | Nanoparticles for delivery of nucleic acids and stable double-stranded RNA |
| WO2005056752A2 (en) * | 2003-10-24 | 2005-06-23 | Gencia Corporation | Methods and compositions for delivering polynucleotides |
| WO2005071116A1 (en) * | 2004-01-22 | 2005-08-04 | University Of Massachusetts | Modulation of hsv infection |
| US8691781B2 (en) * | 2004-11-05 | 2014-04-08 | Sirnaomics, Inc. | Compositions for treating respiratory viral infections and their use |
| CN101060849A (zh) * | 2004-11-17 | 2007-10-24 | 巴尔的摩马里兰大学 | 作为有效的siRNA载体的高分支HK肽 |
| SG161267A1 (en) * | 2005-04-12 | 2010-05-27 | Intradigm Corp | Composition and methods of rnai therapeutics for treatment of cancer and other neovascularization diseases |
| US9505867B2 (en) * | 2005-05-31 | 2016-11-29 | Ecole Polytechmique Fédérale De Lausanne | Triblock copolymers for cytoplasmic delivery of gene-based drugs |
| US20070213257A1 (en) * | 2005-08-12 | 2007-09-13 | Nastech Pharmaceutical Company Inc. | Compositions and methods for complexes of nucleic acids and peptides |
-
2006
- 2006-10-13 EP EP06836308A patent/EP1934360A2/en not_active Withdrawn
- 2006-10-13 AU AU2006304291A patent/AU2006304291A1/en not_active Abandoned
- 2006-10-13 CN CN2006800468655A patent/CN101331231B/zh not_active Expired - Fee Related
- 2006-10-13 WO PCT/US2006/040174 patent/WO2007047482A2/en not_active Ceased
- 2006-10-13 MX MX2008004899A patent/MX2008004899A/es active IP Right Grant
- 2006-10-13 US US12/445,575 patent/US20100129460A1/en not_active Abandoned
- 2006-10-13 KR KR1020087011424A patent/KR20080061397A/ko not_active Withdrawn
- 2006-10-13 CA CA002625473A patent/CA2625473A1/en not_active Abandoned
- 2006-10-13 JP JP2008535735A patent/JP5536334B2/ja not_active Expired - Fee Related
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2012
- 2012-05-18 US US13/475,892 patent/US20130072424A1/en not_active Abandoned
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2014
- 2014-01-09 JP JP2014002769A patent/JP2014110796A/ja active Pending
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2015
- 2015-11-09 JP JP2015219682A patent/JP2016073290A/ja active Pending
Also Published As
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|---|---|
| CN101331231B (zh) | 2012-11-21 |
| EP1934360A2 (en) | 2008-06-25 |
| HK1130506A1 (en) | 2009-12-31 |
| US20130072424A1 (en) | 2013-03-21 |
| KR20080061397A (ko) | 2008-07-02 |
| WO2007047482A2 (en) | 2007-04-26 |
| CN101331231A (zh) | 2008-12-24 |
| US20100129460A1 (en) | 2010-05-27 |
| JP2016073290A (ja) | 2016-05-12 |
| JP2014110796A (ja) | 2014-06-19 |
| WO2007047482A3 (en) | 2007-11-29 |
| AU2006304291A1 (en) | 2007-04-26 |
| JP5536334B2 (ja) | 2014-07-02 |
| WO2007047482B1 (en) | 2008-01-17 |
| MX2008004899A (es) | 2008-09-04 |
| JP2009511600A (ja) | 2009-03-19 |
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