CA2613126A1 - Use of mas g-protein-coupled receptor agonists and antagonists as apoptotic activity modulators for prevention and treatment of diseases - Google Patents

Use of mas g-protein-coupled receptor agonists and antagonists as apoptotic activity modulators for prevention and treatment of diseases Download PDF

Info

Publication number
CA2613126A1
CA2613126A1 CA002613126A CA2613126A CA2613126A1 CA 2613126 A1 CA2613126 A1 CA 2613126A1 CA 002613126 A CA002613126 A CA 002613126A CA 2613126 A CA2613126 A CA 2613126A CA 2613126 A1 CA2613126 A1 CA 2613126A1
Authority
CA
Canada
Prior art keywords
mas
protein
antagonists
diseases
peptidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002613126A
Other languages
English (en)
French (fr)
Inventor
Robson Augusto Souza Dos Santos
Sergio Veloso Brant Pinheiro
Raphael De Faria E Silva
Ivana Silva Lula
Frederico Barros De Sousa
Frederic Jean Georges Frezard
Adelina Martha Dos Reis
Luiz Renato De Franca
Anderson Jose Ferreira
Ruben Dario Sinisterra
Maria Jose Campagnole-Santos
Walkyria Neyde De Oliveira Sampaio
Marcelo De Castro Leal
Lenice Kappes Becker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade Federal de Minas Gerais
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2613126A1 publication Critical patent/CA2613126A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/085Angiotensins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002613126A 2005-06-28 2006-06-28 Use of mas g-protein-coupled receptor agonists and antagonists as apoptotic activity modulators for prevention and treatment of diseases Abandoned CA2613126A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BRPI0502497-8A BRPI0502497A (pt) 2005-06-28 2005-06-28 uso de agonistas e antagonistas do receptor acoplado a proteìna g, mas, como moduladores de atividade apoptótica para o estudo, a prevenção e o tratamento de doenças
BRPI0502497-8 2005-06-28
PCT/BR2006/000125 WO2007000036A2 (en) 2005-06-28 2006-06-28 Use of mas g-protein-coupled receptor agonists and antagonists as apoptotic activity modulators for prevention and treatment of diseases

Publications (1)

Publication Number Publication Date
CA2613126A1 true CA2613126A1 (en) 2007-01-04

Family

ID=37595483

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002613126A Abandoned CA2613126A1 (en) 2005-06-28 2006-06-28 Use of mas g-protein-coupled receptor agonists and antagonists as apoptotic activity modulators for prevention and treatment of diseases

Country Status (7)

Country Link
US (1) US20080312129A1 (https=)
EP (1) EP1904087A2 (https=)
JP (3) JP2008546811A (https=)
CN (1) CN101247818A (https=)
BR (1) BRPI0502497A (https=)
CA (1) CA2613126A1 (https=)
WO (1) WO2007000036A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10172908B2 (en) 2013-07-03 2019-01-08 Arizona Board Of Regents For The University Of Arizona Method for treating cognitive dysfunction
CN116355856A (zh) * 2023-04-19 2023-06-30 陕西慧康生物科技有限责任公司 一种人mas1过表达细胞株及其构建方法和应用

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0602366B1 (pt) 2006-04-26 2017-12-12 Universidade Federal De Minas Gerais Use of agonists of the receptor coupled to protein g, but, in the treatment of metabolic syndrome, its components and their complications
WO2008052295A1 (en) * 2006-10-30 2008-05-08 Universidade Federal De Minas Gerais Process for the preparation of compounds of at1 receptor antagonists with angiotensin-(1-7), analogues thereof and/or mixtures of these systems, pharmaceutical compositions thereof and use of their derivative products
WO2008089532A1 (en) * 2007-01-26 2008-07-31 Universidade Federal De Minas Gerais - Ufmg Pharmaceutical compositions and methods for treating erectile dysfunction
BRPI0800585B8 (pt) 2008-02-13 2021-05-25 Univ Minas Gerais composições farmacêuticas do peptídeo des-[asp1]-[ala1]-angiotensina-(1-7) e uso do peptídeo des-[asp1]-[ala1]-angiotensina-(1-7)
EP2163259B1 (en) 2008-09-12 2012-06-13 Charité-Universitätsmedizin Berlin (Charité) Use of an Ang-(1-7) receptor agonist in acute lung injury
DE102009013456A1 (de) * 2009-03-18 2010-09-23 GÖPFERICH, Achim, Prof. Dr. Nanopartikel für die Erkennung von Zellen, durch Bindung an G-Protein gekoppelte Rezeptoren
CN102337298B (zh) * 2011-08-19 2013-11-06 黄开红 一种输送siRNA的免疫纳米载体及其制备方法和应用
KR20140140546A (ko) * 2012-02-10 2014-12-09 타릭스 파마슈티컬스 엘티디. 말초 혈관 질환의 치료를 위한 조성물 및 방법
US8557958B1 (en) 2012-06-18 2013-10-15 Tarix Pharmaceuticals Ltd. Compositions and methods for treatment of diabetes
US8633158B1 (en) 2012-10-02 2014-01-21 Tarix Pharmaceuticals Ltd. Angiotensin in treating brain conditions
BR132012028005E2 (pt) * 2012-10-31 2014-11-18 Univ Minas Gerais Composições farmacêuticas contendo um agonista do receptor mas para o tratamento de doenças degenerativas musculares.
US9333233B2 (en) 2014-02-25 2016-05-10 Tarix Pharmaceuticals Ltd. Methods and compositions for the delayed treatment of stroke
US9796759B2 (en) 2014-07-21 2017-10-24 Arizona Board Of Regents On Behalf Of The University Of Arizona Ang-(1-7) derivative oligopeptides and methods for using and producing the same
US10183055B2 (en) 2014-07-21 2019-01-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications
CN113207799B (zh) * 2021-03-19 2022-03-15 中山大学 一种二型糖尿病小鼠快速心衰模型的构建方法
EP4371556A1 (en) 2022-11-15 2024-05-22 Explicat Pharma GmbH Angiotensin(1-7) pharmaceutical compositions for inhalation

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989363B1 (en) * 1997-12-11 2006-01-24 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
US6548302B1 (en) * 1998-06-18 2003-04-15 Johns Hopkins University School Of Medicine Polymers for delivery of nucleic acids
US6236766B1 (en) * 1998-09-11 2001-05-22 General Electric Company Method and apparatus for zooming digital images
EP1117426B1 (en) * 1998-10-02 2005-12-07 Caritas St. Elizabeth's Medical Center of Boston, Inc. Akt compositions for enhancing survival of cardiomyocytes
WO2000023100A2 (en) * 1998-10-22 2000-04-27 Curagen Corporation Genes and proteins predictive and therapeutic for renal disease and associated disorders
WO2000061141A2 (en) * 1999-04-09 2000-10-19 Au Jessie L S Methods and compositions for enhancing delivery of therapeutic agents to tissues
YU78601A (sh) * 1999-05-05 2005-07-19 Aventis Pharma Deutschland Gmbh. 1-(p-tienilbenzil)-imidazoli kao agonisti angiotenzin-(1-7)- receptora, postupak za njihovu proizvodnju, njihova primena i farmaceutski preparati koji ih sadrže
WO2000071584A1 (en) * 1999-05-20 2000-11-30 Human Genome Sciences, Inc. Seven transmembrane receptor genes
EP1268783B9 (en) * 2000-03-29 2007-01-17 Beth Israel Deaconess Medical Center, Inc. Antiangiogene Eigenschaften von Matin und Fragmenten oder Varianten davon
JP2003532623A (ja) * 2000-06-30 2003-11-05 バイエル アクチェンゲゼルシャフト 抗脈管形成性アンジオテンシン−7およびそれをコードするポリヌクレオチドを使用することによる脈管形成の調節方法
EP1346221B1 (en) * 2000-12-22 2006-03-08 AstraZeneca AB A method of assaying for agonists or antagonist of dynorphin a binding to the mas receptor
BRPI0105509B8 (pt) * 2001-11-05 2021-05-25 Univ Minas Gerais formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga
WO2003072059A2 (en) * 2002-02-27 2003-09-04 Wake Forest University Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth
WO2006005470A2 (en) * 2004-07-15 2006-01-19 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with mas related g-protein coupled receptor e (mrge)
BRPI0503122A (pt) * 2005-05-30 2007-05-02 Univ Minas Gerais composições farmacêuticas do peptìdeo angiotensina-(1-7) [ang-(1-7)] e seus análogos, agonistas e antagonistas usando as ciclodextrinas, seus derivados, e o polìmeros biodegradáveis e/ou dos produtos derivados para uso no controle das funções do sistema reprodutivo

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10172908B2 (en) 2013-07-03 2019-01-08 Arizona Board Of Regents For The University Of Arizona Method for treating cognitive dysfunction
CN116355856A (zh) * 2023-04-19 2023-06-30 陕西慧康生物科技有限责任公司 一种人mas1过表达细胞株及其构建方法和应用

Also Published As

Publication number Publication date
JP2013075911A (ja) 2013-04-25
WO2007000036A3 (en) 2007-05-18
US20080312129A1 (en) 2008-12-18
BRPI0502497A (pt) 2007-02-06
WO2007000036A2 (en) 2007-01-04
JP2008546811A (ja) 2008-12-25
JP2017114901A (ja) 2017-06-29
EP1904087A2 (en) 2008-04-02
CN101247818A (zh) 2008-08-20

Similar Documents

Publication Publication Date Title
JP2017114901A (ja) 病気の研究、予防及び治療のためのアポトーシス活性調節剤としての、mas g−タンパク質結合受容体アゴニスト及びアンタゴニストの使用
Pagliaro et al. Rethinking the renin-angiotensin system and its role in cardiovascular regulation
Xu et al. ACE2/ANG-(1–7)/Mas pathway in the brain: the axis of good
Dinh et al. Angiotensin receptors: distribution, signalling and function
Senzaki et al. Cardiac phosphodiesterase 5 (cGMP‐specific) modulates β‐adrenergic signaling in vivo and is down‐regulated in heart failure
EP2163259B1 (en) Use of an Ang-(1-7) receptor agonist in acute lung injury
Bader et al. Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research
Lazartigues et al. The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases
Steckelings et al. The Renin—Angiotensin—Aldosterone System
Kuruvilla et al. Molecular mechanisms in endothelial regulation of cardiac function
Wong et al. Genetic and pharmacological dissection of pathways involved in the angiotensin II‐mediated depression of baroreflex function
CA2699597C (en) Treatment of cardiovascular disorders using the cell differentiation signaling protein nell1
Diz Bradykinin and related peptides in central control of the cardiovascular system
Levens et al. Could the pharmacological differences observed between angiotensin II antagonists and inhibitors of angiotensin converting enzyme be clinically beneficial?
Zhang et al. Embryonic and uterine expression patterns of peptidylglycine α-amidating monooxygenase transcripts suggest a widespread role for amidated peptides in development
HK1124247A (en) Use of mas g-protein-coupled receptor agonists and antagonists as apoptotic activity modulators for prevention and treatment of diseases
Qadri et al. C-and N-Terminal Angiotensin Fragments: Vasopressin Release and Drinking.
US20140296143A1 (en) Angiotensin-(1-7) As A Chemoprevention Agent
Luft The Bothrops legacy: vasoactive peptides from Brazil
Raynolds et al. The role of genetic variants in angiotensin I converting enzyme, angiotensinogen and the angiotensin II type-1 receptor in the pathophysiology of heart muscle disease
Greenberg Cardiac remodeling
Abdelalim et al. Immunohistochemical mapping of natriuretic peptide receptor-A in the brainstem of Macaca fascicularis
de Jonge et al. Controlling cardiomyocyte survival
Yáñez Bisbe Role of TRPV4 channels in adverse cardiac remodelling
WO2006128266A2 (en) Pharmaceutical compositions of the peptide angiotensin-(1 -7) [ang-(i -7)] and its analogues, agonists and antagonists, for use in controlling the functions of the reproductive system

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20160629