CA2608752A1 - Formulations for alteration of biophysical properties of mucosal lining - Google Patents
Formulations for alteration of biophysical properties of mucosal lining Download PDFInfo
- Publication number
- CA2608752A1 CA2608752A1 CA002608752A CA2608752A CA2608752A1 CA 2608752 A1 CA2608752 A1 CA 2608752A1 CA 002608752 A CA002608752 A CA 002608752A CA 2608752 A CA2608752 A CA 2608752A CA 2608752 A1 CA2608752 A1 CA 2608752A1
- Authority
- CA
- Canada
- Prior art keywords
- formulation
- sodium
- mucosal lining
- administered
- formulations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 179
- 238000009472 formulation Methods 0.000 title claims abstract description 172
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- 239000002245 particle Substances 0.000 claims abstract description 85
- 238000000034 method Methods 0.000 claims abstract description 32
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- 241001465754 Metazoa Species 0.000 claims abstract description 25
- 244000052769 pathogen Species 0.000 claims abstract description 25
- 239000012530 fluid Substances 0.000 claims abstract description 17
- 150000003839 salts Chemical class 0.000 claims abstract description 14
- 208000001797 obstructive sleep apnea Diseases 0.000 claims abstract description 12
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 11
- 239000013543 active substance Substances 0.000 claims abstract description 10
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- 208000002551 irritable bowel syndrome Diseases 0.000 claims abstract description 10
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 10
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- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 9
- 239000002563 ionic surfactant Substances 0.000 claims abstract description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 63
- 235000002639 sodium chloride Nutrition 0.000 claims description 44
- 239000000243 solution Substances 0.000 claims description 36
- 239000011780 sodium chloride Substances 0.000 claims description 32
- 239000000443 aerosol Substances 0.000 claims description 31
- 230000001965 increasing effect Effects 0.000 claims description 18
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 17
- 239000000843 powder Substances 0.000 claims description 14
- 210000002345 respiratory system Anatomy 0.000 claims description 13
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- 150000001793 charged compounds Chemical class 0.000 claims description 11
- -1 vapors Substances 0.000 claims description 9
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 8
- 239000001110 calcium chloride Substances 0.000 claims description 8
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 8
- 235000011148 calcium chloride Nutrition 0.000 claims description 7
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 7
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- 229910021538 borax Inorganic materials 0.000 claims description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 4
- 239000007900 aqueous suspension Substances 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
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- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- 210000000056 organ Anatomy 0.000 claims description 3
- TXUICONDJPYNPY-UHFFFAOYSA-N (1,10,13-trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) heptanoate Chemical compound C1CC2CC(=O)C=C(C)C2(C)C2C1C1CCC(OC(=O)CCCCCC)C1(C)CC2 TXUICONDJPYNPY-UHFFFAOYSA-N 0.000 claims description 2
- GSHCNPAEDNETGJ-HKOLQMFGSA-N 2-[2,3-bis[[(z)-octadec-9-enoyl]oxy]propoxy-ethoxyphosphoryl]oxyethyl-trimethylazanium Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(=O)(OCC)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC GSHCNPAEDNETGJ-HKOLQMFGSA-N 0.000 claims description 2
- 229910021555 Chromium Chloride Inorganic materials 0.000 claims description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 2
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 2
- 239000004115 Sodium Silicate Substances 0.000 claims description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims description 2
- 229910021626 Tin(II) chloride Inorganic materials 0.000 claims description 2
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims description 2
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- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims description 2
- 239000004227 calcium gluconate Substances 0.000 claims description 2
- 235000013927 calcium gluconate Nutrition 0.000 claims description 2
- 229960004494 calcium gluconate Drugs 0.000 claims description 2
- 239000001506 calcium phosphate Substances 0.000 claims description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
- 235000011010 calcium phosphates Nutrition 0.000 claims description 2
- MCFVRESNTICQSJ-RJNTXXOISA-L calcium sorbate Chemical compound [Ca+2].C\C=C\C=C\C([O-])=O.C\C=C\C=C\C([O-])=O MCFVRESNTICQSJ-RJNTXXOISA-L 0.000 claims description 2
- 235000010244 calcium sorbate Nutrition 0.000 claims description 2
- 239000004303 calcium sorbate Substances 0.000 claims description 2
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 2
- 235000013539 calcium stearate Nutrition 0.000 claims description 2
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- 229940095672 calcium sulfate Drugs 0.000 claims description 2
- 235000011132 calcium sulphate Nutrition 0.000 claims description 2
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 2
- QSWDMMVNRMROPK-UHFFFAOYSA-K chromium(3+) trichloride Chemical compound [Cl-].[Cl-].[Cl-].[Cr+3] QSWDMMVNRMROPK-UHFFFAOYSA-K 0.000 claims description 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 2
- 229910000366 copper(II) sulfate Inorganic materials 0.000 claims description 2
- GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 claims description 2
- 208000001848 dysentery Diseases 0.000 claims description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 2
- 239000001095 magnesium carbonate Substances 0.000 claims description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 2
- 235000014380 magnesium carbonate Nutrition 0.000 claims description 2
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- 229940037627 magnesium lauryl sulfate Drugs 0.000 claims description 2
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- 229940099273 magnesium trisilicate Drugs 0.000 claims description 2
- 229910000386 magnesium trisilicate Inorganic materials 0.000 claims description 2
- HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 claims description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 2
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- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
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- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 2
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- 235000010408 potassium alginate Nutrition 0.000 claims description 2
- 239000000737 potassium alginate Substances 0.000 claims description 2
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 claims description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 2
- 235000010235 potassium benzoate Nutrition 0.000 claims description 2
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- DJEHXEMURTVAOE-UHFFFAOYSA-M potassium bisulfite Chemical compound [K+].OS([O-])=O DJEHXEMURTVAOE-UHFFFAOYSA-M 0.000 claims description 2
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- 239000001508 potassium citrate Substances 0.000 claims description 2
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- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 2
- 235000011082 potassium citrates Nutrition 0.000 claims description 2
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims description 2
- 235000010259 potassium hydrogen sulphite Nutrition 0.000 claims description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
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| US20050207983A1 (en) | 2004-03-05 | 2005-09-22 | Pulmatrix, Inc. | Formulations decreasing particle exhalation |
| ES2379775T3 (es) * | 2009-03-26 | 2012-05-03 | Pulmatrix, Inc. | Formulaciones farmacéuticas y métodos para tratar infecciones del aparato respiratorio |
| JP2012522009A (ja) * | 2009-03-26 | 2012-09-20 | パルマトリックス，インコーポレイテッド | 肺炎および人工呼吸器関連気管気管支炎を治療および予防するための方法 |
| WO2010111650A2 (en) * | 2009-03-26 | 2010-09-30 | Pulmatrix, Inc. | Calcium citrate and calcium lactate formulations for alteration of biophysical properties of mucosal lining |
| CN102448438A (zh) * | 2009-03-26 | 2012-05-09 | 普马特里克斯公司 | 抗流行性感冒调配物及方法 |
| KR101639098B1 (ko) * | 2009-03-26 | 2016-07-12 | 풀매트릭스 오퍼레이팅 컴퍼니, 인크 | 폐 질환 치료용 건조 분말 제형 및 방법 |
| US9061352B2 (en) | 2010-08-30 | 2015-06-23 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
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-
2006
- 2006-05-18 EP EP10014830A patent/EP2308469A1/en not_active Withdrawn
- 2006-05-18 US US11/419,165 patent/US20070053844A1/en not_active Abandoned
- 2006-05-18 NZ NZ593475A patent/NZ593475A/xx unknown
- 2006-05-18 EP EP06770654A patent/EP1906922A2/en not_active Withdrawn
- 2006-05-18 NZ NZ564110A patent/NZ564110A/en unknown
- 2006-05-18 WO PCT/US2006/019443 patent/WO2006125153A2/en not_active Ceased
- 2006-05-18 CA CA002608752A patent/CA2608752A1/en not_active Abandoned
- 2006-05-18 BR BRPI0609924-6A patent/BRPI0609924A2/pt not_active IP Right Cessation
- 2006-05-18 JP JP2008512543A patent/JP2008540680A/ja active Pending
- 2006-05-18 AU AU2006247077A patent/AU2006247077A1/en not_active Abandoned
- 2006-05-18 CN CNA2006800261749A patent/CN101237853A/zh active Pending
- 2006-05-18 EP EP11177874A patent/EP2402001A1/en not_active Withdrawn
- 2006-05-18 EA EA200702520A patent/EA016072B1/ru not_active IP Right Cessation
- 2006-05-18 KR KR1020077027567A patent/KR20080018872A/ko not_active Ceased
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| Publication number | Publication date |
|---|---|
| EP1906922A2 (en) | 2008-04-09 |
| US20150196589A1 (en) | 2015-07-16 |
| CN101237853A (zh) | 2008-08-06 |
| EA016072B1 (ru) | 2012-01-30 |
| KR20080018872A (ko) | 2008-02-28 |
| JP2012176990A (ja) | 2012-09-13 |
| WO2006125153A2 (en) | 2006-11-23 |
| US20070053844A1 (en) | 2007-03-08 |
| EP2402001A1 (en) | 2012-01-04 |
| AU2006247077A1 (en) | 2006-11-23 |
| WO2006125153A3 (en) | 2008-02-28 |
| BRPI0609924A2 (pt) | 2010-05-11 |
| NZ593475A (en) | 2012-12-21 |
| IL187427A0 (en) | 2011-08-01 |
| NO20076086L (no) | 2008-02-14 |
| NZ564110A (en) | 2010-06-25 |
| EP2308469A1 (en) | 2011-04-13 |
| EA200702520A1 (ru) | 2008-06-30 |
| JP2008540680A (ja) | 2008-11-20 |
| CN102327285A (zh) | 2012-01-25 |
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